Articles tagged with Tumor Growth
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A single gene, EBNA1, plays a crucial role in the activation of EBV genes responsible for indiscriminate tumor cell growth. The LSUHSC research team discovered that oxidative stress regulates EBNA1's ability to activate these genes, leading to potential therapeutic approaches using existing treatments like Vitamin K.
A recent study found that carbohydrate restriction without weight loss can slow prostate tumor growth by lowering serum insulin levels. The researchers believe that this mechanism is key to fighting prostate cancer growth and potentially improving patient outcomes.
Vanderbilt University researchers have identified a gene signature linked to reduced relapse-free survival in breast cancer patients, especially those with estrogen receptor-positive tumors. The discovery suggests that assessing TGF-β signaling may aid in determining breast cancer prognosis and guiding treatment.
A team of scientists has discovered a compound that can block the growth of brain tumors by reversing the effects of an altered enzyme. The mutation in the IDH1 gene impairs the body's ability to control a protein that promotes tumor growth, but adding a modified form of alpha-KG can restore this balance.
Researchers at Wake Forest University School of Medicine discovered a protein called ferritin binds to HKa, promoting blood vessel formation that assists in tumor growth. The study suggests preventing the binding could block tumor growth, with implications for wound care.
Researchers found that overexpressing SOX9 restores retinoic acid sensitivity in melanomas and stops tumor growth. A combined therapeutic strategy may provide new hope for treating RA-resistant cancers like melanoma.
A study found that docosahexaenoic acid (DHA) can directly suppress arachidonic acid-induced proliferation of colon carcinoma cells, while also reducing viability. DHA supplementation may be a powerful tool to counteract AA- and PGE2-promoted colon cancer cell growth.
A new report published in Disease Models & Mechanisms reveals that tumors trigger the same immune response as wounds, with hemocytes replicating and adhering to tumor surfaces to limit growth. The study identifies key pathways in the fly's immune response to tumor growth and tissue disruption, shared with humans.
Researchers at Medical College of Wisconsin report promising results using drugs to inhibit angiogenesis in rat models of glioblastoma, a deadly brain tumor. Tumor size was reduced by 50-70% and survival time increased by 5-7 days
Researchers at Duke University have synthesized largazole, a marine algae extract with potential as an anti-cancer agent. The team's efficient synthetic route enables the production of gram-sized quantities, paving the way for further study and potential treatment of various cancers.
The study introduces HB-19, an experimental synthetic molecule that inhibits both tumor cell growth and angiogenesis. In mice models, HB-19 treatment suppresses tumor development and eliminates measurable tumors without toxicity.
Researchers at the University of Illinois have identified a new family of agents that inhibit the growth of estrogen-dependent breast cancer cells. These compounds specifically target the binding of estrogen-receptor complex to regulatory regions of genes, effectively retarding protein production and cell proliferation.
Researchers found that primary tumors can encourage the growth of stray cancer cells elsewhere in the body, which may have therapeutic implications. Osteopontin secretion by instigating tumor cells plays a key role in this process.
Researchers at Rutgers University found that beta-endorphin peptide-producing neurons in the brain regulate stress response and immune function, controlling tumor growth. The study shows promise for therapeutic treatments to bolster the immune system.
At 15 mmHg CO2 insufflation pressure, gastric cancer cells' proliferation was inhibited and apoptosis improved. The extracellular pH changed significantly with CO2 versus helium exposure, affecting tumor-cell implantation during laparoscopic surgery.
Researchers found that tumour growth rates vary considerably among patients, with generally slower growth rates with increasing age at diagnosis. The new model estimated the mean time for a tumour to double in size from 10 to 20 mm in diameter is 1.7 years.
Western Australian researchers have made a world-first discovery that could help treat life-threatening tumours by reversing angiogenesis. The team found that the gene RGS5 can normalise blood vessels in tumours, allowing for improved immune cell entry and increased survival rates in laboratory tests.
Scientists have identified 20 new regions of the genome linked to human height, adding to the growing understanding of genetics and growth. These discoveries may shed light on diseases such as osteoarthritis and cancer, and could lead to new avenues for treating various conditions.
A large randomized trial of personalized interventions found that two behavioral interventions did not significantly increase regular mammograms in female veterans. The study's findings support the generalizability to the US female population, which has seen a decline in mammography rates. Meanwhile, another study suggests that viral D...
Researchers at NewYork-Presbyterian Hospital/Weill Cornell Medical Center have identified cancer stem cells as a potential cause of brain tumors. The study aims to develop more accurate and specific cancer diagnoses using these stem cells.
A low-carb diet may help stunt prostate tumor growth by reducing insulin production, according to a new study. The study found that mice on a low-carb diet had longer survival and smaller tumors than those on other diets.
Researchers found that PAX5 stimulates the growth of cancerous tumors by spurring cell division normally observed during B cell immune response. This leads to over-expression of key molecules comprising B cell receptor, driving B cell expansion.
A new study found that a compound in broccoli, known as DIM, may help boost the immune system. DIM was shown to increase blood levels of cytokines and stimulate white blood cells in mice, suggesting potential health benefits against infections and cancer.
Researchers at Duke University Medical Center found that flaxseed supplementation significantly slows prostate tumor growth in men scheduled for surgery. Flaxseed's omega-3 fatty acids and lignans appear to play a crucial role in halting cancer cell proliferation.
Researchers at UCSD School of Medicine targeted heparan sulfate in tumor blood vessels to inhibit angiogenesis and tumor growth. Modifying the action of this sugar uniquely impacted the tumor vasculature, altering its growth rate in lung carcinoma cells in mice.
A new animal study reveals that moderate alcohol consumption significantly increases breast cancer tumor size and angiogenesis, providing insights into the mechanisms of alcohol-induced breast cancer. The study confirms that even low levels of EtOH intake can stimulate tumor growth and malignancy.
Researchers discovered a protein made by microglia that helps accelerate tumor growth, and are looking for others. The findings have implications for both genetic and sporadic brain tumors.
Scientists at Baylor College of Medicine discovered that the protein TCTP plays a key role in regulating cell size and proliferation in fruit flies. When TCTP levels are reduced, cells grow abnormally small, leading to reduced lifespan.
Researchers developed a small-molecule inhibitor of Plk1, a key kinase controlling cell division. The compound BI 2536 effectively halts cancerous cell growth in culture and in animal models, causing cell death and tumor regression. This discovery has therapeutic potential for patients with locally advanced or metastatic cancers.
Scientists at Oxford University have identified a surprising way to switch off a gene involved in cell division using a previously unknown type of RNA. This discovery could lead to new anti-cancer treatments by inhibiting the production of an enzyme that controls thymine production.
A new study published in PNAS shows that combining anti-angiogenic agents can increase the effectiveness of treatment for tumors and retinopathy. The therapy, which targets multiple angiogenic pathways, resulted in complete inhibition of pathological neovascularization in over 60% of treated eyes.
A study by Children's Hospital of Philadelphia researchers found that p53 regulates insulin-like growth factor-I (IGF-I) signaling, which may contribute to cancer progression and aggressiveness. The study also suggests that inhibiting IGF-I signaling could lead to novel therapies for cancer.
New research suggests stress hormones can stimulate tumor cells to produce compounds breaking down tissue and facilitating metastasis. Beta-blocker drugs may slow cancer growth by blocking receptors.
A small subset of glioma cells expressing higher levels of VEGF promote tumor blood vessel formation, making them a potential target for new therapies against intractable brain tumors. Targeting these cancer stem cells may block angiogenesis and prevent tumor growth.
A new study finds that high cadmium levels may increase breast cancer risk, while silibinin has been shown to inhibit lung tumor blood vessel formation. Additionally, researchers have identified a potential anticancer compound in milk thistle and explored the role of KGF and FGFR2b in cancer treatment.
Researchers found that overexpression of Nod1 inhibits estrogen-dependent tumor growth in human breast cancer cells, leading to reduced tumor formation and growth. The study suggests a new mechanism for controlling estrogen-sensitive breast cancers and opens the door for future development of novel therapeutics.
Research reveals omega-6 fatty acids stimulate inflammatory genes associated with cancer, particularly in prostate tumors. Studies found that adding omega-6 to growth medium doubled tumor growth compared to control groups.
A new study published in Cancer Research found that artificial light at night can stimulate the growth of human breast cancer cells in laboratory mice. The researchers discovered that melatonin, a hormone produced by the brain, plays a key role in regulating tumor growth and development.
Researchers have discovered that the IGF-1 receptor controls 50% of body size in a non-redundant way, suggesting its potential as a target for cancer treatment. Targeting the IGF-1 receptor may lead to cell death and growth regulation in cancer cells.
Researchers at Children's National Medical Center discovered a non-toxic chemical compound OGT2378 that blocks ganglioside production, suppressing tumor growth and immune system suppression. The study found tumors in treated mice to be significantly smaller than those in untreated mice.
Researchers found that prostate tumor growth is arrested through cellular senescence, which stops cells from proliferating and responding to normal growth signals. Drugs that support p53 function may delay progression of prostate cancer by triggering cellular senescence.
Researchers found that tumor cells can stimulate blood vessel growth by activating the MAPK pathway and inducing Notch ligand Jagged1, which promotes formation of new vessels. This interplay between tumor cells and blood vessel cells supports tumor growth and progression.
Researchers discovered that overexpression of Down Syndrome Critical Region 1 (DSCR-1) reduces tumor growth and blocks blood vessel formation. This breakthrough could lead to novel strategies for inhibiting endothelial cell dysfunction and abnormal blood vessel formation.
Researchers have discovered an inactive form of scatter factor protein that effectively suppresses tumor growth and dissemination in mice. The study provides promising insights into the development of new cancer therapies.
Researchers found that S1P1 plays a crucial role in tumor angiogenesis, which is the formation of new blood vessels to supply nutrients to growing tumors. The study used RNA interference to block S1P1, demonstrating its importance in tumor growth and progression.
A new study identifies actinonin-based antibiotics as a potential treatment for cancer. Human mitochondrial peptide deformylase is found to be a key target in this approach, offering new avenues for cancer research and therapy.
Research found that breast density and rapid tumor growth significantly affect mammography's ability to detect cancer in women aged 40-49. To address this issue, the study suggests adjusting screening intervals for these high-risk groups.
Researchers found that inhibiting NF-kB or TNFα can prevent inflammation-induced tumor growth, allowing TRAIL to tip the balance in favor of cancer killing. The study suggests using NF-kB inhibitors with anti-TNFα drugs and TRAIL-inducing cytokines to promote tumor killing.
Stanford researcher Matthew Bogyo and colleagues discovered that cathepsin cysteine proteases help build blood vessels to tumors, increase tumor growth and invasiveness. A broad-spectrum inhibitor slowed tumor development in mice with no apparent side effects.
A study published in Journal of the National Cancer Institute found that blocking hypoxia-inducible factor 1 (HIF-1) significantly impairs tumor growth by damaging the vascular microenvironment. The tumors were smaller and had thin-walled, lumenless blood vessels compared to control mice.
A study found that highly processed isoflavone products may pose a risk to postmenopausal women with estrogen-responsive breast cancers. Minimally processed soy flour was associated with less tumor growth in mice, suggesting a potential health benefit for consumers of whole soy foods.
Scientists at Johns Hopkins Kimmel Cancer Center have found a link between the HOXB7 gene and increased activity in breast cancer biomarkers. The study shows that the gene is overexpressed in more than 60% of breast cancer cell lines and 90% of primary breast cancers.
Research at Texas Agricultural Experiment Station has led to a patent for derivatives of DIM, a natural compound derived from certain vegetables, to treat cancer. These compounds have shown promise in inhibiting the growth of breast, pancreatic, colon, bladder, and ovarian cancer cells in laboratory studies.
A new tumour growth model views the tumour as an integral part of the body, dependent on host metabolic rate and food intake. The model predicts that tumours develop faster in younger hosts and have higher life expectancy with low-calorie diets.
Researchers found that combining anti-angiogenic and Hsp90 inhibitor drugs completely inhibited tumor growth in Id deficient mice, but had limited effect in mice with normal Id function. The study suggests a new approach for treating advanced breast cancer.
Researchers have discovered a potential new treatment for certain types of cancer by inhibiting sphingosine kinase. The study found that targeting this enzyme can reduce tumor growth and induce apoptosis in cancer cells, offering hope for new targeted therapies.
Researchers found that Cripto overexpression inhibits Activin signaling, leading to increased tumor cell growth. Antibody blockade of Cripto suppresses tumor cell growth in xenograft models, suggesting a central role for Cripto in tumorigenesis.
Asthma patients treated with bronchodilating beta-agonist medications may develop increased sensitivity to airway constriction, experience exacerbation of their condition. Researchers suggest that therapeutics targeting phospholipase C-beta may have substantial benefit in the treatment of asthma.
Researchers at UIC College of Medicine identified 57 genes involved in cell proliferation, including some not previously known to play a role in cancer cell growth. The study found that certain fragments inhibited the multiplication of breast cancer cells by shutting down genes necessary for cell growth.
Researchers are investigating new methods to combat cancer growth through computer models and cytotoxic treatments. They also discovered that a process called Auger emission can cause electrons to be emitted in well-defined directions by single molecules, leading to potential breakthroughs in physics research.