Articles tagged with Complex Traits
A new computational tool called DANDELION has identified 21 genes related to asthma, most of which haven't been discovered by other methods. The tool focuses on trans-gene regulation and successfully validated the impact of these genes on asthma phenotypes in cell models and human data.
Researchers at Niigata University conducted the first comprehensive reappraisal of Alzheimer's disease risk in Japanese APOE-e4 homozygotes, finding a substantially lower risk than previously cited estimates. The study suggests that the risk is comparable to estimates reported in large studies of people with European ancestry.
Researchers developed a new computational tool using generative AI to identify key gene combinations underlying complex illnesses. The method amplifies limited gene expression data, enabling researchers to resolve patterns of gene activity that cause complex traits.
A novel method has been developed to infer DNA methylation patterns in non-skeletal tissues from ancient specimens, providing new insights into human evolution. The study found over 1,850 sites of differential methylation specifically in prefrontal cortex neurons, linked to genes crucial for brain development.
A new study found that genetic factors contribute around 33% to the variation in levels of trust among individuals, while life circumstances such as age, health, and relationship status also increase trust. The research used twin studies to disentangle genetic and environmental influences on trust.
A recent study has uncovered three previously unreported genetic loci associated with eyebrow thickness in Europeans, as well as rediscovering two of the four genetic loci previously found in non-Europeans. The research expands genetic knowledge on human eyebrow variation, with implications for dermatology and other fields.
Researchers, led by Elizabeth King, aim to develop a knowledge base on complex genetic traits using fruit fly models. The project seeks to address the scientific knowledge gap in this field by focusing on interconnectedness among multiple factors.
A USC researcher and international team identified consistent DNA base pairs across 240 mammals, including humans, that play a key role in human disease. These 'constrained' base pairs remained generally consistent over millions of years of evolution and are significantly linked to genetic variation.
Researchers found that butterfly eyespots evolve from a pre-existing gene regulatory network used to build antennae, legs and wings. The study discovered specific genes and regulatory connections underlying the development of complex traits.
A recent study published in Nature Genetics has identified short tandem repeats, also known as eSTRs, which impact nearby gene expression in the human genome. The researchers found over 28,000 eSTRs associated with various complex traits, including schizophrenia, inflammatory bowel disease, and intelligence.
Researchers at Duke University have identified the genetic variation behind wild mustard plants' varying levels of spicy chemical production. This difference affects their ability to survive in environments with changing conditions. The study sheds light on how complex traits are shaped over thousands of years.
Researchers found that numerous small changes in multiple gene regions impact flowering time, reproductive ability, and other complex traits in corn. The study also identified subtle genetic variations influencing reproductive success, paving the way for more accurate predictions and breeding strategies.
A new study by Yale and Washington University researchers challenges the idea that complex traits have a 'cost of complexity,' suggesting that many mutations only affect a small number of traits. The team identified genomic regions affecting skeleton characteristics, revealing a well-coordinated process in tuning up complex traits.
Researchers discovered that fruitfly wing spots evolved through mutations in cis-regulatory elements controlling the yellow gene, demonstrating how evolution uses existing genetic material to create new traits. The study also highlights the importance of pleiotropic genes in evolution.
Duke University biologists evolved a complex polyphenic trait in tobacco hornworms by applying temperature shocks to create two distinct strains with different color responses. The researchers discovered that the level of juvenile hormone regulated the color change, and their experiments demonstrated genetic accommodation.
Researchers discovered a genetic mechanism in plants that prevents the regrowth of a trait once it's lost, contradicting earlier studies. The findings highlight the importance of considering genetic data when reconstructing evolutionary history.