A new study found that MYC amplification in metastatic prostate cancer is associated with reduced tumor immunogenicity, making it harder for the immune system to detect and attack the tumor. This reduction in immunogenicity was linked to poorer progression-free survival outcomes in patients with MYC-amplified tumors.
Aging gut affects memory formation, new study reveals gut microbiome plays a critical role in cognitive decline, but altering gut-brain communication can reverse effects in mice
MIT researchers have developed a new photonic device that efficiently beams light into free space, enabling advanced displays, high-speed optical communications, and larger-scale quantum computers. The device uses an array of microscopic structures to project detailed, full-color images and precisely control quantum bits, paving the wa...
A new material, benzene-phosphonic acid (BPA), enables self-powered operation of smart sensors and wearables. The breakthrough technology reduces fabrication costs and promotes environmental sustainability.
A Weill Cornell Medicine study found that prior exposure to one flu strain can weaken children's ability to mount an effective antibody response against a different strain, a phenomenon known as immune imprinting. This can lead to reduced effectiveness of future vaccines and increased risk of severe illness.
The Global Coral Tech Transfer Project brings together SECORE International, Australian Institute of Marine Science, and FUNDEMAR to share coral breeding techniques and technologies for large-scale restoration. The partnership aims to create a comprehensive toolbox for boosting reef resilience worldwide.
The study's findings reveal the evolution of venom toxins in the golden lancehead, a venom-rich species isolated from its mainland counterparts. The genome sequencing data can inform conservation policies and potentially lead to the development of anticoagulant drugs or blood pressure-lowering treatments.
The partnership aims to demonstrate advanced microgrid capabilities with dynamic boundaries and networked microgrids, enhancing reliability for utility customers. EPB will add 58 megawatt hours of energy storage in five microgrids, providing backup power to over a thousand residential customers and community resources.
The Alliance trial explores the combination of zanubrutinib and sonrotoclax for CLL treatment, aiming to send cancer into remission and allow patients to stop treatment earlier. The study has the potential to be life-changing for patients and their families, reducing the burden of ongoing therapy and improving quality of life.
A team of international researchers led by a UC Santa Barbara graduate student has confirmed a long-standing theory of stellar death by applying the principles of general relativity to a superluminous supernova. The discovery suggests that a magnetar, a rapidly spinning neutron star with a massive magnetic field, powers the supernova, ...
Researchers discovered that the aging gastrointestinal tract produces specific molecules that blunt the activity of a key gut-brain neuronal pathway, leading to age-related cognitive decline. Stimulating specific gut sensory neurons and targeting the vagus nerve can restore youthful cognitive function in old mice, suggesting that brain...
The IP4OS project has launched a practice-oriented capacity-building programme to support Research Performing Organisations in applying IP and Open Science approach to Research Knowledge Valorisation. The programme equips institutions with tools and collaborative structures to translate IP-OS principles into sustainable practice.
A study found that babies who develop severe E. coli infections lack sufficient germ-fighting antibodies, which mothers transfer to their babies. The research suggests that these antibodies protect against infection, and developing a screening test to identify high-risk newborns could prevent severe illnesses.
A new study estimates that older adults with mild cognitive impairment or dementia develop new cardiovascular diagnoses requiring anticoagulant or thrombolytic therapy each year. This finding highlights the need for clinicians and families to weigh the potential benefits and risks of anti-amyloid treatments.
New research reveals that tumor cells in supratentorial ependymomas cluster into distinct neighborhoods, each with a specific role, such as proliferating or invading. Understanding these cell subtypes could help predict treatment response and inform targeted therapies for this aggressive childhood brain cancer.
A Norwegian University of Science and Technology study highlights seafarers' concerns about autonomous ships' technical safety, trust in technology, and crew competence. The researchers aim to ensure safer use of advanced technology and increase seafarers' trust in autonomy by addressing the challenges highlighted by the seafarers.
A new approach, called INSTALL, enables non-toxic DNA integration in multiple human cell types and successfully inserts large genetic payloads in mice, offering a promising solution for genetic therapies. The study's findings have the potential to broaden the applicability of genome editing therapies.
Sildenafil, an active ingredient in Viagra, shows promising effects in treating Leigh syndrome, a rare genetic disorder causing severe neurological and muscular symptoms. The drug improved muscular strength and neurological symptoms in patients, and also reduced metabolic crises.
Researchers created the most comprehensive single-cell atlas of epigenetic changes in the aging mouse brain, revealing how DNA methylation, genome structure, and gene activity change across brain regions and cell types. The atlas has already shown clear epigenetic differences between different age groups and allowed the development of ...
A study from Tulane University found that consuming more ultra-processed foods is linked to lower bone mineral density and a higher risk of hip fractures. The study involved over 160,000 participants and found that even small increases in ultra-processed food intake can increase the risk of hip fractures.
Severe COVID-19 and influenza infections can prime the lungs for cancer development, according to new research. Vaccination, however, largely prevents these changes, suggesting a reduced risk of lung cancer.
A study analyzing 1,158 confirmed mpox cases in adult men from Spain found that people with HIV did not develop more severe forms of the disease. People with HIV more frequently presented with fever and skin lesions, but the disease progression was favourable with no hospitalizations or deaths.
A new approach for welfare states updates policies to prioritize social investments and effectiveness, combining theoretical contributions and comparative studies. The approach aims to generate long-term benefits for individuals and society, with a focus on targeted solutions and systematic monitoring.
Researchers discovered that subtly disrupting cancer cells' protein production triggers a potent antitumor immune response. By targeting the way tumors produce proteins, scientists can render them more susceptible to immune attack, potentially revolutionizing cancer treatment.
A study by the University of Oulu reveals that PXR activation by chemicals like rifampicin can increase SHBG production, influencing testosterone levels and sex hormone availability. The discovery has significant implications for understanding the impact of everyday chemicals on hormonal systems.
Seven scientists from around the world will receive grants to pursue conservation-focused research aimed at strengthening ocean health and communities that depend on it. The fellows' work includes tracing illegal fishing, improving reef restoration, and developing open-source technology to classify nanoplastic pollution.
Patients with type 2 diabetes and brain metastases who used GLP-1 receptor agonists showed a significant reduction in all-cause mortality. The use of these medications was associated with reduced neuroinflammation, preservation of the blood-brain barrier, and lowered oxidative stress and mitochondrial dysfunction.
The study found that wildfire exposure and its socioeconomic consequences were associated with increased psychological distress beyond the burn zone. Integrating mental health care, housing stability, and economic recovery are crucial for disaster response and climate resilience strategies.
Researchers from the University of Kansas used motion capture technology to analyze shooting mechanics, finding that greater flexibility in the preparatory phase is crucial for accuracy. The study's findings will be used to attempt a new world record for most consecutive made three-point shots.
AI chatbots are homogenizing human expression and thought, reducing collective wisdom and adaptability, researchers argue. Incorporating real-world diversity into LLM training sets can help preserve human cognitive diversity and improve chatbots' reasoning abilities.
Vision sensing systems are crucial for intelligent driving, providing critical road condition data and supporting autonomous driving functions. However, automotive-grade cameras face technical challenges such as limited dynamic range, low light performance, and image processing limitations. To address these challenges, researchers prop...
Researchers discovered that bumble bee queens can survive submersion for over a week by combining underwater gas exchange with anaerobic metabolism. After eight days, their metabolic rate spikes before returning to normal levels, allowing them to survive extreme conditions.
A team of researchers at the University of Chicago has made a groundbreaking discovery in the field of nanocrystals, shedding new light on cation exchange reactions. By applying a cellular automaton model, they were able to demonstrate that a single atom can be replaced with another in a tiny crystal, even as all the atoms remain in or...
A new study published in eNeuro found that people remain engaged with stories even in noisy environments. The research team used fMRI scans to examine brain activity while participants listened to engaging stories in background chatter, revealing distinct neural systems involved in naturalistic speech listening.
Researchers developed a fast, non-invasive, and affordable diagnostic tool using retinal images to differentiate between ALS and Alzheimer's disease. The tool, based on polarized light analysis, accurately predicted disease severity and type with high accuracy.
Researchers at CUNY ASRC have created peptide-based crystalline solids that can switch between soft layered and stiff honeycomb architectures in response to humidity. These dynamic solids exhibit large, controllable changes in mechanical and optical properties, enabling unprecedented adaptability.
A new study found that loneliness and social isolation are independently and jointly associated with subjective cognitive decline in perimenopausal women. The study, published in Menopause, suggests that promoting healthy social connections may help mitigate cognitive deterioration during this time.
Researchers have created the first high-resolution molecular atlas of the adult Drosophila melanogaster brain, uncovering how neurons retain a record of their developmental origins. The study found that the genetic diversity of neurons is far greater than previously thought, and that sex differences arise through selective neuronal sur...
A new study found that people are more likely to place bets during weeks with major sporting events when they believe their friends are doing the same. Researchers say early intervention is key to preventing harmful betting patterns, as it can be associated with depression, anxiety, and increased substance use. The study, led by Univer...
Physicists at the University of Colorado Boulder have demonstrated a new kind of vacuum ultraviolet laser that is 100 to 1,000 times more efficient than existing technologies. The device could enable scientists to observe phenomena currently out of reach, such as following fuel molecules in real time as they undergo combustion, spottin...
Researchers from Michigan Medicine discovered that photoreceptor cell death is reversible and can be rescued by removing damaged mitochondria. The study found that mitophagy, a process that removes dysfunctional mitochondria, plays a crucial role in this recovery process.
A new study from Columbia University Vagelos College of Physicians and Surgeons has found that analyzing the APOL1 gene in Black patients with kidney disease can provide more accurate diagnoses. The study suggests that incorporating M1 into routine APOL1 genetic testing could help doctors determine the true cause of a patient's kidney ...
The University of Cambridge has launched a major strategic partnership with IonQ to develop the UK's most powerful quantum computer, accelerating research and discovery in quantum science and technology. The partnership will support the creation of the IonQ Quantum Innovation Centre, housing a state-of-the-art 256-qubit quantum computer.
The latest issue of Current Pharmaceutical Analysis features advanced analytical characterization and emerging trends in pharmaceutical science. Open access articles can be freely viewed and downloaded on ScienceDirect.
A new experimental rat model reproduces creeping fat in Crohn's disease, characterized by mesocolic adipose tissue hyperplasia with macroscopic, histological, immunological, and molecular similarities to human disease. The model supports the hypothesis that intestinal microbiota contributes to remodelling of mesenteric adipose tissue.
A 16-year study found that 87% of children with single-ventricle heart disease either died or developed a major health problem over time. The study provides new direction for improving care and offers guidance for tailoring therapies to each child.
A study in mice suggests that matcha may reduce the need to sneeze in people with nasal allergies, suppressing brainstem neuronal activation without changing major immune markers. The findings provide a potential, food-based option to complement standard care for allergic rhinitis symptoms.
A UK study found that a 12-week ketogenic metabolic therapy program led to significant reductions in depression and anxiety scores. The program, delivered remotely, showed a 62% reduction in depression symptoms and a 46% reduction in anxiety, with 100% of participants completing the program.
A study published in Environmental Science & Technology reveals distinct roles of NO2 versus NO in β-myrcene photooxidation and their synergistic interactions with SO2. NO2 enhances SOA yield and increases oxygen-to-carbon ratio, while NO suppresses particle nucleation and promotes particle growth.
A new VR app is being developed to tackle violence against women and girls, using virtual reality to raise awareness and educate people about harassment. The app places users in realistic scenarios commonly experienced by women, aiming to educate people about attitudes and behaviours towards women and girls.
Researchers have found magnesium-containing materials to be effective in cognitive improvement and neural regeneration for neurological disorders. These materials, including magnesium oxide nanoparticles and magnesium alloys, have neuroprotective properties and can modulate the gut-brain axis.
Researchers developed hybrid spheroids with biodegradable nanogels to improve stem cell function and survival in injured swallowing muscles. The approach significantly improved muscle regeneration, cell retention, and functional recovery in a rat model.
Research finds that fasting induces accumulation of TCA cycle metabolites in brain lysosomes, suggesting a dynamic metabolic node for coping with fluctuating nutrient availability. This new understanding reframes lysosomes as active contributors to neuronal metabolism.
A joint international research team has identified the core principle by which specific inhibitory neurons in the prefrontal cortex regulate cocaine-seeking behavior. The study revealed that addiction relapse is not due to a decline in brain function, but rather an imbalance in specific neural circuits.
Researchers at SKKU develop hafnium oxide-based ferroelectric transistor arrays for AI hardware, achieving high endurance and precise analog weight control. The devices demonstrated scalable operation and stable synaptic learning behavior, paving the way for next-gen in-memory computing technologies.
A national study published in the Journal of the American College of Surgeons found that breast cancer stage at diagnosis differs sharply across rural US regions, with geographic, racial, and insurance factors influencing stage. The study analyzed data from 52,287 rural women diagnosed with breast cancer between 2004 and 2021, revealin...
A conductive bioglue was developed to ensure firm adhesion and stable electrical signaling within the human body. It overcomes challenges in connecting damaged tissues or attaching bioelectronic devices, promoting muscle and nerve regeneration and stable implant stability.
Researchers at the University of Jyväskylä have developed new synthetic molecules that capture sulfate with exceptional efficiency, rivaling natural protein binding sites. The unique architecture of the molecules, known as
Genethon's GNT0004 gene therapy shows long-term efficacy in patients with Duchenne muscular dystrophy, maintaining clinical efficacy and safety at two years. The trial included 72 boys aged 6-10 with retained walking ability, treated with GNT0004 at a therapeutic dose.
Researchers develop Fourier ptychographic coherence scanning interferometry for high-aspect-ratio micro-trenches, achieving high-resolution 3D topography and lateral resolution beyond the incoherent diffraction limit. The method overcomes challenges of strong optical modulation, enabling robust and accurate measurements.