Articles tagged with Tumor Growth
A protein called PEDF has been shown to halt excessive blood vessel growth in the eye, potentially treating diabetic retinopathy and macular degeneration. Researchers found that increasing PEDF levels could slow vision deterioration and prevent new vessels from overgrowing.
Researchers found a protein called GON-1 that regulates organ shape in Caenorhabditis elegans, a microscopic worm. This discovery could lead to the development of inhibitors to slow or stop cancer cell spread and may one day enable growing human organs in labs.
Researchers find potential anti-cancer agents in ethanol extract of soybean molasses from crop-processing plant waste. The active compound, phytochemical complex 100 (PCC 100), contains saponins and suppresses cancer cell growth, reducing human colon cancer rates.
Researchers at UNC-CH discovered three genes crucial to cell survival and protein disposal. The proteins ROC1, ROC2, and APC11 are involved in the ubiquitin ligase enzyme that marks proteins for degradation. Disruption of this mechanism may promote cancer development by driving cells to proliferate uncontrollably.
Scientists discover that breast tumors produce high levels of a fetal form of insulin receptor, stimulating rapid cell division and cancer growth. The finding offers a potential target for new cancer drugs, which could block or slow breast tumor growth.
Researchers at the University of Wisconsin-Madison have identified two compounds, gamma-tocotrienol and beta-ionone, that suppress the growth of three types of human cancer cells. These isoprenoids, found in cereal grains and fruits/vegetables, work by interfering with cell division and disrupting cholesterol synthesis.
Duke University researchers found that angiostatin works by depleting the chemical energy needed for blood vessel cells to grow. This discovery offers a novel insight into the body's use of ATPsynthase as a power pack and suggests a new route to developing drugs to block tumor growth.
Researchers link Fas and FasL interaction to immune-privilege in the eye, affecting age-related macular degeneration. Deficiency of Fas or FasL leads to increased growth of new retinal vessels.
The US blood supply is considered extremely safe, with the risk of contracting viruses such as HIV being estimated at one in 676,000. However, a growing aging population will lead to increased demands on the blood supply, resulting in a potential shortage, and more units may need to be imported from abroad.
Researchers discovered that green tea's EGCg compound inhibits an enzyme required for cancer cell growth and can kill cultured cancer cells. Drinking more than four cups of green tea a day may provide enough of the active compound to slow and prevent cancer cell growth.
Physicians at the University of Chicago Medical Center have found a way to bring full immune system power against cancer using co-stimulation technology. Patients with advanced or recurrent lymphoma have experienced anti-tumor effects and complete remissions after receiving expanded, co-stimulated T cells.
Scientists at Thomas Jefferson University have demonstrated that a normally protective anticancer gene can block tumors from growing. Led by Dr. Antonio Giordano, they found that the damaged version of the gene, pRb2/p130, suppresses tumor growth in animal models, paving the way for gene therapy to treat lung cancer and other cancers.
Scientists are using NASA Bioreactors to culture breast cells on Earth, learning what controls their growth and how to thwart malignancies. The research has the potential to improve healthcare for women, including those traveling to Mars, by developing new therapies that target cancer's genetic weaknesses.
Scientists have grown healthy human placental cells in a laboratory using a new technique, providing a means to test the safety of drugs during pregnancy. The cells can survive and function like those in the womb, mimicking blood flow and nutrient exchange.
Researchers have discovered a gene called E2F1 that helps bring about tumor cell death yet is also necessary for their growth. The study found that without E2F1, tumors grew slower but cell death was reduced by 80 percent.
A protein found in copperhead snake venom retards breast tumor growth by blocking tumor cell adhesion and invasion, as well as inhibiting new blood vessel development. Studies with mice implanted with human breast cancer cells showed a 60-70% reduction in growth rate and 90% reduction of tumor metastasis to the lungs.
Squalamine, a novel liver steroid, has been shown to inhibit the growth of brain tumors called gliomas by disabling blood vessel formation. In laboratory tests, it proved as effective as carmustine in slowing tumor growth and constricting blood vessels, suggesting potential as a human therapy.
Researchers at The Wistar Institute have identified a key role for the GA733 antigen in inhibiting colorectal cancer cell invasion. The discovery has led to the development of an antibody that increases survival rates for CRC patients.
Researchers found that fragments of chromosome 11 slow tumor growth in mice and cell cultures, suggesting a tumor suppressor gene may be present. The study provides new hope for treating lung cancer patients by identifying a potential target for therapy.
Researchers at Duke University Medical Center have found that a Tie2 inhibitor can significantly slow the growth of tumors on rats by preventing nearby blood vessels from forming capillaries to feed the cancer. The treatment slowed tumor growth by 75 percent and reduced vessel length density by 40 percent.
Researchers found that captopril inhibited the growth of new blood vessels essential for tumor growth, potentially reducing cancer incidence and severity. The drug's mechanism may differ from its blood pressure-lowering effects.