Articles tagged with Enzymes
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers have created a microgel that can recover costly enzymes, overcoming significant obstacles in using natural enzymes in laboratory and industrial settings. The microgel enables efficient enzyme recovery, allowing for repeated use in catalyzing commercially important reactions.
Scientists at Georgia Tech are testing compounds that may inhibit the enzyme essential for the HTLV-I virus's reproduction, with potential as treatments for the fatal adult T-cell leukemia. The research aims to develop better inhibitors of the protease enzyme, which could lead to a new pharmaceutical agent in about five years.
Researchers developed a disposable sensor using carbon nanotubes and enzymes to detect OP nerve agents. The sensor can detect traces of up to 5 parts per billion, making it a promising tool for identifying toxin exposure.
A study found that a component of snake venom can help remove stubborn bloodstains from clothes, with fibrinolytic enzymes facilitating the breakdown of blood protein fibrin. Researchers successfully tested the enzyme on blood-stained denim swatches, showing significantly fainter stains after treatment.
Researchers at UCSD and TSRI have developed a method for creating highly specific inhibitors of the AChE enzyme, a key target for treating neuromuscular and cognitive disorders. The new approach utilizes click chemistry to bring reactant components into proximity on an enzyme template, resulting in potent and selective inhibitors.
A peptide, MUC7 12-mer, has shown promise for treating drug-resistant fungal strains. When combined with a protease inhibitor cocktail, its anti-microbial action was significantly increased.
A new computer method called FamClash has been developed to predict the activity of hybrid enzymes, which are created by combining similar enzymes from different organisms. The approach identifies incompatible residue pairs that can lead to reduced enzyme activity, and provides valuable insights for protein engineering interventions.
Researchers at the University of Illinois have discovered a new enzyme that can create antibiotic compounds by nature's machinery. This breakthrough could lead to the development of new antibiotics and combat antimicrobial resistance.
Purdue researchers discovered a method to boost the production of ferulate 5-hydroxylase, an enzyme used in pharmaceuticals. By altering nutrients and controlling fermentation time, they increased the enzyme's activity by 45% and productivity by twice its normal rate.
Researchers have discovered a brain receptor, GABA-A, that can be manipulated to control the switch between addicted and non-addicted states in the brain. By controlling this switch pharmacologically, it may be possible to take drug addicts back to a non-addicted state in a relatively short period of time.
Researchers found that diesel exhaust particles trigger more severe allergic responses in individuals with certain genetic variations, particularly the GSTM1 and GSTP1 genes. This study suggests a new route of intervention for pollution-related lung health problems.
Researchers at Northwestern University have made a breakthrough in treating Alzheimer's disease by targeting the gene that causes memory loss. The study found that inhibiting an enzyme called BACE1 can prevent memory deficits and brain cell functional abnormalities in laboratory models of Alzheimer's disease.
A bacterial enzyme keratinase has been found to fully degrade transmissible prions responsible for bovine spongiform encephalopathy and other diseases. Researchers plan to test its effectiveness in mice to confirm non-infectious levels of prion after degrading it to undetectable levels in vitro.
Researchers develop a method to capture enzyme activity in real-time, revealing detailed information about molecular interactions. This breakthrough enables the design of targeted synthetic drugs for cancer treatment.
A study of 100 patients with abnormally high liver enzymes found that 57 had HCV RNA in their liver biopsies, suggesting occult infection. HCV RNA was also detected in peripheral-blood mononuclear cells from 40% of patients, potentially allowing for easier detection and monitoring.
Telomeres protect chromosome ends, but when they're short, enzymes called exonucleases nibble away, causing gene loss. This discovery challenges the long-held assumption that chromosome fusion is the primary mechanism behind genomic instability.
A team of researchers has identified an enzyme, protein kinase C, that may play a crucial role in turning fleeting experiences into lasting memories. The study found that this enzyme helps to activate genes that express proteins involved in forming long-term memories.
A study by Duke University researchers found that a fungus's ability to breach the immune system is linked to an enzyme called flavohemoglobin. The team discovered that this enzyme plays a crucial role in defending against nitric oxide produced by the immune system, and that disabling it can significantly reduce fungal virulence.
Researchers at The Wistar Institute report new insights into the role of sirtuins in gene expression, revealing a mechanism likely to be general for the entire sirtuin enzyme family. This discovery may offer an explanation for the connection between metabolism and aging.
A newly discovered protease enzyme, Taspase1, plays a crucial role in the MLL protein's dual-function. Blocking Taspase1 may provide a novel way to halt runaway cell proliferation in leukemia. Enzyme inhibitors with few side effects could be effective against various cancers.
Melatonin levels are high at night and low during the day, but a newly discovered regulatory mechanism reveals how exposure to light accelerates melatonin disappearance. The study identified a critical phosphate group in enzyme AANAT that determines its stability, shedding new light on cellular processes.
A study published in Neurology reveals that Gulf War veterans under 45 have developed ALS, a neurodegenerative disorder, at an alarming rate. The Department of Veterans Affairs confirms the findings using a different method, raising questions about environmental exposures during the war and potential links to Gulf War syndrome.
Researchers found genetic mutations in PHF9 disrupt critical intracellular repair mechanisms, leading to Fanconi Anemia's serious complications. The discovery highlights the importance of PHF9 as a potent cog in DNA repair machinery, with potential implications for preventing excessive DNA damage and cancer.
Scientists, led by Bartel, develop RNA enzymes in lab that can replicate and act as enzymes, but still short of the 200-nucleotide goal. The RNA-world hypothesis proposes RNA played both DNA and protein roles in early evolution, with researchers re-creating this system to study its feasibility.
Silverman's research focuses on inhibiting an enzyme that produces nitric oxide, a compound linked to high blood pressure, stroke, and neurological diseases. His work aims to block the overproduction of nitric oxide in the brain without affecting its normal function.
Researchers from Imperial College London and UCLA have visualized the structure of lactose permease, an enzyme in E. coli that pumps lactose into cells. The structure data reveals a possible mechanism of action for this protein family, which plays critical roles in depression, stroke, and diabetes.
Researchers have found that the enzyme Pin1 plays a crucial role in protecting neurons from age-related degeneration and tangle formation in Alzheimer's patients. By understanding how Pin1 works, scientists hope to develop new therapies to prevent or slow down neurodegenerative processes.
Researchers have identified new serum biomarkers for ovarian cancer, which may be used in conjunction with existing methods such as CA125 marker and ultrasound to improve diagnosis. These newly discovered markers show promise in detecting the disease at an early stage, leading to better treatment outcomes.
Scientists at Vanderbilt University Medical Center have identified a new compound that activates glucokinase, an enzyme that regulates blood sugar levels. The compound has shown promise in improving insulin secretion and glucose usage in animals with diabetes, paving the way for potential clinical trials.
UCSD researchers define multiple steps initiated by COX-2 enzymes, including cyclic adenosine monophosphate and Inhibitors of Apoptosis, leading to suppressed cell killing and uncontrolled growth. The study also explains how aspirin and NSAIDs can reduce colon cancer incidence by inhibiting COX-2.
Researchers at USC developed synthetic enzymes that can combat oxidative damage, leading to improved memory in mice. The findings suggest these compounds may be more effective than traditional antioxidants in humans and could potentially treat various diseases with an oxidative component.
Weizmann Institute researchers have solved the 3D structure of the glucocerebrosidase enzyme involved in Gaucher disease. The discovery may lead to the design of more effective therapies, including enzyme replacement therapy and small molecule supplements.
Researchers at Purdue University have developed a new method to accurately measure quantities of a cheese-ripening enzyme in milk. The study combines infrared spectroscopy with statistical analysis to determine the concentration of plasminogen, enabling the creation of a model of the enzyme system function.
Researchers aim to develop anti-microbial drugs by targeting enzymes in microbial pathways that synthesize essential amino acids. Structural information of these enzymes will be obtained using x-ray crystallography, paving the way for designing candidate inhibitors.
Researchers have developed DNA enzymes that can produce branched and lariat RNAs, key intermediates in the biological process of splicing. The discovery could provide new insights into RNA splicing and its connection to genetic diseases.
A newly discovered enzyme from Thermus brockianus may transform industrial bleaching from environmentally problematic to environmentally green. The catalase enzyme works well in hot, alkaline wastewater, breaking down hydrogen peroxide into water and oxygen.
A study published in Proceedings of the National Academy of Sciences found a relationship between insulysin and Alzheimer's disease. The researchers discovered that even partial decreases in insulysin activity raised amyloid-beta peptide levels in the brain, increasing the risk of Alzheimer's.
Researchers at Ohio State University have identified a viral protein called p12 that mimics the way HIV-1 enters and infects human cells. The discovery provides valuable insight into how retroviruses overwhelm the human immune system, shedding light on the mechanisms of HTLV-1 infection.
Researchers found that a bacterial enzyme, peroxiredoxin, controls the balance of hydrogen peroxide in cells. The enzyme regulates hydrogen peroxide levels to prevent damage while allowing it to signal important cellular processes.
Researchers have discovered the first crystal structure of human carboxylesterase 1 (hCE1), an enzyme that metabolizes cocaine and heroin. The enzyme's structure holds promise for developing treatments for acute overdose and detoxifying chemical weapons, including nerve agents such as sarin and VX.
USC researchers have discovered the molecular mechanism behind immunoglobulin class switching, which enables antibodies to adapt to different areas of the body. The study reveals that an R-loop forms between the DNA and RNA strands, creating a stable bond that determines the cut point for DNA splicing.
Researchers have found that heating broccoli to 60°C increases the levels of anti-carcinogenic sulphoraphanes, which may help prevent cancer. To achieve high levels of these beneficial compounds, plant breeders could consider eliminating genes that code for a protein called ESP.
St. Jude researchers have gained insights into the critical role of E1 enzymes in controlling cellular functions by modifying ubiquitin-like proteins. The discovery sheds light on how cells maintain order and perform vital activities like immune responses and cell division.
Researchers have developed a new type of biofuel cell that runs off of alcohol and enzymes, potentially replacing rechargeable batteries. The cells can be charged instantly with a few milliliters of alcohol and may last up to a month without recharging.
Scientists have found that the DNA-repair enzyme functions uniquely in different organisms, with varying electron transfer pathways. This discovery may lead to the development of a novel enzyme for treating skin cancer in humans.
Researchers have developed a technology that uses gold nanoparticles to attach enzymes to electrodes, improving the measurement of biological molecules. The technique enables more sensitive and specific glucose monitoring in diabetic patients, with higher flow rates detected than with traditional methods.
Researchers discovered that a gene mutation in mice leads to severe glaucoma by disrupting ocular drainage structures. Administering L-DOPA to pregnant mice with the mutation improved pup outcomes, suggesting potential therapeutic benefits.
Researchers discovered a new gene mutation that affects L-DOPA production, potentially leading to new treatments for glaucoma. The study found that administering L-DOPA prevented severe abnormalities in mice with a genetic defect similar to primary congenital glaucoma.
Researchers increase vitamin C content in plants by introducing a gene that boosts the enzyme responsible for recycling vitamin C. The technology could provide an important means of increasing vitamin C levels in crops, improving nutrition and public health.
A Texas chemist has won a national award for his work on vitamin B12, a natural product he has worked with for about 30 years. He is now working on recreating the pathway for taxol, an anti-cancer drug derived from yew trees.
Walsh's research team has focused on developing selective antibiotics that target bacterial enzymes while leaving human ones intact. His work has helped design new variants of vancomycin, some of which are now in human trials to combat antibiotic-resistant bacteria.
Scientists at the University of Iowa have gained insight into how naphthalene dioxygenase, a bacterial enzyme, utilizes oxygen to catalyze reactions. This breakthrough has implications for developing microorganisms that can clean up toxic waste and creating novel drugs.
Researchers developed a microchip with light-impeding holes to observe individual enzymes interacting with other molecules. This technique enables detailed analysis of fluctuations and variability in enzyme behavior, crucial for understanding molecular movement and predicting less predictable behavior.
Researchers have visualized the molecular structure of succinate dehydrogenase, a key enzyme in cellular respiration, revealing its anti-aging function. The study shows that the enzyme's three-dimensional shape prevents the formation of destructive oxygen atoms, which can cause cellular aging.
Research reveals bilirubin's role in protecting cells from oxidative damage, potentially improving outcomes for conditions like stroke and heart attack. The study also sheds light on the paradox of bilirubin's production, suggesting it may be an evolutionary development to combat cellular stress.
Researchers discovered a key molecule regulating multiple genes in yeast and humans, potentially enabling rapid response to stress. The molecule, inositol polyphosphate, affects hundreds of genes by regulating enzymes that alter chromatin structure.
Preservatives can be grouped into three types: antimicrobials, antioxidants, and enzymes that fight natural ripening. Sulfur dioxide blocks microbial growth in foods, while propionates and benzoates help keep bakery products fresh.
Researchers at Scripps Research Institute have developed a new treatment for Gaucher disease by using small molecules to partially correct the genetic defect that underlies most cases of the disease. The therapy targets the most common mutation and could be more convenient and less costly than current enzyme replacement therapy.
Scientists have identified a unique mechanism used by the Esa1 enzyme to relax DNA packaging, differing from other enzymes in its family. This discovery opens up new possibilities for developing targeted cancer therapies.
Patients receiving enzyme replacement therapy for a near-two-year period show improved pain levels and reduced organ damage. The treatment continues to be effective despite the presence of antibodies in some patients.