Articles tagged with Liver Tumors
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A new molecule, ARC, has shown promise as a potential anticancer drug that selectively kills tumor cells without harming normal cells. The compound inhibits RNA synthesis in normal cells but induces cell death in cancer cells by blocking the cell cycle, making it an attractive alternative to existing drugs that can harm healthy tissue.
Duke University scientists increased chemotherapy drug molecular weight to improve tumor penetration and concentration while reducing healthy tissue toxicity. The optimal molecular weight range was found to be between 40,000 and 70,000.
Researchers found that Botox injected into mouse tumors opened their cellular vasculature, allowing effective destruction of previously resistant cancer cells. This approach aims to alleviate tumor hypoxia, making them more susceptible to treatment.
In a largest study of its type, researchers treated 2,506 liver tumors and found that MR-guided laser-induced thermotherapy (LITT) improves average survival rate from diagnosis by 3.8 years, outperforming traditional surgery. Laser treatment offers several advantages, including outpatient basis under local anesthesia.
Researchers have developed a biocompatible polymer that briefly changes from liquid to gel at body temperature to block gene-bearing viruses from leaking into the bloodstream and harming other tissues. This method reduces misdirected virus dissemination by a factor of 100-1,000 times, solving the problem of toxic leakage in gene therapy.
Researchers at the University of Rochester Medical Center have successfully treated 72 patients with metastatic liver lesions using precision radiation therapy. The treatment resulted in a median survival time of 13 months, showing promise as an effective option for patients who previously had limited treatment options.
Mayo Clinic's new treatment protocol combining radiation therapy, chemotherapy, and liver transplantation has significantly improved the five-year survival rate for patients with bile duct cancer to 82%. The treatment enables surgeons to remove the entire liver and obtain better tumor clearance.
A study published by Massachusetts General Hospital found that radiofrequency ablation (RFA) is an effective long-term treatment for kidney tumors, with success rates of 100% for surface tumors and 78% for central tumors. The procedure has been used to treat over 100 renal cell carcinomas in 85 patients with similar results.
A new study published in the American College of Radiology shows that expandable electrodes are safe and effective for radiofrequency ablation of liver tumors. The procedure resulted in high survival rates and low complication rates, comparable to those achieved through surgery.
Researchers have found promising results from an early clinical trial of a novel treatment for uveal melanoma that has spread to the liver. The two-pronged treatment cuts off oxygen supply to tumors and stimulates the immune system, leading to tumor shrinkage and prolonged survival in patients.
Researchers found that ablation therapy extended median survival to 33 months compared to 20 months for chemotherapy-only treatment. The study also showed improved disease recurrence rates and overall 3-year survival rate of 51%.
Researchers analyzed tumor DNA from 324 GIST patients and found that those with a KIT exon 11 mutation responded better to Gleevec. The study confirms the need for new drugs for patients whose GIST genotype is less responsive to Gleevec.
Breast cancer tumors hijack normal wound-healing processes by exploiting stromal cells' production of SDF-1, which recruits endothelial precursor cells for tumor growth. This process enables tumors to access nutrients and grow unchecked.
Research finds that high cyclosporine levels are associated with increased risk of hepatocellular carcinoma (HCC) recurrence after liver transplantation. The study suggests tailoring immunosuppressive schedules to individual patients based on their tumor biology, and recommends minimizing exposure to cyclosporine to prevent recurrence.
Researchers have developed oncolytic viruses that can infiltrate and destroy tumor cells while leaving surrounding healthy tissue intact. These 'cancer-killing' viruses are being tested in patients with various tumor types, including melanoma, breast, head and neck, and colorectal cancer.
Researchers found that RF ablation was a safe and effective treatment option for early-stage liver cancer patients, with survival rates comparable to surgical resection. The procedure proved more successful with smaller tumors, offering a viable alternative for inoperable patients.
Qdot molecular imaging enables precise tracking of tumors, identification of cancer types, and real-time optical biopsy. The technology holds promise for a one-two punch approach to diagnose and treat cancer.
Using MRI guidance, doctors can target and freeze liver tumors with cryotherapy, achieving high success rates and minimal scarring. The non-invasive procedure results in quicker recovery times and shorter hospital stays.
Researchers found that adding alcohol injections to RFA significantly improved treatment outcomes, eradicating 34 of 41 liver tumors with no bowel-related complications. The combination therapy also showed promise for treating large tumors and other types of tumors in the body.
The study used wireless capsule endoscopy to detect 73 small bowel tumors, including 65% that were malignant. Capsule endoscopy provides a new option for diagnosing small bowel tumors, previously difficult to access through traditional endoscopic methods.
The American Society of Plastic Surgeons recognizes five 'Patients of Courage' who have overcome incredible obstacles, inspiring others to do the same. Through their stories, these individuals demonstrate the potential strength within us all.
Researchers found that ginger compounds slowed tumor development in mice, while Scutellaria barbata inhibited apoptosis in prostate cancer cells. These findings suggest potential chemopreventive effects of these natural herbs against certain cancers.
Researchers used transarterial chemoembolization (TACE) to treat patients with liver tumors, shrinking them by up to 35% in size. Patients who responded successfully were then treated with laser-induced thermotherapy (LITT), allowing for a more aggressive approach to tumor treatment while preserving patient quality of life.
Researchers used alginate, a major constituent of brown algae, to block viral leaks and reduce the concentration of toxic protein IL-12 in mice's livers. The solution improved the effectiveness of gene therapy by preventing sudden animal deaths caused by uncontrolled protein expression.
A new treatment approach blocks liver tumor angiogenesis by manipulating the Tie2 receptor. In mice with colon cancer metastasis to the liver, this approach shrinks tumors and extends survival. The mean survival time increased significantly compared to control mice and endostatin-treated mice.
A study by Te Velde found that the Pringle manoeuvre increases tumour growth and recurrence after liver surgery, reducing patient survival chances. Medicines preventing blood vessel regeneration can be combined with chemotherapy to control tumours.
A new study found that combining radiofrequency ablation with chemotherapy can effectively treat larger liver tumors. The treatment, which involves using heat to destroy tumor tissue and administering a chemotherapeutic agent intravenously, resulted in a tripling of survival rates compared to those receiving no treatment.
Chemoembolization is the treatment of choice for widespread or diffuse tumors, enabling patients with primary liver cancer to live longer and maintain a quality of life. The procedure uses oil droplets to transport chemotherapy agents directly to the tumor, reducing toxicity and improving outcomes.
The tob gene is a newly characterized tumor suppressor that prevents cell proliferation by constraining the cell growth cycle. Tob-deficient mice develop various spontaneous tumors, including liver cancer, at a significantly higher rate than normal mice.
Researchers identified a specific gene required for liver cancer metastasis, which may serve as a diagnostic marker and therapeutic target. The study found that the activity of genes in tumors with metastatic potential differed from those without, enabling early detection and potentially improving treatment outcomes.
A combined approach of photodynamic therapy (PDT) and radiation shows promise in treating mouse tumors, with increased oxygenation improving the effectiveness of both treatments. The study used verteporfin, a light-activated drug that targets tumor tissue, leading to improved outcomes.
A new study found that patients in higher-spending regions receive more care, but it does not translate to better outcomes, patient satisfaction, or access to care. Removing liver tumors by ethanol injection therapy followed by interferon therapy may reduce the risk of tumor recurrence in patients with chronic hepatitis C virus.
Researchers successfully treated 42 individual kidney tumors using minimally invasive RFA, with all surface tumors completely destroyed. Patients with limited kidney function maintained good kidney function and had no local recurrence of the treated tumor.
Researchers discover 3-bromopyruvate selectively kills liver cancer cells while sparing healthy tissue. The compound, which blocks energy production in cells, may offer a promising alternative to existing treatments for liver cancer.
Researchers at CWRU have developed a new cancer treatment using dual-release kinetics, which could potentially allow for more effective and safest local drug therapy. The device is designed to work in synergy with image-guided thermal ablation and aims to reduce exposure of normal tissues to drugs while increasing the dosage to the tum...
Researchers combine a gene that shuts off angiogenesis with a nanoparticle that selectively targets cancer tumor cells, effectively cutting off their blood supply and killing the tumor. This approach shows strong regression of large tumors in every system tested.
A new treatment option called TheraSphere appears safe and effective in reducing liver tumors and improving quality of life for patients with advanced stage hepatocellular carcinoma. The novel treatment emits beta rays via microscopic glass beads, delivering a higher dose to the liver than standard radiotherapy.
A multicenter randomized trial found that chemoembolisation significantly improves survival rates compared to conservative treatment, with 82% and 63% survival probabilities at 1 year and 2 years, respectively.
Researchers at Stanford University Medical Center have developed a novel approach to fighting cancer using a modified cold virus that targets cancer cells while leaving normal cells unharmed. In a phase I study, 28 patients who received the highest dose of the virus survived for nearly a year and saw significant tumor shrinkage.
Researchers have successfully treated metastatic disease using a modified herpesvirus, providing a promising treatment option for patients with advanced cancer. The therapy has shown promise in early trials, demonstrating its potential as a novel approach to combatting this devastating disease.
Researchers have developed a new liver cancer treatment using electrolysis, which destroys tumors and surrounding tissue with minimal impact on healthy liver cells. The technique has shown promising results in an ongoing trial, with eight out of ten patients showing no evidence of residual tumor.
Researchers at the University of Florida have found a new heat-based therapy that kills inoperable liver tumors without initiating an onslaught of harmful hormones. The technique, known as radiofrequency ablation, is less risky and cheaper than surgery or cold-based therapies.
A study by University of Pittsburgh surgeons found that liver cancer patients wait nearly a year for transplants, allowing tumors to grow too large to be cured. Modifying the policy could improve survival rates for Stage IV patients with four or more nodules less than 3 cm.
Researchers are developing a new alternative treatment for cancer using radio-frequency ablation, which heats diseased cells with a fine electrode. The technique has shown promising results in treating liver cancers, with nine out of twelve patients remaining cancer-free for more than a year.
A new study found that shrinking tumors can reduce blood vessel pore sizes, making it harder for chemotherapy agents to reach their targets. Researchers recommend designing smaller, more agile drugs to overcome this challenge.
A promising hepatitis-based gene therapy has been developed to target and eliminate liver cancer cells. The treatment, created by a team of physicians, recruits the body's immune system to attack and wipe out cancerous tumors.
Cryosurgery has been used to treat prostate and skin cancers, but recently began treating advanced liver cancer. The procedure freezes tumors using liquid nitrogen, with Emory University Hospital as one of the few medical centers offering it.
Researchers found that captopril inhibited the growth of new blood vessels essential for tumor growth, potentially reducing cancer incidence and severity. The drug's mechanism may differ from its blood pressure-lowering effects.