Researchers found that umbilical cord-derived mesenchymal stem cell infusions safely reduce the risk of death and quicken recovery time for severe COVID-19 patients. Patient survival at one month was 91% in the treatment group versus 42% in the control group.
Several patients using germicidal lamps developed painful inflammation of the cornea after exposure, prompting warnings from ophthalmologists. Manufacturer recommendations must be closely followed to prevent injury.
Sylvester researchers have identified a potential protein target, STING, that may help mitigate graft versus host disease in stem cell transplants. In preclinical models, inhibiting the STING pathway reduced symptoms of GVHD.
A recent study suggests that coronary calcium scoring can guide personalized preventive care for individuals with moderate cardiovascular risk. The test identifies calcium deposits in the arteries, indicating atherosclerosis and high heart attack and stroke risk.
The COVID-19 pandemic exacerbates existing difficulties for individuals with autism, including communication barriers, sensory issues, and stress. Researchers recommend healthcare providers train staff to recognize signs of autism and adapt care strategies to ensure safe and optimal treatment.
Researchers investigate DPP4 enzyme inhibition as a possible treatment for coronavirus. Preliminary studies suggest that inhibiting the DPP4 enzyme could effectively treat COVID-19, offering new hope for treatment options.
A study published in the American Heart Association journal Hypertension finds no credible evidence that ARBs increase COVID-19 susceptibility. Discontinuing these medications would pose significant health risks for patients with hypertension and chronic kidney disease.
A recent animal study found that adding L-serine to the diet of vervets exposed to cyanotoxin BMAA significantly reduced signs of ALS-like pathology. The study provides a promising model for understanding ALS development and potential treatments.
A new study published in Cortex journal reveals that visual rehabilitation therapy improved vision in almost 80% of stroke and traumatic brain injury patients. The NeuroEyeCoach therapy was shown to improve daily activities, such as navigating surroundings, identifying obstacles, and avoiding collisions.
A new study found that cyberbullying significantly increases symptoms of post-traumatic stress disorder (PTSD), depression, anger, and fantasy dissociation among young people. Participants who reported being cyberbullied also showed higher levels of lifetime emotional abuse.
A University of Miami study has found that the profiles of genes influencing cognition are similar across people with schizophrenia, bipolar disorder, and the general population. This discovery could lead to more effective therapies for improving cognitive function in patients with severe mental illness.
A new study led by a University of Miami neurologist found that sleep disturbances among Hispanics may increase their risk of cognitive impairment and Alzheimer's disease. Insomnia and prolonged sleep duration were linked to declines in memory, executive function, and processing speed, which can precede the onset of dementia.
The University of Miami will track cardiovascular and pulmonary disease in men and women with HIV, exploring differences between sexes. The seven-year study aims to understand comorbid conditions and their impact on people with HIV infection.
The National Cancer Institute has recognized Sylvester Comprehensive Cancer Center as a top-tier US cancer center due to its outstanding research and clinical care. The designation is a testament to the dedication of every member of the cancer center.
A study published in Neurology found that having a bigger waistline and high BMI in the 60s is associated with greater signs of brain aging. The study suggests that obesity accelerates brain aging, which can increase the risk of Alzheimer's disease by at least a decade.
A new study identifies a 'midlife crisis' in human molecular aging, where key longevity programs cease functioning after 50 years. Researchers found that humans use the same biochemical pathways as short-lived animals but stop using them from about age 50.
A University of Miami medical team reported acute neurosensory symptoms in 25 US diplomats who experienced severe symptoms after exposure to a unique sound and pressure phenomenon. The study found evidence of balance disorders, cognitive dysfunction, and psychological issues, which do not resemble traumatic brain injury.
A study of 28 middle school and high school students found that they take on significant responsibilities in managing medications, often without formal education. The investigation also highlights the importance of recognizing and supporting youth caregivers to promote their well-being and contribute to patient care.
The article discusses the challenges in managing common ankle fractures, particularly those above and below the level of the syndesmosis. Researchers recommend assessing medial clear space on radiographs and patient pain ratings to guide management. They also emphasize the importance of dynamic imaging with stress radiographs to detect...
Researchers have devised a novel strategy to identify people with mild cognitive impairment at risk of developing Alzheimer's disease. The Loewenstein-Acevedo Scales for Semantic Interference and Learning (LASSI-L) tool measures specific memory deficits that align with imaging findings for abnormal brain amyloid accumulation.
The NIH grant will support research on biological treatments and clinical diagnosis for patients with hearing loss, a condition affecting over 28 million Americans. Xue Zhong Liu's team will expand a genomic database and assess the impact of genomic testing on patients.
A pre-clinical pilot study found that a combination therapy of CBD and an NMDA antagonist improved cognitive functions and showed no adverse effects in animals. Researchers believe this treatment could reduce symptoms associated with concussion, traumatic brain injury, and post-injury brain cell inflammation.
Researchers from the University of Miami Miller School of Medicine used an HPV vaccine as an off-label treatment for a patient with advanced squamous cell carcinoma. The patient's tumors completely resolved after direct intratumoral injections, providing promising results in this innovative approach to skin cancer treatment.
A new UM study reveals that ornamental bromeliad plants contribute to the breeding of the Aedes aegypti mosquito, a key culprit behind vector-borne diseases like Zika. The study found that water retained in bromeliads' leaf axils becomes breeding sites for mosquitoes.
Cardiovascular expert Robert Myerburg argues that routine electrocardiogram (ECG) screening for asymptomatic adults may not be effective in improving health outcomes due to high false positive rates. For higher-risk patients, he advocates for focusing on treatable risk factors and individualized risk assessment.
The University of Miami Miller School of Medicine's Department of Otolaryngology-Head and Neck Surgery has received a National Institutes of Health (NIH) research training grant, providing funding for interdisciplinary research training in otolaryngology. The five-year grant will support individual awardees with research training in ba...
A collaborative study led by the University of Miami Miller School of Medicine found that a monoclonal antibody cocktail therapy was effective in clearing the virus from pregnant women's blood but failed to prevent fetal transmission and treat infected fetuses. Researchers are now working on engineering antibodies to target the fetus.
A collaborative study has found that a combination of three monoclonal antibodies prevents Zika virus infection in primates. The treatment completely blocked the virus from taking hold in the animals, indicating a promising intervention to protect uninfected pregnant women and their fetuses.
The SRK-015 antibody program demonstrated beneficial effects in a preclinical model of spinal cord injury, reducing muscle atrophy, fat infiltration, and improving muscle function. The findings support the potential of SRK-015 to address unmet needs in treating degenerative neuromuscular conditions.
A novel study found that cortical targets can be used to enhance hand motor output in humans with spinal cord injury, showing improved force and electromyographic activity. The research provides new insights into the potential of cortical targets for rehabilitation therapies targeting beneficial plasticity.
TET2 mutations are found in various blood cancers, including myelodysplastic syndrome and acute myeloid leukemia. The enzyme plays a crucial role in controlling gene expression, and its loss allows other genes to mutate, creating conditions for cancer to thrive.
A new study finds gunshot wounds in Miami-Dade County cluster in poor, black neighborhoods, with a fatality rate of 15.4%. The researchers call for urgent community engagement and prevention strategies to reduce firearm violence.
Scientists at Sylvester Comprehensive Cancer Center have found that p300 protein acts as a tumor suppressor, preventing myelodysplastic syndrome (MDS) from developing into acute myeloid leukemia (AML). Eliminating p300 in mice results in rapid leukemia development.
Researchers are exploring whether two over-the-counter medications can diminish alcohol abuse in diagnosed bipolar patients. A five-year clinical trial is currently underway to assess the effectiveness of citicoline and pregnenolone in treating alcohol-use disorders in people with bipolar disorder.
The University of Miami's Miami project successfully completes a Phase I clinical trial of schwann cell transplantation to treat spinal cord injuries. The trial demonstrates the safety and feasibility of transplanting autologous human Schwann cells to repair damaged spinal cords.
The University of Miami announces the creation of the Frost Institutes for Science and Engineering, a global network focused on scientific discovery and innovation. The initiative aims to elevate STEM fields and attract top scientists to address pressing global issues.
A multidisciplinary team of University of Miami physicians published a case study detailing the nation's first locally-transmitted case of Zika. The study highlights the skin rash associated with the virus and its potential implications for future Zika screening and diagnoses.
Researchers have discovered that Dab2 controls a population of fat stem cells that slowly disappears with maturity. This finding may reinforce the importance of steering children away from high-fat diets and lead to new pharmaceutical strategies to combat childhood obesity.
Scientists have discovered a potential biomarker, GHRH-R, for gastric cancer, which can aid in earlier diagnoses and better staging. The team also found that the GHRH-R antagonist MIA-602 inhibited gastric cancer growth in cell lines and human xenografts.
Researchers at the University of Miami are investigating a combination of CBD and NMDA antagonist to reduce brain inflammation and symptoms associated with concussion. The goal is to develop a clinically proven medication to treat cognitive and emotional consequences of single and repetitive brain injuries.
Researchers discovered that certain proteins associated with Alzheimer's disease are stored in dormant cancer cells as amyloid bodies. Disaggregation of these bodies can reactivate the cancer cells. The study identified ribosomal intergenic noncoding RNA as a target for drug discovery to prevent amyloid body disaggregation.
Researchers developed an objective test to diagnose mild traumatic brain injury (mTBI) using the I-Portal goggle, achieving 95% specificity and 89% sensitivity. This technology has the potential to revolutionize concussion diagnosis and treatment in sports, leading to better outcomes for athletes.
Researchers at Sylvester Comprehensive Cancer Center have identified a receptor that slows breast cancer metastasis when targeted. By blocking the receptor for advanced glycation end-products (RAGE), scientists decreased tumor growth, reduced angiogenesis and inflammation, resulting in lower metastatic rates to the lung and liver.
Researchers at Sylvester Comprehensive Cancer Center have identified two leukemia-targeting drugs that could be used to treat breast and ovarian cancers by inhibiting HDACs. The study's genetically engineered cell line, BPLER, exhibited key traits associated with cancer stem cells and showed long-lasting effects of the inhibitors.
A new study maps zones most prone to sea level rise impacts in South Florida, identifying socially and economically vulnerable communities at risk. The research provides a foundation for adaptation and mitigation planning, informing regional resilience efforts.
A new study published in Preventing Chronic Disease suggests that incorporating walking meetings into the workday can significantly increase physical activity levels among white-collar workers. By converting one seated meeting per week to a walking meeting, participants reported a 10-minute increase in work-related physical activity.
Researchers from University of Miami Miller School of Medicine's John P. Hussman Institute for Human Genomics are studying genetic factors contributing to Alzheimer's disease risk. The institute is expanding research to include African-American populations, a diverse and underrepresented group in Alzheimer's disease research.
Researchers identified a small-molecule inhibitor that disrupted the recruitment of Mastermind-like protein 1 to the Notch transcription complex, inhibiting cancer cell growth and supressing tumor growth in mouse xenograft studies. This discovery represents a new paradigm for Notch-based anticancer therapeutics.
Researchers at Sylvester Comprehensive Cancer Center identified a novel treatment option for triple-negative breast cancer (TNBC) by targeting vitamin D and androgen receptors. This approach showed promising results in reducing the sustainability of cancer cells, offering new hope for patients with this aggressive form of breast cancer.
A new study shows success with a combination therapy of the sugar 2-Deoxy-D-glucose (2-DG) and fenofibrate, which selectively starves slow-growing cancer cells while sparing normal cells. This approach eliminates toxic chemotherapy side effects, paving the way for non-toxic treatments for various cancers.