Articles tagged with Tumor Growth
A new study published in PNAS shows that combining anti-angiogenic agents can increase the effectiveness of treatment for tumors and retinopathy. The therapy, which targets multiple angiogenic pathways, resulted in complete inhibition of pathological neovascularization in over 60% of treated eyes.
A study by Children's Hospital of Philadelphia researchers found that p53 regulates insulin-like growth factor-I (IGF-I) signaling, which may contribute to cancer progression and aggressiveness. The study also suggests that inhibiting IGF-I signaling could lead to novel therapies for cancer.
New research suggests stress hormones can stimulate tumor cells to produce compounds breaking down tissue and facilitating metastasis. Beta-blocker drugs may slow cancer growth by blocking receptors.
A small subset of glioma cells expressing higher levels of VEGF promote tumor blood vessel formation, making them a potential target for new therapies against intractable brain tumors. Targeting these cancer stem cells may block angiogenesis and prevent tumor growth.
A new study finds that high cadmium levels may increase breast cancer risk, while silibinin has been shown to inhibit lung tumor blood vessel formation. Additionally, researchers have identified a potential anticancer compound in milk thistle and explored the role of KGF and FGFR2b in cancer treatment.
Researchers found that overexpression of Nod1 inhibits estrogen-dependent tumor growth in human breast cancer cells, leading to reduced tumor formation and growth. The study suggests a new mechanism for controlling estrogen-sensitive breast cancers and opens the door for future development of novel therapeutics.
Research reveals omega-6 fatty acids stimulate inflammatory genes associated with cancer, particularly in prostate tumors. Studies found that adding omega-6 to growth medium doubled tumor growth compared to control groups.
A new study published in Cancer Research found that artificial light at night can stimulate the growth of human breast cancer cells in laboratory mice. The researchers discovered that melatonin, a hormone produced by the brain, plays a key role in regulating tumor growth and development.
Researchers have discovered that the IGF-1 receptor controls 50% of body size in a non-redundant way, suggesting its potential as a target for cancer treatment. Targeting the IGF-1 receptor may lead to cell death and growth regulation in cancer cells.
Researchers at Children's National Medical Center discovered a non-toxic chemical compound OGT2378 that blocks ganglioside production, suppressing tumor growth and immune system suppression. The study found tumors in treated mice to be significantly smaller than those in untreated mice.
Researchers found that prostate tumor growth is arrested through cellular senescence, which stops cells from proliferating and responding to normal growth signals. Drugs that support p53 function may delay progression of prostate cancer by triggering cellular senescence.
Researchers found that tumor cells can stimulate blood vessel growth by activating the MAPK pathway and inducing Notch ligand Jagged1, which promotes formation of new vessels. This interplay between tumor cells and blood vessel cells supports tumor growth and progression.
Researchers discovered that overexpression of Down Syndrome Critical Region 1 (DSCR-1) reduces tumor growth and blocks blood vessel formation. This breakthrough could lead to novel strategies for inhibiting endothelial cell dysfunction and abnormal blood vessel formation.
Researchers have discovered an inactive form of scatter factor protein that effectively suppresses tumor growth and dissemination in mice. The study provides promising insights into the development of new cancer therapies.
A new study identifies actinonin-based antibiotics as a potential treatment for cancer. Human mitochondrial peptide deformylase is found to be a key target in this approach, offering new avenues for cancer research and therapy.
Researchers found that S1P1 plays a crucial role in tumor angiogenesis, which is the formation of new blood vessels to supply nutrients to growing tumors. The study used RNA interference to block S1P1, demonstrating its importance in tumor growth and progression.
Research found that breast density and rapid tumor growth significantly affect mammography's ability to detect cancer in women aged 40-49. To address this issue, the study suggests adjusting screening intervals for these high-risk groups.
Researchers found that inhibiting NF-kB or TNFα can prevent inflammation-induced tumor growth, allowing TRAIL to tip the balance in favor of cancer killing. The study suggests using NF-kB inhibitors with anti-TNFα drugs and TRAIL-inducing cytokines to promote tumor killing.
Stanford researcher Matthew Bogyo and colleagues discovered that cathepsin cysteine proteases help build blood vessels to tumors, increase tumor growth and invasiveness. A broad-spectrum inhibitor slowed tumor development in mice with no apparent side effects.
A study published in Journal of the National Cancer Institute found that blocking hypoxia-inducible factor 1 (HIF-1) significantly impairs tumor growth by damaging the vascular microenvironment. The tumors were smaller and had thin-walled, lumenless blood vessels compared to control mice.
A study found that highly processed isoflavone products may pose a risk to postmenopausal women with estrogen-responsive breast cancers. Minimally processed soy flour was associated with less tumor growth in mice, suggesting a potential health benefit for consumers of whole soy foods.
Scientists at Johns Hopkins Kimmel Cancer Center have found a link between the HOXB7 gene and increased activity in breast cancer biomarkers. The study shows that the gene is overexpressed in more than 60% of breast cancer cell lines and 90% of primary breast cancers.
Research at Texas Agricultural Experiment Station has led to a patent for derivatives of DIM, a natural compound derived from certain vegetables, to treat cancer. These compounds have shown promise in inhibiting the growth of breast, pancreatic, colon, bladder, and ovarian cancer cells in laboratory studies.
A new tumour growth model views the tumour as an integral part of the body, dependent on host metabolic rate and food intake. The model predicts that tumours develop faster in younger hosts and have higher life expectancy with low-calorie diets.
Researchers found that combining anti-angiogenic and Hsp90 inhibitor drugs completely inhibited tumor growth in Id deficient mice, but had limited effect in mice with normal Id function. The study suggests a new approach for treating advanced breast cancer.
Researchers have discovered a potential new treatment for certain types of cancer by inhibiting sphingosine kinase. The study found that targeting this enzyme can reduce tumor growth and induce apoptosis in cancer cells, offering hope for new targeted therapies.
Asthma patients treated with bronchodilating beta-agonist medications may develop increased sensitivity to airway constriction, experience exacerbation of their condition. Researchers suggest that therapeutics targeting phospholipase C-beta may have substantial benefit in the treatment of asthma.
Researchers found that Cripto overexpression inhibits Activin signaling, leading to increased tumor cell growth. Antibody blockade of Cripto suppresses tumor cell growth in xenograft models, suggesting a central role for Cripto in tumorigenesis.
Researchers at UIC College of Medicine identified 57 genes involved in cell proliferation, including some not previously known to play a role in cancer cell growth. The study found that certain fragments inhibited the multiplication of breast cancer cells by shutting down genes necessary for cell growth.
Researchers are investigating new methods to combat cancer growth through computer models and cytotoxic treatments. They also discovered that a process called Auger emission can cause electrons to be emitted in well-defined directions by single molecules, leading to potential breakthroughs in physics research.
Researchers investigated the association between alcohol consumption and lung cancer risk, finding no statistically significant link. The Journal of National Cancer Institute also published studies on body surface area-based dosing for anticancer drugs and carbohydrate binding protein's potential to inhibit tumor growth.
Researchers found that a flaxseed-rich diet inhibited tumor growth and reduced aggression in genetically engineered mice. The study suggests that lignans in flaxseed could play a role in inhibiting prostate cancer progression by influencing estrogen and testosterone metabolism.
In a phase II trial, bevacizumab slowed tumor growth by two and a half times, with a highly statistically significant effect. The drug targets the angiogenic process, neutralizing VEGF protein to inhibit blood vessel growth and prevent tumor progression.
Scientists have developed a new compound, TAS-108, which inhibits the growth of tamoxifen-resistant breast tumours. It works by recruiting a co-repressor to help inhibit oestrogen receptors, making it more effective than other anti-oestrogens.
Researchers found that raloxifene did not further prevent the growth of breast tumors previously exposed to more than 5 years of tamoxifen. Raloxifene also failed to block the growth of endometrial tumors caused by low-dose estrogen, suggesting it may increase endometrial cancer risk.
Researchers discovered a natural protein called p22 that inhibits blood vessel growth, preventing tumors from growing. The study showed that p22 is released by cancerous cells and targets only those cells that help tumors grow, reducing the risk of metastasis.
A new study suggests that estrogen found in soy products with high isoflavone content may stimulate human breast-cancer cells in mice. Researchers warn women with estrogen-dependent breast cancer or a predisposition to it to reduce their consumption of such soy products.
A new experimental drug called 2C4 has shown to significantly inhibit tumor growth in hormone-dependent and resistant prostate cancer tumors in mice. The monoclonal antibody targets the HER-2/neu protein, which controls cell growth and stimulates tumor growth.
Two studies found sigmoidoscopy detects few cancerous growths and none in asymptomatic patients with polyps, supporting the use of colonoscopy for regular screening. The research suggests that colonoscopy should be done every 5-10 years for people over 50 to save lives.
Researchers found that tetrahydrocannabinol (THC) promotes tumor growth by impairing the immune system, increasing IL-10 and TGF-beta cytokine production. Marijuana smoke contains higher carcinogenic hydrocarbons than tobacco, posing a potential cancer risk.
Researchers at Duke University Medical Center uncovered evidence of genomic imprinting in marsupial opossums but not monotremes like platypuses. The study suggests that the 'battle of the sexes' theory for imprinting evolution may be supported by competition for nutrient allocation among young animals.
Scientists Yonathan Shapir and Jacob Jorné discovered that natural cycles generate fractal patterns, governing everything from weather to cauliflower heads. This breakthrough enables the prediction of events like car battery lifespan, lawn growth, and tumor cell behavior, with potential applications in engineering and medicine.
Researchers at Fred Hutchinson Cancer Center discovered a protein, Rrn3, that regulates cell growth in both humans and yeast. The protein appears to be a key player in an as-yet-unidentified cell-signaling pathway, potentially making it a unique drug target for cancer treatment.
Researchers successfully differentiated human placental cells by adjusting gap size in a fibrous-bed bioreactor, mimicking the body's natural process. The breakthrough may aid organ production for transplantation and has implications for tissue engineering and cancer research.
Researchers at UT Southwestern Medical Center found that higher PSA levels are associated with faster prostate growth, allowing doctors to predict and potentially slow growth through treatment. This study provides critical information for planning a treatment, emphasizing the importance of annual PSA tests for men over age 50.
Poultry farmers can stop using antibiotics to promote growth in birds by adding antibodies against appetite-suppressing neurotransmitters and a fatty acid found in hamburgers. This alternative method produces similar growth gains as antibiotics, with improvements of 3-5% in growth rates.
Researchers at Beth Israel Deaconess Medical Center have discovered a potent new substance, canstatin, that inhibits the growth of tumors by blocking the formation and growth of new blood vessels. The naturally occurring protein is effective in both prostate and renal cancer models.
A new MGH study has identified thrombospondin-2 (TSP-2) as a natural factor that inhibits tumor angiogenesis and growth in mouse models. The researchers found that TSP-2 completely stopped tumor growth when reintroduced into tumor cells, outperforming earlier anti-angiogenesis factors.
A new animal study suggests that soy isoflavones may slow prostate cancer growth by inhibiting cell proliferation and promoting apoptosis. The study also found lower levels of insulin-like growth factor 1, a hormone that stimulates tumor growth.
Scientists have discovered that the myc gene is even more powerful than previously believed, controlling cell growth and division while disabling brakes on growth. The findings mark a significant step towards understanding how faulty cell signals lead to cancer.
Researchers at MGH discovered TGF-beta-1 inhibits blood vessel growth associated with metastatic gallbladder cancer. The study's results may lead to anti-angiogenesis agents for cancer treatment.
Andrew Hamilton, an organic chemist at Yale University, is being honored with the American Chemical Society's Arthur C. Cope Scholar Award for his work on designing molecules that can control cell growth in cancer treatment. His research focuses on targeting a protein called Ras, which accounts for over 30% of all cancers.
A protein called PEDF has been shown to halt excessive blood vessel growth in the eye, potentially treating diabetic retinopathy and macular degeneration. Researchers found that increasing PEDF levels could slow vision deterioration and prevent new vessels from overgrowing.
Researchers found a protein called GON-1 that regulates organ shape in Caenorhabditis elegans, a microscopic worm. This discovery could lead to the development of inhibitors to slow or stop cancer cell spread and may one day enable growing human organs in labs.
Researchers find potential anti-cancer agents in ethanol extract of soybean molasses from crop-processing plant waste. The active compound, phytochemical complex 100 (PCC 100), contains saponins and suppresses cancer cell growth, reducing human colon cancer rates.
Researchers at UNC-CH discovered three genes crucial to cell survival and protein disposal. The proteins ROC1, ROC2, and APC11 are involved in the ubiquitin ligase enzyme that marks proteins for degradation. Disruption of this mechanism may promote cancer development by driving cells to proliferate uncontrollably.
Scientists discover that breast tumors produce high levels of a fetal form of insulin receptor, stimulating rapid cell division and cancer growth. The finding offers a potential target for new cancer drugs, which could block or slow breast tumor growth.
Researchers at the University of Wisconsin-Madison have identified two compounds, gamma-tocotrienol and beta-ionone, that suppress the growth of three types of human cancer cells. These isoprenoids, found in cereal grains and fruits/vegetables, work by interfering with cell division and disrupting cholesterol synthesis.
Duke University researchers found that angiostatin works by depleting the chemical energy needed for blood vessel cells to grow. This discovery offers a novel insight into the body's use of ATPsynthase as a power pack and suggests a new route to developing drugs to block tumor growth.
Researchers link Fas and FasL interaction to immune-privilege in the eye, affecting age-related macular degeneration. Deficiency of Fas or FasL leads to increased growth of new retinal vessels.