Articles tagged with Polyketides
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A team of researchers from Tohoku University successfully engineered a new version of the pikromycin biosynthesis enzyme, PikAIII-M5, to control the chemical structure of macrolides. This advancement paves the way for creating novel antibiotics and more accurate predictions of naturally occurring macrolide structures.
Researchers discovered that Streptomyces bacteria produce chemical substances called arginoketides, which trigger biofilm formation, algae aggregates, and fungal signalling. These findings shed light on microbial communication and its impact on soil ecosystems and plant diseases.
Researchers at the University of Bristol have created a new technique to construct rare molecules found in Bahamian sediments, which could lead to cheaper and more accessible treatments for diseases. The breakthrough reduces the production time of these complex molecules from over 20 steps to just 14.
Researchers at Leibniz-HKI discovered a yellow natural substance that regulates the multicellular stage of the amoeba <em>D. discoideum</em>. The polyketide, dictyoden, prevents premature hatching from spores, maintaining the development cycle. The study provides insights into the complex transition from single- to multicellularity.
A new biosynthesis method has been developed to produce antibiotics from natural substances with added fluorine, which can strengthen bonding and improve accessibility. This technology has huge potential for optimizing polyketides, a gigantic substance class used in various medicines.
A research team at Leibniz-HKI has developed a new method to produce complex natural products, including the precursor to THC, in amoebae. By leveraging the natural properties of the amoeba, they were able to produce a functional inter-kingdom hybrid enzyme that produces olivetolic acid without additives.
By identifying key residues that affect extender unit selection, scientists can create molecules with improved efficacy against antibiotic resistance. This breakthrough enables precise reprogramming of the biosynthetic assembly line, paving the way for the design and testing of new drug compounds.
Scientists at the University of Freiburg have discovered three key enzymes that play a crucial role in synthesizing natural products. These enzymes restructure a chemical precursor molecule to create the carbon backbone of these compounds, which are used for various pharmacological effects.
Researchers have successfully investigated the basic mechanisms of molecular factories in bacteria, revealing insights into the production of complex structures like polyketides. This discovery inspires targeted manipulation of biochemical processes, leading to potential improvements in antibiotics and other drugs.
Researchers at UT Austin developed a cost-effective method to produce triacetic acid lactone, a biorenewable platform chemical, by engineering yeast Y. lipolytica to increase TAL production tenfold. This breakthrough enables mass production of polyketides for various industrial applications.
Researchers have found a single enzyme responsible for producing a unique chemical defense in mushrooms, which can inhibit the growth of insect larvae. This novel mechanism is crucial for mushroom survival and highlights the importance of polyketide synthases in fungal defense.
Scientists at NC State University have discovered a way to make pinpoint changes to an enzyme-driven assembly line that will enable the creation of new antibiotics with desired properties. By tweaking the function of individual modules in the enzyme, researchers can design man-made molecules with precise control.
Researchers at Scripps Florida Institute uncover a novel mechanism for incorporating sulfur into natural products, which has implications for advancing new therapies beyond cancer. The study provides insights into the chemistry of polyketide synthases and could lead to the development of new antitumor agents.
Understanding the structure and movement within molecular factories in microorganisms enables researchers to design and engineer systems for producing novel drugs. The discovery provides a blueprint for redesigning microbial assembly lines, holding promise for developing new medicines.
Researchers at UCLA have successfully reconstituted the enzyme responsible for producing lovastatin, a widely used cholesterol-lowering medication. By understanding how this large enzyme works, they hope to retune its assembly line to produce other natural compounds with similar benefits.
Researchers successfully engineered E. coli to synthesize bacterial aromatic polyketides, a class of natural products including antibiotics like tetracycline and anticancer compounds like doxorubicin. The breakthrough allows for mass production of these vital compounds using simpler organisms.
Researchers at UC Irvine have discovered the key to controlling polyketide ring formation, enabling the creation of new drugs for cancer treatment and cholesterol reduction. This breakthrough could lead to significant advancements in pharmaceuticals, with potential applications in obesity treatment and stem cell research.
Researchers at Salk Institute and MRC discovered how slime molds synthesise the chemical signal DIF-1 using a unique type III PKS domain arrangement. This discovery informs the development of more efficient methods for producing modified polyketides for human use, highlighting the complexity of natural chemicals in biological systems.
Sheryl Tsai receives $240,000 to pursue her work on polyketide synthases, enzymes that produce natural products used in pharmaceuticals. Her research aims to develop new drugs for cancer and other diseases.
A team from the Salk Institute has revealed the structural basis for tetraketide cyclization in stilbene synthase, which produces resveratrol, a beneficial phytonutrient found in red wine. The mechanism of stilbene synthesis is crucial for its pharmaceutical and medical interest.
Researchers create unnatural polyketides with anti-bacterial properties by altering enzyme feedstocks, promising to multiply the power of combinatorial biosynthesis and generate hundreds of new compounds for lead molecule discovery