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Life Sciences

Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.

447,757 articles | 2542 topics

Health and Medicine

Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.

431,843 articles | 751 topics

Social Sciences

Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.

260,756 articles | 745 topics

Physical Sciences

Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.

257,913 articles | 1552 topics

Applied Sciences and Engineering

Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.

225,386 articles | 998 topics

Scientific Community

Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.

193,043 articles | 157 topics

Space Sciences

Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.

29,662 articles | 175 topics

Research Methods

Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.

21,889 articles | 139 topics

Mathematics

Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.

3,023 articles | 113 topics

Vaccine with University of Rochester roots saves thousands from illness

The Prevnar vaccine, developed at the University of Rochester, has shown remarkable real-world effectiveness in reducing invasive pneumococcal infections by 69% among children under two years old. This translates to approximately 20,000 fewer cases of infection each year in the United States.

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VA increasing flu immunization rate

The study found that vaccinated elderly patients were 48% less likely to die during the 1998-99 season and 50% less likely to die during the 1999-2000 season. Additionally, vaccinated patients were less likely to develop pneumonia, cardiac disease, and stroke, confirming previous VA research on flu shots' life-saving benefits.

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NIAID expands vaccine testing network

The National Institute of Allergy and Infectious Diseases (NIAID) has expanded its vaccine testing network, which has been a national resource for vaccine development since 1962. The new network will test vaccines against potential agents of bioterrorism and assess emerging hypotheses about vaccine-related adverse side effects.

Mathematical analysis could aid flu vaccine selection

Researchers at Princeton University developed a mathematical method to predict the coming year's flu strain based on previous years' genetic sequences. The approach identified clusters of genetically similar viruses that tend to dominate in each season, with an accuracy rate comparable to existing methods.

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Alzheimer's disease and exposure to vaccines

A study by René Verreault and colleagues found that past vaccine exposure was associated with a reduced risk of developing Alzheimer's disease. The researchers used multivariate logistic regressions to compare vaccinated and non-vaccinated subjects, adjusting for age, sex, and education.

Landmark smallpox vaccine study underway

A new study is testing a diluted form of the traditional smallpox vaccine, aiming to increase available doses. Participants will receive either the full or reduced dose and be monitored for signs of successful vaccination.

Rural residents less likely to use preventive health services

Residents from rural areas are less likely to receive preventive health services compared to urban residents, largely due to limited access to healthcare facilities, specialists, and insurance. Cultural factors such as traditional values and reluctance to seek medical care may also contribute to this disparity.

The case for and against flu vaccination programs

A Canadian Medical Association Journal article explores the pros and cons of Ontario's no-cost flu vaccine program, which aims to ease pressure on emergency services. Experts argue that while the program may be a step forward in influenza control, its effectiveness and cost-effectiveness are uncertain.

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Inactivated flu vaccine linked to fewer medical visits than intranasal vaccine

A study found that inactivated flu vaccine (TIV) was associated with lower health care visits and hospitalizations for pneumonia and influenza compared to the intranasal live attenuated influenza vaccine (LAIV) among US military personnel. TIV may be more effective than LAIV in preventing morbidity in highly immunized adult populations.

Beliefs act as barriers to flu immunization

A study found that concerns about unknown ingredients, inconvenience, and previous side effects are major barriers to flu immunization. Addressing these concerns through outreach efforts and physician-patient interactions can increase vaccination rates in low-income populations.

Stress levels can affect success of pneumonia vaccinations

A recent study from Ohio State University found that stress levels can weaken the immune system's response to pneumonia vaccinations. After six months, vaccinated individuals who were highly stressed showed a weaker immune response compared to those with lower stress levels.

Flu vaccine still needed

A University of Michigan professor suggests that flu vaccines should be administered when available to prevent lost work days and reduce physician visits, even if not cost-effective for working adults. The vaccine may have a greater impact on the elderly, who are more prone to complications.

DNA-based flu vaccine raises protective immunity

A DNA-based flu vaccine has shown promising results in a mouse study, generating high levels of neutralizing antibodies and providing protection at a lower dose. The vaccine combines C3d with HA glycoprotein, priming the immune system against influenza.

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Nasal spray vaccine against unexpected flu strain

The nasal spray flu vaccine protected young children against the A/Sydney flu strain with an 86% efficacy rate, reducing disease severity and middle-ear infections. The two-year study showed overall protection of 92% and significant cross-protection against other strains.

Costs of influenza in children higher than previously thought

A new study found that flu in children results in substantial use of outpatient medical resources, including 10 physician visits and over half resulting in antibiotic prescriptions. The study suggests that recommending an annual flu vaccine for all children could be a cost-effective national policy.

Inhaled drug useful in preventing flu

A new study by University of Michigan professor Dr. Arnold S. Monto found that zanamivir, an antiviral drug, is 67% effective in preventing laboratory-confirmed clinical influenza infection. The drug was also shown to be 84% effective in preventing laboratory-confirmed illnesses with fever.

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Study Defines Scope Of Vaccine-Preventable Infections

A study conducted in India found that pneumococcal serotypes 1, 6, 19, and others were commonly prevalent, with type-1 found in 25% of cases. The researchers also discovered high rates of antibiotic resistance among S. pneumoniae, particularly in urban areas.

Study Highlights Flu Risks For Women With Chronic Illness

A new study found that women under 65 with certain chronic medical conditions experience substantial morbidity and mortality from acute cardiopulmonary events during influenza season. The study suggests that stronger efforts to reach younger high-risk patients are needed to improve influenza vaccination levels.

Flu Shots Keep Health Workers On The Job

Healthcare professionals who received the flu vaccine lost significantly fewer days of work due to illness compared to those who did not receive the vaccine. The vaccine also reduced the rate of influenza type A and B infections among vaccinated individuals.

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Nasal Spray Flu Vaccine Proves Effective In Children

A new intranasal influenza vaccine has been shown to provide 93% protection against the flu in healthy young children. The vaccine was well-tolerated and safe for administration in a nasal spray format, offering an attractive alternative to traditional injection-based vaccines.

New Nasal Flu Vaccine Shows Promise In Latest Tests

A new nasal flu vaccine has delivered good antibody responses and proven safe in children, offering a potential solution to stop the spread of the disease. The vaccine's effectiveness is now being analyzed in a larger study, which may lead to FDA approval starting in 1999.