Articles tagged with Nerve Growth Factors
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Researchers at NYU Pain Research Center have found a new receptor for nerve growth factor that plays an important role in pain signaling. The discovery holds promise for finding new treatments for arthritis and other forms of inflammatory and cancer pain without the side effects of recent therapies.
Researchers from Skoltech have developed biodegradable microcapsules that deliver nerve growth factor to guide neuronal development. The microcapsules demonstrate significant boosting of neuronal growth and formation of functional synapses.
Researchers discovered that Epo increases nerve cell production and connections in the brain, leading to improved cognitive performance. Cognitive challenges trigger oxygen deficits, stimulating Epo production, which drives neuroplasticity and neurogenesis.
Researchers have identified a novel form of inflammatory regulation that increases response to painful stimuli. A protein fragment, ARD, plays a key role in this process, increasing PI3K activity and sensitizing pain receptors.
University of Louisville researchers have identified CD2AP as a crucial player in neural growth, which could lead to therapies for various neurological conditions. The protein orchestrates the branching of nerve axons, creating new connections, but excessive growth can be harmful.
A recent clinical study has shown that applying a growth factor to the brain may help preserve dopaminergic cells and fibers, increasing dopamine signaling in patients. The study suggests that future therapies could utilize the brain's own protective mechanisms to limit neuronal cell death and restore natural dopamine production.
Researchers have discovered that growth factor VEGF-B can regenerate damaged peripheral nerves in the cornea without inducing angiogenesis. This finding suggests that VEGF-B may be a suitable candidate to treat nerve damage in areas where blood vessel formation would be detrimental.
Researchers found that rapamycin at a concentration of 1.53 nmol/L significantly promoted Schwann cell migration, whileFK506 had limited efficacy due to its nephrotoxicity and hypertension risks. Rapamycin also upregulated growth-associated protein 43 expression in Schwann cells.
Researchers found that an inside-out vein graft filled with platelet-rich plasma (PRP) improved sciatic nerve function in rats compared to traditional autografting. The study showed increased myelination, axon diameter, and myelin sheath formation in PRP-filled vein grafts.
A lack of standards for experimental design and reporting hinders progress in developing therapeutics for spinal cord injuries. Implementing data standards and ontologies can facilitate transparency and analysis in neural plasticity and regeneration.
Researchers found that intranasal administration of nerve growth factor increases its content and receptor in spinal cord neurons, improving locomotor behaviors after spinal cord injury. This study provides evidence for the use of intranasal nerve growth factor as a treatment for spinal cord repair.
Researchers used amino-functionalized carbon nanotubes to deliver nerve growth factor, improving complex dispersibility and reducing toxicity. This improved the promotion of cell differentiation in PC12 cells and chick embryo dorsal root ganglion.
Researchers at Max Planck Institute found that GDNF promotes the survival of mitochondria, preventing degeneration associated with a Parkinson's-related gene defect. This discovery could lead to more refined GDNF therapies for patients.
Researchers found that the combination of nerve growth factor-releasing microspheres and chitosan conduits significantly increased nerve conduction velocity and amplitude, attenuating muscular atrophy induced by facial nerve defects. The sustained release of active nerve growth factor lasted for at least 90 days.
A study published in Neural Regeneration Research found that mechanical tension contributes to the formation of hyperplastic scars and stimulates nerve growth factor expression. This suggests a possible role of the cutaneous nervous system in hypertrophic scar formation, providing new insights into scar tissue development.
Scientists have developed a method to deliver growth factor to regrow blood vessels, which could lead to revolutionary heart disease treatment. The research, published in PNAS, uses a novel delivery system that increases the activity and stability of growth factor.
Researchers at Rutgers University have identified P75 as a likely culprit in post-seizure brain cell death, which can benefit people with epilepsy and those suffering from traumatic brain injuries and strokes. The study aims to prevent cell death by testing molecules that block the P75 receptor.
Scientists at the Max Planck Institute of Neurobiology have demonstrated using a new animal model that nerve cells do not begin to die until three conditions are met in Parkinson's disease. This finding is an important step forward in understanding this illness and may offer a potential new direction for therapy.
Researchers at OHSU School of Dentistry have discovered a novel function of Nerve Growth Factor in the development of the trigeminal nerve, which provides signaling pathways for periodontal and dental pain. The study has broad implications for trigeminal nerve regeneration and may lead to new treatments for various neuropathic and infl...
Researchers have discovered the biochemical basis of congenital loss of smell, enabling new treatments. Patients' nasal mucus was found to lack growth factors essential for olfactory receptor cell function, leading to premature cell death. Treatment with PDE inhibitors restored smell in some patients.
Researchers have identified a link between the fibroblast growth factor system and major depressive disorder, with those treated with SSRIs showing smaller changes. The study's findings offer new insights into the biological mechanisms underlying mood disorders and potential avenues for targeted therapeutics.
Researchers developed a two-pronged approach to stimulate nerve cell growth and overcome inhibitory proteins, achieving triple the axon regeneration achieved with growth factors alone. The technique aims to restore vision and treat spinal cord injuries, strokes, and neurodegenerative diseases.
Biomedical engineer Shelly Sakiyama-Elbert has designed a novel nerve repair system that uses a gel-filled tube to deliver growth factor proteins stimulating nerve regeneration. The system promotes peripheral nerve regeneration in preliminary rat studies and shows promise for spinal cord repair.
Researchers have identified a new signaling pathway in the brain that may be connected to movement disorders. FGF14 was found to regulate nerve cell function and is involved in the basal ganglia, which are affected by Parkinson's disease.
Researchers at UNC School of Medicine are exploring the role of growth factors in axon regeneration, with a focus on improving spinal cord repair. They have identified a signal transduction mediator that promotes rapid axon growth and widening.
Researchers have found that growth factors play a key role in regulating how embryonic nerve cells acquire the ability to process information. This study suggests possible avenues for treating damaged nerve cells and restoring their function.
Researchers at Howard Hughes Medical Institute successfully directed human embryonic stem cells to differentiate into three germ layers: ectodermal (brain, skin), mesodermal (muscle) and endodermal (liver and pancreas). The study suggests that a combination of growth factors may be needed to achieve specific cell lineages.
Researchers at Duke University discovered that cancer gene c-Abl triggers the internal framework of cells, building nerve cells and aiding movement. Altering levels of growth factors and Src protein revealed c-Abl's normal function.
Researchers at Duke University have demonstrated that two naturally occurring growth factors significantly improved the ability of severed nerve fibers to reconnect with high accuracy. The study could lead to new strategies for improving peripheral nerve repair procedures in humans.