Articles tagged with Breast Neoplasms
The TARGIT-A trial found that targeted intraoperative radiotherapy (TARGIT) is non-inferior to whole breast external beam radiotherapy in reducing local recurrences. Patients who underwent TARGIT had similar recurrence rates to those receiving conventional radiotherapy, with lower rates of radiotherapy toxicity.
A Dartmouth study found that adjuvant radiotherapy can prevent tumor recurrence in patients with borderline-malignant and malignant phyllodes tumors after breast-conserving surgery. The treatment was effective in controlling the growth of tumors in nearly 80% of cases.
A new x-ray imaging technique, diffraction-enhanced imaging (DEI), has been developed to visualize individual amyloid beta plaques in the brain. The study successfully images these tiny structures in a mouse model of Alzheimer's disease, providing promising clues for early diagnosis and treatment.
Duke University researchers developed a light-based system to analyze tumor oxygen levels, helping oncologists choose effective treatments. The system uses diffuse reflectance spectroscopy and can provide immediate feedback during biopsies.
Researchers found that lapatinib delayed tumor development and reduced the number of tumors in a mouse model of hormone receptor-negative breast cancer. Lapatinib is a small-molecule inhibitor that blocks tyrosine kinase activities associated with tumor formation.
A dual-headed dedicated gamma camera used during molecular breast imaging (MBI) can accurately detect small breast tumors less than 2 cm in size. The sensitivity rate of dual-head MBI was found to be 90%, detecting 128 cancers in 88 patients with suspicious lesions smaller than 2 cm.
A study of 249 patients with breast cancer found that using MRI before surgery can lead to better-adapted treatment, including changing surgical approaches for multiple tumors. The technique reduced the need for mastectomies and improved treatment outcomes in 22 patients.
Research found that medial breast tumors primarily receive blood from internal mammary vessels, while lateral tumors have a more complex blood supply. This study supports the use of MRI for analyzing breast cancer's impact on surrounding anatomy, particularly vascular supply and lymphatic drainage.
Researchers have identified a molecule, osteopontin-c, that appears more accurate than existing biomarkers in predicting which breast cancers will develop into advanced forms. The discovery could one day influence therapy decisions and prevent patients from undergoing aggressive treatments.
Recent studies conducted at Mayo Clinic have found that MRI is superior to mammography in detecting additional tumors in the same breast and identifying new tumors in the healthy breast. The technology has also revealed distinct patterns between ipsilateral and contralateral tumors, guiding its use.
A new protein fragment called pHLIP has been demonstrated to target and accumulate in human breast tumors, enabling detection and potentially treating cancer. The protein's ability to navigate acidic environments makes it a promising tool for detecting various disease states.
Researchers at Baylor College of Medicine have developed a new treatment approach that combines three drugs to block the HER-2 receptor, eradicating aggressive breast tumors in mice. The treatment, known as targeted therapy, has shown promising results, with tumors disappearing and not returning even after treatment is stopped.
An international study by the University of Bonn found that MRI can detect up to 30 cancers in the opposite breast of women with recent unilateral breast cancer diagnoses. The study's results show a 99.6% confidence level that no breast cancer is present if an MRI scan is normal, making preventive mastectomy unnecessary.
Researchers found that radiation therapy significantly reduced breast cancer recurrence and tumor development in older women with early-stage disease. The study, published in CANCER journal, recommends standard therapy for women of all ages and comorbidities, including mastectomy or breast conserving surgery with radiation.
Researchers develop computer approach to precisely target breast tumors with electron and x-ray beams, reducing collateral skin damage. The technique helps send accurately targeted doses for 78 patients, providing benefits for shallow tumor treatments in the breast, chest wall, and head-and-neck region.
A study found that pre-menopausal African American women are more likely to have the basal-like breast cancer subtype, which is more aggressive and lacks targeted treatment options. The researchers also noted a higher mortality rate among younger African American women with this subtype.
Researchers found that post-lactation involution matrix promotes breast tumor cell migration and metastasis, even when compared to virgin matrix. The study suggests changes in the breast environment during pregnancy may contribute to poor breast cancer outcomes.
For patients with early-stage breast cancer, MRI improves treatment selection by identifying additional cancer in the breast that may require wider removal of tissue or mastectomy. Breast MRI can help radiation oncologists identify suitable candidates for accelerated partial breast irradiation.
eEF1A2 protein is moderately to highly expressed in two-thirds of breast tumor cells, with significant over-expression in estrogen receptor-positive tumors. The protein's role in breast tumour development remains unclear, but may be related to its function in protein synthesis or cytoskeletal remodelling.
A study of 58 breast cancer patients found that initial tumor volume and changes in tumor volume during chemotherapy are strong predictors of recurrence-free survival. MRI measurements can help tailor treatment strategies for individual patients.
A study found that DCIS tumours tend to occur in areas of mammographically dense breast tissue, with locations correlating strongly with the area of highest average percent density. The findings suggest that some aspect of dense tissue directly influences the carcinogenic process.
The breast CT scanner developed at UC Davis has reached clinical testing and shows promise in detecting breast tumors earlier than mammography. The technology requires no breast compression and takes images of virtual slices to provide a detailed view of breast tissues.
Researchers found that curious female rats with spontaneous breast or pituitary tumors lived an average of six months longer than cautious ones. The study suggests that personality traits may have a significant impact on health and resilience to disease, consistent with earlier findings in human studies.
Researchers discover viral DNA sequence in MMTV Env protein that transforms mouse breast cells. The study suggests a potential new mechanism for virus-induced breast cell transformation.
A new diabody targeting breast tumor growth has been developed, showing significant inhibition of human breast tumor xenografts in mice. The mini-antibody C6.5K-A specifically targets the HER2/neu human tumor-associated antigen and demonstrates great affinity for its target, leading to prolonged retention in antigen-laden tumors.
A study found that mouse mammary tumor virus (MMTV) is linked to aggressive breast cancers, particularly in North African countries. The virus was found in 74% of Tunisian samples but only 36% in US samples, suggesting geographic differences in prevalence.
A new partial breast radiation procedure using balloon brachytherapy has shown promising results in reducing treatment time and improving cosmetic outcomes. The study found that women treated with this method experienced quick recovery, good cosmetic results, and no evidence of cancer recurrence during a 1-2 year follow-up.
Scientists have identified new breast tumor subtypes associated with poor clinical outcomes, which can be recognized and matched with therapies. The discovery uses genomic approaches and microarray analysis to classify tumors into distinct subtypes based on patterns of gene interaction.
A new imaging technique uses MRI and spectroscopy to analyze choline levels in tumors, accurately identifying malignant carcinomas in 8 out of 8 cases. The study suggests MRSI may aid physicians in diagnosing breast cancer and could potentially replace biopsy in certain cases.
A study of 362 patients has shown that breast conservation after neoadjuvant chemotherapy is a safe and effective alternative to mastectomy for many patients. The key to success lies in careful patient selection and coordination among treatment specialists, with low rates of local-regional recurrence reported.
A study at Duquesne University found that black cohosh, commonly used for menopausal symptoms, may promote progression to metastatic disease in women with early stage breast cancer. The research suggests women who develop breast cancer or are at high risk should proceed with caution or avoid taking the herbal extract.
Contrast-enhanced MRI is a reliable method to measure blood flow to tumors, allowing for accurate assessment of chemotherapy response and tumor viability. The study found that patients who responded to treatment had significant decreases in angiogenesis, while non-responders showed increases.
A study published in Cancer Research found that COX-2 inhibitors, such as celecoxib, can delay the onset of breast cancer in genetically bred HER-2/neu mice. The mice treated with celecoxib experienced a significant reduction in tumor incidence and a longer time to disease progression compared to control mice.
A new study found that neoadjuvant therapy can significantly improve long-term survival rates for women with locally advanced breast cancer. The treatment allows for less drastic and breast-sparing surgery, increasing the chances of successful tumor downstaging and improved outcomes.
A new study links human breast cancer to the mouse mammary tumor virus, proposing that humans acquire the virus from infected mice. The authors found a similar viral sequence between human breast cancer and mouse mammary tumor virus, suggesting a potential preventive vaccine.
Researchers discovered that abnormal expression of the WT1 gene is linked to nearly 70% of breast cancers, which may lead to new treatments. The study suggests restoring functional tumor suppressor genes like WT1 could help combat breast cancer.