Articles tagged with Trehalose
Researchers at MIT developed a new cell-preservation technique using naturally occurring sugars, reducing the need for a chemical preservative. This approach significantly improves the viability and function of CAR-T cells, making them easier to deploy in hospitals.
A new freeze-dried blood product called Thrombosomes has shown promise in treating traumatic brain injuries by reducing swelling and bleeding. The product, derived from platelets with trehalose preservation, has been tested on mice and found to be effective in stabilizing damaged blood vessels.
Researchers introduce trehalose into hydrogels to form hydrogen bond interactions, improving dehydration resistance, lubrication performance, mechanical properties, and manufacturing accuracy. This discovery proposes a new design principle for high-precision manufacturing of hydrogel materials.
Researchers discovered a species of grass, seashore paspalum, that can tolerate diverse stresses and aid in crop development. The study revealed the plant responds to nutrient deprivation by doubling its production of a sugary molecule called trehalose, which helped corn seedlings grow faster and larger without added nutrients.
Tardigrades can survive drying, freezing, heat, and space due to their unique trehalose-protein combination. Researchers discovered that trehalose works synergistically with another tardigrade-specific protein called CAHS D.
A new study reveals that birds lost the ability to digest trehalose, a non-reducing disaccharide found in common food sources, likely due to evolutionary divergence from their common ancestor. This loss has significant ecological implications, including reduced access to energy-rich foods and potential adaptations by other species.
The team designed a cascade for flow catalysis to convert glucose into trehalose in two steps using immobilised enzymes. They aim to optimise the process by improving substrate materials and making it more cost-efficient through recycling UTP.
Researchers found that trehalose and glycogen pathways are crucial for stress tolerance in Pseudomonas aeruginosa, a significant pathogen causing pneumonia and hospital-acquired infections. Disrupting these pathways significantly reduced the bacteria's ability to survive on man-made surfaces.
Researchers have developed a method to use ultrasound to insert a sugar molecule called trehalose into red blood cells, allowing them to last for years. This technique could increase the shelf life of blood donations from weeks to years.
Researchers found that trehalose improves insulin sensitivity in mice by activating a gene called Aloxe3, which boosts calorie burning and reduces fat accumulation. Trehalose also has beneficial effects on the liver's metabolism, similar to fasting.
Researchers discovered that trehalose increases cellular waste disposal and improves neurological symptoms in MPS IIIB mice. The study found that trehalose delayed retinal degeneration, vision loss, and improved lifespan by activating a master regulator of the lysosomal system.
Researchers discovered a gene called heat shock factor is co-opted by the sleeping chironomid to survive desiccation. The gene's activation leads to the synthesis of heat shock proteins protecting cells from misfolding, allowing the insect to regain life.
Researchers found that dietary trehalose enhances the virulence of epidemic C. difficile lineages, leading to increased disease severity and mortality in animal models. The study suggests that trehalose may be a key trigger for the predominance of these lineages, contributing to hospital-acquired infections.
Trehalose boosts autophagy in macrophages, allowing them to reduce atherosclerotic plaque. The study shows promise for treating atherosclerosis and other metabolic conditions.
A new diagnostic tool for tuberculosis has been developed to simplify, fasten and improve the accuracy of tests. The experimental new test is currently being tested in South Africa.
Researchers identified a limit where dehydration kills cells due to trehalose network rigidity and mechanical force. The study suggests a new working hypothesis for cell injury during dry preservation.
A team of Duke researchers has solved the structure of an enzyme required to synthesize trehalose, a chemical cousin to table sugar that pathogenic fungi need to survive in human hosts. The research paves the way for designing new antifungal drugs against three deadly fungi: Cryptococcus, Candida, and Aspergillus.
Researchers found that trehalose prevents the buildup of fat in liver cells by blocking the transport of energy from sugar into liver cells. This triggers autophagy, a natural process where cells consume stored fats and other waste materials. The study suggests that trehalose may offer a potential treatment for nonalcoholic fatty liver...
Cornell researchers introduce a trehalose-enhancement gene into Indica rice varieties, demonstrating stress tolerance and increased productivity. The transgenic plants also exhibit improved photosynthesis and nutrient utilization, making them more robust under various environmental stresses.
A team of researchers at UC Davis has developed a method to freeze-dry platelets, which can be stored for at least a year without refrigeration. The innovation uses trehalose, a natural protectant found in certain animals and plants, to preserve the structure of proteins and other large molecules.