Articles tagged with Secreted Proteins
Cyclin D1, a protein linked to cancer, paradoxically promotes chronic inflammation in non-proliferating senescent cells, which can lead to age-related disease. Research suggests that targeting cyclin D1 may be a promising strategy to reduce inflammation and promote healthier aging.
Researchers found that impaired peroxisomal function can increase insulin secretion while promoting insulin oxidation and disrupting pancreatic beta cell maturity. Healthy peroxisomes play a role in protecting insulin from oxidative modification and degradation, and helping beta cells maintain their specialized characteristics.
Scientists have discovered a new connection between energy-producing mitochondria and chronic inflammation in senescent cells, which promotes age-related diseases. Blocking a related gene and using a drug called CTPI-2 reduced inflammation and promoted healthier aging in mice.
Researchers at UT Health San Antonio have uncovered how the liver's internal clock coordinates the release of proteins that regulate metabolism. The findings suggest that understanding this internal clock could help guide future research on metabolic disease and inform optimal timing for meals and medication.
Researchers propose integrating biochemical stabilization, high-throughput screening, AI-based prediction, synthetic biology, and spatial omics to map signaling networks. This integration could improve how researchers understand physiology across tissues and organs.
A Kobe University team identified the cause of pollutant accumulation in pumpkins and their relatives, discovering that specific proteins bind to pollutants and transport them through the plant. By controlling these proteins' behavior, safer crops can be created and polluted soils can be cleaned.
Researchers found that Toxoplasma gondii parasites lacking the protein MYR1 can survive and proliferate when co-infected with normal parasites, thanks to supportive secreted proteins. This study highlights a limitation of pooled CRISPR screens in studying parasite biology in live hosts.
Researchers invent time-resolved assessment of single-cell protein secretion with sequencing (TRAPS-seq) to correlate cell functions with secreted proteins. The technique accelerates the development of new therapeutic strategies for disease treatment, including targeting mechanisms selective for cancer cells.
Researchers at the University of California - Riverside have discovered a way to deactivate mosquito sperm, preventing them from swimming to or fertilizing eggs. This breakthrough could help control populations of Culex mosquitoes that transmit infectious diseases like encephalitis and West Nile Virus.
A study found that Spp24 inhibits osteosarcoma tumor cell proliferation, invasiveness, and promotes apoptosis. It achieves this by neutralizing bone morphogenetic protein 2.
Researchers from Tokyo Metropolitan University have discovered a protein called PDGF-B that not only promotes muscle growth but also enhances myotube maturation, leading to increased contractile strength. The findings offer a game-changing approach to treating muscle injuries and atrophy.
Researchers from University of Cologne and Technical University of Munich discovered that the signal peptidase complex plays a crucial role in quality control of membrane proteins. The complex cleaves faulty membrane proteins to initiate their degradation, maintaining cellular function. This discovery has important implications for und...
Researchers found that knockdown of secreted frizzled-related protein 4 (SFRP4) suppresses SASP and improves age-related skin phenotypes. This suggests a potential candidate for the development of new skin rejuvenation therapies.
Scientists at UC Berkeley developed a new structure prediction method that modeled 500 secreted proteins in fungal pathogen Magnaporthe oryzae. The method revealed novel sequence-unrelated effectors and common folds among plant pathogens.
A new tool called SECRiFY enables training of machine learning predictors of protein secretability, allowing for unprecedented studies on eukaryotic protein secretion. This method improves the predictability of protein manufacturing in biotechnology by identifying sequence properties that allow for secretory processing.
Researchers at UCSB have discovered a mechanism by which secreted proteins age and turn over, shedding light on a crucial aspect of health and disease. The discovery identifies over 600 proteins with molecular signs of aging and turnover, including regulators of proteolysis, blood coagulation, and immunity.
Scientists at Sanford Burnham Prebys Medical Discovery Institute have identified a mechanism by which secreted proteins age and turnover, shedding light on health and disease. The discovery highlights the importance of N-glycan remodeling and lectin recognition in regulating protein abundance.
Golgi lipids play a crucial role in regulating protein trafficking, disrupting the organization of the Golgi apparatus and blocking certain proteins from being trafficked. The study found that PLA2 overexpression causes the fragmentation of the Golgi apparatus, similar to changes during mitosis.