Articles tagged with Preimplantation Embryos
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Researchers at CRCHUM used single-cell RNA sequencing to study guinea pig pre-implantation development, finding striking similarities with early human embryogenesis. The discovery opens new possibilities for understanding women's infertility and developing therapeutics for healthy pregnancy.
A new method captures totipotency using a short-term high-dose treatment of Pladienolide B, reprogramming classical mouse embryonic stem cells into transient totipotent blastomere-like stem cells. These cells exhibit remarkable developmental potential and self-organize into blastoid structures mimicking early embryonic development.
A study found that smaller embryos already hatching are more likely to be chromosomally normal. This insight helps fertility clinics select better embryos during IVF, particularly for women over 35 or those undergoing PGT-A.
A new AI-based system, BELA, accurately assesses IVF embryo quality by analyzing time-lapse video images and maternal age. The system generates a predictive score for euploidy or aneuploidy, offering an objective measure of embryo quality.
Researchers at Karolinska Institutet have mapped how microRNAs control cell development in the human embryo during the first days after fertilization. The atlas identifies crucial sncRNAs that guide embryonic growth and differentiation, shedding light on how to identify healthy embryos for improved fertility treatment.
A Chinese Medical Journal study developed an AI-based system to automate embryo selection and eliminate subjectivity in IVF. The system improved human embryo assessment and selection, achieving higher accuracy in embryo aneuploidy screening than experienced embryologists.
Data from the ESHRE European IVF Monitoring Consortium shows a 20% increase in ART treatment cycles in Europe, with steady rises in IVF and IUI usage. Pregnancy rates per transfer remained similar in 2021 and 2020 for IVF and ICSI, while frozen embryo replacement showed slightly higher rates.
Researchers have made progress in understanding how mosaic embryos, comprising both normal and abnormal cells, self-correct to develop normally. This knowledge will help increase the number of suitable embryos for transfer in women undergoing IVF, reducing stress and improving pregnancy outcomes.
Mosaic embryo transfers from a large-scale study showed only 1.2% of preimplantation mosaicism persisted throughout pregnancy or postnatally. Researchers identified the mechanism behind self-correction, enabling better IVF outcomes for women with mosaic embryos.
A new survey reveals that three-quarters of US adults support using polygenic embryo screening to assess disease risk, while fewer approve its use for predicting traits. The results highlight the need for public education and conversation about the technology's limitations.
The American College of Medical Genetics and Genomics (ACMG) has released a points to consider statement on the safety and efficacy of polygenic risk score assessment for embryo selection. The statement concludes that there is insufficient evidence to support its clinical utility, and further research is needed.
Scientists have successfully mapped the landscape of m6A modification in mouse embryos, revealing intriguing patterns of gene activity and distribution in transposable elements. This study fills a gap in the transcriptome field, providing new insights into the function of m6A during development.
A study found that many IVF embryos with chromosomal abnormalities have the potential to lead to successful pregnancies. Embryos with low-grade mosaicism had similar live birth rates and miscarriage rates as euploid embryos.
Researchers at the University of Kent identified strong evidence-based benefits of preimplantation genetic testing for aneuploidy (PGT-A) in IVF. Live birth rates per embryo transferred and per treatment cycle were significantly higher with PGT-A compared to regular IVF, especially in women over 40.
A University of Illinois study found that supplementing Holstein cows' diets with methionine during prepartum and postpartum periods increased the number of lipid droplets in preimplantation embryos, allowing them to survive more stress. This may lead to lower embryonic death rates and improved pregnancy outcomes.
Dr. Paul Tesar's research enhances understanding of pluriportent stem cells used to study debilitating diseases. His findings have potential to prevent or repair damage caused by disease, aging, and injury.
The world's first controlled study of genetic screening for IVF has resulted in the birth of healthy babies, twins in Germany and a singleton boy in Italy. The technique used is comparative genomic hybridisation (CGH), which can accurately predict chromosomal disorders with a 10% error rate.
A recent study by Hiroki Kurihara's team at the University of Tokyo discovered that Sirt3 helps safeguard mouse embryos against oxidative stress induced by in vitro fertilization and culture. The findings suggest that the negative effects of Sirt3 inactivation can be mitigated by using antioxidants or low-oxygen conditions during IVF.
Researchers at Yale University have discovered a novel protein called Preimplantation Factor, which is crucial for successful pregnancy. The protein modulates maternal immunity and promotes early embryo attachment, influencing uterine cell remodeling.
A recent study found that nearly all human embryos produced through IVF have chromosomal problems, rendering current preimplantation genetic screening techniques useless. Chromosomal instability is likely responsible for low fertility rates and high abortion rates, and could impact spontaneous pregnancies as well.
Researchers found that embryos initially deemed abnormal can undergo chromosomal modifications, leading to a higher rate of mosaicism. This challenges the effectiveness of preimplantation genetic screening (PGS) for increasing pregnancy potential.
Researchers at University College London Medical School have made a major advance in assisted reproductive techniques with a new chromosome testing technique. The technique allows for the assessment of every single chromosome in virtually every cell of a test-tube embryo, potentially leading to improved IVF success rates.
Pre-implantation genetic diagnosis (PGD) is improving fertility outcomes for couples with genetic conditions, drastically reducing miscarriages and birth defects in older mothers. PGD can detect aneuploidy and translocations, allowing only healthy embryos to be transferred.
Researchers have developed a preimplantation genetic diagnosis test for OTCD, allowing them to detect the abnormality in embryos. This breakthrough may enable PGD tests for other families in the future, providing relief to those affected by this rare and distressing disease.
Researchers discovered that mouse embryos have an organizational structure in the inner cell mass, predicting spatial patterning later on. This finding provides a new understanding of how mammals develop their bodies and may lead to advances in regulating embryonic stem cell differentiation.