Articles tagged with Pediatrics
Researchers created a new model to study the effects of undernutrition on the microbiome, which can help identify specific microbes that impact development. The model mimics early childhood experiences and shows promise in understanding the underlying causes of stunted growth and other harmful effects of undernutrition.
The American College of Cardiology and American Heart Association have released a new clinical guideline for effectively managing individuals diagnosed with hypertrophic cardiomyopathy. The guideline recommends exercise as part of a healthy lifestyle, including low-to-moderate intensity recreational activities, while also introducing a...
A new study conducted by researchers at Nationwide Children's Hospital found increases in exposures to delta-8 THC, delta-10 THC, and THC-O acetate among young children, teens, and adults. The study highlights the importance of safe storage practices and improved regulation of these products.
A study published in JAMA Pediatrics reveals that children diagnosed with hypertension are at a higher risk of major adverse cardiac events later in life. Improved detection, follow-up, and control of pediatric hypertension may reduce the risk of adult cardiovascular disease.
A pediatric observation unit with a psychiatric comanagement model significantly lowers pediatric emergency department length of stay and inpatient psychiatric admission rates. This innovative approach also avoids contributing to 30-day readmission rates, presenting potential savings for inpatient psychiatric resources.
A new intervention called FACE Rare improved spiritual and emotional well-being of families with life-limiting rare diseases. The study found that the counseling tools were safe, effective and increased feelings of peace among families.
Researchers will discuss key findings on pediatric mental health, vaccination, autism diagnosis, social determinants of cardiovascular health, and treatment of bronchiolitis. Studies examine the relationship between socioeconomic factors and hypertension in youth, long wait times for autism evaluations, and the impact of HPV vaccine up...
Researchers at the University of Chicago show that a drug molecule targeting RNA modifications associated with neuroblastoma suppresses tumor growth in mice. High levels of METTL3 expression were linked to significantly lower survival rates in patients, suggesting it drives tumor growth.
The American Journal of Respiratory and Critical Care Medicine has released the ATS 2024 International Conference Abstracts, featuring research on heat exposure and RSV among other topics.
A new mRNA cancer vaccine has been shown to trigger a vigorous immune response in both human patients and pet dogs with glioblastoma, the most aggressive form of brain cancer. The breakthrough treatment, which uses a personalized approach and novel delivery mechanism, demonstrates promising results in early clinical trials.
Researchers validated pediatric emergency department guidelines promoting safer CT scan use, finding both predictive rules safe and effective in minimizing unnecessary radiation exposure. The study enrolled thousands of children and adolescents nationwide, showing high accuracy in identifying cases requiring immediate intervention.
A study by Cincinnati Children's Hospital Medical Center found that children aged 3-5 consume a significant portion of their daily calories during the hour after picking up from childcare, with high amounts of added sugar and salt. Experts recommend preparing healthy snacks in advance to instill healthier habits.
Researchers developed a device with AI algorithms to analyze suckling strength and pattern in newborns. The system showed improved accuracy over subjective clinician assessments, identifying abnormal patterns that may indicate the need for surgical intervention or improved feeding practices.
A Swedish study published in JAMA Network Open found that over one million newborns were given unnecessary antibiotics for suspected sepsis despite a reduction in sepsis cases. The researchers argue that the treatment burden is too high, suggesting potential to reduce antibiotic use.
Researchers at Children's Hospital of Philadelphia have discovered the underlying biology behind Fontan-associated liver disease, a condition affecting thousands of patients with single ventricle congenital heart disease. The study identified key cell-type specific changes in livers and potential therapeutic targets, including Activins...
A cohort study found statistical signals for myocarditis and pericarditis after BNT162b2 vaccination in children aged 12-17 years, consistent with previous reports. Seizures after mRNA-1273 vaccinations in younger age groups require a robust epidemiologic investigation to confirm findings.
A phase 3 clinical trial found that 96.7% of patients did not experience severe vaso-occlusive crises, and all remained hospitalization-free for at least one year after receiving the gene therapy CASGEVY.
A new Northwestern Medicine study reveals that 73% of children with skin diseases face stigma and bullying, leading to impaired relationships and mental health issues such as depression and anxiety. The study suggests that clinicians should aggressively treat skin disorders in children and consider referral to evaluation and counseling.
Research found that babies born to mothers infected with dengue fever during pregnancy had lower birth weights and a higher risk of extremely low birth weight. Additionally, children whose mothers were infected had a increased risk of hospitalization from birth to age three, particularly in their second year of life.
A large-scale study of 3.9 million children found that COVID-19 vaccination significantly reduced the incidence of SARS-CoV-2 infection and hospitalization among kids in California. The study suggests that vaccination is an effective strategy to prevent severe COVID-19 cases in pediatric populations.
A new study by Loma Linda University reveals that mechanical bull riding is a real public health concern, especially for young riders. The study found that traumatic brain injuries are the most common outcome, and long-term consequences can be severe, including memory issues and learning disabilities.
A study of 50,000 US children found modest decreases in developmental screening scores, sparking cautious optimism and concern for long-term implications. Continued surveillance is crucial to understand the population-level effects of the pandemic on child development.
Pediatric opioid overdoses show a decreasing trend between 2008 and 2019, with a notable increase during the COVID-19 pandemic. High-risk populations include young children and adolescents, particularly males and those in urban teaching hospitals.
A multidisciplinary team is developing computational models to predict heart valve leakage in children with specific birth defects. The models use 2D and 3D echocardiogram data to simulate the shape of valves and potential weak spots, enabling surgeons to plan surgeries more effectively.
Research using 2011-2021 data found limited associations between recreational cannabis legalization and adolescent substance use. Recreational cannabis retail sales were linked to lower e-cigarette use and an increased frequency of cannabis use among users, leading to no overall change in cannabis use.
Researchers created a proteomics-based imaging mass cytometry marker panel to categorize immune cells at single-cell resolution, identifying unique signatures of active T-cell-mediated rejection. The study aims to find personalized immunosuppression therapies with fewer side effects.
A large study of over 27,000 pediatric patients found that SARS-COV-2 infection does not increase the risk of asthma development. However, children with known risk factors for asthma were more likely to associate with new SARS-COV-2 diagnoses.
A new study from UC Davis Health validates intra-abdominal injury (IAI) and traumatic brain injury (TBI) prediction rules to reduce unnecessary CT scans in pediatric trauma patients. The study found high accuracy rates for IAI and TBI predictions, decreasing the need for CT imaging.
A new study has identified alpha-1-antichymotrypsin as a blood protein marker that can predict delayed recovery of concussion in children. The study found that children with low levels of alpha-1-antichymotrypsin were more likely to experience delayed recovery, highlighting the potential for early diagnosis and targeted treatment.
Researchers at Children's Hospital of Philadelphia and Stanford Medicine discovered the FOXO1 protein plays a crucial role in controlling CAR T cell longevity. The study found that FOXO1 enhances the survival and function of CAR T cells, leading to more effective cancer treatment.
Physicians can use a Barbie doll to help pediatric patients demonstrate musculoskeletal exam movements during virtual appointments. The study found that using the doll reduced verbal corrections and improved patient understanding.
Researchers at St. Jude Children's Research Hospital designed a combination therapy to effectively treat relapsed or resistant B-cell leukemia by targeting the developmental stages of cancer cells. The findings revealed that a protein called BCL-2 is a hidden vulnerability in asparaginase-resistant tumor cells.
Researchers at Children's Hospital of Philadelphia found that teens and young adults with mood disorders are 30% less likely to obtain their driver’s license compared to peers without such disorders. These youths also experienced a slightly elevated risk of crashing, particularly when newly licensed.
A study from Stockholm University found that the Swedish speed premium policy, introduced in 1980, led to a 26% increase in premature birth rates over six years. However, relaxation of the policy to a 30-month window resulted in an 11% decrease in premature birth rates in subsequent years.
A study published in JCI Insight reveals that an unexpected mechanism is responsible for the loss of kidney cells' ability to filter toxins from blood in primary membranous nephropathy. The researchers found that signaling in the C3a/C3aR pathway plays a critical role in disease progression.
A study developed a new referral pathway and Frenotomy Assessment Tool to identify breastfed babies with tongue tie requiring frenotomy. The tool found that 11% of breastfed babies had TT and 66% underwent frenotomy, suggesting that most infants were suffering from the condition.
A Rutgers Health study has found that mothers with mild and moderate to severe depressive symptoms have more emergency department visits for their infants. Infants of mothers with moderate to severe depression had 21% more visits than those without any symptoms, while those with mild symptoms had 10% more visits.
The journal features five original articles from Kennedy Krieger faculty members, providing actionable insights on caring for children with autism. The volume addresses a significant gap in resources for pediatric clinicians and researchers globally.
A new study found that children with chronic medical conditions who also have a diagnosed sleep disorder are nearly two times more likely to have increased health care utilization. The most common sleep disorder diagnosis was sleep-disordered breathing, which was present in 1,796 children.
A survey study in Plastic and Reconstructive Surgery finds that parents overwhelmingly believe surgeons should obtain consent before posting pictures of children on social media. The researchers recommend seeking consent from both parents and children, with an average age of 9.65 years for child assent.
Researchers identified four weight-gain trajectories and factors associated with rapid or gradual weight gain, including age, sex, ethnicity, and baseline body mass index scores.
Researchers at UVA Health discovered a potential explanation for long COVID symptoms by identifying 'abzymes' that act like enzymes regulating important bodily functions. This discovery could lead to new treatments targeting these rogue antibodies to alleviate acute effects of COVID-19 and its complications.
A retrospective cohort study found that PERT significantly reduced the incidence of acute pancreatitis episodes among children with recurrent or chronic pancreatitis. The study also identified genetic markers, such as SPINK1 mutation, that influence treatment outcomes and suggest a tailored approach to patient care.
A randomized clinical trial has shown that delaying surgical repair of inguinal hernias in preterm infants until after discharge from the NICU reduces serious adverse events. The study found a high likelihood of hernia resolution with late repair, allowing for quicker hospital discharge.
A study published in JAMA Pediatrics found that the prevalence of overweight and obesity among 3- and 4-year-olds in Sweden has decreased after the pandemic. The researchers observed a reversal of unhealthy weight trends, indicating that an unhealthy weight status can be reversed.
The COVID-19 pandemic significantly interrupted pediatric healthcare, resulting in foregone care, well-child visits, and vaccinations for vulnerable populations. Non-Hispanic White children were less likely to experience these gaps, while virtual school formats increased the risk of foregone care.
Researchers from USC's Keck School of Medicine synthesized over 23,000 studies to inform updated clinical practice guidelines for ADHD. The comprehensive literature review found that both medications and psychosocial treatments work for treating ADHD and that children can and do get better.
Researchers identified a small set of proteins governing anaplastic large cell lymphoma (ALCL) identity and found that drugs targeting the STAT family of proteins already exist for treatment. The study provides insight into potential vulnerabilities in ALCL cells.
Research from the University of Pittsburgh and UPMC found that primary care telemedicine visits are associated with lower antibiotic prescription rates for children compared to virtual-only direct-to-consumer providers. The study highlights the importance of integrated telemedicine within primary care settings.
A new study calls on pediatric primary care to prioritize menstrual health, highlighting barriers that limit clinician engagement and patient guidance. Researchers offer practical solutions to improve access to menstrual health services for adolescents.
Researchers identified nicotinamide adenine dinucleotide (NAD) as a key component of T cell receptor metabolic reprogramming, enabling rapid immune cell division. This discovery may lead to improved vaccine strategies and enhanced responses in cell-based therapies for cancer treatment.
A recent study found that high school students who use both tobacco and cannabis products miss more school and have lower grades compared to those who don't use either product. The researchers analyzed data from the California Healthy Kids Survey, which showed that students who used both tobacco and cannabis reported the highest percen...
Research finds a nearly 40% decline in respirable particulate matter (PM2.5) in Krakow, Poland, following policy changes targeting coal emissions. This improvement translates to substantial benefits for children's outcomes, including fewer asthma cases and better birth outcomes.
Researchers at Children's Hospital Los Angeles found significant variation in opioid treatment for critically ill infants across different institutions and geographic regions. The study reports wide variability in opioid prescribing practices, which can impact hospitalization length of stay, healthcare costs, and long-term outcomes.
A study of 15,000 preterm infants reveals racial disparities in care treatment, with Black and Hispanic infants receiving less intensive care. The findings highlight the need to address social determinants of health and improve healthcare access for all infants.
A new study finds that Latinx children with unreliable access to food at age 4 are nearly four times more likely to develop fatty liver disease later. The researchers recommend earlier screening for metabolic dysfunction-associated steatotic liver disease (MASLD) and ensuring public meal programs offer nutritious meals.
Researchers found that pre-existing mental health diagnoses lead to a greater emotional burden and prolonged recovery time after a concussion. The study also discovered a 'dose-response' effect, where more mental health diagnoses correlate with increased emotional symptoms and longer recovery periods. Boys with prolonged recovery exper...
A new AI technology has been developed to detect severe cases of retinopathy of prematurity (ROP) with 100% accuracy. The system analyzes retinal images and can identify blood vessel anomalies, enabling early treatment and potentially saving sight for thousands of premature infants globally.
Researchers have developed an injectable hydrogel that mitigates damage to the right ventricle of the heart in children with hypoplastic left heart syndrome. The treatment, made from cardiac extracellular matrix, improves heart function and slows tissue scarring, potentially increasing patient survival time.
A study by Children's Hospital Los Angeles found that only about 20% of young children with sickle cell anemia received adequate preventative antibiotics, while about half received annual brain ultrasounds to assess stroke risk. These findings highlight the need for improved care and support for children with this chronic disease.