Researchers from University of Miami Miller School of Medicine's John P. Hussman Institute for Human Genomics are studying genetic factors contributing to Alzheimer's disease risk. The institute is expanding research to include African-American populations, a diverse and underrepresented group in Alzheimer's disease research.
Researchers identified a small-molecule inhibitor that disrupted the recruitment of Mastermind-like protein 1 to the Notch transcription complex, inhibiting cancer cell growth and supressing tumor growth in mouse xenograft studies. This discovery represents a new paradigm for Notch-based anticancer therapeutics.
Researchers at Sylvester Comprehensive Cancer Center identified a novel treatment option for triple-negative breast cancer (TNBC) by targeting vitamin D and androgen receptors. This approach showed promising results in reducing the sustainability of cancer cells, offering new hope for patients with this aggressive form of breast cancer.
A new study shows success with a combination therapy of the sugar 2-Deoxy-D-glucose (2-DG) and fenofibrate, which selectively starves slow-growing cancer cells while sparing normal cells. This approach eliminates toxic chemotherapy side effects, paving the way for non-toxic treatments for various cancers.
Researchers at Sylvester Comprehensive Cancer Center have developed an animal model of multiple myeloma, allowing them to better understand its mechanisms and test potential treatments. The study has the potential to improve outcomes for patients with this incurable disease.
A new UM study found that higher levels of neighborhood greenness are linked to a significant reduction in chronic illnesses, particularly in low-to-middle income neighborhoods. The study showed a 14% risk reduction for diabetes and hypertension, and 10% reduction for lipid disorders.
A recent study discovered that microRNA miR-181a suppresses tumor cell proliferation and survival in highly aggressive large B-cell lymphomas by reducing NFkappaB signaling. This finding provides hope for developing novel therapies targeting this pathway.
A new biomarker, PRAME mRNA, has been identified as a key indicator of high-risk uveal melanoma patients who are more likely to develop metastasis. This discovery may lead to the development of precision medicines for melanoma patients.
A new study by University of Miami researchers identified a potential connection between attention-deficit/hyperactivity disorder (ADHD) and increased academic expectations in young children. The study found that rising academic demands since the 1970s may have contributed to the doubling of ADHD diagnoses over the past four decades.
Researchers found African-American children and adolescents with Hodgkin lymphoma had significantly lower overall survival rates at 25 years compared to their white and Hispanic counterparts. The study, published in Pediatric Blood & Cancer, analyzed data from over 7,800 patients across Florida and the US.
Research links dry eye to multiple chronic pain conditions, including neuropathic ocular pain. A multidisciplinary approach may benefit dry eye patients with underlying pain issues.
A new study by Sylvester researchers describes the immune system's response to tumor development, highlighting the stimulator of interferon genes (STING) signaling pathway's potential suppression of colorectal cancer. Impaired STING responses may enable damaged cells to evade the immune system.
Researchers from Sylvester Comprehensive Cancer Center are presenting their latest hematology research at the American Society of Hematology (ASH) Annual Meeting. Highlights include the discovery of a potent inhibitor of Lysine demethylase Lsd-1, which augments pro-differentiation effects in acute myeloid leukemia (AML), and targeting ...