Articles tagged with Hematology
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
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Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Two promising blood cancer researchers, Giovanni Roti and Marta Crespo, will each receive $75,000 to fund their research in the US. The EHA-ASH International Fellowship Award aims to build stronger ties between European and North American scientific communities.
Researchers at Mayo Clinic Cancer Center have led efforts to test new therapies in multiple myeloma, improving effectiveness and reducing toxicity. Studies show high response rates with lenalidomide and bortezomib, and a synergistic effect when targeting both tumor cells and microenvironment.
Dr. E. Richard Stanley has been recognized with the 2006 E. Donnall Thomas Prize for his groundbreaking research on CSF-1, which plays a crucial role in regulating cell proliferation, differentiation, and function in various diseases. His studies have also shed light on the roles of CSF-1 and its receptor in development and cancer.
A recent study found that elevated lactate dehydrogenase (LDH) levels can define a subgroup of sickle cell patients at risk for serious complications such as pulmonary hypertension and leg ulcerations. Patients with high LDH values had reduced survival rates compared to those with lower LDH values.
Hematologists say coagulation-factor concentrates from plasma are now deemed safe from most infectious agents, but challenges from new agents remain. Recombinant products offer a risk-free alternative, but safety studies have not definitively made the case for either.
Recent studies have shown that treatment of chronic myeloid leukemia has improved significantly, with a focus on reducing residual disease through continued therapy and new treatment options. These advances have led to better prognosis for patients, providing substantial prolongation of normal life.
ASH's Minority Medical Student Award Program (MMSAP) aims to motivate minority medical students to enter the field of hematology. The program provides a research experience for students from the US and Canada, with the goal of increasing diversity in hematology.
A new study shows that hydroxyurea is an efficient and safe treatment option for young children with sickle cell anemia, improving spleen function and reducing acute chest syndrome incidents
A large study comparing thalidomide and traditional chemotherapy in multiple myeloma patients found that thalidomide was more effective, with 76% of patients achieving at least partial remission. The treatment also had fewer side effects, particularly deep vein thrombosis compared to granulocytopenia.
A new diagnostic test is being developed to target a range of blood disorders by detecting a single point mutation in the JAK2 gene. The mutation was found in virtually all patients with polycythaemia vera, as well as half of those with essential thrombocythaemia and idiopathic myelofibrosis.
Researchers developed T cells targeting Epstein Barr virus antigens to treat advanced nasopharyngeal carcinoma. Six out of ten patients remained disease-free after treatment, with some experiencing partial remission.
The McMaster researchers developed a detailed bleeding history questionnaire to discriminate between patients with QPD and those without. The tool helps identify higher likelihoods of bleeding that leads to lifestyle changes, bruises or bleeding in joints, providing valuable clues for doctors diagnosing the condition.
A USC/Norris Comprehensive Cancer Center study reveals significant differences in survival rates between HIV-related lymphoma types, including DLCL and SNC. The research suggests that optimal therapy may differ for these sub-types of disease.
The study found that low- and intermediate-risk MDS patients benefit from delayed bone marrow transplantation after diagnosis, while high- and intermediate-risk patients may maximize overall survival with immediate transplantation. This research provides valuable insights for managing myelodysplasia patients.
Researchers found that higher doses of imatinib were more effective in achieving complete cytogenetic response (CCR) and complete molecular response, with a CCR rate of 90% compared to 60-75%. The high dosage was also well-tolerated with similar side effects as standard dose imatinib.
The American Society of Hematology has awarded Gary Gilliland and Janet Rowley for their significant contributions to hematology research. Dr. Gilliland's work on the molecular pathogenesis of leukemia and discovery of a cause for hypereosinophilic syndrome have provided new ways to understand cancer, while Dr. Rowley's discoveries of ...
A new direct thrombin inhibitor, ximelagatran, has shown promising results in preventing recurrent venous thromboembolism in patients with acute deep vein thrombosis. The study found that oral ximelagatran was as effective as enoxaparin/warfarin in preventing this condition, while also reducing major bleeding and mortality rates.
The study found that adding rituximab to the CHOP regimen as a first-line treatment did not significantly impact overall response rates or early disease progression. Maintenance rituximab showed promise in prolonging time-to-treatment failure, but had no effect on overall survival.
The American Society of Hematology presents the 2003 Public Service Award to Sen. Dianne Feinstein for her leadership on medical research and patient care issues. ASH also awards Dr. Claude Lenfant with its first-ever Lifetime Service Award for his decades-long dedication to hematology research and training.
Decitabine, an antimetabolite drug, has been found to improve fetal hemoglobin levels and reduce symptoms in patients with sickle cell disease who are resistant or intolerant of hydroxyurea. The study suggests that decitabine could be a viable alternative therapy for these patients.
The American Society of Hematology's Journal of Blood is the most cited peer-reviewed publication in the field, featuring latest research on blood disorders. New articles will be made available online about three months ahead of print.
Durable responses were reported with Bexxar in a clinical trial of 582 patients with relapsed or refractory low-grade NHL. A total of 57% of patients achieved an overall response, while 28% showed a complete response. The average follow-up was 1.3 years, and half of the patients remained in remission for over 14 months.