Researchers have developed a new sensing device using nanomotors to detect chemicals at extremely low concentrations and high contamination. This technology has the potential to facilitate early disease diagnosis and treatment, such as cancer detection.
A major breakthrough in treating geographic atrophy, a form of age-related macular degeneration, has been made by University of Kentucky researchers. The discovery highlights the role of the NLRP3 inflammasome and MyD88 in triggering vision loss due to retinal pigmented epithelial cell death.
A recent study published in the Annals of Behavioral Medicine reveals that survivors of multiple cancers exhibit poorer physical and mental health status compared to those with a single cancer diagnosis. These individuals also engage in more unhealthy behaviors, such as smoking and excessive alcohol consumption.
A study by University of Kentucky researchers found that colorectal cancer screening rates were higher in the Appalachian population with multiple morbidities compared to those with no morbidities. The study revealed a dose-response relationship between the number of morbidities and the prevalence of colon cancer screening.
Researchers at the University of Kentucky have identified a key protein interaction that promotes metastasis in triple-negative breast cancer. Snail interacts with G9a to suppress E-cadherin expression, which is critical for cell adhesion and preventing tumor spread.
A recent study published in the Journal of Clinical Neurophysiology found that physiological problems from concussions can last longer than symptoms, even after standard testing subside. MEPs showed delays in response time and smaller size, which continued until day 10, with these changes increasing as symptoms decreased.
A pilot study shows promise for analyzing bladder pain syndrome by analyzing cells shed into the urine, providing a noninvasive alternative to bladder biopsies. The results show distinct gene signatures for inflammation in patients with Hunner lesions, similar to those found in previous studies of bladder biopsies.
A UK study provides insight into the relationship between manganese superoxide dismutase (MnSOD) and cancer progression. The research found that MnSOD expression was suppressed early in skin carcinogenesis but increased at late stages, highlighting its role as a p53-regulated gene.
A new study has found that an autoinjector pen is a faster and more effective way to treat serious seizures, with 73% of patients becoming seizure-free upon arrival at the hospital. The treatment involves delivering medication directly into the thigh muscle via intramuscular injection, reducing precious time for paramedics.
Researchers found that patients with initial metastatic breast cancer tend to be older and have lower-grade tumors, while those with early relapse after treatment are younger and have more aggressive cancer. The study emphasizes the importance of increasing awareness about breast care and the need for novel therapeutic strategies to im...
A new study found that applying vaginal progesterone to women at risk of preterm birth significantly decreased the odds of premature delivery. The treatment was effective in reducing both early and late preterm births, as well as hospitalizations and complications.
A large study group of Kentucky women found that only 30% were receiving warfarin for atrial fibrillation. The study suggests warfarin anticoagulation treatment is underutilized in this population, but not due to economic or educational disparities.
Researchers will collect cancer incidence data from 13 Appalachian states to identify differences in relative survival and avoidable death between sub-regions and non-Appalachian areas. The findings will inform the development of effective evidence-based cancer control interventions for the region.
A study led by the University of Kentucky found that hospice family caregivers experience 'second-order patient' stress due to caregiving tasks and emotional impact. Researchers recommend routine care interventions to address these unique needs and improve caregiver outcomes.
Researchers discovered a statistically significant association between occupational exposure to trichloroethylene, percholorethylene, and carbon tetrachloride and an increased risk of developing Parkinson's disease. The study suggests a lag time of up to 40 years between exposure and onset of the disease.
Researchers suggest that transfusion may not be the best treatment for hospitalized patients with anemia, as the age of stored blood may contribute to negative effects. Studies found that transfusions do not always restore levels of sphingosine 1-phosphate (S1P), a lipid mediator required for maintaining blood vessel integrity.
New research by University of Kentucky investigators found that short-interfering RNAs can induce retinal degeneration via TLR3 and IRF3. This discovery highlights the need for caution when designing or using siRNAs intended for eye treatment.
A University of Kentucky research team, led by Dr. Susanne Arnold, has been awarded a $1.43 million grant to investigate potential environmental factors contributing to the high lung cancer rates in Eastern Kentucky. The study will examine exposure to trace elements and their role in promoting carcinogenesis.
A novel alloy has been developed that can produce hydrogen fuel from sunlight using photoelectrochemical water splitting. The GaN-Sb alloy, made of inexpensive materials, functions as a catalyst in the process and can be reused indefinitely. This discovery could potentially have profound implications for the future of solar energy.
Researchers discovered the expression of cancer-killer SAC-GFP activity in bone marrow cells after transplantation, suggesting successful transfer and colonization of anti-cancer tissue. The study shows promise for treating primary and metastatic tumors with genetically modified stem cells that secrete potent Par-4/SAC killer proteins.
The University of Kentucky Sanders-Brown Center on Aging is receiving over $7 million from the National Institute on Aging to continue its research and clinical initiatives focused on treating Alzheimer's disease. The funding will support ongoing programs, including telemedicine services, brain donation, and outreach efforts.
A new study suggests that increases in public health spending result in healthier people, particularly in communities with limited resources. Communities investing more in local public health activities saw significant reductions in mortality from preventable causes of death.
A recent study by the University of Kentucky found that smoke-free legislation does not negatively influence local economies in either rural or urban communities. The study, which examined economic data from 2001-2009, showed that smoke-free laws are good for business regardless of location.
The University of Kentucky has received a $20 million grant from the National Institutes of Health to enhance its clinical and translational science programs. The funding will support research initiatives, educational programs, and community engagement, ultimately leading to improved health outcomes for Kentuckians and beyond.
A study published in Pediatric Pulmonology found that azithromycin can reduce the risk of bronchopulmonary dysplasia in preterm infants colonized or infected with Ureaplasma bacteria. The treatment showed a 21% reduction in BPD development and death rates in treated infants, compared to placebo.
Researchers have discovered that polymers of amino acid lysine can block the propagation of prions, halting their spread in test tubes and cultured cells. In animal models, mice treated with polylysines showed improved symptoms, longer survival, and lower prion levels
Hippocampal sclerosis (HS-AGING) is a serious condition causing cognitive decline and impaired memory in aged persons. Researchers analyzed autopsy data from 1,100 individuals to define HS-AGING as a distinct disease entity.
A team of researchers led by Dr. Jayakrishna Ambati has discovered a molecular mechanism implicated in geographic atrophy, the major cause of untreatable blindness in the industrialized world. The study identified Alu RNA toxicity as the underlying cause and developed two potential therapies to prevent geographic atrophy.
Researchers at University of Kentucky Sanders-Brown Center on Aging are developing a treatment for Alzheimer's disease by targeting the protein kinase p38alphaMAPK. Their goal is to suppress overactive production of pro-inflammatory cytokines, which disrupt brain function in people with Alzheimer's.
Researchers at the University of Kentucky have discovered that plasminogen accelerates prion disease progression. The study identifies plasminogen as a potential therapeutic target for prion diseases, which could improve treatment options for patients.
A University of Kentucky study found changes in white matter connections in high-risk Alzheimer's patients before symptoms manifest. The research used MRI to assess microstructural integrity of axons and myelin in the brains of high- and low-risk groups.
Researchers at the University of Kentucky Markey Cancer Center have discovered a key molecular mechanism behind breast tumor cell spread. The finding focuses on Snail's interaction with LSD1 enzyme, which regulates DNA structure and shuts down E-cadherin gene expression, leading to metastasis.
A University of Kentucky researcher is studying respiratory weakness as a factor in ICU morbidity, which can lead to prolonged stays and lengthy recovery times. The study aims to develop new treatments that could slow down muscle wasting and reduce reliance on mechanical ventilation.
Scientists at the University of Kentucky have discovered that withaferin A can simultaneously target two key proteins, vimentin and GFAP, implicated in reactive gliosis. This finding could lead to new treatments for diseases such as multiple sclerosis, Alzheimer's disease, stroke, and traumatic brain injury.
Researchers at the University of Kentucky have identified a visible response to head trauma called the 'fencing response,' which can indicate damage to brainstem regions. This finding has immediate value for coaches and trainers, as it provides an objective cue to assess whether an athlete should return to play after a blow to the head.
The University of Kentucky Center for Public Health Systems and Services Research has received a $600,000 grant to create an integrated dataset that will provide researchers with access to critical information to inform translational practice decisions. The dataset will combine survey data from various organizations, enabling users to ...
A new UK-based study published in the Journal of the American Dietetic Association found that meal replacements aided substantial weight loss among obese patients, with Medically Supervised participants losing an average of 43.4 pounds over 19 weeks.
A new molecule known as soluble VEGFR-2 has been identified that selectively blocks lymphatic vessel growth but not blood vessel growth. This breakthrough could lead to targeted treatments for diseases such as lymphedema, transplant rejection, and tumor metastasis.
Researchers at the University of Kentucky discovered that tumor-suppressor protein Par-4 is secreted by most human and rodent cells and can target large numbers of cancer cells by binding to receptors on the cell surface.
A novel DNA repair pathway, referred to as DNA hairpin repair (HPR), targets TNR hairpin removal in the daughter strand to ensure fidelity of TNR sequences. This finding may be responsible for TNR instability in diseases such as Huntington's disease.
A team of researchers led by Dr. Jayakrishna Ambati at the University of Kentucky has discovered a biological marker for neovascular age-related macular degeneration (AMD). The marker, CCR3, shows strong potential as a means for both early detection and preventive treatment.
A new study by Dr. Jayakrishna Ambati and colleagues found that the siRNA treatment is toxic to both blood and lymphatic endothelial cells, with potential applications in cornea transplantation and treatment of lymphatic diseases.
Researchers have discovered a genetic mutation that offers protection against age-related macular degeneration (AMD), a leading cause of blindness in adults over 50. The study identifies a functional link between toll-like receptor 3 (TLR3) and geographic atrophy, a type of dry AMD.
A study of 600 adolescent girls found that 90% experienced sexual harassment, with varying levels of reporting depending on age, socioeconomic status, and exposure to feminist ideas. Girls who felt pressure to conform to gender stereotypes or were unhappy with traditional roles were more likely to report sexism.
The University of Kentucky Center for the Study of Violence Against Children hosts a national scientific meeting on child mental health, featuring research presentations on violence against children and trauma. The event showcases findings on relational poverty, early experiences, and psychotherapy's effects on adult brains.
A study by University of Kentucky researchers found that targeted mass media campaigns can be successful alone in convincing young adults to adopt safer sex practices. The campaign effectively increased condom use and intentions to use condoms, resulting in a significant reduction in unprotected sex occasions.
A UK physician's groundbreaking study reveals that siRNA therapies may have unintended consequences, such as blocking blood vessel growth in various organs. This discovery underscores the need for cautious approach in clinical trials using gene silencing technology.
A meta-analysis conducted at the University of Kentucky found Transcendental Meditation to be an effective treatment for controlling high blood pressure, with significant reductions in systolic and diastolic blood pressure.
Researchers say a solution for atherosclerosis is many years away due to the complex disease process, which involves genetics, metabolism, and inflammation. Huge investments of time and money are needed to develop effective therapies.
Researchers at University of Kentucky discovered that aliskiren, a new blood pressure medication, significantly reduces artery-clogging lesions and lowers blood pressure. The study's findings contribute to the understanding of the underlying disease causing heart attack and stroke.