Researchers at Sanford Burnham Prebys Medical Discovery Institute found that using a drug as a blocker to outcompete the SUMO2 protein may be a winning strategy against synovial sarcoma. This approach aims to reverse aberrant epigenetic rewiring driven by the SS18::SSX fusion oncoproteins and impair sarcomagenesis.
Mönch's research focuses on developing partial power processing converters to minimize losses in energy conversion, with potential applications in electromobility and innovative heat pumps. He aims to explore the limits of complete losslessness and develop efficient technologies for capacitive loads.
A meta-analysis of four trials found that beta-blocker therapy significantly reduced all-cause mortality, new myocardial infarction, and heart failure in patients with mild left ventricular ejection fraction reduction after a heart attack. The study showed a 25% relative reduction in the composite endpoint
Dr. Anna Czarkwiani has received an ERC starting grant to study the biology of gravisensation, focusing on otoconia formation and restoration. She will use the axolotl as a model organism to explore the sense of gravity and develop new therapies for balance disorders.
Researchers have developed a system that captures high-speed jet images of activated sludge to predict moisture content with remarkable accuracy in under 20 seconds. The convolutional neural network (CNN) model VGG-16 emerged as the most effective for moisture prediction, achieving impressive validation results.
Researchers achieved excellent passivation of perovskite top cells on textured silicon surfaces, leading to improved efficiency and conductivity. The breakthrough enhances understanding of processes occurring in top cells and paves the way for further innovation in tandem solar cell development.
The study introduces a new approach to enhance energy density in sodium-ion batteries by introducing flexible Al-O bonds into P2-type layered oxides. This strategy successfully suppresses irreversible phase transitions and stabilizes local structures, significantly improving sodium-ion diffusion kinetics.
This study identifies critical gene networks in pearl millet that explain its robust survival and offer molecular targets for engineering more resilient crops. The analysis reveals a complex, tissue-dependent transcriptional network that mobilizes both conserved and distinct molecular pathways to counter abiotic stress.
UC San Diego researchers have discovered that spaceflight accelerates the aging of human hematopoietic stem and progenitor cells, leading to increased DNA damage and telomere shortening. The study's findings offer insights into aging and disease risks during long-duration space travel and suggest potential rejuvenation strategies.
Researchers optimized diazotization reaction parameters to minimize thermal hazards, providing practical guidance for safer industrial production. The study's findings emphasize the importance of precise temperature control, careful feeding, and efficient cooling systems to ensure stability.
Two studies published by the Universitat Autonoma de Barcelona team reveal how extreme temperatures impact the reproductive process in reptiles and fish. The research found that changes in temperature can increase DNA fragmentation and alter chromosomal structures, leading to increased genetic diversity and adaptation to climate change.
The Korea University College of Medicine hosted the K-CLUB International Symposium to promote interdisciplinary collaboration and address global health challenges. Distinguished global scholars explored the future of human health from diverse perspectives, including clinical care, biomedical convergence, and health policy.
In-hospital initiation of SGLT2 inhibitors did not significantly reduce short-term risk of cardiovascular death or worsening heart failure in patients admitted for heart failure. However, combining trial data shows positive effects of SGLT2 inhibitors on reducing early risk of cardiovascular death or worsening HF and all-cause mortality.
The new guidelines provide clear practical recommendations for diagnosing and treating patients with valvular heart disease, emphasizing the importance of shared decision-making and patient-centered care. The updated guidance aims to reduce under-treatment, especially in the elderly, and promote more equitable access to high-quality care.
A new study using two-photon microscopy shows that brief interruptions in brain capillary flow can cause rapid drops in oxygen levels, potentially leading to tissue damage. The research found that even minor stalls can lead to significant hypoxia, highlighting the importance of uninterrupted blood flow to the brain.
The new guidelines introduce a unifying term for inflammatory myopericardial syndrome and provide easy-to-use flow charts to support medical professionals in diagnosing and treating myocarditis and pericarditis. The recommendations also prioritize patient return to work and exercise, aiming to improve clinical outcomes.
A new study found that caffeine can damage red blood cells during storage and reduce their effectiveness after transfusion, especially in individuals with certain genetic variations. The research suggests a personalized approach to blood transfusion based on lifestyle factors and genetic traits.
The REBOOT trial found that beta-blocker therapy had no significant impact on all-cause death, reinfarction, or heart failure admission in patients with myocardial infarction and left ventricular ejection fraction (LVEF) ≥40%. In contrast, a meta-analysis suggests potential benefits for patients with mildly reduced LVEF (40–49%).
The ESSENCE-TIMI 73b trial found olezarsen to substantially lower triglyceride levels, achieving normal levels in over 80% of patients. The treatment also showed efficacy in reducing other lipoproteins with no significant effect on LDL-C.
Researchers at Johns Hopkins Medicine reveal a potential molecular link between air pollutants and an increased risk of developing Lewy body dementia. Exposure to fine particulate air pollution (PM2.5) triggered the formation of abnormal alpha-synuclein clumps in mice, similar to those found in human patients with Lewy body dementia.
A new fossil discovery confirms that ancient bugs, not just bees and butterflies, played a significant role in plant pollination during the Mesozoic era. The iridescent bug found in Burmese amber likely visited flowers and was likely involved in pollination.
Researchers at RIKEN Center for Sustainable Resource Science identified ancient protein SCORE to help plants defend against various pathogens. By engineering synthetic SCORE variants, plants can be made resistant to multiple pathogen types.
The $3.5 million gift will enable the center to triple its patient capacity and expand into a new, 16,000-square-foot space, centralizing care for clinical trial patients. This expansion will bring potentially life-extending treatments to more patients than ever.
Researchers at Osaka University have identified transcription factors RUNX2 and BHLHE40 as crucial for inducing T cells involved in Crohn's disease. Overexpression of these factors promotes inflammatory cytokine production and tissue-retentive properties, making them potential novel therapeutic targets.
A single dose of MM120 (lysergide) produced a dose-dependent reduction in anxiety in participants with moderate to severe generalized anxiety disorder. The study supports the efficacy of MM120 and informs dose selection for phase 3 pivotal trials.
New research suggests that rapid brain growth in marmoset infants, similar to human babies, enables them to learn language through feedback from caregivers. This learning strategy makes humans an oddity within the animal kingdom.
Researchers at the University of Konstanz are developing new methods to modify natural substances using enzymes, with potential applications in pharmaceuticals. Meanwhile, ecologist Catalina Chaparro-Pedraza is studying how organisms adapt to environmental changes and their impact on ecological resilience.
Researchers found no reduction in total mortality, cardiac death, or sudden cardiac death among patients with these high-risk profiles. ICD therapy added to standard medical treatment failed to improve survival outcomes.
Researchers developed a new tool to measure language learning strategies of Japanese university STEM students. The Strategy Inventory for Language Learning-STEM (SILL-JP/STEM) assesses six categories of learning strategies, revealing insights into students' behaviors, including underutilized affective strategies.
A study by Umeå University and Ghent University reveals that immune cells orchestrate the mobilization of zinc to fight microbes, making them more vulnerable. The balance of trace metals in the immune system plays a crucial role in the efficiency of neutrophils to kill microbes.
A new study suggests that the shift from eelgrass to widgeon grass in the Chesapeake Bay could lead to a 63% reduction in invertebrate biomass by 2060. The change may favor smaller creatures and reduce the total animal biomass per square meter, impacting fisheries and ecosystem functions.
Research reveals that even thermally tolerant coral species like Stylophora pistillata can experience reduced growth and increased metabolic demand under chronic elevated baseline temperatures. However, some corals can recover when waters cool in the winter, suggesting a potential for resilience.
Lantidra, the only FDA-approved therapy for brittle type 1 diabetes, allows patients to stop taking daily insulin injections. The treatment has been shown to preserve health and prevent complications associated with diabetes.
The UT San Antonio Health Science Center has been ranked No. 495 globally for its biomedical research, highlighting its impact on health worldwide. The institution's researchers have made significant breakthroughs in medicine, strengthening its reputation as a powerhouse of medical research.
A study found that most rodents have thumbnails instead of claws, which helps explain how they thrived in various environments. This discovery suggests that thumbnails provide more manual dexterity than long, sharp claws, enabling rodents to exploit high-energy resources like nuts.
The C-Path Translational Therapeutics Accelerator has completed a record year of funding and mentorship, supporting seven projects in 2025 with approximately $2.48 million in awards. The program awarded grants to teams advancing treatments for rare liver disease, drug-resistant lung infections and pediatric brain tumors.
A new method, AEquity, identifies and corrects bias in health care datasets used to train machine-learning algorithms. The tool can spot well-known and previously overlooked biases across different datasets.
Professor Paul Motzki is developing ultra-flat, compact, and lightweight cooling units using shape memory alloys and dielectric elastomer actuators. He aims to create climate-friendly and energy-efficient alternative to conventional systems.
Drones are enhancing farming sustainability by boosting yields, reducing waste and lowering chemical exposure, while also creating new opportunities for rural livelihoods. However, risks of labor displacement, gender inequality and chemical drift remain, highlighting the need for inclusive adoption and smart regulation.
Researchers at Harvard SEAS have developed a gentler, more sustainable way to break down keratins and turn leftover wool and feathers into useful products. The process uses concentrated lithium bromide to create an environment favorable for spontaneous protein unfolding.
The BaxHTN trial found baxdrostat 1 mg and 2 mg significantly reduced seated SBP in patients with uncontrolled or resistant hypertension. The medication showed substantial ambulatory SBP reductions and controlled SBP rates of 40% after 12 weeks.
Advanced filtration systems can cut levels of cancer-causing DBPs, nitrates, and heavy metals, in addition to removing toxic PFAS from drinking water. The Environmental Working Group study found significant reductions in these contaminants across 19 US utilities.
Researchers developed a powerful new AI algorithm called RoboBallet that enables large sets of robotic arms to work together faster and smarter. The system plans movements and tasks automatically, unlocking new levels of flexibility and efficiency in manufacturing.
University of Iowa researchers have created an underwater hydrofoil with a coiled spire design that reduces drag and creates more lift, enabling it to move with ease in any underwater environment. The technology mimics the skin, muscles, and tissue of an octopus, allowing for increased portability and maneuverability.
Research in Brazil found that glycemic delta, a measure of blood sugar variability, is associated with the size of the heart attack and the strength of heart contractions. The study suggests that high glycemic delta may be a biomarker for worse outcomes in patients who have experienced their first acute myocardial infarction.
A recent study sequenced human cancers and found little evidence of microbial DNA sequences, contradicting earlier claims. However, microbes linked to human cancer were detected, including HPV, Helicobacter pylori, and Fusobacterium nucleatum.
A new study published in Nutrients found that both whole and refined grain foods can contribute to improved dietary patterns and health. The study analyzed data from over 14,000 Americans and identified healthy grain foods based on nutrient density, fiber, protein, and essential nutrients.
Cornell researchers develop 3D eye-on-a-chip model that mimics ocular fluid flow, revealing the signaling mechanism behind steroid-induced glaucoma. The team identified ALK5 receptor's role in downregulating VEGFC, which impairs drainage and increases intraocular pressure.
Researchers analyzed 10 SEP events with inverse velocity dispersion signatures to investigate underlying mechanisms. The study found that energy-dependent release and longer timescales for high-energy particles explain the counterintuitive behavior.
The UCD researchers will explore a range of research topics, including the evolution of infectious diseases in livestock and sustainable solutions for environmental and industrial sectors. The grants support excellent research across diverse fields and are estimated to create over 3,000 jobs.
A new diagnostic system has been developed to identify ADHD-like symptoms in family dogs. The system combines owner-rated questionnaires with a short behavioral test to assess inattention, excessive activity, and impulsivity levels.
A team at University of Tokyo successfully created nanodiamonds using electron radiation on adamantane molecules. This method offers new techniques for imaging and analysis, and could lead to breakthroughs in fields like quantum computing and sensors.
A research team developed a photochemical strategy to realize heterolytic H2 dissociation using gold-loaded titanium dioxide as a model photocatalyst. The reaction was driven by electron-hole pairs formed upon UV irradiation, producing reactive H2 species that selectively reduced polar functional groups.
Researchers associated with a fictitious network have collectively netted millions of dollars in funding from the US, Japan, Ireland, and other nations. The investigation highlights weaknesses in research and publishing systems that can be exploited for personal gain.
Smitha Vishveshwara, a UIUC physics professor and author, has been honored for her work blending science teaching, theater, and art. Her award recognizes her innovative approach to communicating complex physics concepts through storytelling and artistic expression.
A new study from North Carolina State University reveals that not all dietary proteins are digested the same way. The research found that specific proteins from different sources, such as soy and egg white, can be resistant to host digestion and interact with the gut microbiota in the large intestine.
Researchers from Carnegie Mellon University found six million fake stars on GitHub, used to boost repository reputation and steal user data. The use of fake stars muddies the waters, making it challenging to differentiate between legitimate and malicious repositories.
Researchers discover how heme bound proteins catalyze hydrogen sulfide signaling in bacteria, leading to stress tolerance and antibiotic resistance. Disrupting this mechanism could inspire new antibiotic strategies against drug-resistant infections.
A study by São Paulo State University found a direct association between adults' levels of physical activity and their children's sedentary behavior. Children of inactive parents tend to be more sedentary, but when mothers and fathers maintain an active routine, their children usually follow suit.
Researchers are using bird flight insights to create drone systems that can save energy and fly more efficiently. The goal is to develop technology that can dramatically reduce the amount of energy required for uncrewed aircraft, enabling longer flights.