Articles tagged with Protein Synthesis
A study led by Jennifer Doudna and Eva Nogales used cryo-EM to create a 3D model of the eIF3 protein complex, showing its structural mechanics in loading human or viral RNA onto ribosomes. This understanding could lead to new therapies for viral infections.
Researchers found that riboorganisms, which use RNA for genetic information and metabolic reactions, can have a much bigger genome than previously believed. This discovery greatly relaxes the conditions necessary for the first living organisms to develop, allowing them to contain more than 100 genes.
Researchers found that the SXL protein blocks the synthesis of MSL-2 proteins in females by acting on two separate steps. This discovery reveals an entirely new mechanism for controlling protein dosages at the level of RNA, which could have implications for understanding diseases and animal development.
Researchers have solved the mystery of the Shoenheimer effect, a 72-year-old cholesterol feedback mechanism. The study reveals that Insig proteins are essential components of this response and play a crucial role in regulating cholesterol synthesis.
A study found high concentrations of arsenic in a sample of the King's hair, suggesting exposure to heavy metals may have exacerbated his porphyria attacks. The researchers believe antimonial medications containing arsenic were the probable source of the toxin.
Researchers have developed a new method that uses so-called 'caged compounds' to control protein synthesis, which can be activated by light. This technique could lead to more intricate studies of biological processes, such as protein synthesis in nerve synapses.
Research reveals that chronic alcohol consumption impairs the heart's protein synthesis ability in males but not females. The study found altered phosphorylation of a particular protein factor involved in protein synthesis was affected in males following prolonged ethanol consumption.
Researchers found that inhibiting SCD1 decreased body fat and prevented obesity and metabolic syndrome in mice. Blocking SCD1 also increased expression of genes involved in energy expenditure, providing insights into its role in metabolism.
Researchers found that treatment with Viagra increases therapeutic levels of nitric oxide in heart cells, stabilizing mitochondria and reducing cell death. This may lead to new treatments for patients with heart failure where loss of cells is primarily due to apoptosis.
Researchers at Northwestern University propose a new theory that challenges the widely accepted model of long-term memory storage. According to this new theory, memories are stored through a dynamic and meta-stable process, rather than permanent representation in the brain.
A study of 502 patients with coronary artery disease found that statin therapy lowered both LDL cholesterol and C-reactive protein levels, leading to slower disease progression. The research suggests that inflammation plays a key role in cardiovascular disease and may be useful in patient management.
A study published in Nature Structural and Molecular Biology reveals that cellular modifications to tRNA enhance its ability to decode genetic information at the atomic level. The research supports Agris' Modified Wobble Hypothesis, suggesting that modified nucleosides enable tRNA to decode more than one DNA code.
Researchers have identified a gene essential for the synthesis of a novel plant hormone that regulates shoot branching. The hormone is believed to be a carotenoid derivative, with a protein that can cleave carotenoids such as carrots' orange pigment.
Professor Ekström received the IADR Salivary Research Award for his pioneering work on non-conventional transmitters in salivary glandular function. His research has significantly advanced our understanding of autonomic neurotransmission mechanisms and their effects on salivary secretion.
A new study found that carbohydrate intake has a limited positive impact on muscle protein synthesis after resistance exercise, but not enough to achieve the desired effect. Muscle protein breakdown decreased and net balance improved in the carbohydrate group compared to the placebo group.
The study reveals a direct activational signal from the synapse to the protein synthesis machinery, enabling neurons to boost protein production rapidly during long-term memory formation and synaptic strengthening. This discovery has significant implications for understanding psychiatric and neurologic diseases, potentially leading to ...
Researchers at UNC School of Medicine have identified a novel enzyme that halts histone synthesis when no longer needed, preventing lethal cell damage. The discovery sheds light on the complex regulatory mechanisms governing histone mRNA expression.
Drs. Brown and Goldstein's research on low-density lipoprotein receptors and Sterol Regulatory Element Binding Proteins (SREBPs) led to effective new drugs for high cholesterol treatment and discovery of a potential insulin-sensitive regulator for diabetes therapy.
Estrogen exposure triggers structural changes in the hippocampus, a primary memory center, increasing connections among neurons. The study provides new insights into the role of estrogen in learning and memory, suggesting potential benefits for postmenopausal women and a possible link to Alzheimer's disease prevention.
Scientists have created a completely autonomous organism that uses 21 amino acids, enabling site-specific incorporation of novel amino acids into proteins. This breakthrough expands the genetic code's capabilities and paves the way for innovative medical research and protein modification technologies.
A study by National Space Biomedical Research Institute found that amino acid supplements can maintain protein synthesis rates and body mass during bed rest, a model for muscle loss in space. The supplements also showed potential in reducing muscle atrophy in elderly, burn patients, and those after major operations.
Researchers from the University at Buffalo have developed a programmable 'Sugazyme' that can efficiently attach unnatural amino acids to proteins. The technology has the potential to aid researchers working in proteomics by expanding the amino-acid repertoire for protein synthesis.
Researchers at UNL have discovered a glycoprotein complex, p67, that correlates directly with cells' resistance to viruses. The team found that encouraging the growth of p67 could be a useful means of preventing viruses from taking over cells' reproductive machinery.