Articles tagged with Experimental Replicability
A recent study published in PLOS Biology found that behavioral experiments with insects exhibit a high level of non-reproducibility, with some results varying as much as 42%. Despite this, at least half of the findings could be successfully reproduced.
A new study from the Cusack group sheds light on how avian influenza virus can mutate to replicate in mammalian cells. The key enzyme polymerase must adapt to overcome two main barriers: entering and replicating within host cells, as well as acquiring human transmission capabilities.
Early-life air and noise pollution exposure were associated with increased risk of psychotic experiences, depression, and anxiety from adolescence to young adulthood. Interventions to reduce pollution exposure could potentially improve population mental health.
A study at TUM has debunked the assumption that people overestimate dramatic causes of death due to media attention. Instead, deaths in personal environments have a more significant impact on risk perception. Respondents can consciously engage with news reports and incorporate other sources into their judgment.
A recent analysis of over 750 papers found that more than 90% rely on shortcut citations in their methods sections, significantly impeding the ability to reconstruct original experiments. This practice is prevalent across journals, with less than a quarter adhering to policies governing previously described methods.
Scientists have discovered two new end-replication problems in DNA replication, affecting both the leading and lagging strands. This revelation changes our understanding of telomere biology and may hold clinical implications for individuals with telomere disorders, such as Coats plus syndrome.
A recent US study challenges the notion of a replication crisis in psychology, arguing that flawed intuition and low power in replication studies are to blame. The researchers propose using formal models to estimate expected replication rates, rather than relying on intuitive assumptions.
Two papers advance understanding of PFOS effects on aquatic life, particularly fish, by testing multiple concentrations and confirming its presence in water. The results indicate that earlier findings were non-repeatable and likely due to biological variation rather than PFOS toxicity.
Researchers at DTU Energy replicated a 2021 experiment where a fast-spinning magnet caused another magnet to hover. The force affecting the magnets is attributed to coupling between movement and magnetic force, allowing it to defy classical physics.
Researchers identified a novel bacterial protein, MceF, that can prolong cell longevity by acting directly on mitochondria. The discovery could lead to new treatments for diseases relating to mitochondrial dysfunction, such as cancer and auto-immune disorders.
A new study reveals that autophagy plays a crucial role in the gradual loss of DNA content in diploid Saccharomyces cerevisiae cells undergoing chronological aging. The researchers found that only diploids survived, and autophagy induction was responsible for the DNA loss.
SARS-CoV-2's nucleocapsid protein (N) uses human body temperature to replicate, binding to RNA motifs at specific spatial folds. The study reveals new functions and potential targets for antiviral drugs.
Researchers at Johns Hopkins Medicine have identified a new target for treating HIV infection by blocking the neutral sphingomyelinase-2 (nSMase2) enzyme. Inhibiting this enzyme can prevent HIV replication and kill infected cells, offering a promising therapeutic approach.
Researchers at Weill Cornell Medicine have identified a crucial mechanism that prevents cells from replicating extra DNA, reducing the risk of cancer and genome instability. The study reveals that a licensing protein called CDT1 acts as a brake on DNA replication, preventing it from progressing once licensed sites are established.
A team of researchers, led by Prof. Ehud Pines, has confirmed his theory that a proton moves through water in trains of three water molecules, contradicting the long-held Grotthuss Mechanism. This breakthrough resolves one of the holy grails of physical chemistry after 17 years of research.
A University of Iowa research team has developed a way to isolate replicating DNA molecules for studying the replication process. This advance will allow investigators to better understand DNA replication and may lead to improved therapies for treating diseases such as cancer.
A Purdue University study shows that proteins can replicate themselves and adapt to changes, expanding the scientific view of how life began. The study also found that changes to the environment affect the types of peptides that can be formed.