A study found that at least 1 in 3 gene expression studies contain mislabeled samples, leading to incorrect conclusions. Researchers used a sex-specific gene expression approach to detect mislabeling and found that 46% of human tissue datasets contained discrepancies.
A new study suggests that dispensary-grade cannabis may contain harmful yeasts and toxic molds, compromising its medicinal benefits. The researchers recommend re-evaluating culture-based techniques and conducting additional sequencing-based studies to investigate the cannabis microbiome.
A new system devised by clinicians uses blockchain technology to prevent changes to clinical trial documents, reducing the risk of ineffective or unsafe medications being distributed. This approach has the potential to prevent issues such as outcome switching and selective publication in clinical trials.
A WHO Task Force calculated illnesses, deaths, and disability-adjusted life years (DALYs) for four chemicals: dioxin, aflatoxin, peanut allergen, and cyanide in cassava. Aflatoxin was associated with the highest global DALYs, while dioxin caused the most illnesses.
The article introduces a proof-of-concept figure that generates data 'on the fly' when an online article is viewed. Readers can select parameters to alter the generated figure, allowing for self-evaluation of the data. This innovation aims to improve transparency and reproducibility in scientific publishing.
A team of researchers led by Professor Kenneth Lee attempted to replicate a controversial stem cell acid bath study published in Nature, but were unable to induce pluripotency in mouse somatic cells. The full experimental results are now available online, providing an open and transparent record of the attempt.
F1000Research has launched a new data plotting tool that enables users to replot, analyze, and interpret the supporting data from journal articles. The tool allows for easy visualization of numerical values in CSV files as scatter plots, helping researchers spot outliers and correlations.
Researchers discover histone H1 protein's role in neurodegenerative disease and stroke; protein can trigger immune response and drive brain cell death. The study may lead to the development of new treatments for neurodegenerative diseases and stroke.
Current MS treatments focus on dampening the immune system, but Dr. Peter K. Stys suggests an alternative: addressing nervous system degeneration as a primary cause of the disease. Recent studies indicate that neuronal structures are also damaged in MS.
A study estimating 32 million people in the US have used psychedelics reveals a widespread prevalence, particularly among young adults. Psychedelic use has remained relatively stable since the 1960s, with no significant increase or decrease over time.
Researchers found that Arabidopsis thaliana plants exhibit genetic traits from older generations, contradicting Mendelian inheritance. New experiments support these findings, providing evidence for novel DNA-based genetic phenomena and implications for plant biology and agriculture.
Intrinsically disordered proteins (IDPs) may still have functions without a rigid structure, while protein flexibility is crucial in molecular recognition. The debate highlights the complexity of protein behavior and the need for experiments to determine the true nature of protein recognition.
Two articles debate causal link between cannabis and psychotic illnesses like schizophrenia. David Castle argues for a causal link, while Suzanne Gage et al suggest stronger evidence is needed.
Advanced time-lapse imaging techniques show promise for increasing IVF success rates by selecting high-quality single embryos for transfer. Reliable assessment of embryonic quality could reduce emotional costs and improve procedure efficiency.
Recent research suggests that plant-derived biofuels could meet 30% of the global demand for liquid transportation fuels without affecting food production. Scientists have identified non-edible plants as a promising area of research to produce biofuels sustainably.
The Faculty of 1000 awarded $250 travel grants to 74 Associate Faculty Members who submitted six or more evaluations in 2011. The highest number of evaluations came from Faculties of Cell Biology, Immunology, Neuroscience, and Anaesthesiology & Pain Management.
The invention of optogenetics enables scientists to control and observe brain circuits using genetically encoded molecules targeted by light. This technique reveals how entire neural circuits operate, allowing researchers to determine the roles of specific neurons in various behaviors and brain functions.
A study found that women taking oral contraceptive pills had significantly fewer recurring ovarian cysts after surgery. Long-term treatment appears to be key to preventing endometrioma recurrence, suggesting a change in clinical practice.
A British study found that Westerners reliably recognized six basic human emotions through non-verbal vocalizations, but culturally isolated Himba people only recognized a subset of these emotions. The study highlights the importance of considering positive emotions in cross-cultural research.
A large multicenter trial in Japan found that patients with early gastric cancer who received H. pylori antibiotics after surgical resection had a significantly lower risk of developing gastric cancer. Certain strains of H. pylori may carry an increased risk of developing gastric cancer, but more research is needed to fully understand ...
A recent study published in the Journal of Clinical Psychopharmacology found that chamomile extract therapy significantly reduced the severity of GAD in patients with mild-moderate symptoms. The study's findings suggest that chamomile may be a potential treatment option for those who are averse to traditional pharmacotherapy.
Recent enhancements to Autologous Chondrocyte Implantation (ACI) therapy, such as matrix-assisted ACI (MACI), show promise in repairing cartilaginous tissue. These therapies may help delay or prevent the need for total joint replacement in OA patients.
A sudden increase in antibiotic-resistant E. coli strains is spreading globally, posing a significant threat to public health. Researchers warn that the misuse of powerful antibiotics may lead to the development of even more resistant strains, rendering current treatments ineffective.
A recent study suggests that a protozoan parasite may have contributed to the extinction of dinosaurs. The parasite, which infects birds and eats away at their jawbones, could have been transmitted through head biting among dinosaurs. The similarity between fossilized jawbones and modern-day samples supports this theory.
A study by Natividad et al. found that adolescent rats exhibit fewer physical and neurochemical withdrawal signs than adult rats after nicotine withdrawal, suggesting age alters neurological systems relevant to nicotine use. This increased sensitivity makes adolescents more prone to drug abuse.
A recent study found that only 60% of pregnant women in Eastern and Southern Africa were tested for HIV in 2007. The authors suggest that women may be avoiding testing due to opt-out policies or concerns about the stigma associated with HIV. This highlights the need for increased awareness and access to HIV screening in these regions.
A study of over 2500 pregnant women found that those in long-term relationships with their biological fathers were less likely to develop pre-eclampsia and have undersized babies. Prolonged exposure to paternal antigens may induce tolerance in the maternal immune system, reducing the risk of these conditions.
Researchers at the Max-Planck Institute for Brain Research found that brain cells can generate nerve impulses while being energy efficient. This discovery challenges previous estimates and has implications for understanding brain metabolism and non-invasive brain imaging techniques.
A Canadian study found that giving caffeine to newborn rats causes detrimental effects on sleep and breathing patterns in adulthood. Adult rats showed reduced sleeping time, increased time to fall asleep, and fragmented non-REM sleep. Breathing problems were also more common in caffeine-treated rats.
Dabigatran, a new blood-thinner, has been shown to be as effective as warfarin in preventing strokes and major bleeding, but with significantly fewer side effects. This finding could lead to a change in standard anticoagulant therapy.
A study published in Psychological Science found that reminders of money can reduce feelings of pain and social exclusion. The researchers suggest that acquired symbolic value of money can influence responses to both emotional and physical pain.
A recent study published by Faculty of 1000 Medicine discovered that brain-derived neurotrophic factor (BDNF) levels are higher in women who have recovered from anorexia. This suggests that low BDNF levels may be reversible and could potentially serve as a biomarker for recovery from eating disorders.
The Wellcome Trust validated the Faculty of 1000's assessment model through a study analyzing over 900 publications. The scores from both models showed high agreement, highlighting the value of post-publication peer review. However, the study also emphasized that merit cannot be judged solely by citation scores.