Researchers at UT Health San Antonio have uncovered how the liver's internal clock coordinates the release of proteins that regulate metabolism. The findings suggest that understanding this internal clock could help guide future research on metabolic disease and inform optimal timing for meals and medication.
SourceThe University of Texas at San Antonio Health Science Center·JournalNature Communications·DateAug 12, 2026
Researchers propose integrating biochemical stabilization, high-throughput screening, AI-based prediction, synthetic biology, and spatial omics to map signaling networks. This integration could improve how researchers understand physiology across tissues and organs.
SourceScience Exploration Press·TypeLiterature review·DateMay 22, 2026
A Kobe University team identified the cause of pollutant accumulation in pumpkins and their relatives, discovering that specific proteins bind to pollutants and transport them through the plant. By controlling these proteins' behavior, safer crops can be created and polluted soils can be cleaned.
SourceKobe University·JournalPlant Physiology and Biochemistry·TypeExperimental study·DateOct 30, 2025
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Researchers found that Toxoplasma gondii parasites lacking the protein MYR1 can survive and proliferate when co-infected with normal parasites, thanks to supportive secreted proteins. This study highlights a limitation of pooled CRISPR screens in studying parasite biology in live hosts.
Researchers invent time-resolved assessment of single-cell protein secretion with sequencing (TRAPS-seq) to correlate cell functions with secreted proteins. The technique accelerates the development of new therapeutic strategies for disease treatment, including targeting mechanisms selective for cancer cells.
SourceNational University of Singapore·JournalNature Methods·DateJun 5, 2023
Researchers at the University of California - Riverside have discovered a way to deactivate mosquito sperm, preventing them from swimming to or fertilizing eggs. This breakthrough could help control populations of Culex mosquitoes that transmit infectious diseases like encephalitis and West Nile Virus.
SourceUniversity of California - Riverside·JournalPLOS ONE·DateMar 16, 2023
A study found that Spp24 inhibits osteosarcoma tumor cell proliferation, invasiveness, and promotes apoptosis. It achieves this by neutralizing bone morphogenetic protein 2.
SourceWiley·JournalJournal of Orthopaedic Research®·DateMar 8, 2023
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Researchers from Tokyo Metropolitan University have discovered a protein called PDGF-B that not only promotes muscle growth but also enhances myotube maturation, leading to increased contractile strength. The findings offer a game-changing approach to treating muscle injuries and atrophy.
SourceTokyo Metropolitan University·JournalBiochemical and Biophysical Research Communications·DateJan 14, 2023
Researchers from University of Cologne and Technical University of Munich discovered that the signal peptidase complex plays a crucial role in quality control of membrane proteins. The complex cleaves faulty membrane proteins to initiate their degradation, maintaining cellular function. This discovery has important implications for und...
SourceUniversity of Cologne·JournalScience·TypeObservational study·DateDec 1, 2022
Researchers found that knockdown of secreted frizzled-related protein 4 (SFRP4) suppresses SASP and improves age-related skin phenotypes. This suggests a potential candidate for the development of new skin rejuvenation therapies.
SourceImpact Journals LLC·JournalAging-US·TypeExperimental study·DateOct 31, 2022
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Scientists at UC Berkeley developed a new structure prediction method that modeled 500 secreted proteins in fungal pathogen Magnaporthe oryzae. The method revealed novel sequence-unrelated effectors and common folds among plant pathogens.
SourceAmerican Phytopathological Society·JournalMolecular Plant-Microbe Interactions·DateJan 19, 2022
A new tool called SECRiFY enables training of machine learning predictors of protein secretability, allowing for unprecedented studies on eukaryotic protein secretion. This method improves the predictability of protein manufacturing in biotechnology by identifying sequence properties that allow for secretory processing.
SourceVIB (the Flanders Institute for Biotechnology)·JournalNature Communications·TypeNews article·DateNov 5, 2021
Researchers at UCSB have discovered a mechanism by which secreted proteins age and turn over, shedding light on a crucial aspect of health and disease. The discovery identifies over 600 proteins with molecular signs of aging and turnover, including regulators of proteolysis, blood coagulation, and immunity.
SourceUniversity of California - Santa Barbara·JournalProceedings of the National Academy of Sciences·DateOct 19, 2015
Scientists at Sanford Burnham Prebys Medical Discovery Institute have identified a mechanism by which secreted proteins age and turnover, shedding light on health and disease. The discovery highlights the importance of N-glycan remodeling and lectin recognition in regulating protein abundance.
SourceSanford Burnham Prebys·JournalProceedings of the National Academy of Sciences·DateOct 19, 2015
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Golgi lipids play a crucial role in regulating protein trafficking, disrupting the organization of the Golgi apparatus and blocking certain proteins from being trafficked. The study found that PLA2 overexpression causes the fragmentation of the Golgi apparatus, similar to changes during mitosis.
SourceJCI Journals·JournalJournal of Clinical Investigation·DateOct 10, 2000