VCU Massey Comprehensive Cancer Center is the first US site to enroll patients in a global Phase 2a clinical trial of PTX-100, a small molecule inhibitor for cutaneous T-cell lymphoma. The trial aims to evaluate the efficacy and safety of PTX-100 in patients with relapsed or refractory disease.
A new study uses deep learning to map microscopic structures and simulate mass transport in CO₂RR catalyst layers, providing a scalable blueprint for industrial CO₂ electrolyzers. By optimizing catalyst layer composition, high current densities can be sustained without sacrificing selectivity or durability.
A recent study by JAMA Network Open reveals racial differences in care quality among men with newly diagnosed prostate cancer. Black men had lower odds of overtreatment, suggesting better care, while having lower odds of confirmatory testing on active surveillance, indicating worse care.
Researchers have identified two brain waves, alpha and delta waves, as key markers for obsessive-compulsive disorder (OCD). These findings could lead to more targeted deep brain stimulation treatments, improving outcomes for patients. The discovery provides a significant breakthrough in understanding OCD and its neural mechanisms.
A new study has identified genetic changes in the parasite responsible for trichomoniasis that may have helped it adapt to human hosts. The research found dozens of genes associated with key functions such as phagocytosis and exosomes, which could be exploited for future treatments.
Researchers discovered antibiotic-resistant Staphylococcus saprophyticus in the Southern Ocean, showing complete resistance to multiple antibiotics. The study highlights the need for greater awareness of human impact on pristine ecosystems like Antarctica, which may exacerbate public health issues through the food chain.
Researchers found that billing codes may mistakenly identify diseases in up to 45% of cases, highlighting a significant limitation in using administrative data for clinical research. The study examined records of 1.36 million patients and found discrepancies between coded diagnoses and actual disease presence.
A new study has found that TAF1 operates as a key molecular switch in adult hematopoietic stem cell maintenance and lineage commitment. This discovery challenges prevailing models of gene regulation and has the potential to lead to new therapeutic strategies targeting the molecule, which could improve blood production and transplantation.
Answer ALS is launching a groundbreaking collaboration with Tulane University and the Pennington Biomedical Research Center to harness AI for ALS treatment discovery. The Louisiana AI Drug Development Infrastructure for ALS (LADDIA) will prioritize therapeutic targets using AI-driven insights from the Answer ALS' Neuromine Data Portal.
The Josep Carreras Leukaemia Research Institute is launching a joint research programme on childhood leukaemia, aiming to develop common strategies and improve treatments for the disease. Paediatric leukaemia remains a significant challenge due to its low incidence and high mortality rate.
Physicists developed a method to control atomically thin semiconductors using terahertz light pulses, enabling ultrafast signal control devices. The technique allows real-time control of electronic structure on timescales of less than a picosecond.
Colorectal cancer claims more lives in Black communities than any other racial group, with incidence and mortality rates about 20% and 30% higher respectively. A new review by UCLA researchers highlights the need for equal access to screening, diagnosis, and treatment to eliminate these disparities.
Recent advances in chemistry have led to innovations in industrial carbon capture technologies, reducing energy consumption by over 30% and improving efficiency. The research highlights novel amine blends, metal-organic frameworks, and electroswing technologies that can selectively capture CO2 with high efficiency.
Scientists discovered that marine copepods rely on both genetic and epigenetic changes to survive climate change. Epigenetic changes, which are temporary chemical modifications, play a crucial role in helping these tiny crustaceans adapt to ocean acidification and warming conditions.
Researchers have discovered star-shredding black holes in dusty galaxies, confirming that these events are powered by dormant black hole accretion. The study uses the James Webb Space Telescope to detect clear fingerprints of black hole activity in four galaxies, revealing key differences between active and dormant black holes.
A recent clinical trial found MyMenoplan.org effective in increasing treatment intentions and menopause knowledge among users. The website offers personalized information and decision-making tools, guiding women through symptom discussions and outlining treatment options.
Researchers found that certain antibodies can reduce antitumor immune cells, highlighting the need to consider ADCC activity when designing or selecting ICI therapeutics. This study could help improve cancer treatment by engineering antibodies that avoid damaging essential immune cells.
A new study reveals a significant association between neighborhood firearm violence exposure and adolescents' perceived ability to obtain a firearm outside the home. Fighting behavior was found to mediate 32% of the relationship, highlighting the layered risks faced by youth in high-violence settings.
Research found passing rates peak at noon, lowest in early morning and late afternoon, with implications for high-stakes evaluations like job interviews. Strategies like quality sleep and mental breaks can help counteract time-of-day effects.
Tonic signaling in CAR-T therapy allows for precise tuning of signaling intensity and duration, enabling personalized treatment optimization. By balancing activation thresholds and duration, researchers can predict therapeutic efficacy and mitigate exhaustion.
Researchers have engineered a novel enzyme, PET2-21M, to enhance the biodegradation of bottle-grade polyethylene terephthalate (PET) plastics. This breakthrough offers a sustainable and efficient alternative to conventional recycling processes, achieving significant improvements in catalytic activity and substrate efficiency.
Researchers argue that hepatitis B treatment should be expanded to include more people, as current drugs are safe and effective in slowing disease progression and reducing transmission. By treating more people earlier, the net disease and death rate can be significantly reduced.
Researchers at Sanford Burnham Prebys found that blocking macropinocytosis reshapes the tumor microenvironment, allowing more access to immune cells. This change made immunotherapy and chemotherapy more effective in treating PDAC tumors in mice.
Standard perovskite solar cells perform well during summer months but decline in efficiency during darker periods. Small-scale perovskite cells can achieve up to 26.95% efficiency under standard conditions.
Researchers have developed a novel polymer nanocomposite from COVID-19 waste masks, achieving record-high thermal conductivity and electromagnetic shielding. The closed-loop upcycling strategy reduces environmental impact and cost, paving the way for sustainable electronics and circular economy applications.
Research at University of Arizona Health Sciences found PFAS exposure affects gene activity, tied to cancers, neurological disorders, and autoimmune conditions. Changes in miRNA activity indicate potential health risks, suggesting a link between environmental exposures and disease.
Researchers used satellite data and AI methods to assess industrial fishing activity in MPAs, finding that strongly protected areas had significantly less fishing activity than surrounding waters. In some cases, no vessels were detected at all.
Diana Hargreaves will receive $1 million to advance her project on improving immunotherapy in patients with pancreatic cancer. Her previous work identified better drug targets for cancers with SWI/SNF mutations, leading to breakthroughs in treating difficult-to-treat cancers.
Researchers found that metastable epialleles in mice, which determine gene expression through DNA methylation, are remarkably scarce. In contrast to earlier studies, the study revealed that maternal diet had no effect on these epialleles, challenging previous findings.
A groundbreaking study found significant mitochondrial cardiolipin dysregulation in patients with bortezomib-induced peripheral neuropathy. The researchers identified diosmin as a promising candidate for targeting this condition, providing new avenues for therapeutic intervention.
Coral reefs face severe threats from climate change and heat stress. Researchers are turning to assisted gene flow (AGF) to restore genetic diversity and boost resilience. International collaboration and revisions to conservation laws are necessary to proactively expand AGF efforts, safeguarding and restoring coral reef ecosystems.
Researchers used IntelliCage to assess spontaneous behavioral changes in a mouse model of schizophrenia, finding increased hyperactivity and exploratory behavior after treatment with MK-801. However, cognitive flexibility was impaired, suggesting schizophrenia-like behaviors.
Researchers from the University of Illinois have demonstrated a viable and high-performance modular architecture for superconducting quantum processors. Their work enables system scalability, hardware upgrades, and tolerance to variability, making it an attractive option for building system networks.
A new study by Mass General Brigham found that over 35% of responses from large language models contained stigmatizing language related to alcohol- and substance use-related conditions. However, targeted prompts can reduce this language substantially. The authors recommend using patient-centered language to build trust with patients.
A new robotic slip-prevention method has been developed to improve robots' grip and handling of fragile or slippery objects. This bio-inspired approach allows robots to predict when an object might slip and adapt their movements in real-time, outperforming traditional strategies.
Researchers from NUS develop non-alternant carbon nanobelts featuring five-membered cyclopentadienyl units, allowing for improved electron flow and new electronic properties. The novel structures emit bright red light and exhibit small energy gaps, making them suitable for organic light-emitting diodes and solar cells.
A study published in PLOS One found that AI-generated music triggered greater physiological responses and was perceived as more emotionally stimulating compared to human-created music. The complexity of the prompt used also affected the impact of the music, with more complex prompts causing higher cognitive loads.
A new study identified seven immune-related genes downregulated in hepatocellular carcinoma and intrahepatic cholangiocarcinoma, which are associated with immune surveillance and complement pathways. The findings also revealed macrophage migration inhibitory factor signaling as a critical communication channel in ICC.
The TherVacB vaccine aims to activate the natural immune response to eliminate the hepatitis B virus. In a new phase 1b/2a clinical trial, 81 patients will receive increasing doses of the vaccine components to determine its safety and effectiveness.
Hospital and nursing home food are found to be lacking in healthy plant-based options, with too many refined grains, added sugars, and saturated fats. The study recommends reducing animal-source foods and increasing plant-based options to improve both human and planetary health.
The team aims to deliver AI power directly to devices, improving resilience and speed in constrained environments. By processing data step-by-step across a network of devices, they can create a safe and adaptable system that can withstand attacks and extreme conditions.
BASILISK, a global esports organization for science, partners with CalTech's IQIM and The Planetary Society to amplify science advocacy. BASILISK's players introduce respected scientific institutions to over 3.5 million gamers, expanding science outreach.
Researchers create AI model called UNITE that detects fakes by analyzing faces and backgrounds, making it one of the first tools capable of identifying synthetic or doctored videos. The system can flag a range of forgeries, from simple facial swaps to complex fully synthetic videos.
A national study found that healthcare providers exhibit varying levels of stigma towards patients with substance use disorders (SUD), particularly for opioid and stimulant use. This stigma leads to missed opportunities for care and is often embedded in clinical encounters.
Researchers found that protein structures are more like Lego than Jenga, with only a few critical amino acids in the core. A machine-learning algorithm created a tool to predict protein stability, potentially speeding up the development of new medicines and enzymes.
Researchers create metasurfaces to control photons and entangle them for quantum computing and sensing. The discovery could lead to miniaturized optical setups with improved stability, robustness, and cost-effectiveness.
A new case report describes the use of extracorporeal blood filtration to treat stage IV poorly differentiated pancreatic adenocarcinoma. The patient experienced clinical improvement, reduced pain, and no signs of new tumor growth over 12 months of follow-up.
The 2023 marine heatwaves were the most intense and persistent in recorded history, with temperatures reaching 96% of the global ocean surface. Regional drivers, including increased solar radiation and weakened winds, contributed to their formation and persistence.
A team of researchers led by Simona Stäger identified IRF-5 as a guardian of T cell metabolism and mitochondrial function. The discovery provides new strategies for boosting immunity to chronic infections or cancers, where T cell exhaustion is observed. IRF-5's role in preserving immune cell energy could play a key role in this approach.
The American Heart Association trained Duke student-athletes in Hands-Only CPR to equip them with the knowledge and confidence to act in emergencies. Nearly 9 out of 10 people who experience cardiac arrest outside a hospital die due to lack of immediate CPR, highlighting the importance of this skill.
Researchers use AI to solve differential equations, such as Schrodinger's equation, for large-scale systems, improving efficiency and accuracy in fields like drug discovery and material design.
A team at HZB used 3D X-ray tomography to create a digital copy of a Mongolian scroll, then virtually unrolled it using mathematical methods, revealing the scripture and ink traces. The scrolls contained Tibetan script in Sanskrit language and traditional Chinese ink with metal particles.
Researchers at Fox Chase Cancer Center have provided a detailed assessment of how fast breast cancers grow in patients and how surgical delays may affect breast cancer staging. The study found that upstaging rates associated with delays are relatively small and consistent with prior data.
A recent study detected titanium dioxide particles in 100% of animal milk samples and 83% of infant formulas, revealing widespread contamination. The findings suggest that infants' exposure to these particles does not end at birth, raising concerns over human and animal health.
Researchers analyzed 96 years of forest census data, revealing homogenization trends and loss of tree species. The study suggests that reduced forest diversity makes the ecosystem less resilient to future disturbances.
Researchers found that oxidative stress actually suppressed cancer development in rats with BRCA2 gene mutations, contrary to prior expectations. This discovery suggests that avoiding radiation exposure may not be the best method for people with BRCA2 pathological variants.
Research analysis of over 29 million people reveals a positive association between three types of air pollutant and dementia. The study found that long-term exposure to PM2.5, NO2, and soot increases the relative risk of dementia by 17%, 3% and 13%, respectively.
Researchers developed an AI-based screening tool using pangrams to detect Parkinson’s disease with nearly 86 percent accuracy. The web-based test analyzes voice recordings for subtle patterns linked to the neurodegenerative disease, identifying potential warning signs.
Researchers at Duke University School of Medicine have identified a new system linking the microbiome to the brain, which influences behavior and appetite. The discovery was made by detecting flagellin in gut bacteria, triggering an appetite-suppressing signal to the brain.
Researchers found that cultivating bread wheat with arbuscular mycorrhizal fungus Rhizophagus irregularis increases grain size and micronutrient levels, especially phosphorus and zinc. This process enhances the bioavailability of these essential nutrients in bread wheat.