Articles tagged with Planarians
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New research from the Stowers Institute for Medical Research reveals planarian stem cells ignore their nearest neighbors and respond to signals further away in the body. This discovery may help explain the flatworm's extraordinary ability to regenerate and offer clues for developing new ways to replace or repair tissues in humans.
Researchers have discovered that planarians can regenerate body parts and even grow new heads, reversing signs of aging such as lost neurons and muscle mass. This finding has implications for understanding age-related decline in mammals, including humans.
Researchers developed tomoseqr, a user-friendly software to estimate 3D spatial gene expression distribution. The software successfully reproduced known gene expression patterns and mapped the 3D spatial distribution of genes in zebrafish and planarians.
A WVU biologist is studying how genes establish animal body plans and contribute to regenerative abilities. He has identified Hox genes as key players in planarian regeneration, suggesting their functions may differ in highly regenerative versus poorly regenerative organisms.
In planarian flatworms, biogenic monoamines play a critical role in regulating female and male germ cells. Researchers discovered that these molecules form a novel signaling pathway controlling planarian germ cells, producing the 'BATT Signal' to regulate reproductive development. The study highlights the importance of monoamine conjug...
Researchers from the University of Barcelona have identified a new molecular mechanism that allows planarians to regenerate their bodies. The study reveals that the modulation of the Wnt pathway modifies chromatin and lets wound stem cells know the fate of the new tissue, which is crucial for regenerating heads or tails.
Researchers at Stowers Institute for Medical Research discovered that Hox genes, known to orchestrate early development, continue to be expressed in adult tissues and are required for asexual reproduction in flatworms. The study suggests new roles of these genes in adulthood.
A new study from Peter Reddien's Lab at Whitehead Institute has identified muscle cells that serve as guideposts to help regrow axons from the eyes to the brain in regenerative flatworms. The discovery sheds light on neural circuit regeneration in adults and could have implications for understanding human brain or nerve damage.
Researchers have found that stem cells in planarians can postpone their own death to respond to an injury, allowing them to gather around the site of the wound and mount a response. This unique ability has implications for cancer research and therapies, particularly when examining chemotherapy and surgery options.
The invasive flatworm Obama nungara has been found across metropolitan France, covering three quarters of the country. Molecular studies reveal a single population originating from Argentina, posing a potential threat to European soil ecology.
Researchers have isolated a potent chemical, 'schistosome paralysis factor', that can immobilize cercariae and prevent infection. This discovery could lead to new treatments for schistosomiasis, which causes devastating health problems in Africa, Asia, and parts of South America.
Five species of giant hammerhead flatworms have been discovered in metropolitan France and French overseas territories, including two species reaching up to 40 cm in length. The discovery raises concerns about the potential threat to native animals and soil ecology due to their predatory nature.
The study provides a complete genome assembly of the planarian flatworm Schmidtea mediterranea, revealing novel giant repeat elements, new genes, and the absence of certain essential genes. The discovery has potential implications for understanding regeneration research and stem cell biology.
A Northwestern University research team found a conserved mechanism for nociception in planarian flatworms, fruit flies, and humans. The discovery could lead to new strategies for treating acute pain in humans by designing analgesic drugs targeting the transient receptor potential ankyrin 1 (TRPA1) receptor.
Researchers have discovered that planarian fission occurs in three stages: waist formation, pulsation, and rupture. This process is crucial for the regeneration of missing structures, allowing flatworms to reproduce asexually and potentially giving rise to diversity in populations.
A new report from the Stowers Institute for Medical Research has discovered that adult planarian stem cells called neoblasts arise during a specific stage of embryonic development. These cells retain the ability to access embryonic developmental programs during adulthood, allowing them to drive regeneration of lost body parts.
Researchers at Stowers Institute have identified a key molecule, EGFR-3, that directs planarian stem cells to make copies of themselves. The discovery has important implications for advancing regenerative medicine and developing effective cancer therapies.
A new study has identified the Nuclear Factor Y-B gene as essential for sperm production in the parasitic blood fluke Schistosoma mansoni. The researchers found that suppressing this gene reduced sperm-producing stem cell numbers, highlighting its role in maintaining a balance between self-renewal and differentiation.
Scientists at UC San Diego discovered that freshwater planarians are comparably sensitive to tested chemicals as zebrafish larvae and nematodes, but offer unique advantages such as studying genetically identical adult and developing animals. This could reduce the use of laboratory mammals in toxicology tests.
Researchers at Tufts University developed an algorithm that used evolutionary computation to predict the results of published laboratory experiments on planarian regeneration. The approach identified a comprehensive regulatory network that correctly predicted all 16 key experiments, shedding light on the mechanisms behind head-tail pat...
A new species of obligate cave-dwelling flatworm was recently discovered in the Brazilian savanna, providing insight into the rich biodiversity of Brazilian caves. The species, Girardia multidiverticulata, has a unique reproductive apparatus that distinguishes it from other related species.
Researchers have discovered the gene zic-1, which enables planarians to regenerate their heads after decapitation. The study suggests that this ancient mechanism could be used to create tissue organizers for enhancing injury repair in humans.
Researchers have successfully cultured and studied the three-banded panther worm, a new model organism for understanding regeneration. The worm's ability to regenerate any body part has been linked to Wnt and Bmp signaling pathways, offering potential clues for human regenerative therapies.
Researchers have discovered a key role for the follistatin/activin-1-2 switch in regulating regeneration in planarian flatworms. The more severe the tissue loss, the higher the expression of follistatin, which inhibits activin proteins and allows regeneration to begin.
Researchers have identified muscle cells as the primary source of positional control in regenerating planarians, enabling them to respond to wounds and regenerate missing tissues. This discovery opens new avenues for understanding regeneration and could potentially inform treatments for human injuries and diseases.
Scientists discovered a molecular switch that regulates regeneration in flatworms, enabling them to grow heads complete with brain, eyes, and wiring. This breakthrough could lead to insights into why some animals regenerate while others don't, potentially informing regenerative therapies for humans.
Planarians can regrow missing organs, including the intestine, after injury. Researchers identified genes that control intestinal growth and regeneration using RNA interference. The study provides insights into stem cell division, cellular events, and molecular signaling pathways involved in organ regeneration.
Researchers at the Stowers Institute for Medical Research discovered that planarian stem cells, known as neoblasts, can mobilize and rebuild tissues lost to amputation. The team found that these stem cells remain pluripotent even in fully mature animals and migrate to the site of injury when needed.
Researchers at Whitehead Institute have published a comprehensive catalog of genes active in planarian eyes, shedding light on eye development and regeneration. The study identifies key genes involved in eye biology, including ovo, which plays a critical role in eye formation and regeneration.
Scientists at Whitehead Institute have made a breakthrough in understanding planarian stem cells, discovering genes that regulate two main functions: differentiation and renewal. The study, published in Cell Stem Cell, provides insights into the molecular mechanisms underlying regenerative medicine.
Planarian worms, a species of flatworm, have been found to maintain telomere length indefinitely, allowing them to regenerate tissues and cells without aging. This discovery sheds light on the mechanisms underlying their immortality and may shed new insights into alleviating aging in human cells.
Researchers discovered that planarians lack centrosomes and yet retain regenerative powers. By studying planarian homologs, the team identified conserved proteins required for centriole assembly in human cells, suggesting alternative functions for centrosomes.
A team of researchers at the Berlin Institute for Medical Systems Biology has identified thousands of gene products expressed in planarian flatworms, revealing new insights into the molecular mechanisms of regeneration. This study, which combined two existing sequencing methods, expands and refines planarian research.
Researchers at Whitehead Institute have discovered that planarian flatworms possess pluripotent stem cells called clonogenic neoblasts, which can differentiate into various tissue types and even replace all tissues in a host. This finding has significant implications for understanding regeneration in mammals.
Researchers studied peptide hormones in planarian flatworms to understand their reproductive output and potential link to parasitic diseases. The study found that disrupting neuropeptide processing in sexually reproducing planaria causes reproductive organs to regress.
Researchers have identified 60 new microRNA genes in planarians that may play a role in regeneration. Additionally, they discovered millions of piRNAs, which are essential for genome stability and likely function similarly to mammals.
The use of multiple model organisms is expanding due to decreasing genome sequencing costs and advancing gene expression manipulation techniques. Emerging model organisms, such as planarians and snapdragons, are being introduced to the laboratory, enabling comparison and refinement of existing models.
Researchers have identified two genes that regulate stem cell function in planarians, which could provide insights into adult tissue maintenance and regeneration. The study also reveals the role of PTEN in controlling stem cell proliferation and regeneration.
A team of researchers from the University of Illinois has made significant discoveries about germ cell development in planarians, a tiny flatworm species. They found that planarians express a key gene, nanos, which plays a critical role in germ cell formation and maintenance, similar to mammals.
Researchers discovered that Bruli protein plays a crucial role in maintaining stem cells in planarians, enabling their remarkable ability to regenerate lost body parts. The study provides new insights into the fundamental mechanisms of stem cell self-renewal and its potential applications in human therapy.
Scientists have discovered 142 human disease genes in the flatworm planarian Schmidtea mediterranea, which may provide insights into human diseases. The findings suggest that flatworms could be a valuable complementary model for studying gene function and developing new treatments.
Scientists have identified 35 genes essential for regeneration in planarians, a discovery that could lead to new insights into human regenerative biology and the development of potential treatments for diseases. The study also highlights the potential of planarians as a genetically sound model for human biology.
Researchers identified genes required for stem cell function and regeneration in planarians, providing insights into human development and health. The study used RNA interference to analyze gene function in intact animals and on proliferation of adult stem cells.