Articles tagged with Chemotherapy
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Studies presented at the WCLC confirm that targeted therapies have improved efficacy and prolonged progression-free survival time compared to chemotherapy. Patients with EGFR mutations who received gefitinib experienced longer progression-free survival and greater objective response rates, while erlotinib showed prolonged progression-f...
Researchers developed a novel therapeutic delivery system that targets EphA2 protein in ovarian cancer cells, delivering chemotherapy with high specificity and reducing tumor growth by up to 98%. The therapy shows promising results in preclinical models and is expected to enter phase I clinical trials soon.
A novel immunoconjugate targeting EphA2 protein shows substantial antitumor activity in ovarian cancer cell lines and mice. The agent inhibits tumor growth by 85% compared to control, with significant effects on proliferation and apoptosis.
Researchers from Université de Montréal and McGill University have engineered an enzyme that resists harmful agents like methotrexate, a breakthrough in treating genetic diseases. The study's discovery provides new avenues for therapies to combat conditions like leukemia.
A new trial shows that chemotherapy plus radiotherapy, either with or without surgery, are viable options for patients with stage IIIA (N2) non-small-cell lung cancer. The treatment improved overall survival and progression-free survival rates compared to standard concurrent chemotherapy and radiotherapy alone.
A study by MU researchers found that cancer survivors experience mild decreases in skills like verbal fluency and problem-solving ability, impacting their daily lives. The researchers identified specific interventions, such as pharmaceuticals and cognitive behavior techniques, to help patients manage these challenges.
Scientists at Stanford University School of Medicine have created fluorescent probes that can noninvasively image apoptosis in living tumors, allowing for the gauge of treatment effectiveness. The probes bind exclusively to caspases, enzymes regulating cell death, and respond with light emission, highlighting dying cells.
A new chemotherapy regimen, ABVE-PC, has been identified as a successful treatment for pediatric Hodgkin lymphoma, reducing long-term risks and improving survival rates. The treatment delivers dose-dense drug delivery while minimizing cumulative doses, resulting in lower toxicity and improved outcomes.
A study by Columbia University's Mailman School of Public Health found that elderly women with localized breast cancer are less likely to receive chemotherapy, with only 15% receiving treatment. In contrast, younger women with nonmetastatic breast cancer received adjuvant chemotherapy at a rate of 70%.
A new study from the University of Michigan Comprehensive Cancer Center found that a single round of chemotherapy can identify patients most likely to benefit from preserving their speech. After three years, 78% of T4 study participants were still alive and 58% had an intact larynx.
Survival rates for placental-site trophoblastic tumours (PSTTs) vary depending on how long ago the related pregnancy occurred. The study found that patients with stage I disease had a 10-year probability of overall survival of 90%, while those with recurrent disease or disease resistant to treatment had poor survival.
The report emphasizes the importance of identifying specific types of breast cancer and tailoring treatment to individual patients. It recommends adjuvant endocrine therapy for most patients with oestrogen receptor-positive tumours, anti-HER2 therapy for HER2-positive disease, and chemotherapy for triple-negative disease.
Researchers design a minimally invasive system combining ultrasound and chemotherapy to target brain tumors without surgery or radiation. The approach aims to provide real-time imaging and localized temperature increases to melt liposome shells and release chemotherapy directly to the tumor.
UCF researcher J. Manuel Perez's nanoparticles could potentially replace chemotherapy with targeted cancer treatment. The nanoparticles, carrying Taxol and other molecules, selectively target cancer cells while leaving healthy tissue intact.
Researchers found that applying a chemotherapy medication to the face reduced actinic keratoses by 87% and improved signs of aging. The treatment also showed promise in addressing photo-aging, with patients reporting improved skin appearance and willingness to undergo therapy again.
A study from Northwestern University found that Cremophor-based paclitaxel caused life-threatening allergic reactions in 38% of patients, leading to 109 deaths. The solvent is believed to trigger severe reactions, even in patients with premedication.
The I-SPY trial offers critical insights into locally advanced breast cancer, emphasizing the importance of not ignoring growing breast masses. The study found that most interval cancers are discovered between routine mammogram exams, suggesting a need for better screening strategies.
Researchers identified a way to boost cisplatin's effectiveness by targeting DNA repair proteins in cancer cells. Attenuating the function of RAD50 protein complex sensitizes human tumor cells to cisplatin-based chemotherapy.
Researchers found that adding gefinitib to standard chemotherapy improved tolerability in advanced head and neck cancer patients, but did not increase survival rates. The combination therapy showed potential in delaying the spread of the disease.
A new study reveals that combining chemotherapy agents with 5FU increases disease-free survival for patients under 70, but does not provide similar benefits for those aged 70 and older. The research found that the aggressive treatment strategy is better tolerated by younger patients, while older patients may experience more side effects.
Researchers at the University of Michigan have developed a new understanding of how chromosomes separate during mitosis, a crucial process in cell division. By manipulating chromosome size and observing its effect on movement, they validated the theory that polar ejection forces play a central role in guiding chromosome movements.
The shift towards oral chemotherapy agents poses risks of non-adherence, which can lead to increased healthcare costs and reduced efficacy. Studies show that non-adherence is often linked to financial constraints, education issues, and side effects, highlighting the need for innovative strategies to improve patient compliance.
A national survey reveals that nearly all oncologists and ID specialists are highly concerned about the negative impact of infection on treatment outcomes in chemotherapy patients. Infections among chemotherapy patients are common, with one in four patients experiencing an infection in the last 12 months.
AT-101, a cottonseed-derived compound, has shown promise in treating glioblastoma multiforme by halting the growth of tumor cells. The treatment, which must be properly dosed and monitored, has been effective in slowing cancer progression in many patients, offering new hope for those with this aggressive form of brain cancer.
Research from Northwestern University found Abraxane effectively prevents metastatic breast cancer progression and has fewer side effects compared to Taxotere. The study prolonged progression-free survival by almost seven months.
Researchers at Boston University School of Medicine found that conventional methods to adjust for confounding, such as restriction and multivariable regression, leave residual confounding because of unmeasured factors. Propensity scores and instrumental variable methods have limitations in resolving confounding by indication.
Researchers at Northwestern University have developed a Nanofountain Probe that can precisely deliver tiny doses of drug-carrying nanomaterials to individual cells. The tool enables targeted cancer treatments and improves drug delivery by reducing side effects and increasing targeting accuracy.
A study found that 45% of older women with early-stage breast cancer choose chemotherapy, higher than the national average. The researchers suggest that these women are weighing risks and benefits more thoroughly, making informed decisions about their treatment.
A study by M. D. Anderson Cancer Center researchers found that over one-third of metastatic breast cancer patients receive chemotherapy off-label, with 34.9% of women treated with an unapproved drug at some point during their care. The most common off-label chemotherapies noted were vinorelbine and gemcitabine, both shown to be efficac...
Researchers at the Mayo Clinic have found a triple drug combination to be an effective and tolerable option for treating metastatic HER2+ breast cancer. The regimen, which combines capecitabine, vinorelbine, and trastuzumab, has shown promising results in reducing tumor size and improving survival rates compared to traditional treatments.
A Phase II/III study found that ginger supplements, taken three days prior to and after chemotherapy, reduced nausea levels in cancer patients by 40%. The study included 644 participants who received at least three chemotherapy treatments and showed significant anti-vomiting effects.
A recent study found that chemotherapy in addition to surgery or radiation improves survival rates among older women with early-stage breast cancer. Combination therapy showed significantly better outcomes than single-drug treatment, with a 17% higher relapse-free survival rate at three years.
A Phase III trial found that adding casopitant mesylate to a conventional two-drug regimen significantly reduced chemotherapy-induced nausea and vomiting events. The study showed that 86% of patients achieved complete response with the new regimen compared to 66% with the placebo.
A phase III study found that adding cetuximab to standard chemotherapy for non-small-cell lung cancer (NSCLC) extends survival by almost one month compared to chemotherapy alone. The treatment has been shown to target epidermal growth factor receptor, which plays a key role in tumour growth.
Researchers found hypofractionated stereotactic radiotherapy improved symptoms and survival time in patients with recurrent low-grade glioma. The treatment was well-tolerated and allowed patients to complete the full course of therapy.
A new combination of chemotherapy drugs, topotecan and docetaxel, has produced clinical benefit for patients with recurrent gynecologic cancers. The treatment showed an unusually high proportion of women experiencing clinical benefit, with a median survival time of 18.5 months.
A study at Duke University Medical Center has led to the development of a new technique that uses light scattering to determine whether chemotherapy is working. The method, called angle-resolved low coherence interferometry, measures changes in cellular structure following treatment with chemotherapeutic agents.
Researchers at UCLA's Jonsson Comprehensive Cancer Center have developed a non-invasive method to determine whether chemotherapy is working after a single treatment cycle, allowing oncologists to discontinue ineffective treatments sooner. This breakthrough enables faster decision-making and potentially improves patient outcomes.
A new study by researchers at the University of Michigan Comprehensive Cancer Center found that higher doses of radiation combined with chemotherapy improve survival in patients with stage III lung cancer. Concurrent chemotherapy increases treatment effectiveness and overall survival rates.
Researchers at NC State University have discovered that a molecule found in soy, genistein, can inhibit the growth of canine lymphoma cells. The study's findings suggest that this compound could be used to enhance traditional cancer treatments like chemotherapy, leading to reduced stress and costs for dog owners.
DHA reduces tumour size and enhances chemotherapy's effects while limiting its harmful side effects, according to a new study. The researchers call for greater deployment of omega-3s in the fight against cancer.
Researchers developed mouse models of human acute myeloid leukemia (AML) that accurately predict response to chemotherapy and identify key genes promoting resistance or sensitivity. These models provide valuable insights into AML's genetic heterogeneity and may help redesign therapy for maximum benefit.
A randomized controlled trial found that a 3-drug chemotherapy combination of docetaxel, cisplatin, and 5-fluorouracil (TPF) increased organ preservation rates in patients with locally advanced larynx cancer. Compared to the single-agent TPF, the addition of docetaxel improved larynx function and overall response rates.
Researchers reviewed data on Japanese herbal medicines and found them to be effective in reducing symptoms of functional dyspepsia, constipation, and postoperative ileus. The use of standardized formulations of herbal medicines requires further examination for their health benefits.
A national study of over 700 patients will measure the cost and clinical effectiveness of acupressure wrist bands in reducing chemotherapy-related nausea. The device aims to provide a drug-free alternative for a debilitating symptom that affects quality of life, social life, and mental health.
Researchers found that blocking dual leucine zipper kinase (DLK) gene may help prevent degeneration of ailing nerve cell branches, a potential trigger for painful neuropathy. The study could lead to the development of a drug to spare cancer patients considerable pain during chemotherapy.
A new study has found that maintenance rituximab therapy improves progression-free survival in patients with stage III-IV indolent lymphoma. The treatment showed significant benefits, including a 22% improvement in disease response and a 68% three-year progression-free survival rate.
The EORTC-NCIC trial found that adding chemotherapy to radiotherapy significantly increases survival in glioblastoma patients, with improved outcomes seen across all clinical prognostic subgroups. The study suggests testing tumour MGMT gene methylation status to identify patients most likely to benefit from this treatment.
The IU Simon Cancer Center has launched a new web site section providing information on diagnosis, treatments, and unexpected symptoms for cancer patients. The section, funded by the Walther Cancer Foundation, aims to improve patient support and communication between patients and healthcare providers.
Researchers have developed a new drug delivery technology that targets cancer cells specifically, leaving surrounding healthy cells intact. The technology utilizes tiny bubbles containing therapeutic drugs to deliver medication directly to cancer cells, enhancing treatment effectiveness and reducing side effects.
A new study published in The Lancet Oncology found that azacitidine significantly improves the survival of patients with high-risk forms of myelodysplastic syndromes (MDS). Patients treated with azacitidine had a median overall survival of 24.5 months, compared to 15 months for those receiving conventional care.
A new method uses circulating tumour cells to monitor disease status and predict survival in patients with advanced prostate cancer. Changes in CTC number before and after treatment are strongly associated with risk, making it a more predictive biomarker than PSA.
Patients with relapsed follicular lymphoma who continue on maintenance rituximab therapy after chemotherapy have better overall survival than those without treatment. Rituximab maintenance therapy was associated with a 40% improvement in overall survival relative to observation or retreatment.
Researchers at USC found that green tea extract (GTE) renders the cancer drug Velcade ineffective in treating multiple myeloma and mantle cell lymphoma. The study suggests that patients on Velcade should avoid green tea products to minimize side effects, which may be misattributed to the supplement's beneficial effects.
A new genomic signature has been developed to predict how breast cancer patients respond to chemotherapy. The study found that the magnitude of the tumor's microenvironment, or reactive stroma, is predictive of a response to treatment. Patients with strong stroma reactions are more likely to have a bad response.
UCLA researchers have created a non-invasive probe that enables real-time monitoring of chemotherapy drug activity in living bodies. This allows doctors to quickly pinpoint the most effective treatment and personalize it to each patient's unique biochemistry, reducing wasted time and toxic side effects.
Researchers describe a technique to determine tumor blood vessel leakiness using digital mammography, allowing prediction of chemotherapy efficacy. The method is closely correlated with the ability of clinically approved chemotherapy agents to enter tumors.
Researchers developed an imaging method to analyze thousands of living cells and reveal how a chemotherapy drug affects each one. They identified two proteins, DDX5 and RFC1, that play a role in cancer cell survival and boosted the effectiveness of current drugs.
Scientists at St. Jude Children's Research Hospital discovered 102 inherited genetic variations that affect chemotherapy response in acute lymphoblastic leukemia. These variations can help predict early treatment success and identify potential targets for novel drugs.
A randomized controlled trial found that alternating cycles of chemotherapy and radiation have similar outcomes to sequential chemotherapy followed by radiation in treating larynx cancer. The study showed no significant difference in clinical outcomes between the two treatment groups.