Articles tagged with Genome Wide Association Studies
Researchers at The Feinstein Institute for Medical Research have discovered a new gene that increases the risk of developing schizophrenia. The study, which analyzed over 500,000 genetic markers, found a significant link between a chromosomal region called PAR1 and the disease.
Researchers have identified several genes linked to nicotine dependence, including CHRNA5 and NRXN1, which play a role in regulating communication between nerve cells. These findings could lead to the development of more effective smoking cessation therapies tailored to an individual's genetic traits.
Researchers mapped genetic makeup of type-2 diabetes in unprecedented detail, identifying four loci that correspond to a 70% genetic background risk. The study also reveals a mutation in the zinc transporter SLC30A8, potentially leading to new treatments for insulin deficiency.
A Stanford-led study has identified a specific region on chromosome 15 that may be linked to severe depression. The research, which analyzed 650 families with a history of repeated bouts of severe depression, found highly significant evidence for genetic linkage to the condition.
Researchers analyzed 1,200 genome-wide polymorphisms in 432 Indian individuals, revealing low levels of genetic divergence across geographically and linguistically diverse populations. The study provides a foundation for future research on the genetic basis of common diseases in Asian Indians.
Researchers have compiled genetic information on over 1,000 patients and controls in the largest-scale search for genes underlying sporadic ALS. The study aims to clarify the role of genes or lack thereof in the disease, with potential implications for therapies and a cure.
The Genetic Association Information Network (GAIN) has selected six studies to undergo whole genome analysis to identify genetic contributions to common illnesses. The studies focus on disorders of the brain, skin, and kidney, including depression, bipolar disorder, and diabetes.
An international team, led by UCLA's Roel Ophoff, is conducting a four-year study on schizophrenia that will analyze the human genome of approximately 850 Dutch patients and 750 control subjects to pinpoint related genes. This approach aims to separate false clues from true genetic variants associated with the disorder.
A new study recruiting up to 2,000 people from the remote Isles of Orkney aims to discover genes that predispose individuals to osteoporosis. The research will utilize a unique population isolated from the UK mainland, allowing for easier tracking and identification of genetic factors.
Researchers will test 400,000 SNPs in 552 patients to clarify the role of genes in sporadic ALS. The study's results could strongly shape the search for a cure if it finds gene associations or suggests an environmental cause.
Researchers identified VAMP8 and HNRPUL1 gene variants associated with increased risk of early-onset myocardial infarction. The study analyzed over 2,000 patients and found that carriers of these variants had a comparable risk to conventional risk factors such as smoking and high blood pressure.
Researchers have identified a genetic region on chromosome 2 that appears to be involved in causing high blood pressure in people who do not respond to ACE inhibitors and beta blockers. This discovery brings hope for developing targeted therapies for patients with uncontrolled high blood pressure.
A study published in Science reveals the vast potential of small RNAs in regulating gene expression, with over 77,000 unique small RNAs identified in Arabidopsis plants. This breakthrough has significant implications for understanding small RNA function and regulation, which may also contribute to cancer diagnostics.
Researchers identified genetic regions on chromosomes 6, 7, and 19 associated with prediabetes in response to aerobic exercise. The study found that individuals differ in their blood sugar equilibrium after exercise, allowing for unique analysis of insulin sensitivity and glucose metabolism.
Researchers at Perlegen and Calit2 have developed a method to analyze whole-genome data, making it possible for genome-wide association studies to be performed on a reduced budget. The study reveals that most functional human genetic variation is not population-specific, with only 18% of SNPs segregating in one population sample.
Researchers at New York University have discovered over 150 additional genes required to make an embryo, bringing the total estimated number of genes needed to around 2,600. The study also sheds light on how these genes work in humans and provides clues for understanding human diseases.
Researchers developed a mouse model that replicates human adult onset alopecia areata, shedding light on the disease's complicated genetic basis involving multiple genes. The study provides insights into treating AA and other complex polygenic diseases.
Researchers have created a molecular timetable that can accurately determine an animal's body time based on gene expression levels. The study identified 168 genes with high amplitude circadian patterns and organized them into a daily schedule, revealing a highly accurate method for measuring body time.
Researchers found that a significant percentage of microarray probes don't match the latest RefSeq database information, leading to inaccurate results. Sequence-verified probes perform more consistently and accurately, improving diagnostic power and analysis of existing data sets.
A new study links psoriasis to genetic variations on chromosomes 6 and 4, specifically the MHC region. This meta-analysis confirms previous findings and highlights a potential focus for future research.
Researchers found a genetic link between GAD2 variants and obesity. The study suggests that overexpression of the GAD2 gene may increase GABA levels in the hypothalamus, leading to increased orexigenic effects and overeating.
Scientists have discovered how the strep bacterium evades destruction by the human immune system, leading to new research on vaccine candidates and therapy interventions. The study found that GAS becomes more resilient to ingestion and killing by PMNs over time or produces factors that alter normal PMN function.
Researchers at Northwestern University are using genome-wide mutagenesis to identify gene mutations that cause sex reversal in mice. The study aims to understand the function of mammalian genes and their role in gonad development, as well as infertility in humans.
Researchers are studying the molecular pathophysiology of FSHD using genome-wide approaches and developing animal models to understand the disease. The goal is to gain insight into the cellular and molecular processes leading to neuromuscular system dysfunction in FSHD patients.
Researchers at University of Chicago and Johns Hopkins Medical Institutions identify genetic regions on chromosomes 1p, 3q, and 4q that appear to contain genes triggering the onset of inflammatory bowel disease. The study confirms the role of previously localized gene IBD1 in concert with another disease gene on chromosome 1.