Articles tagged with Allergic Inflammation
A new study found that ultrafine particles from vehicular emissions can boost allergic inflammation in the lungs, exacerbating asthma. The researchers used a real-time testing method to isolate the effects of ultrafine particles on the immune response in mice, and found significant enhancement of allergic airway inflammation with expos...
Researchers discovered that corticosteroids reduce allergic inflammation by inhibiting the nuclear translocation of GATA-3, a key regulator of cytokine expression. This finding may lead to new treatments for allergic diseases, targeting interaction between phosphorylated GATA-3 and importin-α.
Researchers at Massachusetts General Hospital have developed noninvasive methods to visualize eosinophils in real-time, revealing the impact of dexamethasone on allergic airway inflammation. These techniques may improve diagnosis and treatment assessment for asthma.
Researchers at Erasmus University found that inhaling iloprost, a pulmonary arterial hypertension treatment, inhibits the Th2 cell inflammatory response in mice with allergic asthma. This study suggests targeting dendritic cells via iloprost may provide a new treatment for individuals with asthma.
The IL-21 receptor plays a pivotal role in the Th2 immune response, which is often disrupted in chronic diseases. This receptor is essential for regulating T-cell function and cytokine production.
Research reveals a previously unknown role for histamine receptors in asthma, suggesting that blocking these receptors could alleviate symptoms. Additionally, a novel peptide inhibitor has been discovered to prevent bone loss in osteoporosis by targeting the RANK/TNF pathway.
Researchers found that blocking the H1 histamine receptor can effectively reduce allergic lung responses and alleviate symptoms of hay fever. The study suggests this approach could provide new treatment options for individuals suffering from allergies.
Researchers found that probiotic bacteria can prevent the 'leakiness' of the gut wall and reduce bacterial adherence to cells, alleviating symptoms of irritable bowel syndrome and inflammatory bowel disease. Probiotics offer a promising approach to managing intestinal problems caused by chronic stress.
Researchers found that IL-25 promotes type 2 responses driving asthma, but also limits destructive inflammation associated with inflammatory bowel disease. The study suggests IL-25 may offer a treatment avenue for chronic inflammatory diseases.
Researchers have found that C5aR blockade promotes Th2 sensitization upon first exposure to inhaled allergen, while during established inflammation suppresses the cardinal features of asthma. This study provides new insights into the role of the anaphylatoxin C5a receptor in type 2 immunity and asthma.
A team of researchers discovered a gene called Nrf2 that plays a critical role in regulating inflammation and susceptibility to asthma. The findings provide insights into the human body's defense mechanisms against stress and may hold potential for developing new treatments.
A recent study by Dr. Irene Leal-Berumen and colleagues reveals that asthma patients' immune systems exhibit distinct responses to allergens depending on the presence or absence of allergic rhinitis symptoms. The findings have significant implications for the development of personalized treatment therapies.
The study found that low pulmonary function and allergic inflammation are key factors in responding well to inhaled corticosteroids. Younger patients with fewer years of asthma tend to respond better to leukotriene receptor antagonists.
Researchers developed a novel fluorosugar modifier that prevents leukocyte migration to inflamed skin. This finding offers new hope for treating inflammatory diseases.
Researchers at Imperial College London have discovered that targeting eosinophils can disrupt airway scarring and remodelling, a process contributing to chronic asthma. The study's findings suggest a potential breakthrough for developing more effective asthma treatments.
Researchers found that viral infections in infancy can cause long-term changes in the body's anti-viral system, leading to chronic respiratory inflammation and distress. Mice infected with paramyxoviral virus developed airway hyperreactivity and mucus-producing cells, symptoms similar to asthma.
A new study found that caregivers with higher perceived stress levels had infants who experienced more wheezing episodes during the first 14 months of life. Additionally, exposure to German cockroach allergen was associated with increased risk of asthma attacks in susceptible children. Researchers also developed a molecular model of th...
Dynavax's proprietary ISS-DNA alters immune response in allergic asthma, inhibiting symptoms and modifying inflammation. The company believes ISS-DNA therapy may provide a novel treatment for chronic allergic pulmonary inflammation.