Articles tagged with Centrioles
A study by National University of Singapore researchers found that NuSAP, a microtubule-associated protein, stabilises centriole architecture and recruits proteins necessary for proper centrosome engagement. This mechanism is critical to maintaining chromosome integrity and preventing developmental disorders.
Researchers have discovered a key protein structure in the germ cells of male mice that causes deformations in sperm flagellum leading to infertility. The study used ultrastructure expansion microscopy to visualize the centriole, a tiny cylindrical structure critical for sperm movement.
Scientists discover that multiciliated cells use cell division to control hair-like projections called cilia. This adaptation breaks the cancer-preventing rule of making only four centrioles per cell, producing hundreds instead.
Researchers at the University of Geneva have successfully visualized and reconstructed the assembly of the human centriole, a critical structure in the cell skeleton. By combining high-resolution microscopy and kinematic reconstruction techniques, they were able to model the first 4D assembly of the centriole, providing new insights in...
Researchers at the University of Bonn have identified a mechanism that helps dendritic cells migrate more quickly to lymph nodes. The discovery reveals that forming multiple centrosomes enables these immune cells to stay on course longer before continuing their search.
A team from UNIGE has identified a molecular mechanism that causes degeneration of photoreceptors in retinitis pigmentosa, a genetic disease leading to blindness. The discovery could lead to therapeutic treatments targeting this mechanism.
Researchers at IRB Barcelona have identified γTuRC as a centriole stabilizer, revealing its role in maintaining centriole stability and preventing microcephaly. The study's findings suggest that defects in γTuRC may contribute to various human diseases, including adolescent scoliosis and male infertility.
Researchers at UToledo have identified a new sperm movement that helps diagnose and treat male infertility. The study reveals the centriole's role in sperm evolved from a shock absorber to a transmission system, enabling more efficient movement.
The University of Toledo has received a three-year $500,000 grant from the USDA to develop tools for selecting bulls with superior fertility. The project aims to reduce dairy production costs and advance ongoing human fertility research by identifying atypical centrioles in bull sperm.
Researchers have overcome the limitation of super-resolution microscopy by combining dSTORM and expansion microscopy, achieving a distance error reduction to just five nanometers. This enables fluorescence imaging with molecular resolution for the first time, allowing detailed insights into molecular function and architecture.
A new super-resolution microscope reveals unprecedented detail of the centriole's twist, a nanoscale structure important for cell division. The technology could be used to study other cellular structures like mitochondria or viruses.
Researchers from Université de Genève have discovered an internal structure at the center of centrioles, crucial organelles that form the cell skeleton. This finding provides a better understanding of centriole functions and pathologies associated with their dysfunction, including ciliopathies and retinal disorders.
Researchers at Johns Hopkins Medicine found that specialized cells use a process more common in non-mammalian species to create hundreds of cilia, challenging the long-held assumption that deuterosomes play a central role. This discovery could lead to new treatments for cilia-related disorders.
Researchers have gained new insights into the mechanisms of cell division by examining the function of centrioles. They found that centrioles play a crucial role in promoting mitotic spindle assembly and maintaining centrosome structural integrity. The study's findings help to elucidate the critical functions of centrioles in the process.
Researchers at the University of Würzburg have successfully applied U-ExM to image multi-protein complexes with unprecedented molecular resolution. This breakthrough resolves long-standing doubts about the method's reliability and preserves ultrastructural details.
The University of Extremadura researchers have developed a methodology with new algorithms to analyse the location of centriole in a model cell. They discovered how the actin cytoskeleton influences polarised placement of centrioles in Drosophila and vertebrates.
A study at the University of Toledo identifies a new centriole in human sperm that functions in zygotes, potentially contributing to male infertility and early embryo developmental defects. The research provides new avenues for diagnostics and therapeutic strategies.
Researchers found that cancer cells have extra and longer centrioles, disrupting cell division, in aggressive breast and colon cancers. This discovery may aid in classifying tumors for prognosis and predicting treatment response.
A team of researchers has identified the earliest-acting protein needed for cell division, which is critical for organizing cell division in animals. The discovery, made using roundworms, revealed a key advance in understanding centriole duplication, a process vital to cell division and cilia function.
Researchers at Instituto Gulbenkian de Ciencia cracked the mystery of centriole elimination in oocytes, showing that losing this structure is crucial for sexual reproduction and female fertility. The study found that centrioles are eliminated step-wise due to a regulator called polo kinase protein.
Researchers discovered that the cell cycle clock inhibits the formation of centrioles, ensuring each daughter inherits a single copy. This mechanism is critical for maintaining homeostasis and preventing infertility and cancer.
Researchers at EMBL have observed the elimination of centrioles from starfish egg cells, a process essential for viable embryo development. The study reveals the role of appendages in directing centriole expulsion and provides insights into the molecular logic underlying this mechanism.
Researchers have identified a key protein in cilia assembly, which is essential for sensing chemicals and mechanical forces in the body. The discovery, published in Current Biology, sheds light on how cilia are assembled and could lead to a better understanding of ciliopathies, a group of disorders affecting millions worldwide.
Researchers discovered that protein p53 monitors centriole numbers to prevent potentially disastrous cell divisions. Without centrioles, cells are unable to divide due to the presence of p53, which acts as a backup to prevent abnormal cells from forming.
Researchers found that paternally contributed centriole proteins can persist up to ten cell generations, raising the possibility that centrioles may be a non-genetic information carrier. This discovery has profound implications for biology and disease treatment, particularly for understanding centriole-related diseases.
Researchers from Instituto Gulbenkian de Ciencia discovered that Polo-like kinase 4 (PLK4) must self-destruct to ensure normal centriole formation. This destruction mechanism controls centriole number and prevents diseases like cancer and infertility in fruit fly model organisms.
A team of scientists has discovered a crucial mechanism controlling centriole separation during cell division, shedding light on the process and its potential links to cancer. The study's findings suggest that the dense mass surrounding centrioles, called PCM, plays a key role in regulating their separation.
Researchers discovered that planarians lack centrosomes and yet retain regenerative powers. By studying planarian homologs, the team identified conserved proteins required for centriole assembly in human cells, suggesting alternative functions for centrosomes.
A Florida State University researcher has identified the important role that CDK5RAP2 plays in maintaining centriole engagement and cohesion, thereby restricting centriole replication. This discovery could lead to a greater understanding of stem cells and their connection to human diseases such as small brain syndrome.
Researchers discover HYLS1 is a centriolar protein required for cilia formation in humans, linking hydrolethalus syndrome to the emerging class of human ciliopathies. The study expands knowledge on human ciliopathy diseases, providing insights into severe birth defects and early neonatal death.
CSHL scientists identify Orc1 as a protein controlling centrosome duplication, preventing excess centrosomes and ensuring genetic stability. The study reveals Orc1's role in regulating centriole pairing and centrosome duplication, with implications for cancer research.
Researchers at Rockefeller University Press have uncovered a mechanism that limits centriole duplication, allowing cells to fashion extra centrioles only once per cell cycle. This discovery could lead to the development of new cancer treatments by restricting tumor cells' ability to replicate centrioles.