Researchers have identified shared gene signatures and key mechanisms underlying the progression from chronic liver cirrhosis to acute-on-chronic liver failure. Metabolic dysfunction, including altered glycolysis and gluconeogenesis pathways, plays a central role in both conditions.
A Stanford-led study suggests that adopting a positive perspective on catastrophic experiences, such as the COVID-19 pandemic, can lead to reduced depression and lower levels of inflammation. The intervention group showed lower levels of depression and C-reactive protein compared to the control group.
Researchers explore the benefits of nucleic acid aptamers in targeted therapies for bone tissue regeneration, revealing their potential in managing orthopedic conditions. Aptamers can modulate key molecular pathways involved in bone repair, advancing the standard of care for fractures and various types of bone diseases.
Researchers have successfully produced antibodies that kill the parasite carried by the 'kissing bug' that causes the potentially deadly Chagas disease. These antibodies target the parasite's infective stage and show neutralization rates exceeding 95%, making them a key step towards developing an effective vaccine.
Researchers found that faster biological aging is associated with lower scores on digital cognitive tests, particularly among older adults. DNA methylation patterns were used to estimate biological age acceleration, and protein markers PAI1 and ADM showed strong associations with lower cognitive scores.
Researchers detected a new planet, WISPIT 2b, at an early stage of formation around a young analog of our Sun, estimated to be about 5 million years-old. The discovery provides valuable insights into planet-disk interaction and subsequent evolution.
A meta-analysis of 92 studies worldwide found that nearly one in three people avoid or are likely to avoid medical information. The strongest predictors of this behavior were not related to demographic factors but rather social and structural environment. Restoring trust in the medical system could lead to greater engagement with medic...
A new power flow algorithm for modern shipboard microgrids incorporating inverter-based resources has been developed, enabling the efficient management of energy at sea. The method incorporates grid forming control characteristics of inverter-based resources and can handle multiple energy sources sharing power proportionally.
Researchers from Japan and USA discover midline tissues use formation control to grow harmoniously, with the notochord leading elongation and adjacent tissues migrating together through fibroblast growth factor gradients and cell adhesion. Computer simulations confirm this mechanism is essential for synchronized tissue development.
Research reveals that women and girls exhibit higher levels of direct aggression towards their siblings compared to boys and men. In contrast, women and girls tend to engage in reputational aggression with non-siblings, similar to men and boys.
Researchers found that chemicals used to replace BPA can disrupt human ovarian cell function and change gene expression. The study calls for further investigation into the safety of these alternatives, which are not regulated or routinely tested.
A key contributor is the lab of Prof. Ayal Hendel at Bar-Ilan University's Goodman Faculty of Life Sciences, focusing on evaluating CRISPR-based gene editing precision and safety. The project aims to decentralize CAR-T cell therapy production, making it available to more patients by reducing costs and increasing accessibility.
Researchers uncover how EZH2 gene mutations sabotage healthy copy, leading to intellectual disability and overgrowth, with implications for related diseases and cancer. The study provides new insights into chromatinopathies and potential targeted therapies.
Researchers identified three distinct molecular subtypes of follicular lymphoma, offering insights into personalized treatment plans. The subtypes C1, C2, and C3 differ in their genetic profiles and tumor microenvironments, guiding the use of specific therapies.
Researchers based calculations on six different methods and found life expectancy for those born between 1939 and 2000 is rising more slowly. The rate of increase slowed by 37-52% depending on the method used, with forecasts indicating none of these cohorts will reach 100 years of life expectancy.
A team of researchers from ICFO has achieved a major milestone in the development of solid-state quantum memories. They have successfully stored qubits in arbitrary combinations of memory cells and retrieved them on demand using an array of ten individually-controllable memories. This achievement opens up new possibilities for processi...
Researchers developed a novel nano-eutectic structured Al2O3-ZrO2 composite coating using CS-AA feedstock powder, exhibiting improved microstructure and mechanical properties. The coating showed higher hardness, toughness, and wear resistance compared to traditional coatings.
University of Iowa researchers have successfully tested a technique that stimulates a gene to prevent craniosynostosis, a condition causing infants' skulls to close prematurely. The treatment involved injecting nano-sized packets containing the miR-200a gene into newborn mice, allowing their brains to expand and preventing skull fusion.
A large-scale study found that people who made successful guesses in a sequence of fair coin tosses rated their chances of further success higher and were more willing to bet on it. In contrast, unlucky guesses led to pessimistic predictions about future performance, with a stronger negative effect than the positive one.
A new study in the American Journal of Preventive Medicine found that two-thirds of women of reproductive age in the US have at least one modifiable risk factor for birth defects. The analysis highlights the need for improved preconception health and identifying and addressing these changeable risk factors before pregnancy.
A new deep-learning model calculates urban heat stress per square meter in the future, considering geodata and weather forecasts. The model simulates a range of climate scenarios, including increased heat stress due to rising greenhouse gas emissions.
Network meta-analysis reveals Qigong and Taichi as most effective exercises for pain alleviation in cancer patients. These mind-body therapies are proven to be more beneficial than conventional exercise and have fewer adverse reactions.
The Institute for Healthier Living Abu Dhabi is sponsoring the 12th Aging Research & Drug Discovery Meeting, a global conference on aging research. IHLAD will present its approach to advancing healthspan through keynotes and strategic briefings.
A new Finnish study reveals that nature experiences play a significant role in people's long-term well-being, particularly in boosting self-acceptance and purpose in life. The research found that younger and older participants alike valued the sense of connection with nature, which helped them tap into their own values and agency.
The EU's Farm to Fork strategy aims to halve the nitrogen surplus by 2030 but calculations show a 10-16% reduction is necessary. Countries like Germany and the Netherlands would need to reduce fertilizer use, while others might see yield losses, impacting food production.
A new research study from Edith Cowan University found that Australian children's picture books are lacking in disability representation. Only one of the 90 analyzed books portrayed a character with a physical disability, and even then, it was only visible as a background character on two pages.
A new Mayo Clinic AI tool, UNISOM, has shown promising results in identifying early signs of clonal hematopoiesis of indeterminate potential (CHIP), a condition that raises the risk of leukemia and heart disease. The tool helps detect CHIP-related mutations in standard genetic datasets, opening new avenues for research and discovery.
The American Thyroid Association has released new guidelines for managing adult patients with differentiated thyroid cancer, emphasizing evidence-based recommendations for diagnosis, treatment, and monitoring. The guidelines highlight the importance of patient-reported outcomes and areas for further research.
People with schizophrenia are more likely to develop chronic obstructive pulmonary disease (COPD) due to shared genetic, socioeconomic, and environmental factors. The lack of adequate medical care also contributes to the under-diagnosis of COPD in this population.
A neural network trained on the World Values Survey predicts an individual's country of origin with 90% accuracy from their attitudes and values. The top predictors include political attitudes, environmental attitudes, family values, and interpersonal relationships.
Lung cancer subtypes differ in metabolic profiles, with metabolomics offering insights into subtype-specific alterations. Metabolomics enables effective subtype differentiation and identification of potential biomarkers for early diagnosis and personalized therapy.
Researchers at Kobe University have discovered a specific set of neurons that direct mice's attention to peers in need and those who are friends. These 'PV interneurons' play a crucial role in modulating social behavior, including empathy and preference for social targets.
A team of microbiologists has mapped the multitude of microbes present in mine water, influencing its chemistry and impact on geothermal energy capture. Understanding microbial activity is crucial for designing efficient and resilient geothermal systems.
Researchers found that pygmy seahorses lose genes responsible for normal nose growth, resulting in short snouts. They also discover a loss of immune genes due to adaptation to coral toxins, allowing them to thrive without their full immune system.
The study found a decline in underrepresented in medicine student matriculation into US medical schools following the SCOTUS ruling. This decline was particularly pronounced in states without pre-existing state-level affirmative action bans.
Nancy Brown, American Heart Association CEO, receives Lifetime Achievement Award from World Heart Federation for her visionary leadership and global impact on transforming cardiovascular health. The award recognizes her dedication to improving access to quality healthcare worldwide.
The ISSCR will host its 2028 Annual Meeting in Copenhagen, Denmark, bringing together researchers, clinicians, industry leaders, and policymakers from over 80 countries. The event will support new frontiers in stem cell science and regenerative medicine, fostering global collaboration and discovery of cutting-edge scientific advances.
Researchers have developed a new technology to detect light dark matter particles, which could generate direct evidence of dark matter or rule out broad classes of theories. The detector is designed to capture tiny energy signals from dark matter collisions with atoms, using silicon skipper CCDs to detect single electrons.
Surya is a visual AI model trained on massive amounts of solar data, leveraging NASA's deep scientific expertise in cutting-edge AI models. The system aims to determine the Sun's magnetic field generation and structure, as well as its impact on the heliosphere and geospace.
A new algorithm, bimodularity, breaks the code in network theory by detecting not only which nodes belong together but also how information flows between them. This allows for the identification of bicommunities, where one community sends and another receives information, revealing new organizational structures.
The American College of Cardiology recommends flu, COVID-19, RSV vaccinations and others for adults with heart disease to reduce risks of infection, hospitalization, and death. Vaccination has been shown to be highly effective in reducing these risks, yet only 30% of primary care physicians assess patients' vaccination status.
A new study found that genetic variants in the IL6 gene are associated with a reduced lifetime risk of coronary heart disease, stroke, and peripheral artery disease. These variants also reduce the risk of pneumonia and sepsis, countering fears about impaired immune response.
Individuals with a parent who died from liver disease face more than double the risk of developing alcohol-associated hepatitis. This study highlights the importance of identifying family history as a red flag for early intervention and counseling.
NASA successfully tested the Roman space telescope's solar panel system and its 'visor' mechanism, a novel approach to deployable solar arrays. The test paves the way for future deep space missions that require efficient and reliable power generation.
Dendritic cells, key immune messengers, respond differently to vaccine elements, with some promoting a calm and balanced response and others driving a full immune attack. Researchers have mapped these reactions using cutting-edge methods, revealing the potential for safer and more effective vaccines.
Researchers developed an AI model called DeepMVP that predicts protein modification sites and variant-induced alterations, significantly outperforming previous models. This tool has implications for developing novel therapeutics and studying genetic mutations in diseases like cancer and neurological disorders.
Simpler, physics-based models can generate more accurate predictions than state-of-the-art deep-learning models for certain climate scenarios. However, simple models are more accurate when estimating regional surface temperatures, while deep-learning approaches excel at local rainfall estimation.
The Pennington Biomedical Research Center has opened a new Endocrinology and Diabetes Clinic in Baton Rouge, providing specialized care for patients managing diabetes and endocrine disorders. The clinic is led by Dr. Timothy Gilbert, who brings nearly 20 years of private practice experience to the region.
Concordia researchers develop a faster way to trace how diseases spread indoors by using dynamic modeling and real-time camera- and sensor-based tracking. The tool can simulate the spread of germs for longer periods, allowing for better estimation of infection risk levels.
Researchers have found a strong link between abnormal changes in retinal blood vessels and increased risk of Alzheimer's disease. The study, published in Alzheimer's & Dementia, suggests that routine eye exams could potentially reveal early signs of the condition.
A study of Bennu samples reveals the asteroid reflects light differently at red and blue wavelengths, offering insights into solar system evolution. The findings also enable future research on asteroid navigation and selection.
According to UMass Amherst research, only 16% of US counties offer access to vaginal labor after C-section. Despite the American College of Obstetricians and Gynecologists' guidelines supporting this option, access remains limited due to factors such as hospital availability and provider comfort.
In his new book, Prof. Ludwig Morenz reveals how ancient Egyptian graffiti and rock carvings attest to the emergence of the world's first territorial state in Wadi el Malik. The researchers used digital technologies to analyze images and discovered a 'royal rock art tableau' with multiple rulers linked by their names and animal symbols.
A researcher at MMRI is working on a project to monitor the health of vascularized composite allografts in wounded veterans. He aims to enable more widespread adoption of VCA transplantation by developing technologies to detect rejection early, allowing for modification of immunosuppressive therapies.
A new University of Michigan study found that critically ill patients without health insurance are less likely to receive inter-hospital transfers for treatment, leading to higher mortality rates. Patients with commercial insurance have a significantly lower risk of death compared to those without insurance or with Medicare/Medicaid.
The University of Tennessee is working with several institutions to address health disparities research and enhance AI performance. The projects aim to train participants in using high-performance computing, cloud-based AI applications, and open data tools in medical research and healthcare delivery.
The SFU-Exeter Accelerated Law Program allows students to graduate in six years with a BA from SFU and an LLB from the University of Exeter, qualifying them for legal careers in Canada and the UK. Students benefit from a tuition discount, extensive advising, and professional support.
The American Heart Association's Connected Care program, powered by Cadence, provides remote patient monitoring and clinical support to patients with heart failure. This initiative aims to bridge the gap in care after hospital discharge and improve long-term outcomes.
Honeybees use various strategies to build hives that accommodate different space constraints, including merging cells, tilting borders and layering combs. Researchers observed these adaptations using X-ray microscopy and found that the bees' behavior is intuitive and physics-based.
A new MSU-led study analyzed 38 million US obituaries to examine values people are most remembered for, cultural events' impact on memory, and legacy reflections. Researchers found that tradition and benevolence are the most prevalent personal values in obituaries.