Articles tagged with Worms
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A random screening of 19 approved human medications revealed that anticonvulsants like ethosuximide and trimethadione increased lifespan in C. elegans worms by delaying age-related declines in neuro-muscular activity.
Researchers have developed a femtosecond laser nanosurgery technique to study genetic and molecular factors controlling nerve regeneration in C. elegans worms. The technique allowed for precise axon severing, enabling rapid recovery of function and new insights into neural regeneration.
A new laser scalpel allows for precise cutting of nerves in worms, enabling researchers to study the basic mechanisms of nerve regeneration. The technique involves making mutations in genes believed to be involved in nerve regeneration and observing the effects on regeneration following laser severing of the nerves.
The editorial concludes that deworming programs have substantial public health benefits and reductions in global burden of disease. Simple, effective, safe, and cheap treatments are already available, but systematic delivery requires industry, funders, and political will.
The Planaria worm is an attractive study subject due to its simple biochemistry, brain, and spinal cord, allowing researchers to study the effects of multiple drugs on withdrawal. The worms respond to dopamine, opioids, cocaine, and cannabinoids, making them a promising model for understanding complex drug interactions.
Researchers are exploring the use of genetically endowed worms to replace rodent studies in toxicology testing, potentially saving millions of dollars. The C. elegans worm has a unique biology that makes it an ideal model for testing chemicals, with its short lifespan and transparent body allowing for direct monitoring of internal organs.
The NSF's Cyber Trust program awards funding for two new centers: the Center for Internet Epidemiology and Defenses and the STIM Center. The former focuses on understanding internet vulnerabilities to prevent malware outbreaks, while the latter explores network interactions to create effective defenses against cyberattacks.
A team of researchers has developed a fast-track method to identify regulatory sequences in the genome that control cell growth and development. The study, published in Science, used a unique algorithm called Improbizer to predict where these regulatory sequences might be found in the genome.
A team of researchers led by Guy A. Caldwell found that worms with a mutated LIS1 gene experience convulsions similar to those in humans with lissencephaly, a rare birth defect. The study reveals the mutated protein's impact on neuronal trafficking and neurotransmitter release, providing insights into the complexities of epilepsy.
Researchers found that worms seek mates when alone but remain near food sources with potential mates. In cone-only retinas, rod bipolar neurons maintain their morphology and connectivity despite lacking rods, while remaining light-sensitive.
Researchers have developed a C. elegans-based screening tool to identify novel protein regulators of a potassium channel involved in the heartbeat, which may help prevent arrhythmias and sudden death associated with blockage of the HERG gene.
Researchers find two new species of worm that feed on whale bones, using symbiotic bacteria to digest fats and oils. The worms, Osedax frankpressi and Osedax rubiplumus, are closely related to hydrothermal vent worms and have unique features such as feathery plumes and green roots.
Researchers at U of T found that animals absorb environmental information to modulate behavior, associating smells with starvation cues. A mutation affecting environmental role in memory recall was identified, highlighting the importance of environment in learning.
Researchers found a nematode's oxygen-sensing mechanism can regulate blood pressure. The discovery reveals that worms prefer lower oxygen concentrations, which may explain their unique behavior.
The nematode C. elegans prefers 6% oxygen, which helps it survive in environments with low oxygen. The worm's oxygen sensors are similar to those used by humans and other animals to detect nitric oxide.
Researchers at the Medical College of Georgia have identified a gene called Indy that plays a critical role in delivering energy to cells, which may contribute to aging. By altering the activity level of this gene, they found that tiny worms lived longer and were thinner, raising hopes for potential human benefits.
Scientists have identified a genetic basis for alcohol response in roundworms, discovering that subtle variations in the NPR-1 gene affect tolerance. The study found that strains with higher levels of NPR-1 protein exhibit reduced ability to recover from alcohol exposure.
Researchers found that a specific gene, lin-48, helps Caenorhabditis elegans survive high-salt environments, giving it a key advantage over its relatives. This genetic difference may hold insights into how organ systems in more complex animals evolved.
Researchers discovered that a single gene and brain protein are responsible for alcohol's intoxicating effects, leading to neural depression and uncoordinated movement. The finding suggests that targeting this channel could lead to new treatments for alcohol addiction.
Researchers Bass and Tonkin found that ADARs interact with the RNAi pathway to regulate behavioral defects in C. elegans worms, particularly in detecting food. By disabling both ADAR genes and RNAi pathways, they eliminated behavioral defects associated with ADAR mutations.
The C. briggsae genome sequence enhances biologists' ability to mine C. elegans for biological insights, revealing new genes and functional elements. The study also highlights the rapid evolution of C. elegans and C. briggsae genomes compared to mammals.
Researchers developed a hardware platform called FPX that scans for malware signatures in parallel, allowing it to scan every byte of network traffic at an unprecedented rate. This technology can quarantine viruses and worms within sub-networks, protecting thousands of users with just a few devices.
A new study shows that C. elegans progeny derived from sexual reproduction can undergo sex change after birth to better survive chemical changes in the environment and shortages of food. This development allows for increased survival flexibility and gene expression, suggesting that sex is a beneficial strategy for this species.
The nematode worm can alter its sex based on the perceived food availability, affecting the sex ratio. The research helps understand how animals adapt to variable environments and why sex exists.
The DETER project aims to create a closed, isolated network that can represent the entire Internet for testing and improving cybersecurity tools. The facility will enable researchers to test existing and new security technology using various attack techniques.
A study found that cows can be genetically classified into three groups based on their resistance to intestinal worms. The research suggests that understanding the genetic factors behind this resistance could lead to the development of a vaccine to prevent gastrointestinal worm infections.
Researchers found that the polychaete worm's jaws are hardened by zinc due to its high concentration towards the tip. The study reveals a new paradigm in nature and sparks ideas for materials science, potentially leading to lighter tires and protective coatings.
Researchers discovered that a single life-extending mutation affects multiple genes, including those controlling cellular stress response and metabolic processes. The study reveals the intricate connections between genetic pathways and their impact on lifespan.
Researchers evaluating environmental impact of common nightcrawler on forest ecosystem in the Northeast. The invasive earthworm species is feeding on leaf litter and duff layers, affecting native plant seeds and animals.
Tube worm aggregations, created by Lamellibrachia luymesi, provide habitat for deep-sea animals with lower sulfide tolerances. These ecosystems persist for centuries, taking up high quantities of sulfide from seep sediments.
A new screening method uses glowing worms to test neuroprotective compounds, which may lead to new Parkinson's disease treatments. Researchers can selectively kill dopamine neurons in living worms using neurotoxins, and the green glow dims when they die.
Researchers discovered that a mutated gene associated with early onset dystonia helps manage protein folding and is normally used as a quality control mechanism. TorsinA's failure to function correctly may lead to protein aggregation, causing neuron malfunction, which is linked to various movement disorders.
Researchers have identified about 400 genes in Caenorhabditis elegans that control fat storage, including many with human counterparts. These genes may hold the key to developing new therapies for obesity and its associated diseases.
Researchers at Vanderbilt University Medical Center have identified a sperm-sensing receptor in worm eggs, enabling egg maturation and ovulation. The discovery sheds light on reproductive problems in humans, including failed meiosis leading to chromosome instability.
Researchers have identified several genes necessary for fat accumulation in nematode worms, which are also present in humans. These findings provide a crucial platform to rapidly identify key proteins regulating fat formation, potentially leading to new therapies for obesity and diabetes.
Researchers discovered that nociceptive neurons trigger group feeding behavior in Caenorhabditis elegans, a species of worm. The findings build on earlier research and have potential relevance to understanding human eating behaviors and obesity.
A recent study on Brazilian brachiopods has provided valuable insights into the life and times of ancient creatures. The research, led by David Rodland, sheds light on the encrustation patterns of modern brachiopods and their potential to estimate water depth and plankton productivity in ancient oceans.
Researchers at UCSF used a new technique to decouple hormone pathways controlling reproduction and longevity in worms, finding that daf-2 activity can be turned on or off independently. This allows for the potential extension of lifespan without suppressing reproduction, offering a promising avenue for human aging research.
Scientists at Rutgers and Albert Einstein College of Medicine investigate C. elegans worm model to understand age-related muscle deterioration. They find a key enzyme involved in this process, which could lead to novel therapeutic strategies for sarcopenia in humans.
Researchers found that the bloodworm's jaw tip contains an ordered crystalline structure of copper-based biomineral atacamite. This discovery could lead to the development of new materials with properties such as hardness, lightness, and durability. The study also suggests a possible application in drug delivery.
Sydney Brenner's groundbreaking research on Caenorhabditis elegans revealed genes controlling human processes, while his contributions to molecular biology and systems biology paved the way for major discoveries. His work at the Molecular Sciences Institute continues to advance our understanding of biological systems.
Researchers have found an enzyme that activates specific RNAs outside the nucleus, enabling them to carry out important steps of germ line development. The discovery provides an important piece of the puzzle in understanding how genes are controlled and may lead to new ways of regulating genetic information.
A study by Kevin Lafferty and Leah Gerber found that non-otter diseases, such as parasitic worms and toxoplasmosis, are contributing to the decline of California sea otter populations. Improving waste disposal and reducing human exposure to these diseases may help protect the otters.
Scientists at UC Davis have found a gene in nematode worms Caenorhabditis elegans that matches a gene altered in one form of dystonia. The discovery may lead to new insights into the disease and potential treatments. Researchers plan to study how OOC-5 interacts with other proteins to better understand its role in human nerve cells.
Researchers at UNC Chapel Hill have found a way to tap into the gene-silencing process RNA interference to identify key parts of its machinery. This breakthrough could lead to the development of new treatments for cancer and other serious illnesses.
Researchers have found a way to efficiently study early blood-cell development using the pag-3 gene in both mice and the common worm Caenorhabditis elegans. The study revealed that knocking out genes in mice results in blood formation defects consistent with predictions made by the worm research.
Recent studies suggest that treating river blindness with antibiotics like doxycycline could be effective in reducing the severity of symptoms. The bacteria Wolbachia is found in the parasitic worm Onchocerca volvulus and is believed to play a major role in the development of the disease.
A team of researchers discovered a protein that controls animal cell fusion, which is crucial for proper development and tissue formation. The study found that mutations in this gene lead to birth defects and organ malformations, highlighting the importance of understanding the fusion mechanism.
Researchers used C.elegans to study molecular mechanisms of dopamine neuron degeneration in Parkinson's disease. The study found that exposure to a neurotoxin, 6-OHDA, caused rapid death of dopamine neurons, and blocking dopamine transporter function eliminated the toxic effect.
Research by UCLA chemists suggests that too much Coenzyme Q can be harmful to adult worms, extending their life span. The study, published in the journal Science, found that lower amounts of Coenzyme Q significantly extended the life span of Caenorhabditis elegans worms.
The STAT intrusion detection system utilizes real-time packet analysis to identify patterns of attacks, aggregating individual alerts to provide an overall pattern of intrusion. The system's modular design enables centralized monitoring and control, allowing for flexible configuration and response to locally detected intrusions.
University of Colorado researchers have identified a protein called DAF-16 that controls lifespan in roundworms. This protein is part of a complex signaling pathway involving insulin and glucose, and its presence or absence affects an organism's lifespan.
Researchers discovered that parasitic worms develop normally into adults when in contact with specific immune cells in their host's liver, producing fewer eggs if disconnected. This adaptation allows the worms to thrive by exploiting their host's immune response.
Researchers have identified a new class of microRNAs in the roundworm C. elegans, which are tiny regulatory RNAs that can regulate gene expression without producing proteins. The study found dozens of these genes, including two that are also present in humans and could play a role in heart tissue development.
C. elegans has a large number of genes due to its genetic makeup and the need for robust development and morphology. The worm's ability to fend off bacteria and other microorganisms in its soil environment is also thought to contribute to its high gene count.
Researchers at Ohio State University have discovered a natural parasite that can control leaf-eating slugs, which destroy crops every spring and fall. The parasite, known as Phasmarhabditis hermaphrodita, is effective in killing American slugs just as well as the most popular slug poison, metaldehyde.
A gene similar to the human cancer-suppressing gene has been identified in a nematode worm, which protects against cancer-causing agents and extends life span under stress conditions. The discovery may lead to novel anti-cancer drugs and a better understanding of human longevity.
A Rutgers researcher discovered the rapid revival of life around hydrothermal vents on the Pacific Ocean floor after a lava flow appeared to exterminate it. Over 500 new species have been found at these sites, including unique organisms like giant tube worms and hairy Pompeii worms.
Researchers used SAGE technique to identify 2016 genes active exclusively in dauer, a non-reproductive, long-lived form of C. elegans. Chromosome stability and structure are linked to dauer biology, with tts-1 gene playing a crucial role.
Researchers have discovered that synthetic superoxide dismutase and catalase can extend the lifespan of C. elegans nematode worms by approximately 50%. These catalytic drugs convert oxygen radicals into water, reducing oxidative stress and protecting mitochondrial function.