Articles tagged with Tumor Growth
A study published in the Journal of Leukocyte Biology suggests that pre-existing inflammation can promote the spread of cancer by raising levels of chitinase-3-like-1, a known biomarker of cancer. This increase in CHI3L1 leads to faster cancer growth and increased metastasis.
A new Stanford University School of Medicine study has found that brain tumor growth is stimulated by nerve activity in the cerebral cortex. The research, conducted in mice with human brain cancer implants, identified a specific protein called neuroligin-3 as responsible for the increase in tumor growth associated with neuronal activity.
Research shows exercise slows tumor growth and improves blood vessel perfusion, leading to reduced hypoxia and better response to chemotherapy. Exercise combined with chemotherapy results in slower tumor growth compared to sedentary mice or those treated with the drug alone.
A recent study has explored the effect of mutations in PKC on tumour growth, revealing that most 'loss of function' mutations stop PKC from working. The study found that correcting these mutations in bowel cancer cells resulted in a reduction in tumour growth.
Researchers at Indiana University School of Medicine identified a novel pathway that enables solid tumor cancer cells to grow. The protein Mdm2 plays an active role in making p53 ineffective, providing a new target for therapeutic approaches.
Scientists from the University of Manchester discovered that ATF2 protein suppresses tumour growth in liver cancer models. The study suggests that ATF2's tumor-suppressing function may be more widespread than previously thought.
Researchers discover PHD3 controls EGFR uptake, leading to uncontrolled cell growth and tumor proliferation. PHD3 loss is crucial for human malignant brain tumour growth under hypoxia.
Researchers inhibit autotaxin, an enzyme that promotes cancer cell survival and metastasis, decreasing tumor growth by up to 70% and improving chemotherapy effectiveness. The discovery offers a new therapy potential for breast and thyroid cancer patients.
Researchers have developed a synthetic anti-cancer molecule JK-31 that blocks the signalling of a 'growth factor' chemical promoting blood vessel networks to feed tumours. The molecule also inhibits a protein controlling cancer cell division and proliferation.
Researchers at UC Davis found that diets rich in whole walnuts or walnut oil slowed prostate cancer growth in mice. The walnut diet also reduced levels of the hormone IGF-1, which had been previously implicated in both prostate and breast cancer.
Researchers have discovered a new target for treating kidney cancer by targeting the Transient Receptor Potential Melastatin 3 channel. This channel promotes tumor growth and stimulates autophagy in cancer cells.
Researchers have discovered a new drug combination that disrupts two key signaling pathways that drive breast cancer growth, showing promise in treating the disease. The combination of rapamycin and dasatinib was found to be more effective than using either drug alone in killing tumors.
A new study found that high levels of miRNA-378a-5p cause cell division anomalies in breast cancer cells, leading to abnormal chromosome numbers and promoting cancer growth. Elevated levels of this microRNA also correlate with aggressive forms of breast cancer.
A new computational model developed at Princeton University may help understand tumor dormancy, a phenomenon that can last up to 25 years in pancreatic cancer. The model predicts that tumors are likely to grow rapidly when the number of dividing cells reaches a certain critical level.
A study published in the Journal of Clinical Endocrinology & Metabolism found that mutations in the ARMC5 gene promote the growth of benign tumors in the adrenal glands and meninges. This discovery provides new insights into the causes of Cushing's syndrome, a disease characterized by elevated cortisol levels.
Researchers identified a tumor vessel-specific protein, L1, as a potential therapeutic target to reduce tumor growth and metastasis. Loss of L1 in mouse pancreatic cancer models reduced tumor angiogenesis and promoted vessel normalization.
Scientists at Scripps Research Institute have successfully disrupted MYC, a cancer regulator thought to be undruggable, using a credit card-like molecule called KJ-Pyr-9. This breakthrough discovery shows the drug candidate can stop tumor growth in animal models and may offer new hope for cancer treatment.
Researchers at Dana-Farber Cancer Institute found that subgroups within tumors drive growth, rather than the fastest-proliferating cells. Targeting these growth-driving cells could improve treatment outcomes and prevent tumor expansion.
Researchers have created a combination drug that controls both tumor growth and metastasis by combining a COX-2 inhibitor and an epoxide hydrolase (sEH) inhibitor. The study found that the dual inhibitor blocked angiogenesis, limiting tumor growth and metastasis in human lung and breast tumors.
Scientists at UEA discover the cannabis compound THC can reduce tumor growth by targeting two specific cell receptors. The findings could lead to the development of a synthetic equivalent with anti-cancer properties.
A team of scientists found that losing p62 in surrounding cells enhances tumor growth and progression. The study suggests therapies targeting the tumor microenvironment may be as important as targeting the tumor itself.
Activation of estrogen receptor β (ERβ) has been shown to limit tumor cell growth in breast cancer. In mouse models, cancer cells with activated ERβ did not grow well. Conversely, breast cancer patients with activated ERβ in their tissue had increased disease-free survival rates.
Researchers at Rochester Institute of Technology create algorithms to quantify lung nodule growth on CT scans, identifying small cancers and obviating risky biopsies. The software compensates for background factors and estimates nodule volumes, enabling accurate doubling time calculation and malignant growth detection.
Researchers identified a protein called CFIm25, which regulates messenger RNA length and promotes tumor growth. Restoring CFIm25 levels in brain tumors dramatically reduced their growth, providing a potential novel therapeutic strategy.
Researchers at JAX Laboratory have identified a protein involved in both wound healing and tumor growth as a potential therapeutic target. The study found that manipulating this protein could stimulate healing in wound patients while dialing back cancerous proliferation.
Researchers from the University of Notre Dame have uncovered a novel mechanism by which carcinoma-associated fibroblasts (CAFs) contribute to tumor progression. CAFs block cell death through insulin-like growth factor-binding proteins, highlighting potential therapeutic targets for slowing breast cancer metastasis. Further pre-clinical...
Researchers discovered microRNA-10a regulates human airway smooth muscle cell growth and inhibits PI3 kinase, a master regulator of cell proliferation. This finding offers a new approach to treating both asthma-induced muscle thickening and cancerous tumor growth.
Researchers found that triclosan and octylphenol promote breast cancer cell growth and tumor development in lab tests. The study's findings suggest that exposure to these endocrine-disrupting chemicals may significantly increase the risk of breast cancer development.
Researchers at Uppsala University discovered a new type of cell communication that suppresses blood vessel formation and delays tumour growth. Fluctuating levels of the molecule NRP1 can inhibit VEGF signals, leading to delayed tumour growth and potentially complete inhibition if trans communication occurs early in tumour development.
Researchers found that hypoxia stimulates the mislocation of SPOP to the cytoplasm, promoting rapid tumor growth. This shift enables SPOP to degrade key tumor-suppressor proteins, such as PTEN, leading to cancer progression. Understanding this mechanism may lead to new therapeutic approaches.
Researchers at UT Arlington found that exposure to BPA can increase HOTAIR expression in breast tissue and tumor cells, potentially contributing to breast cancer growth. The study's results suggest a link between BPA and tumor genesis in addition to tumor growth.
A new study published in Cancer Research found that fragmented sleep accelerates cancer growth by altering the immune system's response to tumors. Well-rested mice had primarily M1-type tumor-associated macrophages, while sleep-fragmented mice had primarily M2-type macrophages that promoted tumor growth.
Researchers found a significant inverse association between aspirin use and vestibular schwannoma growth in a retrospective series of 689 people. Aspirin intake may inhibit tumor growth, providing a potential therapeutic role for this anti-inflammatory medication.
Researchers found that metformin inhibits mTOR pathway, which supports cancer growth, rather than activating AMPK. Metformin may still be useful for cancer treatment, but clinicians should use caution when interpreting data.
Scientists at the University of Copenhagen have identified a specific sugar molecule that aids in the growth of cancer cells. The discovery, published in PNAS, could lead to new ways to diagnose and treat cancer.
Scripps Florida scientists discover that angiomotin is required for Yap-mediated tumor growth, challenging earlier findings of its inhibitory role. The study sheds light on a previously unknown pathway regulating cancer progression.
Researchers found that ERBB3 expression was enhanced in luminal breast cancers compared to other subtypes. The addition of an ERBB3 antibody promoted cancer cell death and decreased tumor growth in vitro.
Researchers at Johns Hopkins Bloomberg School of Public Health found that NRF2 signaling plays a role in regulating cell metabolism, leading to increased energy production and tumor cell proliferation. The study demonstrates the importance of targeting Nrf2 with small molecule inhibitors to intervene in therapeutic resistance.
Research published in BioMed Central's Stem Cell Research & Therapy found that injecting human stem cells into mice with tumors slowed down tumor growth. The study suggests that stem cells may restrict oxygen and nutrient delivery to the tumor, limiting cell division.
A novel monoclonal antibody targeting SFRP2 has been shown to inhibit tumor growth in pre-clinical models of breast cancer and angiosarcoma. The antibody is the first therapeutic discovered that targets SFRP2, a protein linked to angiogenesis and cancer progression.
The novel inhibitor XL-184 (Cabozantinib) showed significant tumor growth decrease in 12 colorectal cancer explants, with 8 exhibiting stable disease. The drug targets both VEGFR2 signaling pathway and c-MET for survival of tumor cells.
A team of UC Davis scientists found that epoxy docosapentaenoic acid (EDP) inhibits angiogenesis, cutting off oxygen and nutrients that fuel tumor growth. EDP reduces the growth and spread of tumors in mice by starving them of necessary blood vessels.
Researchers found that blocking substance P binding to its receptor NK1 with the anti-nausea drug Emend halted brain tumor growth and caused cell death in tumor cells. This breakthrough offers new opportunities for studying possible brain tumor treatments.
A recent UEF study reveals that high cell sugar concentrations boost hyaluronan production, which can fuel cancer growth. Regulating hyaluronan levels may hold the key to preventing cancer progression.
Researchers discovered that interfering with Hexokinase-2 reduces medulloblastoma's aggressiveness and allows long-term survival in mice. The enzyme plays a key role in aerobic glycolysis, a process also used by rapidly dividing cells, including cancer cells.
Researchers at Yale School of Medicine have identified a key link between stem cell factors that fuel ovarian cancer's growth and patient prognosis. The study reveals a connection between Lin28 and BMP4, which has implications for developing novel targeted therapies.
Researchers at McGill University have discovered AMPK's role in restricting cancer cell growth by regulating metabolism and preventing the use of sugar to fuel growth. AMPK, a tumour suppressor, can help control tumour development by targeting energy levels and promoting healthy cellular function.
A new study reveals that the SIRT6 gene plays a critical role in suppressing cancer growth by repressing aerobic glycolysis and inhibiting Myc activity. The loss of SIRT6 protein in mice increases tumor size and aggressiveness, highlighting its potential as a tumor suppressor.
A study by Georgetown University Medical Center researchers found that high glucose diets increase mutant p53 gene expression in mice, which drives tumor growth. Reducing glucose intake through starvation or low-carb diet slows down cancer growth.
Researchers at UCLA's Broad Center of Regenerative Medicine have discovered that the Trop2 protein promotes the self-renewal of cancer cells through a mechanism involving cleavage. This finding may lead to the development of new therapies that block Trop2 molecular signaling, stopping tumor growth in various epithelial malignancies.
Research reveals that Col6 protein's endotrophin alter tumor environment promoting growth and metastasis in mice. Reduced endotrophin expression linked to lower tumor burden and fewer metastases.
Researchers found that blocking galectin-1 in mice with established Kaposi sarcomas slowed tumor growth by suppressing blood vessel formation. This breakthrough holds promise for new treatment options for patients with KS and may also be effective for other diseases characterized by aberrant blood vessel growth.
Research at Thomas Jefferson University discovered that senescent cells in the tumor microenvironment produce nutrients for cancer cells via autophagy, supporting their growth. This finding suggests that aging is a key factor in driving tumor growth and metastasis.
Researchers have identified a molecule, PDE4, that plays a key role in regulating the division of tumor cells and blood vessel growth in lung cancer. By blocking PDE4, they were able to significantly reduce tumor growth in laboratory experiments and mouse models.
A new study published in Radiology journal reveals that lung cancers diagnosed through annual rounds of computed tomography (CT) screening exhibit similar growth rates and cell-type distributions compared to those found in clinical practice. The findings suggest a less aggressive approach for diagnosis and treatment of sub-solid lesions.
Princeton University researchers created a cellular automation model to investigate complex tumor-host interactions in cancer, revealing diverse growth dynamics and morphologies under varying pressures.
Scientists have combined NO- and H2S-releasing designer aspirins into a hybrid substance called NOSH-aspirin, which appears more effective in controlling cancer growth than either of its predecessors. The new compound inhibits the growth of various cancer cells, including breast, colon, and leukemia, with minimal harm to normal cells.
A new study reveals how tumours exploit the lymphatic system to evade immune cells, but also identifies a weakness that can be targeted to boost vaccine efficacy. By understanding this mechanism, future cancer vaccines may be able to bypass the tumour's defence and effectively kill cancer cells.
Researchers at Boston University have created a 3D model that simulates the growth of cancer tumors, suggesting that softening of cancer cells accelerates proliferation and extends lifetime, leading to rapid tumor growth. The study provides a new quantitative approach to understanding tumor development based on mechanical properties.
DIM inhibits ovarian cancer cell growth by blocking STAT3 activation and reducing IL-6 levels. The combination of DIM and cisplatin suppresses tumor growth in mice by an extra 50% compared to cisplatin alone.