Articles tagged with Genome Wide Association Studies
A comprehensive analysis of childhood acute myeloid leukemia (AML) found only a few genetic mistakes contributing to the disease. The study, published in the Proceedings of the National Academy of Sciences, highlights the need for more detailed examination of AML's complete genome.
Researchers at UC Berkeley and TGen found a gene variant, rs6457327, associated with nearly twice the risk of developing follicular lymphoma, a cancer of the body's disease-fighting network. The presence of the G allele was protective against the disease, while the A allele increased risk.
A study found five genetic variants associated with high systolic blood pressure in African-Americans, suggesting potential new treatments. The variants were located near genes that code for proteins involved in hypertension regulation, offering hope for improved prevention and treatment options.
Researchers at McGill University discovered significant genetic disparities between blood and tissue cells, undermining the validity of genome-wide association studies. This finding has implications for vascular diseases, such as abdominal aortic aneurysms, where tissue samples are often used.
A UBC study found that people's early-life experiences can lead to chronic diseases later in life by affecting gene expression and inflammation responses. The researchers identified a link between low socioeconomic circumstances in early life and increased risk of infectious, respiratory, and cardiovascular diseases.
Researchers at Mayo Clinic and University of California San Francisco have discovered a connection between DNA alterations on human chromosome 9 and glioblastoma. The study found that individuals with specific single nucleotide polymorphisms (SNPs) are 50% more likely to develop the aggressive brain cancer.
A study published in JNCI found that carrying one allele of SNP 2q35-rs13387042 increases the risk of breast cancer, particularly in ER-positive and -negative cases. The association was observed in over 31,000 women with invasive breast cancer and those without the disease.
Genome-wide studies identify a vast array of genetic variation that may account for at least one third of the genetic risk for schizophrenia. The studies found a shared chromosomal neighborhood between schizophrenia and bipolar disorder, implicating an area of Chromosome 6 in immunity and gene expression regulation.
Researchers identified a significant association between gene variations on chromosome 6 and schizophrenia risk. The study, combining data from 27,000 individuals, found evidence of immune function's potential role in the disease.
A recent genetic association study failed to support a causal relationship between C-reactive protein levels and coronary heart disease (CHD). The study, published in JAMA, found that variants associated with lower CRP levels were not linked to reduced CHD risk.
A recent study published in the Journal of the American Medical Association (JAMA) suggests that C-reactive protein, a commonly used marker for coronary heart disease risk, may not cause the disease. Researchers found no association between genetic variations in the gene coding for C-reactive protein and coronary heart disease risk. Ho...
Researchers found the malfunctioning ABCG2 gene can lead to high urate levels, causing inflammation and pain. The gene is responsible for transporting urate out of the kidney and into urine, and its mutation may be linked to 10% of gout cases in Caucasians.
Two new studies have identified genetic events that increase a child's susceptibility to high-risk neuroblastoma. Common variants in the BARD1 gene and a specific copy number variation at chromosome 1q21.1 are found to be associated with the development of this childhood cancer.
A meta-analysis of 14 studies failed to find an association between a genetic marker, stressful life events, and the risk of major depression. The study did find a significant association between the number of stressful life events and depression.
A research team has identified genetic variants that influence the timing of female puberty, a finding with implications for later life health outcomes. The study, published in Nature Genetics, also found a link between earlier menarche and increased body mass index.
Researchers at Mayo Clinic have identified a novel molecular path linked to primary biliary cirrhosis, a disease affecting 1 in 2,500 Americans. The study found variants of two genes, interleukin 12A and interleukin 12RB2, strongly associated with the condition.
Scientists discovered that a protein complex called cohesin plays an important role in regulating genes in humans, particularly in the rare genetic disease Cornelia de Lange syndrome. The study identified hundreds of genes that were dysregulated compared to controls, and also detected gene expression profiles unique to CdLS.
A genome-wide association study identified 20 single nucleotide polymorphisms related to an earlier menopause, which could affect fertility in women. The study suggests that understanding these genetic variants may help improve fertility treatment for women with infertility issues.
A recent study found that genetic variations involving endothelial dysfunction and platelet aggregation contribute to depressive symptoms in individuals with heart disease. Researchers discovered a significant association between one marker within the vonWillebrand factor gene and depressive symptoms.
Researchers have identified two chromosomal regions associated with the age at which females experience their first menstrual period (menarche) and the onset of natural menopause. The study may help shed light on the prevention of breast and endometrial cancer, osteoporosis, and cardiovascular disease.
Researchers used sophisticated statistical analyses to study genomic patterns of human population structure, revealing 18 significant axes of variation. These findings provide insights into the history of human evolution, evolutionary forces shaping local populations, and geographic correlations with genetic variation.
A team of researchers has identified three genes containing common mutations that are associated with altered kidney disease risk. The UMOD gene produces Tamm-Horsfall protein, which is normally present in healthy individuals' urine, but its relationship to chronic kidney disease risk was not known previously.
A large-scale genome-wide association study identified eight key genes associated with high blood pressure, including ATP2B1, CACNB2, and CYP17A1. The research provides new insights into blood pressure regulation and may lead to the development of novel therapeutic approaches.
A recent genetic study has confirmed the immune system's role in narcolepsy, revealing that autoimmunity plays a crucial part in the disorder. The study found unique variants of genes HLA-DQB1*0602 and TCRA associated with narcolepsy-cataplexy.
Researchers identified genetic factors affecting autism risk, including genes involved in forming and maintaining brain cell connections. These findings may lead to better diagnostic strategies for children with autism.
Two studies identify genes that may contribute to autism, including a region of chromosome 5 associated with neuronal cell-adhesion molecules. These findings suggest a significant role for genetics in the development of autism, potentially leading to new treatments.
A study published in The New England Journal of Medicine found a common genetic variant linked to increased ischemic stroke risk in the US, affecting approximately 20% of whites and 10% of blacks. This discovery may lead to new strategies for detecting at-risk individuals and developing targeted treatments.
Researchers identified two genetic variants associated with an increased risk of stroke, providing strong evidence for specific genes involved. The study, funded by the NHLBI and other NIH institutes, analyzed over 19,000 participants and replicated results in independent samples.
Researchers have identified a gene variant on chromosome 11 that is linked to an increased risk of atopic dermatitis, a chronic inflammatory skin disease. The study found that this variant is also associated with Crohn's disease and affects approximately 36% of the European population.
Scientists have identified 10 genetic variants linked to an elevated risk of arrhythmias and sudden cardiac death (SCD). These variants influence heart repolarization and raise or lower the risk of cardiac arrhythmias, with a prolonged QT interval increasing the risk up to five-fold.
Researchers at Boston University School of Medicine identified a gene variant on chromosome 4 associated with an increased risk of COPD. The study, conducted in collaboration with the Framingham Heart Study, found that genetic factors play a role in susceptibility to cigarette smoke and impaired lung function.
Scientists at Duke University Medical Center have discovered two genetic markers that significantly increase the risk of developing chronic obstructive pulmonary disease (COPD) in smokers. These variants, located near a nicotine receptor, may be reduced by quitting smoking before COPD symptoms appear.
Researchers have identified three genes - VKORC1, CYP2C9, and CYP4F2 - responsible for over 40% of warfarin dose variability. The study provides a comprehensive overview of the genetic landscape influencing dose variability, paving the way for more accurate warfarin dosing and reduced patient risk.
Scientists from the University of Cambridge discovered four rare genetic mutations that reduce the risk of developing type 1 diabetes, a link between T1D and enterovirus infections established. The IFIH1 gene variants were found to protect against T1D by reducing immune activation caused by enterovirus infections.
Researchers have discovered new genes involved in Crohn's disease using a novel approach that combines statistical tools and automated gene-hunting techniques. The study identified genes on the same biological pathways as those already known to be relevant to the biology of Crohn's disease.
Researchers developed AssociationViewer to analyze genetic differences and uncover new genetic markers for diseases. The software displays SNPs on a large scale, enabling scientists to visualize significant variations in the genomic context.
A new NC State University study reveals that fruit flies have a genetically wired sleep pattern, with males sleeping more during the day and females having more frequent bouts of sleep. The research identified 1,700 genes associated with sleep variability, shedding light on how these genes may influence human sleep.
Researchers found that fruit fly females' genes are activated similarly to an immune reaction when they mate, leading to a heightened defense system. The cost of mating is also revealed to be high, as females produce fewer offspring due to male harassment and toxic sperm fluid.
Researchers have identified novel genetic markers associated with an increased risk of heart attack, which are more than twice as great in individuals carrying multiple genetic markers. The study found that genes on chromosomes 3 and 12 play a crucial role in cardiovascular biology.
Scientists have developed a new molecular tool that pinpoint 'on-off switches' in genomes using next-gen sequencing technology. The research promises to clarify the role of vast stretches of non-coding DNA sequence, revealing powerful regulatory influence.
A large-scale genome-wide association scan found sequence variants associated with asthma, shedding light on disease mechanisms and potential biochemical pathways. The study also confirms previous findings linking the interleukin-1 gene cluster to asthma.
Researchers at Mayo Clinic have identified a gene variant on the X chromosome associated with an increased risk of developing late-onset Alzheimer's disease. Women who inherited two copies of the PCDH11X variant were found to be at substantially greater risk, while men with one copy also showed a significant increase in risk.
A study published in Nature Genetics identified genetic markers associated with risk for ulcerative colitis, bringing researchers closer to understanding the biological pathways involved in the disease. The findings may lead to the development of new treatments that specifically target these genes.
A new genetic study has identified variations in 31 genes that increase a child's risk of developing Kawasaki Disease, a rare and severe childhood disorder. The findings will enable scientists to develop more effective treatments by revealing new targets for therapy.
A genome-wide study has identified a new subtype of childhood acute lymphoblastic leukemia associated with a poor treatment outcome. The study found that patients with this subtype have a high relapse rate and poor disease-free survival, highlighting the need for further research and treatment options.
A recent whole-genome study identified genetic variants associated with Kawasaki disease, an inflammatory condition in children that affects the cardiovascular system. The research team found that genes involved in cardiovascular function and inflammation are key players, suggesting potential new diagnostics and treatments.
A genome-wide study has identified new genes involved in Kawasaki disease, a serious illness that affects young children and can cause coronary artery damage. The study found that genes related to cardiovascular function and inflammation may be key factors, leading to potential new diagnostics and treatments.
Two studies examine over 600,000 genetic markers in ADHD patients, finding that multiple genes contribute to the disorder. The findings highlight the need for larger studies to fully understand the genetic mechanisms underlying ADHD and to develop more effective treatments.
A study by University of Maryland researchers has identified a common gene variant associated with an increased risk of developing high blood pressure. The STK39 gene produces a protein that helps regulate salt processing in the kidneys, which plays a key role in determining blood pressure.
Scientists have found a genetic variation at the hexokinase-1 gene associated with glycated hemoglobin, an index of long-term blood glucose concentration. The study analyzed 14,618 women and found that variations at this gene are an important determinant of glycated hemoglobin concentrations.
A new study uncovers 11 gene variants associated with three blood lipids measured to determine cardiovascular disease risk. Researchers believe that these variants could lead to precise dietary recommendations for individuals at risk, such as carriers of certain gene variants who may benefit from low-cholesterol or Mediterranean diets.
Researchers discovered a gene mutation that significantly reduces triglyceride levels and produces a favorable cholesterol profile in the Old Order Amish population. Carriers of this mutation have higher levels of HDL-cholesterol and lower levels of LDL-cholesterol, reducing the risk of cardiovascular disease.
A genome-wide study has identified 23 regions of the genome associated with nine metabolic traits, including cardiovascular disease, type 2 diabetes, blood pressure, and inflammation. The study found 14 known genetic variants and nine novel variants, five of which are good candidates for important variants.
Researchers at Indiana University have created a comprehensive map of genes likely involved in bipolar disorder, identifying hundreds of genes that contribute to the illness. The study also lays the groundwork for personalized treatments and preventive measures using genetic risk scores.
A recent study has identified four novel genes associated with Alzheimer's disease, including a gene on chromosome 14 that may influence age of onset. The research also found connections to other diseases, such as spinocerebellar ataxia and innate immune system disorders.
A genome-wide study has uncovered a significant increase in genetic distances towards Northern Europe compared to Central Europe. The analysis of dense single nucleotide polymorphisms across the whole genome found substantial genetic differences between Eastern and Western Finland.
Researchers at Salk Institute and Burnham Institute for Medical Research have identified 295 human host cell factors involved in HIV infection. This study may lead to the development of novel therapies aimed at disrupting human-HIV interactions and preventing viral replication.
A genetic risk score was developed from three identified genes associated with increased uric acid levels and a 40-fold increased risk for developing gout. The study analyzed over 20,000 participants and found that more than 3 million US adults have gout due to factors such as obesity, diet, and certain medications.
A study found three genes associated with an increased risk of gout, enabling the development of a genetic risk score that can predict those at highest risk. This score could facilitate early and targeted treatments, improving outcomes for individuals affected by gout.
Researchers identified two new genes and confirmed a third's role in increased uric acid levels, associated with up to 40-fold gout risk. Genetic testing may one day identify individuals at risk before symptoms develop.