A new study published in Cell Metabolism found that a low-protein, amino acid-supplemented 'longevity diet' improved cardiometabolic markers and reduced frailty and fat mass in mice. The diet was associated with longer healthy lifespan and better metabolic health in both mice and humans.
Researchers at Brown University have found a way to extend the lifespan of flies by suppressing a hormone that regulates insulin secretion. The study suggests that certain medications used to treat human obesity and diabetes may also impact aging, making it a promising area of research for future studies.
Researchers at Shimane University have found a way to prolong the therapeutic effects of botulinum toxin-A by blocking the insulin-like growth factor 1 receptor. This breakthrough could lead to reduced frequency and cost of injections, improving patient outcomes and convenience.
Researchers identified how prostate cancer cells achieve cell growth free from usual growth cues and regulators. A protein called PLEKHS1 was found to be a major driver of PI3K activation and cancer growth progression in mouse models.
Researchers found that verapamil prevents the decline of insulin-like growth factor 1 (IGF-1) in Type 1 diabetes patients and promotes IGF-1 signaling in pancreatic beta cells. This mechanism may contribute to the beneficial effects of verapamil on preserving beta-cell function in Type 1 diabetes.
Researchers determined the cryo-EM structure of IGF Ternary complex and its assembly & activation mechanism. The study reveals how IGFBP3 and ALS form a stable complex with IGF1, regulating its activity. The findings provide new insights into growth-related diseases such as growth hormone deficiency and ALS deficiency.
A multi-pillar approach to nutrition can help increase lifespan by promoting optimal carbohydrate intake from non-refined sources, low but sufficient protein from plant-based sources, and enough plant-based fats. The 'longevity diet' may also involve intermittent fasting and a 5-day cycle of a fasting or fasting-mimicking diet every 3-...
A new study published in Nature Communications identifies a harmful cellular pathway that causes pancreatic beta cell death, leading to type 1 diabetes. Blocking this pathway preserved beta cells, increased insulin production, and prevented or delayed diabetes in mice models.
A genome-wide screen of zebrafish identified an enzyme, pregnancy-associated plasma protein-aa (pappaa), that promotes learning and memory by increasing IGF availability to neurons. The study's findings have implications for understanding human neuropsychiatric disorders, such as schizophrenia, autism, and obsessive-compulsive disorder.
Researchers at the University of Helsinki have uncovered a new regulatory system that senses nutrient deprivation and inhibits growth in fruit flies. This system, which involves protein kinase ERK7, prevents secretion of insulin-like peptides during starvation.
A study in Cell Communication and Signaling reveals an extensive interactome of over 500 novel interactions between SH2 domains and phosphotyrosine peptides. The researchers identified six general classes of SH2 domain specificity, which may control the selectivity of individual domains.
Scientists at the University of Michigan have identified a crucial biochemical pathway involved in catch-up growth, which is triggered by changes in oxygen levels. The research has implications for understanding why babies who experience catch-up growth are at higher risk for later life health problems.
A research team has discovered the first functional insulin-like growth factor binding protein (IGFBP) ortholog in invertebrates. The newly identified protein, called imaginal morphogenesis protein-late 2 (Imp-L2), binds to insulin and inhibits its growth-promoting function, regulating growth control and insulin signaling.