Articles tagged with Drug Abuse
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A study found that modafinil increases dopamine levels in the brain and blocks dopamine transporters, raising concerns about its potential for abuse. The drug's effects on dopamine may be linked to its therapeutic actions.
Researchers found that rats deficient in sodium chloride shied away from pleasurable activities, leading to a potential link between salt cravings and depression. High salt intake contributes to high blood pressure and other health problems, but the study suggests salt may have a mood-elevating effect.
A national-level analysis confirms that Physician Health Programs, which couple referral to treatment with rapid responses to noncompliance, are successful in helping doctors stay drug-free. The study found that over three-quarters of enrolled doctors stayed sober for five years and were able to return to medical practice.
The American Pain Society and American Academy of Pain Medicine have published comprehensive clinical practice guidelines to assist clinicians in prescribing potent opioid pain medications for patients with chronic non-cancer pain. The guidelines emphasize the importance of monitoring patients on chronic opioid therapy to weigh benefit...
The new guideline provides recommendations for clinicians on how to safely prescribe potent opioid pain medications for patients with chronic non-cancer pain. Key findings include the importance of careful patient selection, monitoring, and ongoing assessment to minimize risks of abuse and addiction.
Current government programmes targeting young people at risk of drug misuse may be too individual-focused and neglect the importance of peer pressure. Detached, street-based youth work has been shown to be more effective in reaching those most at-risk, as it works with young people in their existing friendship groups.
A study of 153,268 TB patients in the US found that substance abuse is a significant modifiable behavior impeding TB elimination efforts. Substance abusers were more likely to have contagious forms of TB and experience treatment failure compared to non-abusers.
Researchers found that rapid-fire inputs initiate a cellular memory process in single cells lasting as long as a minute, holding moment-to-moment information. The study has implications for addiction, attention disorders and stress-related memory loss.
Researchers found that individuals with a higher novelty-seeking personality trait have decreased dopamine autoreceptor availability, making them more responsive to novel and rewarding experiences. This may contribute to the development of drug abuse and other unsafe behaviors.
Researchers at Vanderbilt University Medical Center have discovered a functional link between the brain's reward and stress signaling circuits. Dopamine, the chief reward signal, works through corticotrophin-releasing factor (CRF) to increase activity in a brain region involved in addiction relapse.
A Princeton University scientist has demonstrated that sugar can be an addictive substance, with lab animals showing signs of craving and relapse. The study suggests that bingeing on sugar can lead to long-lasting effects in the brain and increased motivation for other substances of abuse.
A new study published in PLoS Medicine reveals that China's antinarcotics policies compromise the health and human rights of detained injection drug users. The study found routine HIV testing without consent, lack of medical treatment, and inadequate information on HIV prevention.
Researchers found that teens engaging in risky behaviors like sex, smoking, and drinking are more likely to use crystal meth. In high-risk youth, family history of alcohol abuse, psychiatric treatment, and juvenile detention were associated with methamphetamine use.
A $1.7 million study will investigate how the body metabolizes ecstasy, a 'hug drug' with serious negative effects on brain function. The research aims to identify individuals at risk of long-term adverse effects from the drug.
A new study suggests that vigabatrin may prevent human methamphetamine addicts from relapsing by blocking reinstatement of drug-seeking behavior. The research found that rats pre-treated with vigabatrin lost interest in spending time in a location where they had previously been given methamphetamine.
A study found that adolescents addicted to opioids who received extended treatment with combination medication had lower rates of testing positive or reporting use of opioids compared to those in short-term detoxification programs. Patients in the extended treatment group reported less use of opioids and cocaine, as well as a lower nee...
A study by Brookhaven National Laboratory found that methamphetamine's quick entry and slow clearance from the brain contribute to its long-lasting effects. The researchers used PET scans to track the drug's uptake, distribution, and clearance in healthy volunteers.
A study by Lifespan and Hasbro Children's Hospital found that nearly one in 10 American children received free drug samples in 2004. The top four most frequently distributed medications have significant new safety concerns, including schedule II controlled substances that carry high potential for abuse.
Researchers found that treatment with stimulant drugs significantly decreased the risk that girls with ADHD will begin smoking cigarettes or using alcohol or drugs. The study's results mirror those of earlier studies in boys and suggest a potential protective effect of stimulant treatment.
A new study found that obstetrical care providers are not comfortable discussing substance abuse with pregnant patients unless specifically asked. The researchers call for providers to learn about drug and alcohol cessation programs and ask questions to engage women in discussions about risks. This could lead to better health outcomes ...
Energy drink manufacturers should label their products with prominent warnings about caffeine doses and potential health risks, says a study by Johns Hopkins Medicine. The high caffeine content of many energy drinks poses a risk to consumers, particularly young adults.
A new study identified five counties in Oregon with the most meth-linked incidents per capita, including sparsely populated Umatilla County. The analysis found that every lab or dump site was 11.5 times more likely to be in Umatilla County than anywhere else in the state.
New research finds that adolescent brains exposed to painkillers like Oxycontin can sustain permanent changes in their reward system, making them more vulnerable to addiction later in adulthood. Adolescent mice self-administered the drug less frequently than adults, and re-exposed adult mice had higher dopamine levels.
A new study found that college freshmen believe occasional nonmedical use of prescription pain killers and stimulants is less risky than cocaine, but more risky than marijuana. Sensation-seekers are more likely to use these drugs nonmedically regardless of their perceived harm.
A recent study found that over 10 million Americans use opioids, with 4 million using them regularly, reflecting a need to strike a balance between opioid misuse and chronic pain control. Opioid regular use increased with age, decreased with education level, and was more common in females and non-Hispanic whites.
A recent study published in the Journal of Applied Physiology examines the validity of recombinant human erythropoietin (rHuEpo) testing. The research found that the detection power of the test is poor, with high rates of false negative results. This has significant implications for anti-doping efforts and fair competition.
A study found that state policies requiring comprehensive diagnostic criteria and specific services are associated with positive treatment outcomes. Most programs performed diagnostic assessment, group and individual therapy, but had lower rates of family counseling.
A study published in the Journal of Substance Abuse Treatment reveals that 14% of hospital admissions are due to alcohol/drug abuse and addiction disorders. The study found that these disorders were associated with significantly higher hospital costs, particularly for opioid abuse, which increased by 482%.
A study found that Ritalin works in the prefrontal cortex to enhance cognition and focus, while having limited effects elsewhere. The medication tunes neuron sensitivity to signals, leading to improved cognitive function and attention.
A study examining two medications and two behavioral treatments found that medication adherence is still essential for success in treating alcohol dependence. High medication adherents fared better than low adherents across all treatment combinations.
Researchers used PET imaging to assess the effects of methylphenidate on brain function in healthy adults. The study found that MP improved performance in those who needed it, but deteriorated it in others.
A study by UT Southwestern Medical Center has linked amphetamine abuse to a higher risk of heart attacks in young adults. Researchers analyzed data from over 3 million people and found a significant correlation between amphetamine abuse and heart attack diagnoses.
A study confirms that bipolar adolescents face a significant risk of smoking and substance abuse, with rates of 34% in the bipolar group compared to 4% in controls. Early preventive measures and screening are essential for this high-risk population.
A large-scale analysis of monkeys addicted to cocaine reveals more numerous and long-lasting protein changes than previously thought, potentially explaining why cocaine addiction is difficult to overcome. The study provides a comprehensive assessment of biochemical changes in the cocaine-addicted brain.
A University of Alberta study found that middle-class Canadians use marijuana for relaxation and focus, challenging criminalization. The study suggests decriminalization and legalization could reduce crime and generate revenue.
A Swedish study found that female sex offenders are more likely to suffer from mental illness or drug abuse than male perpetrators. The research compared 93 convicted women with over 20,000 normal women and 13,000 women convicted of non-sexual crimes.
Research presented at the American Pain Society annual meeting found that less than 3% of patients with no history of drug abuse who are prescribed opioids for chronic pain will show signs of possible drug abuse or dependence. Most chronic pain patients do not rely on drugs as a sole solution, and multi-faceted treatment involving phys...
A Yale University study found that individuals who used a computer-assisted training program in addition to traditional counseling stayed abstinent significantly longer. The subjects had fewer positive drug tests at the conclusion of the study.
Researchers used PET scanning to track salvinorin A distribution in primates' brains, finding a peak concentration within 40 seconds. The drug's effects were localized to the cerebellum and visual cortex, causing psychoactive effects with just 10 micrograms.
A new policy implemented in a Michigan clinic helped identify 35% of patients misusing opioid medications, while steering dependent patients to treatment. The approach logged and screened all patients receiving opioids for non-cancer pain, with the goal of protecting doctors' ability to prescribe these drugs.
Researchers found that repeated methamphetamine use depresses brain areas and leads to permanent changes in neural terminals. Re-administering the drug reverses these changes, suggesting potential new treatment approaches for methamphetamine addiction.
Adult male monkeys exposed to cocaine in the womb show altered function of dopamine 3 receptors, linked to increased vulnerability to drug abuse. The study's findings have implications for human cocaine overdose victims with higher D3 receptor numbers.
Animal research in monkeys shows that treating with amphetamine reduces self-administration of cocaine for up to a month by about 60 percent. The study demonstrates the feasibility of using amphetamine-like drugs to treat cocaine addiction.
A new study found that references to illegal drug use in rap music increased dramatically between 1979 and 1997, depicting marijuana as a positive activity. Rap music's shift towards glorifying drugs was linked to commercialization and social factors, distorting the reality of African American communities.
A randomized trial of 498 patients found that second-generation antipsychotics did not outperform first-generation drugs in reducing symptoms. The study's results suggest that clinicians should consider cost and treatment duration when selecting an antipsychotic medication for first-episode schizophrenia.
A survey of 3,639 college students found that those who used prescription medications without a prescription were more likely to screen positive for drug abuse than those who used them for medical reasons. The study highlights the importance of proper diagnosis and treatment of college students taking frequently abused medications.
A new study found that stimulant treatment for children with ADHD has no effect on their future risk of substance abuse. The 10-year follow-up study analyzed over 100 young men and controlled for conditions like conduct disorder, which are associated with substance abuse.
A specific gene variant associated with a better response to naltrexone in treating alcohol dependence has been identified, according to a large-scale analysis of the COMBINE Study. Patients carrying the variant experienced significantly improved clinical outcomes compared to those without it.
Researchers used fMRI to show that cocaine-related images stimulate activity in the limbic system, a brain network involved in emotion and reward, even when subjects are unaware they've seen anything. The study suggests new drug treatment strategies by targeting the brain's sensitivity to conditioned drug cues.
Researchers found that brain-derived neurotrophic factor (BDNF) and its receptor TrkB play a crucial role in age-specific responses to stimulants. The study suggests that BDNF/TrkB might be used as a target for new treatments for childhood neuropsychiatric disorders or addiction.
A study in PLOS Medicine found that Somali combatants' excessive use of khat, a stimulant with amphetamine-like effects, is prevalent across southern and central Somalia. The study also revealed high levels of cannabis and other drug use among combatants, posing significant challenges for post-conflict reintegration programs.
Research at UCSD reveals ketamine impairs brain circuitry by increasing superoxide production, leading to memory and attention problems. Inhibiting NADPH oxidase could provide novel treatments for schizophrenia.
Research by University of Florida scientists found that using club drugs triggers a similar chemical chain reaction in the brain as a traumatic brain injury, resulting in cell death and memory loss. The study suggests that methamphetamine use can cause irreversible brain damage.
The University of Houston will receive a five-year, $2.3 million National Institutes of Health grant to fund a multidisciplinary approach to drug abuse research. The grant will focus on the health and social consequences of drug abuse among aging minority populations, with a particular emphasis on Latino injecting heroin users in the H...
A study found that state Medicaid policies, such as restricting access to pharmacy networks and preferred drug lists, limit the use of naltrexone, an inexpensive therapy proven to reduce problem drinking. Changing these policies could increase naltrexone's availability and address the huge financial burden of alcohol abuse.
A study published in Archives of Pediatrics & Adolescent Medicine found that approximately 15% of teens receiving routine outpatient medical care had positive results on a substance abuse screening test. The study highlights the importance of efficient office-based systems for substance abuse screening and therapeutic interventions.
Researchers found that genes influencing risk for psychoactive drug abuse or dependence vary between illicit and licit substances, with caffeine addiction appearing to be genetically independent. Heritability estimates suggest that genetic factors account for over 70% of risk for cocaine, cannabis, and nicotine dependence.
A Phase 2 study showed ALO-01, an extended-release morphine sulfate plus sequestered naltrexone, provided similar effectiveness and tolerability to KADIAN Capsules for moderate-to-severe chronic osteoarthritis pain. The majority of patients rated both medications as good or excellent.
The opioid system controls pain, reward and addictive behaviors through mu, delta, and kappa receptors. Mice lacking these receptors exhibit altered emotional responses and sensitivity to pain.
The project aims to reveal how some viral infections become resistant to antiviral medications. Researchers will test the interactions between FIV, a cat virus, and an AIDS drug called AZT in the presence of methamphetamine.