Articles tagged with Tumor Growth
Researchers have discovered an inactive form of scatter factor protein that effectively suppresses tumor growth and dissemination in mice. The study provides promising insights into the development of new cancer therapies.
Researchers found that S1P1 plays a crucial role in tumor angiogenesis, which is the formation of new blood vessels to supply nutrients to growing tumors. The study used RNA interference to block S1P1, demonstrating its importance in tumor growth and progression.
A new study identifies actinonin-based antibiotics as a potential treatment for cancer. Human mitochondrial peptide deformylase is found to be a key target in this approach, offering new avenues for cancer research and therapy.
Research found that breast density and rapid tumor growth significantly affect mammography's ability to detect cancer in women aged 40-49. To address this issue, the study suggests adjusting screening intervals for these high-risk groups.
Researchers found that inhibiting NF-kB or TNFα can prevent inflammation-induced tumor growth, allowing TRAIL to tip the balance in favor of cancer killing. The study suggests using NF-kB inhibitors with anti-TNFα drugs and TRAIL-inducing cytokines to promote tumor killing.
Stanford researcher Matthew Bogyo and colleagues discovered that cathepsin cysteine proteases help build blood vessels to tumors, increase tumor growth and invasiveness. A broad-spectrum inhibitor slowed tumor development in mice with no apparent side effects.
A study published in Journal of the National Cancer Institute found that blocking hypoxia-inducible factor 1 (HIF-1) significantly impairs tumor growth by damaging the vascular microenvironment. The tumors were smaller and had thin-walled, lumenless blood vessels compared to control mice.
A study found that highly processed isoflavone products may pose a risk to postmenopausal women with estrogen-responsive breast cancers. Minimally processed soy flour was associated with less tumor growth in mice, suggesting a potential health benefit for consumers of whole soy foods.
Scientists at Johns Hopkins Kimmel Cancer Center have found a link between the HOXB7 gene and increased activity in breast cancer biomarkers. The study shows that the gene is overexpressed in more than 60% of breast cancer cell lines and 90% of primary breast cancers.
Research at Texas Agricultural Experiment Station has led to a patent for derivatives of DIM, a natural compound derived from certain vegetables, to treat cancer. These compounds have shown promise in inhibiting the growth of breast, pancreatic, colon, bladder, and ovarian cancer cells in laboratory studies.
A new tumour growth model views the tumour as an integral part of the body, dependent on host metabolic rate and food intake. The model predicts that tumours develop faster in younger hosts and have higher life expectancy with low-calorie diets.
Researchers found that combining anti-angiogenic and Hsp90 inhibitor drugs completely inhibited tumor growth in Id deficient mice, but had limited effect in mice with normal Id function. The study suggests a new approach for treating advanced breast cancer.
Researchers have discovered a potential new treatment for certain types of cancer by inhibiting sphingosine kinase. The study found that targeting this enzyme can reduce tumor growth and induce apoptosis in cancer cells, offering hope for new targeted therapies.
Asthma patients treated with bronchodilating beta-agonist medications may develop increased sensitivity to airway constriction, experience exacerbation of their condition. Researchers suggest that therapeutics targeting phospholipase C-beta may have substantial benefit in the treatment of asthma.
Researchers found that Cripto overexpression inhibits Activin signaling, leading to increased tumor cell growth. Antibody blockade of Cripto suppresses tumor cell growth in xenograft models, suggesting a central role for Cripto in tumorigenesis.
Researchers at UIC College of Medicine identified 57 genes involved in cell proliferation, including some not previously known to play a role in cancer cell growth. The study found that certain fragments inhibited the multiplication of breast cancer cells by shutting down genes necessary for cell growth.
Researchers are investigating new methods to combat cancer growth through computer models and cytotoxic treatments. They also discovered that a process called Auger emission can cause electrons to be emitted in well-defined directions by single molecules, leading to potential breakthroughs in physics research.
Researchers investigated the association between alcohol consumption and lung cancer risk, finding no statistically significant link. The Journal of National Cancer Institute also published studies on body surface area-based dosing for anticancer drugs and carbohydrate binding protein's potential to inhibit tumor growth.
Researchers found that a flaxseed-rich diet inhibited tumor growth and reduced aggression in genetically engineered mice. The study suggests that lignans in flaxseed could play a role in inhibiting prostate cancer progression by influencing estrogen and testosterone metabolism.
In a phase II trial, bevacizumab slowed tumor growth by two and a half times, with a highly statistically significant effect. The drug targets the angiogenic process, neutralizing VEGF protein to inhibit blood vessel growth and prevent tumor progression.
Scientists have developed a new compound, TAS-108, which inhibits the growth of tamoxifen-resistant breast tumours. It works by recruiting a co-repressor to help inhibit oestrogen receptors, making it more effective than other anti-oestrogens.
Researchers found that raloxifene did not further prevent the growth of breast tumors previously exposed to more than 5 years of tamoxifen. Raloxifene also failed to block the growth of endometrial tumors caused by low-dose estrogen, suggesting it may increase endometrial cancer risk.
Researchers discovered a natural protein called p22 that inhibits blood vessel growth, preventing tumors from growing. The study showed that p22 is released by cancerous cells and targets only those cells that help tumors grow, reducing the risk of metastasis.
A new study suggests that estrogen found in soy products with high isoflavone content may stimulate human breast-cancer cells in mice. Researchers warn women with estrogen-dependent breast cancer or a predisposition to it to reduce their consumption of such soy products.
A new experimental drug called 2C4 has shown to significantly inhibit tumor growth in hormone-dependent and resistant prostate cancer tumors in mice. The monoclonal antibody targets the HER-2/neu protein, which controls cell growth and stimulates tumor growth.
Two studies found sigmoidoscopy detects few cancerous growths and none in asymptomatic patients with polyps, supporting the use of colonoscopy for regular screening. The research suggests that colonoscopy should be done every 5-10 years for people over 50 to save lives.
Researchers found that tetrahydrocannabinol (THC) promotes tumor growth by impairing the immune system, increasing IL-10 and TGF-beta cytokine production. Marijuana smoke contains higher carcinogenic hydrocarbons than tobacco, posing a potential cancer risk.
Researchers at Duke University Medical Center uncovered evidence of genomic imprinting in marsupial opossums but not monotremes like platypuses. The study suggests that the 'battle of the sexes' theory for imprinting evolution may be supported by competition for nutrient allocation among young animals.
Scientists Yonathan Shapir and Jacob Jorné discovered that natural cycles generate fractal patterns, governing everything from weather to cauliflower heads. This breakthrough enables the prediction of events like car battery lifespan, lawn growth, and tumor cell behavior, with potential applications in engineering and medicine.
Researchers at Fred Hutchinson Cancer Center discovered a protein, Rrn3, that regulates cell growth in both humans and yeast. The protein appears to be a key player in an as-yet-unidentified cell-signaling pathway, potentially making it a unique drug target for cancer treatment.
Researchers successfully differentiated human placental cells by adjusting gap size in a fibrous-bed bioreactor, mimicking the body's natural process. The breakthrough may aid organ production for transplantation and has implications for tissue engineering and cancer research.
Researchers at UT Southwestern Medical Center found that higher PSA levels are associated with faster prostate growth, allowing doctors to predict and potentially slow growth through treatment. This study provides critical information for planning a treatment, emphasizing the importance of annual PSA tests for men over age 50.
Poultry farmers can stop using antibiotics to promote growth in birds by adding antibodies against appetite-suppressing neurotransmitters and a fatty acid found in hamburgers. This alternative method produces similar growth gains as antibiotics, with improvements of 3-5% in growth rates.
Researchers at Beth Israel Deaconess Medical Center have discovered a potent new substance, canstatin, that inhibits the growth of tumors by blocking the formation and growth of new blood vessels. The naturally occurring protein is effective in both prostate and renal cancer models.
A new MGH study has identified thrombospondin-2 (TSP-2) as a natural factor that inhibits tumor angiogenesis and growth in mouse models. The researchers found that TSP-2 completely stopped tumor growth when reintroduced into tumor cells, outperforming earlier anti-angiogenesis factors.
A new animal study suggests that soy isoflavones may slow prostate cancer growth by inhibiting cell proliferation and promoting apoptosis. The study also found lower levels of insulin-like growth factor 1, a hormone that stimulates tumor growth.
Scientists have discovered that the myc gene is even more powerful than previously believed, controlling cell growth and division while disabling brakes on growth. The findings mark a significant step towards understanding how faulty cell signals lead to cancer.
Researchers at MGH discovered TGF-beta-1 inhibits blood vessel growth associated with metastatic gallbladder cancer. The study's results may lead to anti-angiogenesis agents for cancer treatment.
Andrew Hamilton, an organic chemist at Yale University, is being honored with the American Chemical Society's Arthur C. Cope Scholar Award for his work on designing molecules that can control cell growth in cancer treatment. His research focuses on targeting a protein called Ras, which accounts for over 30% of all cancers.
A protein called PEDF has been shown to halt excessive blood vessel growth in the eye, potentially treating diabetic retinopathy and macular degeneration. Researchers found that increasing PEDF levels could slow vision deterioration and prevent new vessels from overgrowing.
Researchers found a protein called GON-1 that regulates organ shape in Caenorhabditis elegans, a microscopic worm. This discovery could lead to the development of inhibitors to slow or stop cancer cell spread and may one day enable growing human organs in labs.
Researchers find potential anti-cancer agents in ethanol extract of soybean molasses from crop-processing plant waste. The active compound, phytochemical complex 100 (PCC 100), contains saponins and suppresses cancer cell growth, reducing human colon cancer rates.
Researchers at UNC-CH discovered three genes crucial to cell survival and protein disposal. The proteins ROC1, ROC2, and APC11 are involved in the ubiquitin ligase enzyme that marks proteins for degradation. Disruption of this mechanism may promote cancer development by driving cells to proliferate uncontrollably.
Scientists discover that breast tumors produce high levels of a fetal form of insulin receptor, stimulating rapid cell division and cancer growth. The finding offers a potential target for new cancer drugs, which could block or slow breast tumor growth.
Researchers at the University of Wisconsin-Madison have identified two compounds, gamma-tocotrienol and beta-ionone, that suppress the growth of three types of human cancer cells. These isoprenoids, found in cereal grains and fruits/vegetables, work by interfering with cell division and disrupting cholesterol synthesis.
Duke University researchers found that angiostatin works by depleting the chemical energy needed for blood vessel cells to grow. This discovery offers a novel insight into the body's use of ATPsynthase as a power pack and suggests a new route to developing drugs to block tumor growth.
Researchers link Fas and FasL interaction to immune-privilege in the eye, affecting age-related macular degeneration. Deficiency of Fas or FasL leads to increased growth of new retinal vessels.
The US blood supply is considered extremely safe, with the risk of contracting viruses such as HIV being estimated at one in 676,000. However, a growing aging population will lead to increased demands on the blood supply, resulting in a potential shortage, and more units may need to be imported from abroad.
Researchers discovered that green tea's EGCg compound inhibits an enzyme required for cancer cell growth and can kill cultured cancer cells. Drinking more than four cups of green tea a day may provide enough of the active compound to slow and prevent cancer cell growth.
Physicians at the University of Chicago Medical Center have found a way to bring full immune system power against cancer using co-stimulation technology. Patients with advanced or recurrent lymphoma have experienced anti-tumor effects and complete remissions after receiving expanded, co-stimulated T cells.
Scientists at Thomas Jefferson University have demonstrated that a normally protective anticancer gene can block tumors from growing. Led by Dr. Antonio Giordano, they found that the damaged version of the gene, pRb2/p130, suppresses tumor growth in animal models, paving the way for gene therapy to treat lung cancer and other cancers.
Scientists are using NASA Bioreactors to culture breast cells on Earth, learning what controls their growth and how to thwart malignancies. The research has the potential to improve healthcare for women, including those traveling to Mars, by developing new therapies that target cancer's genetic weaknesses.
Scientists have grown healthy human placental cells in a laboratory using a new technique, providing a means to test the safety of drugs during pregnancy. The cells can survive and function like those in the womb, mimicking blood flow and nutrient exchange.
Researchers have discovered a gene called E2F1 that helps bring about tumor cell death yet is also necessary for their growth. The study found that without E2F1, tumors grew slower but cell death was reduced by 80 percent.
A protein found in copperhead snake venom retards breast tumor growth by blocking tumor cell adhesion and invasion, as well as inhibiting new blood vessel development. Studies with mice implanted with human breast cancer cells showed a 60-70% reduction in growth rate and 90% reduction of tumor metastasis to the lungs.
Squalamine, a novel liver steroid, has been shown to inhibit the growth of brain tumors called gliomas by disabling blood vessel formation. In laboratory tests, it proved as effective as carmustine in slowing tumor growth and constricting blood vessels, suggesting potential as a human therapy.
Researchers at The Wistar Institute have identified a key role for the GA733 antigen in inhibiting colorectal cancer cell invasion. The discovery has led to the development of an antibody that increases survival rates for CRC patients.
Researchers found that fragments of chromosome 11 slow tumor growth in mice and cell cultures, suggesting a tumor suppressor gene may be present. The study provides new hope for treating lung cancer patients by identifying a potential target for therapy.
Researchers at Duke University Medical Center have found that a Tie2 inhibitor can significantly slow the growth of tumors on rats by preventing nearby blood vessels from forming capillaries to feed the cancer. The treatment slowed tumor growth by 75 percent and reduced vessel length density by 40 percent.
Researchers found that captopril inhibited the growth of new blood vessels essential for tumor growth, potentially reducing cancer incidence and severity. The drug's mechanism may differ from its blood pressure-lowering effects.