Articles tagged with Dna Repair
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The study found that a protein complex called INO80 plays a crucial role in loosening histone grip on DNA, allowing DNA repair machinery to access damaged areas. The researchers discovered a specific form of histone protein, gamma-H2AX, acts as a code directing DNA repair proteins to breaks.
A Stowers Institute researcher has identified a complex that plays a crucial role in repairing DNA double-strand breaks, a primary cause of cancer. The dTip60 complex increases DNA accessibility for optimal repair and removes the damage-marker phospho-H2A.X/v to signal successful repair.
Researchers found that broken ends of yeast chromosomes remain associated even after cell division, leading to genomic instability. The association was dependent on the molecular DNA repair machinery, which helps resist pulling forces of the mitotic spindle.
Scientists have defined the protein components of DNA repair machinery that allows it to recognize and correct mismatches. The system uses a clamping mechanism to regulate an enzyme that excises faulty DNA strands.
Measuring DNA repair enzyme OGG activity found a significant association with lung cancer risk. Smokers and nonsmokers with low OGG activity had higher lung cancer risk compared to those with normal activity levels, with smokers being at greater risk due to smoking alone.
A new study found that repair enzymes can 'distinguish' between various positions on the DNA strand, varying in effectiveness depending on their orientation relative to the nucleosome. This discovery has significant implications for our understanding of DNA repair and its role in preventing diseases like cancer and Alzheimer's.
Researchers have discovered that the DNA unwinding protein RecBCD uses two motors to move along the DNA, one from 3' to 5' and another from 5' to 3'. This allows the complex to travel long distances before stopping or getting derailed.
Scientists have found that the DNA-repair enzyme functions uniquely in different organisms, with varying electron transfer pathways. This discovery may lead to the development of a novel enzyme for treating skin cancer in humans.
Researchers found that patients with xeroderma pigmentosum had lower DNA repair capacity than control subjects, increasing their risk for melanoma. A natural compound called deguelin may have potential as both a chemopreventive agent and a therapeutic agent against lung cancer.
A study published in the Journal of Clinical Investigation found that HIV protease inhibitors directly promote atherosclerosis in mice. In humans, researchers propose a mechanism by which these drugs might contribute to heart disease, suggesting ways to disrupt it.
Individuals with reduced functional Artemis protein are prone to mild immunodeficiency and increased risk of developing lymphomas. This finding suggests that mutations in Artemis or other DNA repair genes may be responsible for immune deficiency and/or lymphoma cases.
Researchers found that Deinococcus radiodurans' DNA is packed tightly into a ring, preventing breakage and allowing it to withstand extreme stresses. The microbe's unique ring-like DNA structure enables it to repair damaged DNA and survive in harsh environments.
Researchers at Michigan State University and the Cancer Research UK London Research Institute found a way for an enzyme to repair DNA using iron and oxygen, bypassing oxidation. This discovery offers possibilities for understanding biological functions and combating diseases such as cancer and aging.
Researchers found that gene swapping in mice leads to pro-B cell lymphomas, with amplifications of c-myc and IgH genes arising from chromosome translocations. The study uncovered a new mechanism for cancer formation involving the DNA-snipping enzyme RAG.
Richard Setlow, a Brookhaven Lab scientist, is being honored for his discovery of nucleotide excision repair and its application to understanding genetic diseases and cancer. His work has led to significant advancements in the field of environmental mutagenesis.
Researchers discovered that the Rad54 gene plays a vital role in repairing DNA breaks in a neat and efficient manner, preventing mutations. The study's findings suggest that individuals without this gene may be more susceptible to radiation therapy side effects and could benefit from milder treatment protocols.
Scientists have identified a key gene, Rad54, involved in neat DNA repair, preventing mutations and potentially improving cancer treatment. The study found that patients with an inactive Rad54 gene are more susceptible to radiotherapy side effects, leading to the idea of milder treatments.
The Ku heterodimer, a key player in non-homologous end joining (NHEJ), is shown to 'cradle' broken DNA ends with its ring-shaped molecule, forming a precise alignment for repair enzymes. This structure provides insights into the accuracy of the NHEJ process and its importance in genome integrity.
A study by UCSF researchers found evidence of faulty DNA repair in some infertile men, similar to those with certain cancers. The study suggests that defective DNA repair may be a reason for male infertility and potentially increase the risk of offspring infertility and cancer.