The study found a substantial increase of 230% in colon cancer screenings among Medicaid patients post-ACA expansion. Additionally, data showed a 9.3% rise in early-stage colon cancer diagnosis and a 27% decrease in risk of death.
The $2.3 million NIH grant will support Innovative Programs for Enhancing Research Training (IPERT), a mentorship program aimed at increasing diversity in science and health care. The project will provide grant-writing and teaching skills training to faculty from minority-serving institutions.
A new study published in the Journal of Hepatology has identified a pathway connecting some antiretroviral (ARV) drugs with liver disease. The research suggests that ARV drugs interact with the pregnane X receptor, stimulating fatty acid uptake and cholesterol synthesis in the liver.
Researchers at the University of Kentucky have assembled the axolotl genome, a salamander that can regrow body parts. The completed genome will help scientists understand how this animal achieves its remarkable regenerative abilities.
Astronomers have developed a massive library of star spectra, enabling them to reconstruct the composition and history of distant galaxies. By analyzing thousands of stars in our Milky Way galaxy, researchers can build up a "library" of stellar spectra, allowing them to understand the unique mix of stars that makes up each galaxy.
The proposal calls for pharmaceutical companies to collect post-marketing data in all minority groups, classifying responsiveness based on ethnicity. Package labelling should include efficacy data from minority populations.
Researchers found that a ketogenic diet improved neurovascular function and reduced neurodegeneration risk in young healthy mice. The diet also showed beneficial effects on the microbiome, blood glucose levels, and body weight.
A new study suggests targeting collagen XIII could suppress breast cancer metastasis by enhancing anoikis resistance in cancer cells. Researchers found that collagen XIII expression is significantly higher in cancerous human breast tissue and necessary for metastasis in mouse models.
A four-year, $6 million project aims to reduce stalk lodging in corn and sorghum using mathematical modeling and innovative technology. The team plans to breed stronger plants that can withstand various environmental factors, potentially increasing global food production by up to a billion people.
Researchers at the University of Kentucky have discovered a potential target for treating epilepsy seizures: cPLA2, an enzyme that contributes to blood-brain barrier dysfunction. Blocking this enzyme may prevent changes in barrier leakage, offering new hope for patients who do not respond well to current medications.
A multi-arm, placebo-controlled study showed that ACE inhibitors and beta blockers can significantly offset the risk of heart problems for patients with HER2-positive breast cancer. The data demonstrated a significant reduction in cardiotoxicity for patients on these medications who received doxorubicin before Herceptin.
Researchers found that repurposed leukemia drugs can inhibit the secretion of pro-metastatic cathepsins in melanoma. This is due to ABL kinases increasing activity, which regulates transcription factors and induces gene expression. The study also showed that approved leukemia drug inhibitors prevent metastasis.
Researchers are using a unique imaging technique, Quest MRI, to study the earliest signs of Alzheimer's disease in mice. The technique measures oxidative stress in specific brain regions over time and has shown promise as a potential biomarker for AD.
A recent study published in Sexuality & Culture explores how LGBQ* women's sexual desire is influenced by sociocultural factors such as sexism, religion, and body image. The research reveals that these factors have a significant impact on the lives of LGBQ* women, particularly those who identify as women of color or bisexual.
A recent study published in Cancer journal shows that communities with strong smoke-free workplace laws have lower rates of new lung cancer diagnoses. The study found an eight percent reduction in lung cancer incidence in communities with strong smoke-free laws compared to those without such laws.
Researchers at University of Kentucky have developed an after-school program to help children with ADHD succeed academically and build confidence. The program uses small group activities and explicit comprehension strategies to improve academic performance.
Researchers developed a novel rare earth recovery process that recovered over 80% of the elements present in coal sources and produced more than 80% total rare earth elements on a dry whole mass basis. The concentrates contained critical elements like neodymium and yttrium, representing over 45% of the total concentrate.
A UK study published in Scientific Reports has identified a novel cell signaling interaction that may prevent a key step in lung cancer progression. The research, conducted by the University of Kentucky, found that microRNA molecules can alter TGFβ activity and prevent epithelial-mesenchymal transition, a critical process in metastasis.
A team of researchers is working on a computer software that can deliver better therapies for patients with life-threatening heart failure. The computer model will take MRI or genetic data of a patient and build a multiscale simulation of their heart, leading to more personalized treatment plans.
Jessica Blackburn, a University of Kentucky Markey Cancer Center researcher, has received a $1.5 million NIH New Innovator Award to study leukemia relapse in zebrafish models and patient samples.
Cancer survivors experience significant cognitive impairment due to chemotherapy, which can impact multitasking, memory and concentration. Researchers are developing strategies to prevent this condition without reducing chemotherapy efficacy, aiming to improve quality of life for millions of cancer patients.
Researchers identified a 'killer peptide' released by therapy-sensitive cancer cells, which can kill therapy-resistant cells and inhibit metastasis. The peptide enters only cancer cells, preserving healthy tissue.
A UK plant pathologist has uncovered an important genetic link to the devastating wheat blast fungus. The research found that a mutation in a key gene allows the fungus to escape wheat resistance, compromising crop yields and sparking global efforts to breed blast-resistant wheat.
A team of UK and Argentinean chemists developed a catalyst that mimics the Z-scheme mechanism of photosynthesis, reducing atmospheric CO2 levels. The catalyst, combining cuprous oxide and titanium dioxide, transfers electrons to CO2 while breaking water molecules.
Researchers at the University of Kentucky discovered that macrophages play a crucial role in complex tissue regeneration in mammals. The team found that specific subtypes of macrophages are required for regeneration, which could lead to novel clinical approaches to restore damaged tissue in humans.
A team of researchers has found a way to achieve the highly sought-after tetragonal phase of hafnia, a material for computer chips and transistors, at 1100 degrees Fahrenheit. This breakthrough could lead to more powerful and efficient electronics.
The University of Kentucky has been awarded a $11.2 million grant to establish a new center for cancer and metabolism research. The Center for Cancer and Metabolism will focus on understanding the link between dysfunctional metabolism and cancer, with the goal of developing novel therapies.
A recent study by University of Kentucky researchers found a 12-13% lower rate of sexual violence victimization in schools that implemented the Green Dot program, resulting in 120 fewer sexually violent events. The five-year program, funded by CDC and partnering with local organizations, was shown to be cost-effective and culturally im...
A recent study by University of Kentucky researchers found that nearly half of patients with early dementia or mild cognitive impairment reported positive scores on the Silver Lining Questionnaire, indicating improved personal relationships and increased appreciation for life. The results challenge the stereotype of depression and desp...
A new study found that a standard protocol for physical therapy in ICU patients with acute respiratory failure did not shorten hospital length of stay. However, the test group showed improved physical function and health-related quality of life at six months post-discharge.
A new class of galaxies called 'red geysers' has been discovered, hosting low-energy supermassive black holes that drive intense interstellar winds. These winds suppress star formation by heating up the ambient gas in galaxies and preventing it from cooling and condensing into stars.
A recent study published in NeuroImage found a positive correlation between fitness and increased blood flow to areas of the brain where Alzheimer's pathology is usually first detected. Regular physical activity, regardless of age, may provide some protection from dementia.
A UK study published in Nature reveals neurotensin as a potential biological marker for the development of obesity. Neurotensin, produced mainly in the gastrointestinal tract and central nervous system, is released with fat ingestion and stimulates fatty acid absorption in the intestine.
The discovery of three new mouse lemur species in Madagascar highlights the need for conservation efforts to protect these tiny primates. The study, which used advanced statistical methods, provides insight into the evolutionary process and has significant implications for clarifying diversity in other species.
Researchers discovered two signaling chemicals travel through the same opening between cells, while a third chemical takes a distinct route into neighboring cells. This knowledge may lead to new strategies for protecting crops from pathogens.
A new one-atom-thick flat material made of silicon, boron, and nitrogen has been discovered by University of Kentucky physicist Madhu Menon. The material is extremely stable, a property lacking in many graphene alternatives, and can be fine-tuned to suit various applications.
The University of Kentucky researcher has helped draft a comprehensive position paper on nutrition and athletic performance, synthesizing over eight years of research to provide evidence-based recommendations for athletes. The paper emphasizes the need for individualized nutrition plans that account for various factors affecting athlet...
Researchers have identified a potential treatment for traumatic brain injury (TBI) by targeting the inflammatory response. The experimental drug MW151 appears to dampen down detrimental inflammatory responses without suppressing the normal functions cells need to maintain health.
The program aims to attract and support underrepresented groups in geosciences. Students will participate in field work, hands-on activities, and dual-credit courses to explore four career options.
The University of Kentucky has received $6 million in funding to further develop a potential treatment for cocaine abuse. The project, led by Professor Chang-Guo Zhan, aims to create a novel enzyme that can neutralize cocaine in the bloodstream using molecular modeling technology.
The International Society of Neurogastronomy Symposium brought together scientists, chefs, and patients to explore ways to improve quality of life for those with altered taste or smell. Chefs and neuroscientists collaborated on the 'Applied Neurogastronomy Challenge' to create dishes that appealed to cancer patients.
Bingbang Xiang discovered that platelets play a protective role in severe sepsis by producing anti-inflammatory agents to prevent immune cells from becoming too active. His findings suggest that platelet transfusions may be effective for treating severely septic patients.
UK researchers find tissue cysts of Toxoplasma gondii are active, contradicting long-held notion of dormancy. This discovery has significant implications for understanding chronic toxoplasmosis in the brain and its connection to neurological diseases.
A £500,000 National Cancer Institute grant has enabled UK researcher Fredrick Onono to explore the potential connection between high-fat diets and breast cancer development. The study may uncover how fats contribute to cell malfunctions, potentially leading to treatment-resistant cases.
The University of Kentucky's Dr. John D'Orazio is leading a 3-year research project on melanoma, the deadliest form of skin cancer, with a focus on hormonal pathways and DNA repair. The study aims to understand how specific hormones affect melanocortin1 receptor signaling, which is linked to an increased risk of developing melanoma.
Researchers at the University of Kentucky have identified a new mechanism for targeting multi-subunit complexes that are critical to viral, bacterial, or cancer function, reducing drug resistance. This approach could lead to more potent drugs with fewer side effects.
Researchers discovered differences in brain inflammation between people with Down syndrome and Alzheimer's disease alone. The study found higher levels of inflammatory markers M2b in Down syndrome-related Alzheimer's, highlighting the need for tailored treatments.
A University of Kentucky researcher is developing an artificial blood technology for mosquitoes, which can help sustain colonies in resource-limited areas and combat diseases like malaria. The approach involves sterilizing mosquitoes using a bacterium and has already shown promising results in controlling Asian tiger mosquito populations.
A new study suggests that a key prostaglandin metabolic enzyme, 15-PGDH, shows promise as a drug target for tissue regeneration. Researchers discovered an inhibitor, SW033291, which blocks 15-PGDH, leading to increased PGE2 levels and enhanced tissue regeneration.
Researchers discovered a molecular mechanism that contributes to age-related macular degeneration due to excessive iron accumulation in retinal cells. Excessive iron impairs the processing of inflammatory RNAs, leading to inflammasome-mediated cell death.