Articles tagged with Drug Abuse
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A $1.5M study at UH's Office for Drug and Social Policy Research investigates drug abuse, depression, PTSD and HIV/AIDS among 300 Katrina evacuees, mostly African American and Hispanic. The research aims to develop rapid public health responses for large-scale disasters affecting socially disenfranchised populations.
A population-based study of twin pairs in Norway found that genetic factors influence the use and misuse of illicit drugs. The study replicated findings from previous research conducted in Anglophonic countries with higher rates of drug use disorder.
Three studies presented at CPDD show lisdexamfetamine dimesylate has lower euphoric effects and delayed peak effects compared to d-amphetamine sulfate. Lisdexamfetamine dimesylate also produces liking effects in healthy adults with previous history of stimulant abuse.
A new study reveals that ADHD medications mainly affect the prefrontal cortex, a region linked to attention and decision-making. This finding could aid in developing more effective treatments.
A study investigates how methamphetamine use affects children's psychological development and behavior, revealing that despite traumatic experiences, many focus on losing their parents rather than the drug itself. The researchers developed materials for foster parents and child-welfare workers to help these children recover.
People with IED often experience depression, anxiety, and substance abuse disorders. The disorder leads to substantial functional impairment and causes 43 attacks over a lifetime.
A study found that ramelteon, a new sleep medication, does not instigate the same cognitive effects as other commonly prescribed sleep aids. The research suggests that ramelteon is unlikely to promote benzodiazepine-type dependence and may be a safer alternative for treating insomnia.
The Lancet series highlights disparities in indigenous people's health worldwide, with lower life expectancy, higher rates of infectious diseases, and poor access to healthcare. Researchers are calling for greater respect and action to address these issues and preserve unique knowledge about ecosystems and medicines.
A phase II trial of NRP104 demonstrated a statistically significant reduction in ADHD symptoms comparable to mixed amphetamine salts extended-release. The medication was well-tolerated and showed improved behavior, academic productivity, and reduced symptoms in children aged 6 to 12 years with ADHD.
A study published in Chest Journal found that alcohol abuse increases the risk of pneumonia, with decreased immune system activity being a key factor. The consequences of this study could have a significant impact on a high number of people, particularly in Spain where alcohol is a major cause of death.
The COMBINE study found that medication naltrexone, combined with up to 20 sessions of specialized alcohol counseling and structured medical management, is an effective option for treating alcohol dependence. The study demonstrated a small advantage in preventing relapse at 1 year after treatment.
The largest clinical trial on pharmacologic and behavioral treatments for alcohol dependence shows that medication treatment significantly improves outcomes compared to placebo. The study also provides new safety data on prescription drugs naltrexone and acamprosate, suggesting a high degree of comfort for prescribing physicians.
A study by McGill University researchers found that people who expect to smoke soon are more susceptible to visual cues, leading to increased cravings. The study suggests that stress or disruptions to the prefrontal cortex can also trigger relapse, shedding light on nicotine addiction treatment.
Researchers found that low self-esteem in children aged 11 is linked to an increased risk of developing drug dependence by age 20. The study also highlights the importance of identifying at-risk children and intervening early to prevent addiction.
Researchers found that individuals with ADHD were more likely to misuse their medication, particularly selling or taking too much. Immediate release stimulants were most prone to misuse, while extended release formulations were not targeted by abusers.
A new parent therapy program has demonstrated preliminary promise in helping substance abusing mothers recognize their own and their children's emotional states. By improving the emotional quality of mother-child relationships, the program aims to promote children's psychosocial development and reduce preoccupation with drug use.
The American Academy of Pain Medicine calls for a balance between treating legitimate pain and preventing misuse, with healthcare professionals at the forefront. Government initiatives have shifted regulatory authority from health agencies to law enforcement, leading to tension and imbalance in pain care.
A study found that prescription monitoring programs can reduce problematic use of benzodiazepines but also decrease access to appropriate treatment for patients with chronic illnesses. Racial disparities in access to effective care were exacerbated by these policies, highlighting the need for re-examining health policy impacts.
A five-year study found that recovery coaches improved reunification outcomes for a small but significant number of families, with 15.5% of those with coaches being reunited compared to 11.6% in the control group. The intervention also saved $5.6 million over five years by reducing foster care time and costs.
A study examining drug use surveys found significant differences in how willing respondents were to disclose their use, particularly for marijuana and cocaine. The researchers suggest supplementing major surveys with drug tests to estimate willingness-to-disclose and its variation across different drugs and demographic characteristics.
A study compared the abuse potential of two methylphenidate formulations, finding that the delayed-release version took longer to produce maximum effects and was less detectable. Researchers suggest that different formulations may vary in safety characteristics, warranting further study.
A comprehensive scientific study explores the impact of social supports, spirituality, and religiousness on quality of life and long-term recovery from addiction. The research found that participation in 12-step fellowship programs and social support networks significantly enhances recovery outcomes.
A recent study published by the University of South Florida has found that drug use is linked to an increased risk of brain hemorrhage in young adults. The study analyzed data from 307 patients with intracerebral hemorrhage and found that cocaine, marijuana, and amphetamines were common substances of abuse among those under 50.
Liver injuries continue to plague the nation's drug development system, causing costly problems for pharmaceutical companies. Dr. Navarro proposes that patients speak with their physicians about their medications to detect liver injury early, as certain individuals are more likely to develop problems due to genetic makeup.
Orexin strengthens neural communication between dopamine-releasing neurons, playing a key role in drug high experience and craving. Blocking orexin action reverses cocaine-craving behavior in rats.
A team of researchers, led by Xia Zhang, has discovered a potential universal strategy for treating drug addiction. They found that a naturally occurring enzyme called PTEN acts on the ventral tegmental area (VTA) of the brain, where many drugs of abuse exert their rewarding effects.
Researchers at Scripps Research Institute have created a detailed snapshot of a cocaine antibody's dynamics, revealing its potential as a therapeutic agent for treating addiction. The study's findings provide insight into the molecular basis of catalysis and suggest possible mutations to enhance the antibody's efficacy.
A study published in Psychopharmacology found that genetics and environmental factors contribute to the relapse of drug-seeking behavior. The research used rat models to identify glutamate as a neurotransmitter involved in stirring cravings and uncontrollable urges. Dr. Paul J. Kruzich suggests that genetic variations may increase susc...
A new study using an animal model suggests that anabolic steroids can be addictive. Hamsters showed a marked preference for testosterone, nandrolone or drostanolone, indicating the drugs' potential for addiction. The research highlights the need for awareness among coaches and mental health professionals about this risk.
Research at St. Jude Children's Research Hospital found that cocaine exposure alters brain chemistry, making neurons more susceptible to damage from environmental toxins. The study suggests a potential link between cocaine use and the development of Parkinson's disease in both adults and their offspring.
The IUPHAR database provides comprehensive information on GPCRs, including drugs that act on them, target locations in the body, and diseases they may be involved in. This knowledge is freely available to all scientists and drug discoverers worldwide, offering a powerful tool for future research.
A new study published in Neuropsychopharmacology found that bupropion significantly reduced methamphetamine cravings and diminished the 'high' associated with its use. The research suggests that bupropion prevents methamphetamine from entering brain cells, reducing feelings of euphoria.
Researchers found that watching violent scenes can impair cognitive flexibility, while a beta-blocker medication can promote flexible thinking under stress. The study used propranolol to block the brain's normal response to stress and improve performance on word association tasks.
Research by Chuan-Qing Wang and colleagues found that morphine withdrawal and precipitated withdrawal increase HCV replicon expression and inhibit IFN-alpha production in liver cells. This study suggests that opioid abuse may contribute to the chronicity of HCV infection and promote disease progression.
The UK has seen a continued reduction in drug-related deaths, with 73% of all deaths occurring among those under 45. Opiate-related fatalities accounted for the majority (68%) of fatalities in 2004, despite a decrease in the number of deaths involving heroin/morphine.
New research highlights the impact of environmental enrichment on addiction recovery, showing that social rank and stress can affect brain chemistry. Practitioners and family members must understand the importance of abstinence to support brain recovery.
The study analyzed data from 2,567 clients and estimated cost of treatment for an individual, finding reductions in hospital inpatient, emergency room, and mental health services costs. The research team also discovered a significant reduction in the cost of victimization and other criminal activities, averaging $5,676.
A double-blind trial found that buprenorphine combined with behavioral interventions was significantly more efficacious in treating opioid-dependent adolescents than clonidine. The study also showed that 72% of teens who received buprenorphine were retained in treatment, compared to 39% of those given clonidine.
Researchers used PET scanning to track monoamine oxidase (MAO A) levels in smokers and nonsmokers, finding that MAO A was 50% lower in smokers' lungs. Smokers also held onto a tracer chemical longer and had reduced delivery of tracer into arterial blood supply.
A study published in Addictive Behaviors suggests that shame, not guilt, is related to substance-abuse problems. The research found that individuals prone to shame may use alcohol and other drugs to cope with feelings of self-blame, while those who experience guilt are less likely to develop substance-use problems.
The study found that subjective responses to cocaine peak and decline more rapidly than those of methamphetamine. Cardiovascular responses are similar at onset but respond differently over time.
A new tool measures cocaine residue in river and sewage waters, revealing an average daily use of at least 27 doses of 100mg cocaine per 1,000 young adults. This exceeds official national estimates, with 40,000 doses used daily in the Po valley.
A recent study by the University of Florida found that fentanyl patch abuse led to the death of 115 people in Florida last year. The abuse often involves removing the full dose from the patch and taking it all at once, either through injection, ingestion, or smoking.
A study by Yale University researchers found office-based buprenorphine treatment reaches individuals who are unable to use methadone, with key demographic differences including age, sex, and employment status. The treatment has shown success in reaching patients with lower rates of injection drug use and hepatitis C infection.
Researchers found that young intravenous drug users, mainly heroin and methadone abusers, show brain damage linked to Alzheimer's disease. The study suggests increased risk of brain damage associated with opiate abuse, particularly among young individuals.
A study by Ohio State University found that benzodiazepines are widely prescribed for sleep disorders, with nearly two-thirds of visits resulting in medication prescriptions. The study also showed disparities in prescription patterns based on age, insurance type, and physician specialty.
A study found that ramelteon demonstrated no abuse potential, unlike triazolam, with no dose-related effect on task performance. Ramelteon targets the MT1 and MT2 receptors in the brain's suprachiasmatic nuclei, providing a new mechanism of action for insomnia treatment.
A study by OHSU scientist David Grandy found a strong correlation between dopamine supersensitivity and high-affinity D2 receptors in individuals with schizophrenia. This discovery could lead to improved treatments for schizophrenics and amphetamine abusers.
A six-month study found that long-acting naltrexone injections reduced heavy drinking within the first month of treatment and maintained this response over time. The medication was associated with significant reductions in alcohol dependence when used in conjunction with counseling sessions.
Researchers found abnormally low levels of N-acetylaspartate in methamphetamine users, but elevated choline levels in early abstainers, suggesting some degree of normalization over time. The study's findings have important implications for understanding addiction and substance abuse treatment.
A new study found that Geodon significantly reduces time in restraints for patients experiencing severe agitation, regardless of the cause. The medication was also shown to be effective in treating agitation caused by alcohol and drug overdoses.
A retrospective cohort study of 292 healthcare professionals found that family history, co-existing psychiatric disorders, and opioid pain-killer use significantly increase the risk of relapse. State physician health programs should consider specialized treatment approaches to address these concerns.
Researchers discovered that methamphetamine triggers an immune response by forming antibodies, leading to increased tolerance and binge behavior. This finding may lead to the development of specific antibodies as a clinical treatment for addiction.
A randomized, controlled study evaluated four behavioral drug abuse treatments for reducing methamphetamine use and risky sexual behavior among gay and bisexual methamphetamine addicts. Treatment produced immediate, three-fold reductions in both methamphetamine use and risky sexual behavior.
A recent study found that youth with HIV who were treated with highly active antiretroviral therapies (HAART) between 1999 and 2000 reported having more sexual partners, unprotected sex, and drug use compared to those treated before 1996. The researchers suggest targeted interventions are needed to address these risk behaviors.
A recent UCLA study published in the American Journal of Public Health found that people's drinking habits decrease with age, with an average decline of 9-11% per decade. The study used data from the National Health and Nutrition Examination Survey to track changes in drinking behavior over time.
A U of T researcher has discovered a connection between gene mutations and schizophrenia, suggesting the brain overcompensates for these mutations by becoming supersensitive to dopamine. This new understanding could lead to new research directions into schizophrenia.
Researchers found situations of profound neglect, abuse, and physical danger due to drug production at home. The study also highlighted the positive response of rural communities, who stepped up to provide support and care for affected children.
A recent study published by the University of Glasgow found that heroin use among Scots aged 15-54 has declined significantly, from 55,800 in 2000 to 51,582 in 2003. Additionally, the number of people injecting drugs also decreased nationally, while 18,737 still engage in injection drug use.
Scientists at UCSF's Ernest Gallo Clinic and Research Center have shown that Ibogaine decreases alcohol consumption in mice and rats by increasing GDNF levels. In separate studies, they demonstrated that GDNF alone also reduces alcohol consumption.