Articles tagged with Sars Cov 2
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A new study suggests that breakthrough infections generate 'super immunity' to COVID-19, providing a robust immune response against the delta variant and potentially other variants. The study found that antibodies generated from breakthrough cases were 1,000% more effective than those from vaccinated individuals.
Recent preclinical study results demonstrate the Spike Ferritin Nanoparticle (SpFN) COVID-19 vaccine developed by WRAIR elicits potent immune responses and offers broad protection against SARS-CoV-2 variants and other coronaviruses. The SpFN vaccine uses a ferritin platform to present multiple copies of the coronavirus spike protein, i...
A new study warns that Omicron could lead to 100,273 fewer elective operations performed over the three winter months due to increased hospital admissions and COVID-19 patients. The model used NHS England data from September 2020 to July 2021 to project elective surgery activity based on the number of COVID-19 patients in hospital.
The University of Ottawa's CoVaRR-Net has received a $9 million grant extension to continue its rapid research on COVID variants, including the Omicron variant. This renewed funding will allow researchers to accelerate their work and keep policymakers informed of their latest findings.
Leading scientists recommend a new scientific approach called 'living evidence' that provides rigorous and trustworthy summaries of relevant research in real-time. This system aims to overcome the challenges of rapidly shifting research evidence and inform informed decisions.
A novel vaccine, TOH-Vac1, replicates inside the body's cells and generates a powerful immune response in mice and monkeys. The vaccine is based on a strain of vaccinia virus used to vaccinate against smallpox and can be programmed to protect against multiple variants.
The CDC found flaws in the assay design and contamination of one component, leading to false positive reactivity in negative controls. A redesign and improved quality control measures have since been implemented.
A Trinity College study found that severe COVID-19 patients who received care outside of an ICU had a higher mortality rate compared to those in the ICU. The study highlights Ireland's shortage of ICU beds and emphasizes the need for increased critical care capacity.
A review of 95 studies revealed that the percentage of asymptomatic COVID-19 cases varies significantly between individuals with confirmed infections and those who underwent testing. The analysis provides valuable insights into the prevalence of asymptomatic infections worldwide.
A clinical trial has revealed that COVID-19 patients on ventilators have less surfactant in their lungs due to the virus. The researchers suggest that giving extra surfactant for a longer period could help save lives by supporting breathing and allowing lung cells to repair after the infection passes.
A new study from the University of Georgia found that overweight youth are developing signs of artery stiffness, a significant risk factor for cardiovascular disease. Researchers measured visceral fat levels and arterial stiffness in over 600 children, adolescents, and young adults, revealing higher levels of visceral fat and arterial ...
A KAUST-led team developed a biosensor that can detect biomolecules, including the COVID-19 spike protein, with high sensitivity and selectivity. The device uses solid-state metal oxide transistors and can be used to diagnose multiple diseases quickly and easily.
Scientists have developed a fusion protein that successfully blocks replication of SARS-CoV-2 and related viruses in cell culture tests. The protein combines ACE2 with human antibody fragments, providing reliable protection against future mutations.
Researchers found that the SARS-CoV-2 N-protein accelerates the formation of amyloid fibrils in test tube experiments, interacting with α-synuclein protein. This interaction may contribute to the development of Parkinson's disease in COVID-19 patients.
A research team at Aarhus University has developed an RNA aptamer that attaches to the surface of SARS-CoV-2 virus particles, preventing it from entering human cells. This molecule is cheaper and easier to manufacture than current antibodies, making it a promising tool for detecting covid-19 infection.
A study published in CMAJ found that hospital health care workers in Quebec had high seroprevalence of SARS-CoV-2 antibodies after the first wave of the COVID-19 pandemic. The highest rates were reported in hospitals with outbreaks, particularly those from older facilities.
Researchers developed an RNA-based breath test called the Bubbler that can detect SARS-CoV-2 in exhaled breath, revealing a more direct indicator of current infection. The test also provides additional information on viral load and strain identity.
A new guideline outlines 13 recommendations to address health inequities exacerbated by COVID-19, including addressing racism and poverty. Implementing these policy changes can help reduce the burden of COVID-19 on marginalized communities.
A new study found that Omicron's immune-evading capabilities are significant, but some vaccinated and previously infected individuals have 'stronger' protection. However, the protection from Omicron may be compromised over time.
Researchers at UCLA have identified rare T cells capable of targeting a protein found in SARS-CoV-2 and other coronaviruses. By adding a fragment of this protein to vaccines, they hope to create a longer-lasting immune response and increase protection against new variants. This breakthrough could lead to more effective COVID-19 vaccines.
A new UC Davis study tracks firearm violence, assault, and homicide in 13 major US cities by zip code, revealing stark disparities. Firearm violence increased 29.3%, homicides by 27.7%, while robberies decreased 23.3% and rapes by 31.4% during the first five months of the pandemic.
Scientists at Gladstone Institutes developed a new class of antiviral therapy that can track the evolution of SARS-CoV-2, reducing the chance of reduced efficacy against new variants. The single-dose intranasal treatment showed significant reduction in viral load and prevented disease in animals.
The Parallel Amplified Saliva rapid POint-of-caRe Test (PASPORT) has been developed with a two-stage process, producing results in minutes and enabling sensitivity comparable to laboratory-based PCR tests. The test's sensitivity was 97% in a clinical study involving over 100 participants.
Researchers found that a combination of natural infection and vaccination produces maximally potent antibodies against COVID-19. The study suggests that repeated exposures to the spike protein can improve the immune system's ability to produce high-quality antibodies against variants.
Researchers developed a novel computer simulation method that can analyze key proteins in the reproductive cycle of SARS-CoV-2, promising to accelerate the search for bioactive compounds against COVID-19. The method estimates a reduction in research time from two to three years to under a year.
Rutgers Robert Wood Johnson Medical School is part of a $470 million RECOVER initiative studying post-acute sequelae of COVID-19 (PASC) in children. The study aims to investigate long-term effects, symptoms and treatments for PASC, such as Multisystem Inflammatory Syndrome in Children (MIS-C).
Researchers have identified hundreds of tiny llama antibodies called nanobodies that target the SARS-CoV-2 spike protein, which current therapies do not address. Combining these nanobodies into cocktails could create potent treatments against new variants, including Omicron.
A study examining autopsy tissue samples from COVID-19 patients found frequent and extensive blood clots within heart vessels, but no typical endothelial cell changes. Instead, hypercoagulability of the blood caused by activated neutrophils was detected as a likely culprit.
Researchers at Drexel University found a 61% decline in new COVID-19 cases after closing indoor dining during the first two waves of the pandemic. Closing indoor dining could be a tool to curb the spread of new variants globally, alongside other measures such as vaccination and social distancing.
Researchers at Hokkaido University and Texas A¼M University identified a key mechanism used by SARS-CoV-2 to evade host immune systems, targeting the MHC class I pathway. The study found that the virus suppresses the activation of this pathway using the ORF6 protein, allowing it to persist in the body and infect others.
A recent study suggests that severe COVID-19 may cause long-term damage to the testes, leading to reduced sperm count and quality. The virus's interaction with testicular cells and potential effects on fertility are being explored through an experimental framework.
Researchers report that combining infection and vaccination produces high-quality antibodies effective against COVID-19 variants. The study found that prior-infected individuals who received a vaccine had potent antibodies against new variants, contrary to previous findings suggesting reduced potency.
A large field hospital study shows that a rapid Covid-19 test is as accurate as PCR detection, with high sensitivity rates for both symptomatic and asymptomatic patients. The rapid antigen test's ease of use, time savings, and cost effectiveness make it an ideal solution to reduce testing disparities in medically underserved communities.
A study found that obesity is associated with severe COVID-19 outcomes, including hospital admission or death. Additionally, accelerated immunosenescence may be a key mechanism explaining the relationship between obesity and T2DM in severe COVID-19. Vaccination effectiveness may also be impacted by metabolic disorders.
Researchers have discovered miniature antibodies derived from llamas that can neutralize SARS-CoV-2 and its variants, including Delta and Omicron. The nanobodies' small size allows them to access hard-to-reach spots on the virus, making them a potential treatment against future variants.
A study published in Journal of Biological Rhythms found that antibody levels are higher when healthcare workers received the SARS-CoV-2 vaccine in the afternoon. The study suggests that circadian rhythms may play a role in regulating immune responses to COVID-19 vaccination.
Researchers find SARS-CoV-2 infects sustentacular cells in the olfactory epithelium of COVID-19 patients, replicating vigorously within these cells. The virus does not appear to infect nerve cells, instead affecting sensory neurons indirectly through insufficient support from sustentacular cells.
Heidelberg researchers have created a rapid process for 3D imaging of cells using soft X-ray tomography, enabling high-resolution images in just five to ten minutes. This technology provides valuable insights into viral diseases and their impact on infected cells.
A new chewing gum infused with plant-grown ACE2 protein can neutralize the SARS-CoV-2 virus in saliva, potentially reducing transmission risk. The gum, developed by researchers at the University of Pennsylvania, was tested on saliva samples from COVID-19 patients and found to significantly reduce viral load.
Scientists at La Jolla Institute for Immunology and MIT have discovered a new adjuvant called SMNP, which combines saponin and TLR agonist to boost the protective power of vaccines. The study found that SMNP triggers a strong immune response in mice, promoting lymphatic drainage and activating multiple parts of the immune system.
A study by Imperial College London found that the first SARS-CoV-2 spike protein encountered through vaccination or infection influences subsequent immune responses to current and future variants. This 'immune imprinting' affects the rate of decay of protection and impacts antibody levels over time.
Researchers at Georgia State University have developed a new candidate antiviral drug, 4’-FlU, which shows potent activity against SARS-CoV-2 and other respiratory RNA viruses. The study demonstrates that 4’-FlU induces termination of the viral polymerase, aborting replication and offering a strong therapeutic asset.
Researchers found that damaged telomeres increase the expression of ACE2, the human SARS-CoV-2 cell receptor, leading to increased viral susceptibility in the elderly. This DNA damage response is triggered by telomere shortening and dysfunction in aging cells.
A recent study published in PLOS Pathogens found that the COVID-19 Delta variant may have a reduced ability to be neutralized by vaccines. The researchers analyzed serum samples from vaccinated individuals and found that the Delta variant was more effective at evading vaccine-induced immunity than other variants, such as Beta and Alpha.
Researchers at Harvard Medical School identified likely mutations that would allow the virus to evade immune defenses, including natural immunity and vaccine-developed antibodies. The study provides important clues about areas of concern with omicron variant and serves as a primer for future variants.
The study found that the Moderna vaccine offered a lower risk of documented infection (21% reduced), symptomatic COVID-19 (44% reduced), hospitalization (55% reduced), ICU admission (10% reduced), and death (2% reduced) compared to the Pfizer vaccine. The results suggest that either vaccine is effective, but Moderna may be slightly mor...
A recent study by Colorado State University researchers found that COVID-19 can evolve and spread rapidly among animal species after infection from humans. The team analyzed mutation types occurring in cats, dogs, ferrets, and hamsters, discovering a broad range of viral variants that emerged and became prevalent.
The study found that indoor bars, private parties, and nightclubs were high-risk places for transmitting the Delta variant, with men being more susceptible. Previous infection conferred a 95% protective effect, while two doses of mRNA vaccines provided 67% protection against symptomatic infection.
A new computational tool allows precise prediction of protein interfaces for COVID-19 and human interactions. This breakthrough enables researchers to better understand virus development, identify high-risk populations, and develop targeted drugs.
Researchers at Université de Montréal developed a statistical model using blood biomarkers to predict which patients are most at risk of dying from COVID-19. The model is based on the amount of viral RNA in the blood and has been validated on two independent cohorts, showing high predictive accuracy.
Researchers at Duke University have identified chemical compounds that can latch onto the coronavirus's 3D RNA structures and block replication. The compounds, which target the virus's RNA specifically, offer a new mechanism of action against COVID-19.
Researchers found that COVID-19 infection in mothers leads to distinct immune changes in babies, including altered cytokine profiles and T cell responses. The study also identified potential correlations with clinical complications such as preeclampsia and fetal growth restriction.
A new statistical analysis supports the notion that COVID-19 became more lethal in the UK in late 2020, with increased lethality attributed to factors beyond just the alpha variant of the virus. The study used Bayesian inference to draw stronger conclusions from weekly data on cases and deaths.
Antibodies that mimic the SARS-CoV-2 virus may explain lingering symptoms of long-haul COVID-19 and rare vaccine side effects like allergic reactions and blood-clotting. This theory, based on classic immunological concepts, suggests a cascade of immune responses that can lead to adverse effects.
Researchers from Istituto Italiano di Tecnologia have developed a new precision strategy to hinder coronavirus infection by blocking the ACE2 receptor. The study, published in Pharmacological Research, reveals two anti-K353 aptamers that dose-dependently inhibit viral spike protein binding to human ACE2, preventing cell infection.
A study of 2.5 million people found lower COVID-19 infection rates among those with schizophrenia and mood disorders, but higher death rates. The analysis suggests that underlying mental health conditions may impact COVID-19 outcomes.
Researchers found coronaviruses closely related to SARS-CoV-2 in Shamel's horseshoe bats sampled in 2010. The discovery suggests a wider geographic distribution of the virus and its potential spillover from bat-borne viruses. Surveillance in Southeast Asia is crucial for pandemic preparedness.
A real-world study of BBV152 found that two doses resulted in 50% effectiveness against symptomatic COVID-19 in hospital workers. The study's findings support the importance of a second dose for maximum protection, but highlight limitations in estimating vaccine effectiveness against severe outcomes.
Pathologists have discovered that some patients with lingering COVID-19 symptoms may have underlying chronic lung disease prior to their infection. This finding suggests that clinicians should carefully consider alternative explanations for respiratory symptoms beyond long COVID.
The Delta variant of SARS-CoV-2 has become the dominant virus form in Benin, West Africa, with over 60% of cases linked to the variant. Vaccination campaigns are crucial to combat the spread, as only 1% of the population is vaccinated.