Researchers used NMR spectroscopy to analyze pea plant leaves under drought stress, revealing key metabolites that increase in response. The findings could lead to the development of pea varieties more resistant to water scarcity, affecting global food production.
Research funded by the Wellcome Trust suggests that inflammation in the brain resulting from infection or injury may accelerate the progress of dementia. Systemic inflammation can cause changes in memory and learning, leading to accelerated progression of dementia.
Researchers found that combining a thiazide diuretic with a potassium-sparing drug reduced both sudden cardiac death and total coronary mortality in elderly patients with hypertension. The study's findings challenge the current U.S. hypertension treatment guidelines, which recommend using a thiazide diuretic alone as initial therapy.
Researchers at McGill University have discovered a way to make cancer vulnerable to viruses using a new compound called histone deacetylase inhibitors. This approach has the potential to overcome resistance and increase the effectiveness of viral 'magic bullets' in targeting cancer cells.
Johns Hopkins researchers have successfully suppressed levels of the 'hunger hormone' ghrelin in pigs using a minimally invasive procedure. The method, called GACE, produces an effect similar to bariatric surgery by lowering appetite and promoting significant weight loss.
A new study found that children who witness family violence have more symptoms of depression and anxiety, while those subjected to harsh physical discipline are more aggressive. Researchers call for targeted interventions to address the ongoing emotional and behavioral problems in these vulnerable youth.
Stuart A. Lipton will lead a center studying potential environmental causes of Parkinson's disease, examining chemical reactions that alter protein function and screening compounds to prevent disease progression. The center represents a collaborative effort between scientists at Burnham and other institutions.
A study published in JAMA found that higher levels of urinary Bisphenol A (BPA) are associated with an increased prevalence of cardiovascular disease, type 2 diabetes, and liver-enzyme abnormalities. BPA concentrations were linked to a 39% increased odds of cardiovascular disease and diabetes.
A new study found that children concerned about their parents' arguing are more likely to have psychological problems in school due to difficulty paying attention. The study, conducted by researchers at the University of Rochester and others, suggests that addressing attention difficulties may promote children's mental health.
A study of 642 adults with bicuspid aortic valves found that cardiac events and death were more common in younger age groups. However, overall mortality was not significantly different between the group and the general population.
A new coating made from carbon nanotubes improves the signals received and transmitted by electrodes, potentially advancing electrical nerve stimulation therapy. The coating bolsters both stimulation and receptive capabilities, showing promise in treating diseases such as epilepsy, depression, and chronic leg and back pain.
Researchers found that history and physical examinations accurately estimated fluid levels in patients with congestive heart failure. Additionally, those with extra fluid were at increased risk of hospitalization or death within six months.
Research from the University of Missouri has shown a significant relationship between BPA exposure and cardiovascular disease, type 2 diabetes, and liver enzyme abnormalities. The FDA is urged to take action to reduce human and environmental exposures to BPA due to its adverse health effects.
Multidisciplinary approaches combining chemotherapy, radiotherapy, and surgery have shown promise in treating various cancers, including lung and head and neck cancers. The addition of targeted therapies like pazopanib and cetuximab has demonstrated significant activity in reducing tumor size and improving patient outcomes.
Researchers at Vanderbilt University have developed a decision-making instrument called the Test Accessibility and Modification Inventory (TAMI) to address the issue of accessibility for students with special needs. The tool helps test developers apply principles of universal design to create more inclusive assessments.
A new model predicts long-term survival of critically ill patients based on seven commonly collected clinical variables. Age and co-morbidity have a significant impact on survival rates, with age being the most critical factor.
New research by psychologists at the University of Washington indicates that 12- and 18-month-old babies are using their self-experience to judge what other people can see. This 'self-experience model' allows them to attribute internal thoughts and feelings to others, demonstrating an early form of role-taking.
A study published in PLoS One found that a restricted-calorie diet can reduce iron accumulation in muscle cell mitochondria, which can contribute to muscle loss in aging adults. The research suggests that reducing caloric intake early on may help limit muscle wasting in later years.
A team of Michigan Tech researchers is harnessing video game technology to model complex biological systems, such as the human immune response to tuberculosis. Using GPUs, they have created a powerful new tool for medical research, allowing for faster and more efficient simulations of diseases like sepsis.
Researchers at NC State University have discovered a technique to bring nanoparticles to the surface of thin polymer films using heat, allowing for controllable surface patterns. This breakthrough could lead to tiny reusable bar codes and small fluorescent features that turn off with increasing heat or chemical presence.
The City College of New York has received a $5 million NSF grant to establish a center for nanostructure applications, with Dr. Daniel L. Akins as the Director and Principal Investigator. The center will focus on addressing challenges in sustainable energy technologies, environmental monitoring, and national security threats.
Researchers at Lawrence Livermore National Laboratory have developed a new technique that enables creating detailed high-resolution images of cellular molecules. The method uses high-energy X-ray beams and complex algorithms to overcome current technology limitations.
The National Institute of Environmental Health Sciences is awarding three new grants to investigate the role of environmental factors in Parkinson's disease and other neurodegenerative disorders. The research will focus on identifying mechanisms that link pesticide exposure, mitochondrial damage, and altered dopamine storage to the dev...
A Phase IIB study demonstrated dose-dependent increases in bone mineral density (BMD) at the total hip, lumbar spine, and femoral neck fracture sites in postmenopausal women with low BMD. Odanacatib selectively inhibits cathepsin K, a key enzyme in osteoclastic bone resorption.
A new chemotherapy drug combination has shown excellent results in a phase II trial, extending median survival time in patients with inoperable pancreatic cancer by up to 6.4 months compared to standard therapy. The treatment, EndoTAG-1, destroys new blood vessels around tumors, improving patient outcomes.
A recent study by the American Academy of Neurology found that people with migraines are more likely to develop venous thrombosis or blood clots in their veins. The research, which involved 574 participants in Italy, revealed a significant association between migraine and increased risk of blood clots.
A study published in Annals of Internal Medicine found that massage therapy provided immediate benefits on pain and mood among patients with advanced cancer. The treatment improved symptoms greater than simple touch, offering a safe and effective way to provide immediate relief.
A new blood test uses immune system signals to detect early signs of lung cancer, signaling the disease before symptoms appear. The test has a sensitivity rate of 51% and specificity rate of 18%, indicating its potential for improving early detection of lung cancer.
A new study finds that goal priming can backfire when consumers are in unfamiliar situations. In such cases, marketing messages intended to influence behavior may have the opposite effect, leading to decreased consumer choice.
Researchers developed a method to preserve and visualize SARS-coronavirus replication complexes, revealing the dependence on modified host membranes for viral replication. The study provides insights into the interplay between viral proteins and host membranes, opening doors for new antiviral strategies.
A genetic variant in the cyclin D1 gene is associated with a higher risk of developing melanoma. Individuals carrying two copies of the variant are 80% more likely to develop the disease. Extended and escalated dose chemotherapy shows no survival benefit in advanced melanoma cases.
The American College of Physicians (ACP) issues a guideline for the drug treatment of osteoporosis in men and women, recommending bisphosphonates as a first-line therapy. The guideline emphasizes individualized treatment decisions based on risks and benefits.
Scientists recreated materials at extreme pressures and temperatures, revealing rare atomic properties that may affect heat transfer, superplume formation, and seismic wave speed. This discovery requires reinterpreting seismic images of the lowermost mantle.
A retrospective analysis of 30,000 female Medicare patients found that osteoporosis fractures resulted in $15,522 per person in medical expenses over three years. The study also highlighted the need for osteoporosis prevention and treatment to mitigate fracture-related costs.
A study at ESMO found gefitinib to be more tolerable and result in a greater likelihood of response in non-smoking Asian patients with adenocarcinoma of the lung. The targeted therapy is now considered a first-line treatment for this population.
Researchers Chen-Bo Zhong and Geoffrey Leonardelli found that socially excluded individuals experience a physical feeling of coldness, which is linked to their preference for warm food and drinks. This study suggests that warm chicken soup may be a literal coping mechanism for social isolation.
Researchers found that immune-defense cells influenced by embryonic stem cell-derived cells can prevent transplant rejection in mice. The study's results suggest a potential method for reducing the need for immunosuppressive drugs in human organ and bone marrow transplants.
Researchers at UC Davis have developed an interactive multimedia computer program to provide personalized education on colorectal cancer screening. The program aims to increase screening rates among Hispanic patients, who are less likely to receive screenings compared to non-Hispanic whites.
Research shows that female fallow deer are attracted to deep calls from dominant males, who also have higher mating success. The study found a link between the depth of the call and body size, suggesting size exaggeration may be an evolutionary trait.
A new scale identifies consumers with a strong urge to buy, regular spending habits, and difficulty resisting impulse purchases. The study found approximately 8.9% of the population are compulsive shoppers, linked to materialism, reduced self-esteem, depression, anxiety, and stress.
A TGen-led team found a link between the brain protein KIBRA and reduced Alzheimer's disease risk in individuals with the T-allele gene. The study suggests that KIBRA may play a role in Alzheimer's disease, providing promising new targets for treatments.
Researchers from the University of Pittsburgh School of Dental Medicine have identified a series of genetic mutations associated with significant risk for cleft palate and other dental abnormalities. The study, published in Genetics in Medicine, analyzed DNA sequences from over 500 individuals and found more than a dozen gene mutations...
The American College of Physicians released a new clinical practice guideline recommending drug treatment for men and women with osteoporosis or low bone density. In addition, massage therapy may have an immediate positive effect on pain and mood for advanced cancer patients, according to a study from the National Institutes of Health.
Researchers sequenced the genome of Cyanobacterium ATCC 51142, revealing a rare linear chromosome containing genes for pyruvate metabolism. The discovery provides a framework for understanding this organism's ability to produce lactate and other compounds.
A new study from Northwestern University's Feinberg School of Medicine found that ipratropium increases the risk of heart attack or arrhythmia by 34% compared to albuterol or no treatment. The study suggests that the medication may have a systemic cardiovascular effect, increasing mortality risk in COPD patients.
A new $10 million clinical trial is testing a treatment that can chew up deep vein thrombosis (DVT) clots and administer clot-busting drugs, with the goal of preventing long-term complications like post-thrombotic syndrome (PTS). The trial aims to provide a safer, quicker and more effective approach to treatment.
Using MRI, researchers identified soft tissue defects contributing to hearing loss in children, affecting thousands of kids per year. The study found abnormalities in the cochlea and auditory nerve in 40% of ears with sensorineural hearing loss.
A new study reveals that multinational companies should advertise luxury goods in English, while necessities may be more effective in local languages. Multinational corporations marketing to bilingual populations must pay attention to language choices, as perceptions of ads change significantly with different languages.
A new study suggests that remembering past instances of resisting temptation can help impulsive eaters make healthier choices. By reflecting on their previous successes and failures, individuals with self-control difficulties can improve their ability to resist fatty or tempting foods.
A team of Fox Chase researchers has identified a single genetic mutation as a key factor in the development of colorectal cancer. By studying individuals with a inherited 'one-hit' gene mutation, they discovered molecular changes that signal cancer presence and potential targets for preventive drugs.
A new breast cancer vaccine has been tested in mice and shown to completely eliminate HER2-positive tumors, even those resistant to current therapy. The vaccine uses activated immunity to target the HER2 receptor, potentially eliminating the need for existing therapies.
Researchers identified genes controlling rhythmic plant growth, enabling bursts of growth at night and increasing competitiveness in shaded environments. These findings could lead to designing crops that grow faster and produce more food than current varieties.
Research from Michigan Medicine found that estrogen treatments stimulate collagen production in non-sun damaged skin, but have no effect on sun-damaged skin. The study suggests it's difficult to repair photoaged skin due to altered skin response to topical estrogen treatment.
A study published in PLOS Biology reveals the molecular structure of COUP-TFII, a nuclear receptor regulating gene expression in cells. The findings suggest potential drug targets for diseases related to heart development, human embryonic development and female infertility.
Adding intravenous iron to chemotherapy-induced anemia treatment boosts response rates by up to 50% and reduces treatment duration, according to a new study. Lower doses of darbepoetin alfa also show improved results with the addition of iron therapy.
Researchers found that multiple viral genomes can increase overall viral gene expression, leading to a nonlinear effect on gene networks controlling cell fate. This can result in the host cell entering a latent state rather than immediately being killed by the virus.
A new study reveals that hyperopic consumers are not necessarily self-controlled, and instead focus on the future at the expense of present-day experiences. Researchers found that high-hyperopia individuals perceive more products as luxuries, but are less likely to see luxury goods as long-term investments.
Harvard Initiative for Global Health will develop a curriculum in nutrition and global health, addressing infectious disease, perinatal/child health, and chronic diseases. The grant also supports partnerships with Indian and Brazilian research institutions.
A study found that consumers evaluate purchases differently depending on the proximity of time and people involved. When making near-term or personal purchases, convenience and low-level construal are key considerations, whereas future or distant purchases rely on higher-level attributes like attractiveness.
Researchers have discovered that the antiviral drug acyclovir can suppress HIV in patients infected with both herpes and HIV. Acyclovir works by targeting the unique enzyme present in herpes virus HHV-6, converting it into a compound capable of attacking HIV directly.