A new study reveals that blood vessels in the brainstem constrict when oxygen levels rise, unlike other parts of the body. This specialized response helps maintain proper breathing and is made possible by astrocytes releasing signaling molecules.
A new study published in Research in Autism Spectrum Disorders found an inverse correlation between brain stem volume and aggression in children with autism. The researchers discovered that a smaller brain stem is associated with greater aggression, suggesting a potential target for treatment.
SourceBrigham Young University·JournalResearch in Autism Spectrum Disorders·DateFeb 9, 2017
Researchers at EMBL have traced the physical connection between the prefrontal cortex and brainstem that inhibits instinctive behavior. The study found that this connection, specifically to the PAG region of the brainstem, prevents social animals from acting out impulses.
SourceEuropean Molecular Biology Laboratory·JournalNature Neuroscience·DateJan 9, 2017
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A team of researchers has identified a network within the brain that may play a role in maintaining human consciousness. The study, published in Neurology, found that two areas in the cortex were significantly connected to the brainstem region involved in arousal and awareness.
SourceBeth Israel Deaconess Medical Center·JournalNeurology·DateNov 4, 2016
Researchers discover that a mutation in the RyR2 gene, which regulates intracellular calcium, can trigger blackouts of the brainstem, increasing the risk of sudden unexpected death in people with epilepsy. This finding may help explain why some individuals with epilepsy are at higher risk for SUDEP.
SourceBaylor College of Medicine·JournalProceedings of the National Academy of Sciences·DateAug 1, 2016
Scientists at Karolinska Institutet have discovered a new brainstem model that shows how the brain controls breathing in response to changes in oxygen and carbon dioxide levels. The study found that when exposed to decreased oxygen or increased carbon dioxide, the brain releases PGE2 to regulate breathing.
Researchers at Drexel University have discovered that the pre-Bötzinger complex in the brainstem generates the breathing rhythm through mixed-mode oscillations. This finding challenges previous theories and may impact how scientists research and clinicians treat respiratory disorders.
Researchers detected frequency-following responses coming from the auditory cortex, in addition to known sub-cortical generators, using magnetoencephalography (MEG) technology. This discovery will inform further research into neuroplasticity and its potential to improve auditory processing.
SourceMcGill University·JournalNature Communications·DateApr 6, 2016
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Researchers identified two tiny clusters of neurons responsible for transforming normal breaths into sighs. Sighing is vital to lung function and helps preserve lung function, but frequent sighing can be debilitating.
SourceUniversity of California - Los Angeles Health Sciences·JournalNature·DateFeb 8, 2016
Researchers at Gladstone Institutes uncover a neural circuit that controls walking and find a new target for treating Parkinson's disease. Dopamine depletion disrupts movement by miscommunicating between the basal ganglia and thalamus, leading to an imbalance between go and stop pathways.
Researchers studied gustatory computations in zebrafish brainstem circuits, revealing that taste categories are represented by dissimilar responses and generate different behaviors. The study proposed a central role for encoding category, concentration, and mixtures of taste in these circuits.
SourceVIB (the Flanders Institute for Biotechnology)·JournalScientific Reports·DateDec 7, 2015
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A team of scientists identified a population of 'stop cells' in the brainstem that enable mice to halt their locomotion. These cells depress neuronal networks involved in generating locomotor rhythm, allowing animals to make graceful stops. The findings may provide insights into how locomotion is affected in diseases like Parkinson's.
Researchers have detailed two surgical approaches for auditory brainstem implantation, including a translabyrinthine and retrosigmoid approach, to minimize damage to the brainstem and improve speech recognition. The procedures aim to restore hearing in patients with NF2 and other causes of retrocochlear deafness.
SourceWolters Kluwer Health·JournalOperative Neurosurgery·DateMay 21, 2015
Researchers found a specific type of neuron in the parafacial zone responsible for deep sleep, allowing unprecedented control over brain function. The discovery may lead to new medications for treating sleep disorders and developing safer anesthetics.
SourceUniversity at Buffalo·JournalNature Neuroscience·DateSep 18, 2014
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A study published in Neural Regeneration Research reports on a patient with subarachnoid hemorrhage who showed an unusual neural connection between the injured cingulum and brainstem cholinergic nuclei. The authors used diffusion tensor tractography to investigate this phenomenon.
SourceNeural Regeneration Research·JournalNeural Regeneration Research·DateAug 25, 2014
A study published in Neural Regeneration Research found an unusual neural connection between the injured cingulum and brainstem cholinergic nuclei in a patient with subarachnoid hemorrhage. This phenomenon was detected using diffusion tensor tractography, revealing a novel pathway for neural communication.
SourceNeural Regeneration Research·JournalNeural Regeneration Research·DateMay 12, 2014
Research finds that people with stroke-related brainstem injuries have a significantly higher risk of developing sleep apnea. Among the 355 study participants, 84% with brainstem injury had sleep apnea compared to 59% without brainstem involvement.
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A study by Boston Children's Hospital reveals that brainstem abnormalities are present in infants who die suddenly and unexpectedly, regardless of their sleep environment. The researchers found that these abnormalities impair breathing, heart rate, and temperature control during sleep, making the babies vulnerable to sudden death.
SourceBoston Children's Hospital·JournalPEDIATRICS·DateNov 11, 2013
Artificial neural networks (ANNs) improve patient survival prediction in advanced brain cancers, with a pooled voting method correctly predicting risk of death within one year in 84% of patients. A new proposal calls for medical professionals and specialty societies to play an increased role in evaluating 'off-label' uses of medications.
SourceWolters Kluwer Health·JournalNeurosurgery·DateJun 19, 2013
Researchers used optogenetics to map the neural mechanisms underlying motivation, revealing multiple switches that control behavioral patterns. They identified key regions in the brain stem and prefrontal cortex involved in motivation, shedding light on the causes of depression and psychomotor retardation.
Researchers discovered that brain stem cells monitor chemical communication between nearby neurons to determine when to remain dormant or create new cells. The findings may reveal how the brain reacts to its environment and how antidepressants work, increasing brain cell numbers in animals.
SourceJohns Hopkins Medicine·JournalNature·DateAug 6, 2012
Researchers at OHSU have discovered a critical link between brain-derived neurotrophic factor (BDNF) and Rett syndrome, a neurological disorder affecting one in 10,000 baby girls. The study found that mutant neurons in the brainstem fail to produce BDNF, leading to breathing difficulties and other symptoms.
SourceOregon Health & Science University·JournalNeuroscience·DateJan 27, 2012
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Researchers have discovered that Michelangelo's depiction of God in the Sistine Chapel ceiling contains unusual features resembling a brainstem, with implications for our understanding of the artist's anatomy knowledge. The findings suggest another hidden anatomical detail in the painting, potentially related to the spinal cord.
SourceJohns Hopkins Medicine·JournalNeurosurgery·DateJul 28, 2010
Researchers identified a previously unknown brainstem pathway in vertebrates, which stimulates neural activity and locomotion. This finding suggests new research directions for treating Parkinson's disease, particularly targeting the neurotransmitter acetylcholine.
SourceUniversity of Illinois Chicago·JournalNature Neuroscience·DateMay 19, 2010
A new study finds that infants who die from Sudden Infant Death Syndrome (SIDS) have lower levels of serotonin in their brainstem compared to those who die from other causes. This deficiency may impair the function of brainstem circuits, putting babies at risk for sudden death during sleep.
SourceBoston Children's Hospital·JournalJAMA·DateFeb 2, 2010
Researchers at Karolinska Institutet have created a genetically modified mouse that can walk when exposed to blue light. The study provides insight into the neural control of locomotion and has potential implications for treating spinal cord injuries.
SourceKarolinska Institutet·JournalNature Neuroscience·DateJan 22, 2010
Children with dyslexia have trouble distinguishing speech from noise due to a deficit in the brain's ability to focus on predictable voice pitch. This mechanism is crucial for segregating sound streams and excluding background noise, a common symptom of dyslexia.
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Researchers at the University of Kentucky have identified a visible response to head trauma called the 'fencing response,' which can indicate damage to brainstem regions. This finding has immediate value for coaches and trainers, as it provides an objective cue to assess whether an athlete should return to play after a blow to the head.
SourceUniversity of Kentucky·JournalMedicine & Science in Sports & Exercise·DateSep 2, 2009
A new Northwestern University study found that a child's brain has trouble differentiating key sounds in noisy classrooms, leading to reading difficulties. The research suggests that auditory training and reducing background noise can help improve reading skills in poor readers.
SourceNorthwestern University·JournalProceedings of the National Academy of Sciences·DateJul 13, 2009
Researchers have developed a mouse model of SIDS, showing that an imbalance of serotonin in the brainstem is sufficient to cause sudden death. The study suggests that a congenital serotonin defect could play a critical role in SIDS.
SourceEuropean Molecular Biology Laboratory·JournalScience·DateJul 3, 2008
Researchers from Princeton University have developed a new experimental technique to study brainstem activity in humans, tracking changes in blood flow associated with dopamine levels. The findings provide critical insights into the role of brain chemicals in neuropsychiatric disorders such as addiction and Parkinson's disease.
A study published in the World Journal of Gastroenterology found that electroacupuncture at PC6 can decrease the frequency of transient lower esophageal sphincter relaxation (TLESR) induced by gastric distention in cats. The effect appears to act at the brain stem, mediated through nitric oxide (NO), CCK-A, and mu-opioid receptors.
SourceWorld Journal of Gastroenterology·JournalWorld Journal of Gastroenterology·DateOct 10, 2007
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A Northwestern University study finds that music training improves the brain's multi-sensory processing, leading to enhanced verbal communication skills. The research suggests that musical training could help children develop literacy skills and combat literacy disorders.
SourceNorthwestern University·JournalProceedings of the National Academy of Sciences·DateSep 24, 2007
Research finds that music training fine-tunes brainstem's sensitivity to speech sounds, benefiting learning activities, and potentially improving sound encoding skills. The study suggests a dynamic relationship between the brainstem and neocortex, allowing basic sensory circuitry to be malleable.
SourceNorthwestern University·JournalNature Neuroscience·DateMar 12, 2007
Researchers found that SIDS infants had more neurons manufacturing and using serotonin than control infants, but fewer serotonin receptors, suggesting an abnormal level of serotonin. This study provides the strongest evidence to date for a specific brain area controlling breathing and heart rate abnormalities in SIDS.
SourceNIH/Eunice Kennedy Shriver National Institute of Child Health and Human Development·JournalJAMA·DateOct 31, 2006
Scientists have discovered a subset of learning disabilities resulting from a dysfunction in the brainstem's encoding of basic sounds of speech. BioMAP, a simple neurophysiological test, can identify children with sound processing disorders and improve their speech discrimination skills through auditory training.
SourceNorthwestern University·JournalTrends in Neurosciences·DateApr 4, 2005
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Researchers discovered a link between brain activity and abnormal heart rhythms during stressful events, particularly in people with pre-existing heart disease. The study suggests that uneven brain signals can disrupt heart function, leading to potentially fatal arrhythmias.
SourceUniversity College London·JournalBrain·DateDec 23, 2004