Articles tagged with Medical Research Facilities
A small molecule drug improved the fitness of hematopoietic stem cells used in cell transplants, potentially enhancing the success of procedures like ex vivo gene therapy. The study found that targeting extracellular vesicles relieved stress on cells outside the body, improving their performance when transplanted back in.
A new biomimetic chip has been developed to simulate the human gastric mucosa, combining organoid and organ-on-a-chip technologies. The biochip replicates mechanical stimulation and cell-to-cell interactions, mimicking key features of the human stomach's defense mechanisms.
A qualitative study found that staff turnover, staffing shortages, and time constraints are major barriers to participation in quality improvement projects. The authors recommend policy makers provide direct support for primary care to alleviate burnout and address these challenges.
Primary care teams struggle to implement quality improvement efforts due to staff turnover, staffing shortages, and time constraints exacerbated by the COVID-19 pandemic. Researchers recommend direct support for primary care to alleviate burnout and improve participation in quality improvement projects.
The University of Rochester is awarded funding to design and prototype the EP-OPAL facility, which will enable the creation of the highest-power laser system in the world. The facility aims to reestablish US leadership in high-peak-power lasers and fundamental science.
A study using engineered mice found that BA.5, a contagious omicron subvariant, replicates rapidly early during infection, causing significant weight loss and high levels of inflammatory cells and cytokines in lungs.
Researchers developed a scoring system analyzing income, education, geographical location, access to care, and other factors to identify patients at increased risk of poor outcomes. The study found significant socioeconomic disadvantage associated with a 21% decrease in textbook outcomes and a 32% decrease in overall survival.
A team of UC researchers, led by Ashley Kubley, have received a $2.5 million state grant to continue research on improving firefighter protective gear. The project aims to develop a firefighter jacket liner that brings down body temperature through advanced cooling technology and protects against external hazards.
Researchers at West Virginia University have developed a technology that can capture carbon dioxide from the air of buildings and use it to produce methanol, a common chemical with numerous applications. The process is expected to increase the sustainable supply of methanol while removing greenhouse gases from the atmosphere.
The Louisiana Clinical & Translational Science Center has received a $1.3 million NIH grant to support the creation of a network of data warehouses for healthcare providers and researchers in Baton Rouge. The project aims to enhance research capacity, address health care disparities, and improve patient engagement.
A new study suggests that transcranial ultrasound stimulation can be used to change specific types of activity within the brain, paving the way for targeted treatments of mental health conditions. The research found that TUS induced significant changes in GABA concentration and altered communication between brain regions.
Researchers have successfully performed robotic bladder transplantation in human cadaver models and beating-heart donors. The technique aims to reduce surgical times and improve outcomes for patients with terminal bladder conditions.
Research highlights ways to blend caring profession into virtual landscape, focusing on pre-visit, visit, and post-visit phases. Key findings emphasize active listening, reflective listening, and maintaining professional appearance for effective communication.
Researchers at UNIST developed a microfluidic system to process blood into artificial tissue scaffolds for vascular regeneration. Autologous blood-based implants demonstrated superior wound closure rates, increased epidermis thickness, and enhanced collagen deposition in rodent skin wounds.
Researchers developed a photoelectrochemical technique to precisely tune the lasing wavelength of microdisk lasers with subnanometric accuracy. The new approach facilitates the fabrication of micro- and nano-laser batches with precise emission wavelengths.
A study by Pennington Biomedical Research Center and Woman's Hospital found that pregnant women in Louisiana were more likely to exceed recommended weight gain levels during the pandemic, with a 3-7% increase. This rise in non-optimal gestational weight gain may have long-term impacts on maternal and infant health.
A recent MU study found that health and healthcare organizations are increasingly offering basic social services, such as transportation, housing, food, and mental health support, to address disparities in health outcomes. The research team explored innovative solutions implemented by care coordinators and social services to help overc...
Researchers at National Korea Maritime and Ocean University developed a close contact identification algorithm that outperforms conventional clustering algorithms. The algorithm enables accurate tracking and physical isolation of individuals in ship environments, contributing to the health and safety of passengers.
University of Louisville researchers have received a five-year, $11.7 million National Institutes of Health grant to investigate the connection between microorganisms and disease. The study will focus on various chronic conditions, including Alzheimer's disease, heart disease, diabetes, periodontitis, and colorectal cancer.
Researchers at the University of Manchester are enhancing bioprinting technology to create new skin, bone, and tissue for transplantation in space. The project aims to protect astronauts' health from diseases like osteoporosis caused by microgravity exposure.
A new matching system enabled by Boston College economists facilitates the world's first four-way liver exchange and a cascade of additional matches. The system increases the number of transplants that can be matched among a larger group of participants, expanding capacity beyond traditional two-way exchanges.
A recent study by Pennington Biomedical Research Center identifies GDF15 as a protein that acts as a cellular signal to enhance insulin secretion. High-intensity exercise training in patients with type 2 diabetes was found to have elevated levels of GDF15, associated with improved glycemic control.
Researchers at Binghamton University have developed genetically engineered nanovesicles that can target cancer cells more effectively than traditional chemotherapy. These nanocarriers can deliver therapeutic agents directly to the interior of cancer cells, reducing harm to healthy cells and increasing treatment efficacy.
A new scientific statement from the American Heart Association highlights the importance of shared decision-making in cardiovascular care. Key findings include improved patient understanding, acceptance, and satisfaction when healthcare teams involve patients in decision-making processes.
A WVU study found that U.S. cities with new professional sports teams saw increased influenza mortality rates, with the NHL teams causing the largest increase. The researchers analyzed data from 122 cities and controlled for factors like population and temperature to find a significant correlation between team arrival and flu deaths.
Researchers from Tokyo University of Science have developed an innovative method to synthesize azide compounds with a protected azido group, facilitating the efficient synthesis of organonitrogen compounds. This novel approach enables the creation of a wide range of azides through transformations with various electrophiles.
A study found that breast cancer patients with higher body mass index (BMI) are more likely to experience heart damage, or cardiotoxicity, during chemotherapy. The study suggests that addressing obesity and considering the potential risk of cardiotoxicity requires a comprehensive approach.
A new study by MU researcher Roy Thompson found that immigrant nurses in long-term care facilities often have more 'human capital' than their American-born counterparts, including language skills and additional certifications. This diversity can improve patient health outcomes and create a more equitable workforce.
The Global Atlas of Literacies for Health (GALH) is an interactive map displaying levels of health literacy and digital health literacy from evidence-based studies. The atlas provides a critical tool for literacy reform, enabling targeted interventions for marginalized groups.
Dr. Prachi Singh of Pennington Biomedical Research Center has received a $3.7 million grant from the National Heart, Lung, and Blood Institute to investigate the cardiovascular risks associated with limited sleep and extended eating duration.
A Canadian study found that patients were very satisfied with care from their family physicians (90%) and allied health teams (89%), comparable to traditional in-person models. Another pilot program successfully engaged hard-to-reach adolescents in preventive care, demonstrating a 40% increase in show rates for well visits.
Researchers identified key strategies contributing to significant reductions in Medicare acute hospitalization rates at high-performing Comprehensive Primary Care Plus (CPC+) sites. These clinics implemented effective strategies such as improving timely access to primary care, identifying high-risk patients with enhanced care managemen...
Researchers at MSU and Henry Ford Health will study the connections between maternal body mass index (BMI) and childhood obesity. They aim to identify biological mechanisms that contribute to childhood obesity and develop interventions to prevent it in infancy.
Researchers developed a step-by-step approach for creating joint displays of integrated data collection, facilitating comprehensive connections between qualitative and quantitative data. This method tackles the challenge of integrating qualitative and quantitative information in clinical studies, enabling robust mixed methods analysis.
Research reveals that cancer screening awareness is low among people experiencing homelessness, making it difficult for them to receive timely treatment. The study's findings highlight the need for targeted prevention programs tailored to this underserved group's unique needs.
This study shows that shared medical appointments significantly improved patient satisfaction, learning, and medication compliance for patients with primary glaucoma. The research demonstrated no compromise in follow-up rates or measured clinical outcomes.
A study of 290 hospital referral regions found that 53.1% experienced load imbalance due to overcapacity, with Black patients disproportionately affected. The research emphasizes the need for better coordination of patient transfers and real-time data sharing across hospitals.
CEPI and HMRI collaborate to leverage AI technology for faster vaccine development. The partnership aims to identify epitopes that stimulate the immune system, enabling swift clinical testing.
Research reveals e-cigarettes carry potential health risks, including increased blood pressure and heart rate. Long-term studies are needed to fully understand the effects of e-cigarette use on the heart and lungs.
Researchers at MIT are developing a continuous mRNA manufacturing platform to improve vaccine development and production. The pilot-scale system aims to reduce costs, increase efficiency, and facilitate collaboration in the biopharmaceutical industry.
Researchers emphasize the importance of clear causal assumptions and sensitivity analysis to evaluate results' robustness. They advocate for adopting transparent practices in conducting and reporting causal analyses, leading to better understanding of causal relationships and evidence-based decision-making.
A significant rise in caesarean sections in late labour has led to an increase in impacted fetal head (IFH) injuries, resulting in minor damage, lifelong consequences, or even death. New devices like the Tydeman tube and training approaches aim to improve management of this obstetric emergency.
Researchers at Texas A&M University found that substance use impairs cognitive flexibility by inhibiting specific neurons. Chronic cocaine or alcohol use alters the local inhibitory brain circuit, leading to decreased cognitive flexibility and increased risk of academic deficits and lower quality of life.
Researchers examine whether robots and AI can replicate the ethical concepts attributed to human nurses, including advocacy, accountability, cooperation, and caring. While AI can inform patients about medical errors and present treatment options, it questions its ability to truly understand and empathize with patients' values.
A team from the University of Ottawa has developed a comprehensive screening platform and cellular interrogation tool to facilitate novel drug discovery targeting various human diseases. The 'Tango-Trio' platform can identify small molecule modulators for orphan GPCRs, which have significant untapped therapeutic potential.
A WVU researcher is working to understand the unknowns about microorganisms growing inside pipes that bring drinking water to homes and businesses. Biofilms can be detrimental to drinking water quality, but the researcher aims to develop strategies for maintaining water quality throughout complex infrastructures.
Researchers at Korea University Medicine identified a new neuroimaging-based biomarker for MDD, the local gyrification index (LGI), which shows decreased cortical folding in patients. LGI values reflect long-drawn developmental processes and are stable markers compared to previous biomarkers.
Researchers at HKUMed have developed a novel microneedle patch that uses ultrasound-responsive antibacterial nanoparticles to effectively treat skin infections caused by P. acnes bacteria. The treatment promotes pain-free delivery and facilitates skin repair, offering a non-antibiotic approach for acne and other skin conditions.
A recent study found that GPT-3 can generate accurate information, but also produces highly persuasive disinformation. Participants struggled to distinguish between tweets created by the AI model and those written by real users.
Three University Hospitals and Case Western Reserve University research teams received $50,000 Collaborative Science Pilot Awards to explore innovative research projects. The awards aim to increase competitiveness and capacity for major external funding opportunities in key areas such as cancer, brain health and genetics.
A 12-year study by Pennington Biomedical researchers found that metabolic surgery provides better results, less regression, compared to medical or lifestyle intervention for patients with class 1 obesity. The study showed significant improvements in glycemic control and weight loss, with high rates of diabetes remission.
A team of researchers has developed a promising synthesis method for producing 6-(difluoromethyl)phenanthridines, which hold tremendous potential for drug development. The study uses aryl-substituted difluoromethylborates and radical isonitrile insertion to form phenanthridine.
The £72 million investment will support cutting-edge research in fluid dynamics, biological sciences, and astronomy. It aims to maintain the UK's position as a science superpower and accelerate innovation in various fields.
The American Heart Association has launched a $20 million initiative to tackle health challenges in rural America, focusing on novel solutions to heart disease disparities. The Health Equity Research Network on Rural Health aims to explore innovative ways to address unique obstacles faced by rural communities.
Researchers aim to identify best practices for increasing viral suppression in low-income populations with HIV. They will examine state AIDS Drug Assistance Programs to understand disparities in care and outcomes.
A preclinical study has uncovered the role of Y chromosome gene KDM5D in regulating anti-tumor immune responses and promoting metastasis in male patients with KRAS-mutated colorectal cancer. The study reveals that mutant KRAS drives upregulation of KDM5D, leading to reduced cell adhesion and immune recognition by the immune system.
Researchers developed Precious1GPT, a multimodal transformer-based approach for aging clock development and feature importance analysis. The model utilizes methylation and transcriptomic data to predict biological age and identify disease-related genes, providing a pathway for therapeutic drug discovery.
A post-hoc analysis of the ASPREE trial found that low-dose aspirin was associated with a 20% increased incidence of anemia and decline in ferritin levels in healthy older adults. The study recommends periodic monitoring of hemoglobin for patients taking aspirin.
Winship Cancer Institute has received renewal of its National Cancer Institute-designated Comprehensive Cancer Center designation, solidifying its position as Georgia's only NCI-designated Comprehensive Cancer Center. The designation recognizes Winship's strong research programs, robust shared resources, and first-rate scientists.
The American Heart Association invites researchers to compete in a data challenge to better understand how lipoprotein(a) levels impact cardiovascular disease and stroke risk. The winning project can receive a $40,000 cash prize.