A study by the CNIO group has identified a genetic signature in precancerous breast lesions that can predict which ones will evolve into invasive tumours. This discovery could help avoid over-treatment of women diagnosed with ductal carcinoma in situ, a common precancerous lesion.
Researchers at Boston University School of Medicine found that tiny particles in the blood, known as exosomes, can reprogram immune cells inside tumors making them weaker and allowing the cancer to grow and spread more easily. The study provides new insights into why people with type 2 diabetes have worse breast cancer outcomes.
A study published in iScience found that cells in breast tissues of women with African ancestry send cues promoting breast cancer growth. Researchers discovered that PZP cells activate epithelial cells, allowing them to invade surrounding tissue.
Researchers discuss cortactin's impact on cancer progression by modulating the Wnt5a/ROR1 signaling pathway. Cortactin expression is found in various cancers, including breast and chronic lymphocytic leukemia, suggesting its potential role in promoting metastasis.
Researchers found significant decreases in the levels of KRAS, RHOA, RAC1, and CDC42 after PCAI treatment, implicating their role in cancer progression and metastasis. These findings support the potential of PCAIs as potent agents for developing new anticancer therapeutics.
Researchers at Tokyo Medical and Dental University developed a new technique to detect breast cancer-related markers using transistors, offering a less invasive method for monitoring patients. The system successfully detected epidermal growth factor receptor expression on cancer cells.
Australian researchers have discovered a new mechanism by which T cells can react to lower doses of antigens, leading to a 50-fold increase in T cell activation sensitivity. This finding opens up new possibilities for developing more effective immunotherapies.
A team of researchers has identified a promising prognostic and therapeutic target for patients with metastatic breast cancer: integrins αv and β1. These proteins are highly expressed in extracellular vesicles from tumour cells and may help develop new ways to assess, monitor, and suppress cancer metastasis.
A recent study published in Cancer Research identified a unique vulnerability in certain high-risk cancers that can be exploited for targeted therapy. Researchers found that cancer cells with alternative lengthening of telomeres (ALT) have a common weakness, leading to resistance to DNA-damaging agents and chemotherapy.
Researchers identify two genes, GLI1 and Notch1, responsible for aggressive growth and spread of triple negative breast cancers in African American women. A combination approach using inhibitors and chemotherapy agents significantly inhibits tumor growth and metastasis.
New research from UBC Okanagan shows that community-based initiatives and microgrants are effective in increasing physical activity among breast cancer survivors. The program, Project MOVE, supports community-led interventions and fosters social support and confidence
Researchers have identified a molecular marker in normal breast tissue that can predict a woman's risk of developing breast cancer. The study found that women with higher levels of the marker were five times more likely to develop cancer.
A team of researchers found that healthy breast cells can differentiate into various cell types similar to those seen in metaplastic carcinoma, a type of triple-negative breast cancer. This discovery challenges the traditional understanding of terminal differentiation and suggests that mature cells may retain some flexibility.
A study published in Cancer Cell identified a previously unknown vulnerability in triple-negative breast cancers, which can be effectively treated with an FDA-approved drug. The researcher found that targeting the cystine transporter xCT significantly inhibited tumor growth in mice and cell culture.
Researchers at Berkeley Lab identify protein FAM83A as a key player in breast cancer's resistance to widely used cancer therapy EGFR-TKIs. The discovery may provide new insights into the mechanisms behind this resistance and pave the way for novel therapeutic targets.
Researchers from Spain have discovered that extra virgin olive oil's polyphenols may help combat breast cancer by inhibiting the HER2 oncogene. The study confirms the anti-HER2 effect of fractions extracted from olive oil in breast cancer cell lines, suggesting a potential basis for new anti-HER2 compounds.
Researchers have discovered a synthetic cell-signaling molecule called Enigmols that suppresses the growth of human cell lines representing multiple types of cancer and reduces tumors in animal studies. The findings suggest that Enigmols may be a new approach to treating cancer, with potential benefits including minimal side effects.