Researchers created a dual-functional metal-organic framework that both adsorbs and detects perfluorooctanoic acid (PFOA) in real-time, making it a versatile solution for water treatment and environmental monitoring. The material's ability to fluoresce in the presence of PFOA enables efficient quantification and remediation.
An international team of scientists organized a competition to evaluate analytical tools for single-molecule motion analysis, with the goal of extracting meaningful insights from complex molecular trajectories. The results offer practical guidance for experimentalists seeking the right tools for their studies.
The Insilico Medicine recent summer updates webinar introduced new features and functional updates to the company's generative AI platform, including Generative Biologics, Chemistry42, PandaOmics, DORA, and PreciousGPT. These updates aim to accelerate drug discovery and advance life sciences research.
A new report from UCLA and Cal Lutheran University shows that California Latinos account for nearly a quarter of the total U.S. Latino GDP, with an estimated annual output of $400 billion. The state's economy would fall to eighth-largest globally without this significant contribution.
Researchers developed enzyme–PS conjugates that improve PS stability and biocompatibility. Enzyme carriers remodel pathological microenvironments, enabling catalysis-augmented PDT. The study proposed a systematic criterion for assessing binding strength between enzymes and Ce6.
Researchers developed a new microscope that enables high-speed, large-field-of-view visualization of neurovascular activity in awake mice. The LiTA-HM system captures capillary-scale vascular networks and single-neuron soma details across the entire cortex with 6-μm spatial resolution.
Dr. Shivani Sahni, a nutritional epidemiologist, has been awarded Fellow Status by the American Society for Bone and Mineral Research for her outstanding contributions to bone and mineral science. She directs the Nutrition Program at Hebrew SeniorLife's Hinda and Arthur Marcus Institute for Aging Research.
A team of researchers at Memorial Sloan Kettering Cancer Center has made a groundbreaking discovery about why genetically engineered immune cells sometimes fail to fully destroy tumors. They found that FAS ligand, produced by the immune cells themselves, causes self-destruction and reduces therapy's effectiveness.
The American Heart Association has chosen eight healthcare startups to participate in its Heart and Brain Health Accelerator program. The selected companies will receive mentorship, funding, and access to networking opportunities to develop technologies that can positively impact women's cardiovascular and brain health outcomes.
Scientists have analyzed near-complete genome sequences from 65 individuals across five continents and 28 population groups, discovering complex genetic structural variations. These variations are more likely to alter gene expression and may be linked to disease or adaptations.
A team of Northumbria University academics is developing a revolutionary new approach to food security using engineered bacterial conduits. These smart bacteria can sense environmental cues and plant stress signals, then intervene to rebalance plant hormones in real-time, enabling crops to maintain growth under moderate stress conditions.
Researchers at TU Wien found that the solar wind ions' erosive effect on the Moon has been vastly overestimated. The actual yield is up to an order of magnitude lower than previously assumed due to the regolith's porous structure.
Researchers at Penn State developed a novel technique to analyze ice fractures in the Thwaites Glacier, a key indicator of potential collapse and sea-level rise. The new method provides high-resolution profiles of surface elevations and visual cross-sections of fractures, shedding light on fracture depth and activity.
Researchers developed a hybrid approach combining molecular dynamics simulations and Helfrich theory to evaluate bending rigidities of graphene nanosheets with lattice defects. The study reveals insights for designing novel materials with tailored mechanical properties.
A team from The Hebrew University of Jerusalem has developed innovative druglike molecules capable of degrading HuR, a key RNA-binding protein that stabilizes oncogenes and fuels cancer progression. These molecular degraders improve anticancer properties by up to 3-4 orders of magnitude compared to traditional HuR-binding molecules.
A recent study using deep genome skimming reveals the complex evolutionary history of Adenophora and its allies within the Campanulaceae family. The research shows that hybridization played a crucial role in shaping their phylogenetic relationships, leading to redefinition of genera and subspecies.
Research reveals that prenatal PFAS exposure can alter infants' developing immune systems, leading to lasting imprints on their ability to fight disease. Exposure to low levels of PFAS was associated with changes in key T-cell populations, including T follicular helper cells and regulatory T cells.
A new study found that four high-risk population groups - women, adults 45 and older, those living in poverty, and people with metabolic syndrome - are driving the increase. The study also showed that average drinking rates remained unchanged over 20 years before the COVID-19 pandemic.
Researchers developed an IBDV VP2 subunit vaccine that induces specific antibodies and protects against bursal atrophy. The study found that using certain adjuvants, such as Montanide ISA 78 VG, enhances the protective effects of the vaccine.
A new study reveals that the human gut microbiota can pinpoint an individual's city of residence with high accuracy, strongly linked to each city's characteristic diet. The researchers identified unique microbial signatures and interaction networks between cities in China, shedding light on how local environments shape our inner biology.
A team of Penn State researchers has found a new way for the fundamental reaction of oxidative addition to occur, potentially opening up new space for chemical design. This discovery could lead to more efficient industrial processes and the creation of new reactions that break down stubborn pollutants.
Researchers used machine learning to predict patient outcomes in hospitalized cirrhosis patients, outperforming traditional methods. The study found that AI can help hospital teams triage and prioritize patients more effectively.
Researchers discovered a compound, EPS3.9, produced by deep-sea bacteria that triggers pyroptosis to inhibit tumor growth and exhibit potent anti-cancer effects. The study highlights the importance of exploring marine microbial resources for developing new drugs.
The US relies heavily on Chinese graphite for battery production, with prices twice as high as importing it from China. To address this, the STEER initiative proposes lowering costs through financing, technological innovation, and domestic recycling, but faces challenges including lengthy qualification timelines.
The SPUN Underground Atlas reveals that over 90% of mycorrhizal biodiversity hotspots lie outside protected areas, emphasizing the need for conservation efforts. The digital map provides insights into fungal diversity and environmental factors, enabling predictions for previously unmapped regions.
A study reveals that epigenetic changes associated with aging in adults do not occur before sexual maturity. In fact, rDNA copy numbers and methylation increase during childhood and adolescence, suggesting cells actively maintain a youthful state to ensure efficient protein production.
Researchers developed a non-invasive ChlF imaging technique to detect rice blast and brown spot diseases early. The study identified reliable diagnostic indicators, achieving high classification accuracies over 92% at both leaf and lesion levels.
A research team has discovered a native peanut Ubiquitin4 promoter (AhUBQ4) with strong transcriptional activity, driving robust gene expression in various tissues and conditions. The AhUBQ4 promoter also showed improved efficiency in CRISPR/Cas9 editing compared to foreign promoters like CaMV 35S.
The article highlights the need for improved sepsis diagnosis, personalized treatment, and innovative trial designs. It advocates for a multifaceted approach integrating timely diagnosis, tailored therapy, and equitable implementation to tackle the global burden of sepsis.
A 150-year-old fossil specimen has been reidentified as a type of invertebrate called a lobopod, marking the first time this line of sea creatures is known to have left the ocean. The study suggests that the lobopod likely lived in a freshwater environment and had chemical defenses that indicate it may have spent part of its time on land.
Researchers developed an AI-based method to analyze microscope images of corroded metal surfaces, estimating corrosion severity without human input. The technique focuses on two critical indicators: corrosive deposit thickness and porosity, identifying specific pH levels that indicate severe corrosion stages.
Researchers unveiled the link between solid electrolyte interphase structure and nitrogen reduction to ammonia, a promising eco-friendly approach to fertilizer production. The study reveals that ethanol-to-water ratio in the electrolyte significantly impacts ammonia conversion efficiency.
Remote, scalable cognitive behavioral therapy-based treatments improved pain and quality-of-life outcomes for individuals with high-impact chronic pain. These lower-resource treatments could increase availability of evidence-based nonpharmacologic pain treatments.
A $1.1 million grant supports a natural history study for MCHS, collecting vital information about the condition to inform future clinical trials of therapies. The Volāre Study aims to provide baseline developmental trajectory information and establish infrastructure for multicenter clinical trials.
Research found that chronic exposure to PM10 and PM2.5 air pollutants activates harmful allergic-like immune responses in the lungs, leading to inflammation and scarring. The study suggests targeting oxidative stress or modulating NRF2 activity could be a new strategy to treat pollution-induced allergic inflammation.
A team of scientists has decoded hidden DNA variations that influence digestion, immune response, and muscle control. The study maps genomic variation across ancestries with a breadth and resolution never before achieved.
Researchers found that different species of dinosaurs had distinct preferences for plant parts, including leaves, buds, and woody tissues. This discovery helps explain how so many large herbivores coexisted in the same ecosystem without competing for resources.
A new study reveals that infants, toddlers, and preschoolers can exhibit distinct long COVID symptoms, which may be challenging to identify due to their unfamiliarity. The study emphasizes the importance of pediatricians and family physicians considering long COVID in children presenting with similar symptoms.
A team of researchers has discovered a unique fossil structure in the early Middle Triassic reptile Mirasaura grauvogeli, which challenges our understanding of reptile evolution. The fossil's complex skin appendages, resembling feathers but without branching, suggest that such structures evolved independently of bird feathers.
A study by Da Eun Kim and Brenna Ellison found that consumers were more likely to purchase plant-based eggs when they were mixed into something familiar, like pancakes. The team also discovered that environmental impact and animal welfare became major factors in consumer choice. Familiarity with the end product, such as a tasty pancake...
Researchers discovered salicylic acid plays a central role in protecting potato roots from Spongospora subterranea, a soilborne pathogen causing powdery scab. The study used a cutting-edge 'hairy root' system to rapidly test root-pathogen interactions, providing vital insights for developing resistant potato varieties.
Researchers used the Cycles agroecosystem model to simulate nuclear winter scenarios and predict the impact on global corn production. The study found that a large-scale nuclear war could lead to an 80% drop in annual corn yields, resulting in widespread famine and catastrophic consequences.
A study examining Italian medical academia over the last decade reveals a persistent 'leaky pipeline' of women not advancing to senior roles. The research highlights significant gender disparities in academia, affecting women's career prospects and opportunities.
A study in ferrets suggests that pre-existing immunity to H1N1 seasonal influenza virus provides protection against severe illness from H5N1 bird flu. The researchers found that ferrets with immunity to H1N1 or H3N2 showed reduced symptoms and lower viral replication when exposed to the H5N1 virus.
A study published in Neurology found that antiseizure drug use during pregnancy continues despite evidence of birth defect risks, with higher use among people with low resources. The safest drugs saw a 30% increase in exposure, while those with uncertain risks saw an increase over time.
Researchers at the University of Missouri discovered that soybeans employ differential transpiration as a natural defense strategy to cool reproductive tissues under extreme weather conditions. This adaptation allows plants to save significant amounts of water while protecting their flowers and seed pods.
Researchers found that consuming nitrate-rich beetroot juice altered the oral microbiome in older adults, leading to a decrease in blood pressure. The study suggests that encouraging older adults to consume more nitrate-rich vegetables could have significant long-term health benefits.
Researchers tracked adult penguins during return trips from foraging in the ocean off Argentina. The penguins used curved paths shaped by tides to conserve energy and take advantage of feeding opportunities.
A contemporary cohort study found a low risk of isolated locoregional recurrence (5.6%) at 10.1 years follow-up for young women diagnosed with breast cancer under 40. Surgical decision-making should not be influenced by concerns about long-term risk.
Research from UCLA Health Sciences found that individuals with substance use disorders are at a higher risk of unplanned hospital readmissions. Specifically, those with opioid use disorder had the highest 30-day readmission rates.
The KRISS research team has developed a length measurement system that achieves a level of precision approaching the theoretical limit allowed by quantum physics, boasting world-leading measurement accuracy and compact design. The system measures 0.34 nanometers in just 25 microseconds, operating rapidly and reliably for field deployment.
The University of Tokyo researchers developed an unmanned aerial vehicle (UAV) that can withstand ocean currents and wind, enabling the acquisition of reliable seafloor measurements. The system achieved a horizontal root mean square error of approximately 1–2 cm, comparable to existing vessel-based systems.
The CTAO LST Collaboration presents groundbreaking findings on the nature of gamma-ray bursts, supporting theoretical models of structured, multi-layered jets. The observations of GRB 221009A provide new clues about jet formation mechanisms and the central engine behind these cosmic phenomena.
A team of researchers has developed three Nipah vaccine candidates using different viral surface proteins, achieving protection in mice, pigs, and 'backyard' pigs under field conditions. The study marks a major step forward in controlling the virus, which poses a significant threat to public and animal health.
A new study in PLOS One discovers a dinosaur tracksite in Alberta, Canada, showcasing the social interaction between different species 76 million years ago. The tracks reveal that multiple species, including ceratopsians and ankylosaurs, walked together, possibly as a defense strategy against predators.
A recent study led by Kelton McMahon at the University of Rhode Island's Graduate School of Oceanography found that coral reef food webs are more fragmented and specialized than thought. The researchers used a novel technique called compound-specific stable isotope analysis to trace energy flows through the ecosystem, revealing distinc...
Neuroscientist Sora Shin is studying how early-life trauma shapes brain circuit function and contributes to uncontrolled rage, a public health issue linked to psychiatric disorders and societal challenges. Her research could lead to novel treatment strategies for trauma-related aggression.
Allergic responses to tattoo ink can lead to severe symptoms like urticaria, angioedema, and granulomatous reactions. Laser therapy can worsen these conditions, leading to hypertrophic scars or keloids. Alternative treatments like corticosteroids and surgical excision are recommended.
Researchers at the University of Illinois found that benign and cancerous breast calcifications have unique structures and formation processes. The study provides a new classification scheme and opens the possibility of treating benign calcifications using certain drugs.
Scientists discovered a molecular interplay between Shiraia fungus and its bacterial partners, where VOCs boost HA production by 3.86-fold. The bacteria counter-response with antioxidant carotenoids, creating a feedback loop.