Researchers found that Cripto overexpression inhibits Activin signaling, leading to increased tumor cell growth. Antibody blockade of Cripto suppresses tumor cell growth in xenograft models, suggesting a central role for Cripto in tumorigenesis.
The American Association for Cancer Research (AACR) accepts applications for several research fellowships to support salary and benefits for postdoctoral and clinical fellows. The deadline is Wednesday, October 15, 2003, and awards are open to researchers worldwide.
The AACR-Gertrude B. Elion Cancer Research Award supports meritorious basic, translational, or clinical cancer research by a tenure-track scientist at an academic institution worldwide. Five Career Development Awards will be granted in 2004 to support research in various areas of cancer research.
The sequencing of Pseudomonas syringae genome will help scientists understand how bacteria adapt to host organisms, enabling the development of new therapies. The genome also reveals commonalities between plant and animal pathogens.
A Mayo Clinic study found that middle-aged and older adults who engage in regular aerobic exercise can maintain increased insulin sensitivity for up to four days after their last workout. However, this effect is not seen in those over 40, highlighting the importance of frequent exercise for preventing or treating Type 2 diabetes.
A second gene, zinc metalloproteinase (ZMPSTE24), has been identified as a cause of the rare skeletal disorder mandibuloacral dysplasia (MAD). Mutations in this gene may also lead to premature aging, generalized loss of body fat and early death.
Many low-income Medicare beneficiaries will struggle with high drug costs despite new proposals in Congress. Beneficiaries living on $10,000-$20,000 annually face significant financial hardship due to limited coverage and increased out-of-pocket expenses.
Regularly scheduled use of inhaled beta-agonists can result in airway hyperresponsiveness and prolonged asthmatic attacks, according to recent studies. Researchers suggest that targeting phospholipase C-beta may offer a new treatment approach for asthma patients.
Asthma patients treated with bronchodilating beta-agonist medications may develop increased sensitivity to airway constriction, experience exacerbation of their condition. Researchers suggest that therapeutics targeting phospholipase C-beta may have substantial benefit in the treatment of asthma.
Research reveals a gap between national and local elites' views on EU membership. Local officials and business people feel the accession process is irrelevant to them, posing challenges for implementing agreed conditions of EU membership.
A study found that delaying chemotherapy until disease progression was equivalent to immediate treatment in overall survival and specific survival rates. Patients aged over 70 had a higher chance of not requiring chemotherapy after 10 years.
A study examines ethnic differences among adolescents who engage in drinking after driving (DD) and riding with drinking drivers (RWDD), finding a distinct need to direct prevention efforts toward Latino youth. RWDD is identified as even more dangerous than DD for adolescents.
Researchers study women's midlife health, focusing on intra abdominal fat and its impact on heart disease risk. The WISH project examines the mediating role of stress on cardiovascular risk among post menopausal women.
The rat vector hypothesis suggests that rats may have spread SARS in the Amoy Gardens apartment block. Epidemiological case-control studies could be undertaken to identify behavioural risk factors and possible mechanisms for rat-to-man infections. This hypothesis is a strong possibility that needs to be further explored.
A recent study found that diabetes prevalence increased globally between 1993 and 1999. However, mortality rates from diabetes decreased by 3% during this period. The researchers suggest that earlier treatment and improved healthcare may contribute to the decline in mortality rates.
Historical coral reef research reveals that most world reefs were degraded by overfishing and pollution even before grandparents' birth. Top carnivores and grazers are the first to disappear when humans enter the picture.
Scientists have discovered that 'warm' glaciers can use supercooling to trap and transport silt, providing new insights into glacier dynamics. The process involves the formation of 'frazil ice,' which picks up particles from the surrounding water, creating layers of clean and dirty ice.
A new record of nitrous oxide concentration variations reveals that both land and ocean bacteria contributed equally to atmospheric emissions during glacial periods. This finding contradicts the long-held theory of oceanic storage being responsible for low atmospheric carbon dioxide levels.
Researchers at Virginia Tech have developed a high-power semiconductor switch called the Emitter Turn-off (ETO) Thyristor, suitable for fast and dynamic voltage support in the nation's congested power grid. The ETO switch offers fast switching speed, rugged turn-off capacity, and voltage control, reducing energy storage elements and size.
Hirschsprung's disease is caused by mutations in genes expressed in neural crest stem cells that impair their ability to form a normal intestinal nervous system. The study identifies Ret and other genes involved in the disease, offering new insights into its causes.
Researchers found that recovering alcoholics experience persistent sleep disruptions for many months after quitting drinking, with problems with sleep onset being worse than sleep maintenance. Many former alcoholics reported pre-existing sleep problems that predated their alcohol dependence.
A recent study tested pentosan polysulfate sodium and hydroxyzine hydrochloride on patients with interstitial cystitis, a debilitating condition affecting millions. The trial found that neither drug provided statistically significant relief for patients, but gained valuable information for future clinical trials.
A study of 43,000 Indian men found that smoking increases mortality rates from tuberculosis (TB) by four times compared to non-smokers. The researchers also discovered that about a quarter of smokers die prematurely at ages 25-69, losing an average of 20 years of life expectancy.
A recent study found an association between the DdeI polymorphism of the DRD1 gene and sensation seeking among alcoholic males. The research suggests that genetic factors, such as this specific dopamine receptor gene, may play a role in understanding the complex disorder of alcoholism.
Researchers at Rockefeller University have developed a mathematical equation that combines generalized arousal with specific forms of arousal, such as sex and hunger. The study found that genetic changes in mice lacking estrogen receptors can influence overall arousal, providing new insights into the neural mechanisms underlying arousal.
Researchers have discovered a modifier gene, Scnm1, that affects the severity of neurological diseases in mice and is also present in humans. The study found that when the genetic code for this gene is transcribed, it can produce non-functional protein that alters the physical effects of inherited diseases.
Researchers at TSRI introduce a revolutionary method to add unnatural amino acids to the genetic code of Saccharomyces cerevisiae yeast. This allows for unprecedented control over protein structure and function, enabling new insights into biological processes and potential therapeutic applications.
A group of researchers found a strong correlation between the ages of branching points and morphological variation in four lizard groups. The study challenges the general assumption that each lineage's history is unique.
Researchers at Purdue University have developed a new method to separate proteins in the gas phase, allowing for faster analysis and enabling the study of hundreds of proteins simultaneously. The technique uses a mass spectrometer to collect ions onto different locations on a chip's surface, producing highly pure protein samples.
Researchers discover key mechanism underlying Hirschsprung disease by identifying genes that control neural crest stem cell migration. The findings may lead to potential correction of the disease through transplantation of neural stem cells.
Scientists have discovered two key proteins, XCAP-E and XCAP-D2, that remain apart at a critical time before condensation occurs in frog oocytes. These findings may help study chromosome physiology, particularly the functional aspects of these proteins.
Researchers found that coral reef declines followed the same pattern globally, starting with large predators and herbivores, followed by smaller animals and finally sea grasses. The study provides a yardstick for conservation efforts, offering hope for restoring ecosystems with strong management decisions.
A study found that 47% of faculty IRB members who are also researchers served as consultants to industry within three years. This may raise concerns about conflicts of interest and scientific behavior.
Tufts physicists built a crucial $300,000 optical switchyard for the Main Injector Neutrino Oscillation Search project, helping to understand the deepest structures of matter. The data from this experiment will be fundamental to physicists and astronomers seeking to comprehend the universe's building blocks.
A major study in India found that smoking causes half the tuberculosis deaths among men, with most cases linked to respiratory disease. The research highlights the deadly risks of tobacco use and emphasizes the need for proper treatment and prevention measures.
A study found that individuals with lower educational attainment experienced poorer drinking outcomes following alcohol treatment, including a shorter time to relapse. The researchers suggest that future studies address issues related to matching patients to optimal treatments.
A team of researchers discovered a new microbe, Strain 121, that can survive and thrive in extremely hot temperatures, with growth possible up to 121 degrees Celsius. The discovery opens up possibilities for understanding life on a hot early Earth and the potential for life in extraterrestrial environments.
A recent study reveals a long-term decline of coral reef ecosystems globally, dating back to before 1900, with declines in large animals and architectural species. Overfishing is identified as the primary driver of this decline, with synergistic effects from land-derived pollution in some areas.
Meth abuse has increased in the past decade, with admissions to treatment programs more than doubling in the US from 1992 to 1999. Researchers recommend a minimum of 30 days of residential treatment for meth users to regain essential thinking and decision-making skills.
Researchers discover genetic connection between hair and hair channels, finding that GATA-3 is crucial for hair channel development. Without this protein, mice grew short and stubby coats, highlighting the importance of the hair channel for proper hair growth.
Researchers at Wake Forest University Baptist Medical Center found that Zemplar, a drug mimicking vitamin D hormone, sensitizes cancer cells to radiation therapy without harming normal cells. The combination reduced radiation dose by 2.4 times while maintaining treatment efficacy.
A new grant of US$41 million from the Global Fund will support HIV/AIDS treatment and prevention in South Africa over 2 years. Generic antiretrovirals will be developed and produced locally, offering affordable access to life-saving medications.
A study found that ID Migraine screener is reliable in detecting migraines in undiagnosed patients. The three-question survey showed a high accuracy rate of 93% for diagnosing migraines.
Researchers compared genomic regions in 13 vertebrate species, including humans and zebrafish, to identify conserved non-coding sequences with biological roles. The study provides insights into the understanding of our own genome and highlights the importance of sequencing multiple species' genomes.
Researchers discovered that glacial erosion is controlled by the relationships of the ground beneath the glacier, the rubble pile, and the glacier itself. Glaciers achieve a steady state existence when the angle between their toe and sediment pile becomes too steep, causing streams to stop flowing and erosion to cease.
Researchers sequenced the genomes of three Prochlorococcus and one Synechococcus strains, revealing insights into their metabolic machinery and ecological niches. The discoveries may aid studies on global climate change and sustainable energy production.
A UCI biomedical engineer has received a $1.8 million grant to create viable lung tissue similar to that found in bronchial tubes, which will be injured to simulate asthma injuries. The goal is to better understand what causes scarring in the lungs of people with asthma and develop more effective treatments.
Researchers at Queen's University discovered that brain patterns of people watching and performing tasks are similar, suggesting a common neural process. This finding may help assess individuals with impaired movement control and understanding of others' actions.
A University of Washington study found that using the Internet is not a reliable way for most people to find jobs. Despite widespread adoption of internet-based job search tools, researchers found that those who used the internet were actually less likely to land a job than those who didn't.
A recent study published in PLOS Biology tracked the genomic activity of Plasmodium falciparum in human red blood cells, revealing a surprisingly simple pattern of gene expression. This finding could lead to the identification of the biological function of unknown genes and provide new insights into the life cycle of malaria parasites.
Researchers at Texas A&M University found that babies use a clear hierarchy of features to individuate objects, with shape and size being most important until 7.5 months. By 11.5 months, color becomes relevant in this process, revealing insights into how babies perceive their world.
A field study found that spiders ambushing pollinating insects decrease seed production in flowers. Ecologist Kenwyn Suttle suggests these interactions are common and overlooked by biologists. The research supports the idea that predation on pollinators can impact plant reproduction.
Researchers at the University of Central Florida have discovered that engineered nanoparticles can extend the lifespan of brain cells by three- to four-fold, allowing them to live up to 123 days. The study also suggests that these nanoparticles may preserve function and potentially treat age-related disorders such as Alzheimer's disease.
The study finds that the decrease in atmospheric bromine is driven by a large decline in methyl bromide, which has more than offset increases from halons. Global industrial production of methyl bromide has declined due to restrictions on its use, contributing to a faster-than-expected recovery of stratospheric ozone.
Researchers created a technique using validation sets to verify epidemiological data, enhancing vaccine effectiveness studies. This approach helps address reporting bias and improves the reliability of many vaccine research outcomes.
In contrast to many other introduced species, most marine invertebrates increase in size after invasion. This size increase may have significant implications for the impacts of these species on native ecosystems. The study's findings highlight the need for further research into the effects of invasive species on non-native regions.
Researchers pinpointed nerve cells in the nucleus accumbens shell that respond to environmental stimuli associated with prior drug use. This finding may aid in developing targeted treatments for relapse prevention.
Researchers from Scripps Institution of Oceanography have sequenced the genomes of Synechococcus and Prochlorococcus, tiny organisms that account for up to two-thirds of carbon dioxide fixation in the oceans. The discoveries shed light on how these organisms process carbon and adapt to specific habitats, offering insights into global c...
A double-blind, placebo-controlled trial found that creatine supplementation improves working memory and intelligence in both vegetarians and omnivores. The study suggests a significant boost to brain function similar to effects shown previously in muscle and heart.
A team of 71 researchers compared the human genome to 12 vertebrates, including chimpanzees, mice, and rats, to identify conserved genetic regions. These regions are likely to control important functions such as gene expression and can provide clues about how each species evolved.