Researchers propose a strategic framework for STING-targeted therapies, mapping agonists and delivery platforms to distinct tumor microenvironment phenotypes. Acute activation of the cGAS-STING pathway promotes antigen presentation and T-cell priming, while chronic activation drives immunosuppression and treatment resistance.
Researchers have achieved strong coupling between light and acoustic vibrations in an optical fiber, enabling quantum information processing. This breakthrough opens a new platform for studying the quantum properties of massive objects.
Insilico Medicine will exhibit its AI-driven drug discovery and anti-aging science at the Abu Dhabi Future Health Summit and the Regenerative Medicine Congress 2026. The company's CEO will participate in panel discussions and deliver a keynote speech on the future of drug discovery and generative AI.
The book examines how interconnected crises affect economic systems, healthcare, and trade, highlighting the consequences of healthcare system disruptions and geopolitical tensions between the US and China. It provides a multidisciplinary perspective on global crises and their human consequences.
The book provides a systematic and evidence-based approach to diagnosing, treating, and managing impacted mandibular third molars. Key findings include the importance of radiological assessment and the use of cone beam computed tomography (CBCT) in preoperative evaluation.
Three US universities, UT, ASU, and Purdue, form the New Nuclear Academic Consortium to tackle the nuclear industry's workforce shortage. The consortium aims to prepare the next generation of graduates to deploy, manage, and scale the new nuclear economy.
Researchers developed bimodal ceramics with nano-Al2O3 particles, achieving high densification and continuous 3D TiC networks. The composite exhibits improved EDM performance, mechanical properties, and electrical conductivity, offering a robust framework for advanced conductive ceramics.
A study at Heidelberg University found that brief mindfulness exercises at the beginning of psychotherapy sessions can significantly reduce psychological symptoms in adolescents. The researchers also observed a greater improvement in the therapeutic alliance with mindfulness interventions.
The Phase 1b FURTHER trial revealed that firmonertinib achieved durable antitumor activity in patients with EGFR PACC-mutated non-small cell lung cancer, with 43% and 68% objective response rates at 160mg and 240mg daily doses, respectively. Patients with complete clearance of EGFR PACC mutations from their blood experienced higher res...
Researchers examine how composition and processing shape MAB phase behavior, exploring routes from layered ceramics to 2D borides with various mechanical and functional properties. Computational studies identify candidate material systems, while treatments like etching and dealloying create distinct materials with unique properties.
Researchers have developed flexible Mo2TiC2Tx/TaS2 van der Waals heterostructure films that can detect temperature and pressure simultaneously, while also exhibiting electromagnetic shielding capabilities. The films offer a potential solution for wearable devices that require health monitoring and electromagnetic protection.
Researchers explore programmable DNA nanostructures to break the cycle of oxidative stress and inflammation in oral diseases. The review highlights tetrahedral framework nucleic acids as a promising therapeutic platform for oral tissue regeneration.
A recent trial comparing total intravenous anaesthesia (TIVA) and volatile anaesthetic gases found no meaningful difference in patient recovery, including rates of complications and quality of life. However, patients who received TIVA reported lower rates of early postoperative discomfort.
A new study designs an informed consent framework for AI-related clinical trials, highlighting the need for transparency and disclosure. Meanwhile, a Canadian physician-led campaign supports the Safe Social Media Act, aiming to protect children's mental health. Additionally, a promising autonomous oxygenation device shows promise in re...
A new University of Melbourne-led study suggests that reducing battery sizes, extending lifetimes, and promoting shared mobility can help reduce predicted global carbon dioxide-equivalent LIB emissions to around half by 2050. Cleaner production methods, such as switching battery chemistries and greener factories, are also essential, bu...
A new framework, DeepMoCo, uses Graph Neural Networks to correct motion artifacts in in vivo imaging, achieving both global alignment and local deformation recovery simultaneously. This enables high-fidelity monitoring of brain activity in freely behaving animals.
Researchers developed a method to observe antibody interactions with cancer-related proteins on tiny vesicles, showing that protein presence doesn't guarantee accessibility to antibodies. This approach can distinguish between stable and fleeting interactions, providing a new way to investigate differences between individual cancer-deri...
A study analyzing data from 16,296 adults affected by the 2024 Noto Peninsula Earthquake found that greater loneliness was associated with higher odds of serious psychological distress, while a stronger sense of purpose in life was linked to lower odds. The research highlights the importance of considering loneliness and purpose in lif...
Higher CO2 levels alter wheat protein composition, affecting baking quality and potentially tolerability. The study highlights the need to breed wheat cultivars with high baking quality under rising CO2 concentrations.
Recent studies published in The Journal of Nuclear Medicine investigate novel radiohybrid ligands for prostate cancer therapy, AI models predicting prostate cancer survival, and PET tracers for meningioma treatment. These advancements show promise for personalized medicine and improved patient outcomes.
Dr. Katz, a renowned expert in traumatic brain injury and neurorehabilitation, has been honored with the Gold Key award from the American Congress of Rehabilitation Medicine for his groundbreaking contributions to the field. With over 35 years of experience as a medical director of the Brain Injury Program, he has established himself a...
The European XFEL researchers created X-ray flashes with record intensity and fluence, enabling detailed studies of electron behavior in atoms and molecules. The pulses lasted an estimated 300 attoseconds and were focused to a tiny spot, allowing for controlled electron behavior in chemical reactions.
A consensus statement has been reached on the recognition, diagnosis, and management of traumatic brain injury in first responders. The guidelines emphasize shared organizational responsibility, supportive reporting processes, and occupation-specific return to duty progression to improve recovery outcomes and reduce stigma.
A new UVA study finds that Black children are more likely to develop severe asthma due to harmful inflammation, regardless of environmental factors. The research suggests tailored treatments for Black children with severe symptoms, and testing for high levels of T2 inflammation in all children with difficult-to-treat asthma.
FAU's College of Education has received a $1.2M grant to expand access to family-centered mental health services for children and teens with intellectual and developmental disabilities. The OWLS-FLY program will provide free counseling and family support to children ages 6-17 and their families.
Researchers used ancient biomarker evidence to improve climate models and estimate the extent of winter sea ice cover in the Arctic. The study found that winter sea ice loss may be underestimated, with implications for UK and Europe's winter conditions, and potentially underpredicted snowfall and rainfall in certain regions.
A new approach to lensless microscopy uses near-infrared light to recover detail in thick, scattering tissues, outperforming traditional visible-range methods. The study achieved high-quality images of uncleared mouse liver and brain sections, revealing internal structures previously obscured by scattering.
Researchers at the University of Konstanz have developed a microscopic machine that extracts work from information, even when hidden dynamics are inaccessible. By exploiting temporal correlations and environmental memory, the demon can harness energy from degrees of freedom that remain unknown to direct observation.
Researchers developed a framework to detect abnormal lung sounds in children using smartphones, achieving high accuracy and outperforming traditional methods. The framework can provide an assistive tool for home-based respiratory screening, improving remote clinic consultations and community healthcare.
Research using the ABCD Study data found regional differences in brain volume and diffusion tensor imaging among late preterm birth children compared to full-term birth children. DTI measures showed group effects in selected white matter and cortical regions, with longitudinal differences in brain development.
Researchers found that prenatal psychotherapy can change infant brain structure and is linked to lower negative emotionality in early infancy. The study provides some of the strongest evidence to date that maternal mental health during pregnancy can have intergenerational effects on child development.
Researchers systematically summarize how epigenetic modifications and metabolic reprogramming interact to drive hepatocellular carcinoma. The review highlights the epigenetic-metabolism axis as a promising therapeutic target and offers new insights for treatment.
Researchers developed a way to connect artificial sensors with biological neural systems, using brain organoids to decode Braille marks with 83% accuracy. The team found that teams of three organoids performed better than one, but the reason is still unclear.
Cog, a new journal published by AAAS and SJTU, aims to bridge neuroscience, psychology, and artificial intelligence to understand cognition, emotion, and behavior. The journal welcomes interdisciplinary research with clear mechanistic insights and encourages studies bridging fundamental discovery and translational applications.
A recent study developed a multi-objective optimization model to improve healthcare resource allocation during complex health crises. The model considers healthcare worker infection risks and uncertain medical demand, enabling decision-makers to adjust deployment strategies as conditions change.
Dogs can extract directional social cues from human movement, responding more to human walkers than other dogs. The study, published in Cognitive Science Research, suggests that domestication may have shaped dogs' social perception, allowing them to recognize human direction without explicit training.
Researchers at IPC PAS have developed methods to transform lignin-derived molecules into compounds relevant to pharmaceutical research at room temperature and atmospheric pressure. The techniques use light and ultrasound to activate the catalyst, generating energy locally without exposing the system to extreme heat.
Researchers found that rutin significantly improved walking, balance-beam, and rotating-rod performance in rats exposed to acrylamide. Rutin preserved Purkinje neuron structure, boosted antioxidant capacity, and activated the PI3K/AKT molecular pathway.
Japan's unique approach to AI governance, focusing on promotion rather than regulation, has led to high adoption rates and increased use of generative AI. However, a gap remains between large and small firms in actual deployment, and self-assessed transformation maturity, highlighting the need for organizational change and coordination.
A new study from UC Davis reveals that TRPV1 responds differently to various triggers, stabilizing distinct open states with unique functional properties. This finding could lead to more targeted pain treatments, as previous attempts have caused unwanted side effects.
The study of two Magnoliales species, Myristica fragrans and Cananga odorata, reveals insights into the genomic basis of holocentric transition. The research team assembled chromosome-level genomes and compared them using integrated multi-omics analyses, identifying structural and functional differences between the holocentric and mono...
Researchers developed an AI tool that analyzes genetic data to identify risk factors for stroke, which can lead to personalized risk assessments and targeted prevention strategies. The tool was more accurate than previous genetic risk tools in distinguishing people who had suffered a stroke from those who had not.
Researchers compared three mRNA-LNP vaccine platforms in human blood samples, revealing differences in mRNA and lipid component stability. The study provides clues for making vaccines more stable and efficient, potentially leading to lower doses and fewer side effects.
A PhD student at the University of Sydney has developed the first comprehensive classification system and map of Martian soils, grouping them into 10 major realms, 100 assemblages and 2000 detailed forms. The map shows the distribution of different soil types across 92% of the Martian surface, highlighting promising locations for futur...
Researchers developed a tool to analyze gene regulation, revealing new insights into biological variability and potential for genetic medicines. The tool, called FIRE, uses machine learning to identify regions crucial for gene function, suggesting new therapeutic targets for hereditary diseases.
A research team at DGIST has developed a self-cooling film material that utilizes airborne moisture to cool electronic devices, stably reducing surface temperature by up to 18.2°C. The material addresses limitations of conventional passive cooling materials, including corrosiveness and insufficient flexibility and adhesion.
Early assessment with 68Ga-HER2 PET/CT during neoadjuvant therapy can predict pathologic complete response in patients with HER2-positive breast cancer, with a 85% success rate for those with tumor uptake decrease of at least 61%. This finding has implications for timely consideration of alternative treatment strategies or surgery.
A research team led by KAIST proposes a definition of the Anthropocene, using 1952 as a starting point, to better understand human impact on the environment. The proposed framework aims to establish a consistent understanding of the Anthropocene across disciplines.
The 2027 SLAS Graduate Education Fellowship Grant provides up to $50,000 per year for two years to support graduate students pursuing research in life sciences. Eligible applicants must be enrolled in a graduate degree program related to high-throughput screening, quantitative biosciences, and/or drug discovery.
A new genetic study reveals that Native Hawaiians originated from Easter Island, with a 7,000km journey in the Middle Ages. The study identifies strong genetic bottlenecks among Native Hawaiians, which can have significant implications for precision medicine and disease risks.
A new treatment using drug-coated balloons performed just as well as conventional stents in preventing heart attacks and cardiovascular deaths. However, patients treated with drug-coated balloons were more likely to need a repeat procedure in larger arteries.
African genomes show nearly a million more genetic variants than non-African genomes, holding the key to precision medicine and global health equity. Research into African genomics could develop treatments for inherited diseases and improve diagnoses.
Researchers found that when humans receive feedback and explanations, they can outperform the better partner alone. The study highlights the importance of human learning in human–AI teams and suggests a paradigm shift in human–AI interaction research.
A molecular atlas of exercise-associated changes in mice reveals distinct responses to exercise varying by tissue, cell type, sex, and circadian phases. The atlas provides a comprehensive resource for understanding systemic molecular adaptations to endurance exercise, enabling the development of personalized exercise strategies.
Researchers at the University of Pennsylvania have developed a platform that allows opioid activity to be turned on or off with the flick of a light switch, paving the way for bypassing opioid addiction and other adverse side effects. The compound, AM-3, activates painkilling effect only where needed, allowing substantial pain relief w...
Chemists at Emory University have developed a way to significantly improve the performance of hybrid LEDs made with perovskite, achieving rates of up to 40% quantum efficiency. The breakthrough, published in Nature, could hold potential for biomedical sensing, low-light imaging, and automated facial recognition.
University of Michigan researchers discovered that oxalis, a weed commonly known as wood sorrel, produces more flowers after being exposed to low doses of the herbicide dicamba. The finding suggests that farmers and homeowners may inadvertently make weeds stronger by using herbicides on their fields or lawns.
A new study reveals how a plant's internal clock helps it respond to salt stress by triggering protective genes. Researchers found that a clock protein clusters into droplets, freeing protective genes, and that tuning crop clocks can improve stress tolerance. This discovery opens novel ways to breed more resilient crops.
A new study characterizes the use of OpenEvidence, the most widely used AI-powered clinical platform in the US, among 952,000 clinicians. Most queries were related to treatment and management decisions, with frequent requests for information outside primary specialties.
Research estimates that 25.7% of active-duty male Army personnel have a morning testosterone measurement below 300 ng/dL, and 14.7% below 264 ng/dL. Low testosterone levels are more common among older men and those with higher BMI.