Researchers have successfully restored the function of neurons linked to cognitive function and information processing in mice with Alzheimer's disease, a breakthrough that could lead to the development of a targeted therapy. The study, published in Neuron, reveals that manipulating parvalbumin interneurons can increase gamma oscillati...
JAMA AI will publish research on AI capabilities, clinical applications, and evaluation of their safety and effectiveness. The journal will focus on generative and agentic AI, clinical decision support, and AI-enabled diagnostics and therapeutics.
A new USDA-funded research project at Binghamton University's Pasture and Lawn Enhanced Diversity Global-change Experiment (PLEDGE) site investigates the effects of short-term drought on lawns. The study aims to improve water and fertilizer management, considering the growing concern of climate change and its impact on lawns.
NYU researchers have developed an AI tool to piece together broken archaeological fragments, allowing archaeologists to reconstruct fragments and gain new insights into past cultures. The project aims to improve the efficiency of refitting, a process that is currently slow and labor-intensive, and will enable researchers to analyze mor...
A study of over 3.3 million patient records found three genes (CYP2C19, SLCO1B1, and CYP2C9) covering medication exposure in at least 98% of records. This provides a basis for targeted genetic testing to support personalized medication management.
Researchers at Mount Sinai will test a community-based primary care model to address high blood pressure in rural Ghana. The approach aims to provide care through community health workers and nurses, with a 90% success rate in a pilot study.
UT MD Anderson Cancer Center has made significant advancements in cancer care, including the development of a covalent Werner helicase inhibitor, which showed promising antitumor efficacy in a Phase 1 trial. Additionally, a multicenter clinical trial found that tile-based radiation therapy improved tumor control and lowered the risk of...
A new study by University at Buffalo researchers found that delivering fresh produce directly to participants' homes significantly increased redemption rates, reaching nearly 90%. The study also found that adding meal kits to the program did not improve produce use, but provided additional food security benefits.
A new study at UT Arlington uses AI to reduce radiation exposure in heart scans without sacrificing diagnostic accuracy. The project, led by Mingwu Jin, aims to substantially lower radiation doses using deep learning-based reconstruction methods.
Dr. LaBelle leads the pediatric cancer and blood diseases program at the Chicagoland Children's Health Alliance and UChicago Medicine, expanding clinical trials and integration of services. He brings expertise in stem cell transplant, cellular therapies, and cancer immunology to improve outcomes for children with cancer and sickle cell...
Researchers at Aarhus University discovered how plants use a receptor called CHIP13 to detect long chitin chains associated with fungal attacks, while another receptor CERK6 is necessary for passing on signals to the plant's immune system. This complex system allows plants to recognize and respond to different microbial signals.
A new study of 50 bird and bat species found that once atmospheric conditions are accounted for, flying can be the cheapest form of travel. The study, published in Science, showed that birds that ride rising currents and soar can significantly reduce their energy bill, making flying cheaper than swimming. This new framework offers a ke...
A team of researchers found that immune cells can both attack and protect cells needed to rebuild tissue, highlighting the delicate balance of immune cells in tissue regeneration. Regulatory T cells protected the bone-making cells from attack by other immune cells, while CD4+ T cells inhibited regeneration.
A recent study found that paid family and medical leave policies are widely available but inconsistently implemented across US academic radiology and radiation oncology departments. Most programs require faculty to use vacation or sick time with variable allowance, and few employees utilized leave in the previous year.
Researchers analyzed data from 461,682 adults and found no association between overall ultra-processed food intake and colorectal cancer incidence, but found associations with whole grains and dairy products, and a 2% lower incidence with replacing 10% of UPF intake with minimally processed foods
A global survey using satellite observations of 15,000 ice cliffs provides new evidence to evaluate the Marine Ice-Cliff Instability theory, which proposes that extremely tall ice cliffs can become structurally unstable and trigger rapid ice loss. The study suggests that ice-sheet models may underestimate how quickly tall ice cliffs ca...
Southern right whales were tracked from New Zealand to Australia, finding that different routes, with varying travel times, allowed them to reach feeding grounds simultaneously.
Tall ice cliffs in Antarctica and Greenland calve more quickly than thought, with the likelihood of catastrophic ice retreat being limited by gradual changes in ice thickness. Researchers found that cliffs in areas with rapidly flowing glaciers tend to be taller and more prone to calving.
Researchers analyzed 17 years of GPS and acceleration data from 850 animals to find that atmospheric conditions play a crucial role in reducing energy costs of flight, with soaring birds experiencing minimal energy expenditure. The study challenges traditional views on flight energetic costs, suggesting that atmospheric conditions shou...
Researchers introduced RFdiffusion3, a generative AI system that designs proteins and nucleic acids at the atomic level, enabling precise control over molecular interactions. The tool outperforms previous approaches in designing protein structures and organizing catalytic sites, producing functional enzymes from scratch.
Researchers at FSU used ultrahigh-resolution mass spectrometry to identify molecular fingerprints of human activity in water systems worldwide. The study reveals changes in dissolved organic matter composition can diagnose human impacts on aquatic environments.
A study from Tufts University found that exposure to hormone-disrupting chemicals may alter normal breast development, leading to molecular changes that could increase breast cancer risk. The study used 3D organoid models of breast tissue to simulate the effects of different chemicals on breast development.
Caltech-led researchers create a deep-learning model that can predict irreversible shifts in climate and other systems, known as tipping points. The model, called a recurrent neural operator (RNO), uses a built-in memory to track changes in physics and detect when predictions no longer make sense, indicating a tipping point is imminent.
Researchers at Ohio State University have discovered a method to strengthen metal alloys by organizing defects in dense networks, resulting in increased stress resistance and resistance to warping at high temperatures. This approach could complement conventional materials design and pave the way for richer design principles in engineer...
Upstate Medical University has been awarded $1.5 million to create an advanced research center for brain diseases, including Alzheimer's, Parkinson's, and stroke, as part of the SUNY Brain Institute. The center will integrate biospecimens, induced pluripotent stem cells, and organoid models to support human-centered neuroscience research.
A new study found significant disparities in access to anti-amyloid Alzheimer's treatments, with Black adults and Hispanic adults having lower odds of receiving the medication. However, once treatment began, patients were equally likely to take the medication as prescribed, regardless of their race or ethnicity.
Researchers have identified genetic differences between humans and chimpanzees that affect gene activity, shedding light on human evolution and degenerative skeletal diseases. The study suggests humans evolved to have lower levels of molecules that help cartilage retain water and withstand pressure, potentially contributing to conditio...
A Michigan State University study found that anger can motivate political activism, but only if people believe they can effect change. Those who felt powerless due to their anger were less likely to vote. The study suggests that campaigns should focus on offering concrete ways for people to act, rather than relying on extreme anger to ...
A new study found that contact with natural environments positively influences intuitive eating habits, with pathways involving body appreciation and self-compassion being key. The research suggests that nature exposure can promote healthier eating behaviors, particularly when combined with greater self-awareness and emotional regulation.
Researchers at the Stowers Institute for Medical Research have discovered that cell division plays a crucial role in reshaping tissues, allowing them to maintain their structure despite constant cell growth. By studying epithelial tissues, including the intestinal lining, the team found that cell division triggers a coordinated series ...
Researchers at McMaster University discovered that a naturally occurring protein, interferon lambda, helps control viral infections, lowers inflammatory molecules, and strengthens immune responses. The protein appears to strike a balance between fighting viruses and reducing inflammation, offering a promising approach to future therapies.
In a breakthrough, scientists discovered that Alzheimer's disease disrupts the brain's pacemaker cells, causing gamma oscillations to falter. By boosting levels of a specific protein, researchers were able to restore normal brain rhythms and improve cognitive function, offering a promising therapeutic target for the disease.
A large-scale study has developed a comprehensive method for detecting DNA mutations across the human genome, improving the detection of somatic mutations in noncancerous tissues. The analysis of over 90 trillion DNA letters revealed significant increases in the detection of large DNA changes using long-read sequencing, which also unco...
A Rutgers study of 7,810 adults found that knowing someone who died by firearm suicide increases recognition of suicide risk but doesn't necessarily lead to more secure storage. Firearm owners who experienced a loss due to firearm suicide are more likely to store their firearms both unlocked and loaded.
A new study found evidence of identical genetic changes in multiple lineages separated by over 600 million years, suggesting adaptive molecular convergence is more common than previously thought. The study suggests a complex relationship between genetic and phenotypic convergence, with genetic similarities not always predicting physica...
Researchers have developed a new method to deliver disease-fighting antibodies directly to the brain, using extracellular vesicles to bypass the blood-brain barrier. This approach shows potential in treating neurodegenerative diseases such as Alzheimer's, Parkinson's, and ALS, by improving the elimination of pathological proteins.
Emerging market dilution theory proposes AI-generated content could undermine entire markets for human-created works, but experts argue it oversimplifies human-AI creativity relationships. The authors suggest clarification through collaboration, data, and surveys to evaluate AI's impact on creative markets.
Researchers analyzed 15,000 ice cliffs over 4 years, finding cliffs that collapsed did so faster than predicted, but quickly stabilized, contradicting a key glacial science model. Thicker mélange and deeper water also stabilized cliffs, suggesting a more complex system than previously thought.
Researchers at the Hubrecht Institute discovered that chemical signals oscillate at different rhythms in different cells of the small intestine. Altering the frequency of these oscillations changes the balance of cell types that form, which may improve our understanding of tissue maintenance and disrupted signaling dynamics contributin...
Researchers developed a modular fabrication method to convert individual atomic layers of a 2D crystal into semiconducting, insulating, and semimetallic regions. This approach achieved highly efficient switching and improved electrical contacts, enabling the creation of complete high-performance transistors.
Researchers at Drexel University analyzed data from four Philadelphia watersheds, finding that dissolved oxygen levels fluctuate with temperature, flow volume, and microorganisms. The study highlights the need to understand how different watersheds respond to sewage overflows to mitigate their negative effects on ecosystems.
Children and young people are broadly supportive of using health data for research, but want strong safeguards, transparency, and greater involvement in data use decisions. They are concerned about data loss, misuse, and lack of trust, especially with private companies involved.
Researchers developed a novel composite hydrogel film with controlled release of antioxidant phycocyanin, showing strong antibacterial activity and remarkable antioxidant capacity. The film's structure and release mechanism were optimized for sustained release and bioactivity retention.
Researchers at Kyoto University developed a new super ductile steel alloy that achieves both high strength and flexibility through sequential activation of strengthening mechanisms. The alloy has exceptional uniform elongation of nearly 140 percent, delaying strain localization over a large strain range.
The study analyzed data from 4,258,033 adults and found that different obesity indices, such as the Chinese visceral adiposity index (CVAI) and triglyceride-glucose index (TyG), can identify risks for major chronic diseases like cardiovascular disease and diabetes more accurately than BMI alone. However, these measures have limited abi...
Researchers found silicate melts can store substantial excess oxygen, which could have oxidized the shallow mantle, crust, and atmosphere. The study proposes a possible pathway linking Earth's deep interior to its oxygen-rich surface and atmosphere.
In a groundbreaking study, researchers found that the immune system of mice relies on continuous signals from their gut microbiota to maintain immune competence after weaning. This discovery redefines postnatal immune maturation, highlighting the crucial role of microbiota in shaping the immune system.
Researchers at RIKEN have developed a scalable protocol to mitigate control errors in silicon spin qubits, enabling high-fidelity control of multiple qubits. This breakthrough paves the way for the creation of larger quantum processors capable of complex computations.
Researchers found that naming a chicken and its individual characteristics can reduce children's willingness to eat poultry, promoting empathy and environmental sustainability. However, the effect only applies to children with moderate meat interest and not to pork meat or those who strongly like meat.
Umbilical cord blood's diverse components, including T cells and regulatory T cells, offer therapeutic strategies for cancer and immune disorders. Researchers explore ways to expand and engineer immune cells, as well as tune immune responses to reduce inflammation and graft-versus-host disease.
New research found that positive childhood experiences, such as supportive friendships and relationships, are linked to better mental health in early adulthood. The study suggests that these experiences provide additional protection for mental health, alongside other influences, and may be more important than previously thought.
This book examines the nutritional value and health benefits of Brassica vegetables, including their bioactive compounds such as glucosinolates, phenolics, and carotenoids. It discusses their potential benefits for human health and disease prevention, as well as their use as functional foods.
Researchers propose a novel self-supervised reconstruction framework for single-pixel imaging that decouples measurement and reconstruction resolution. This enables high-pixel-resolution imaging from low-dimensional measurements, overcoming resolution limitations in conventional single-pixel imaging.
Biosensor technology is being explored for neurological diagnosis, monitoring, and personalized care. Advances in biosensors and biomarker research are creating new opportunities for effective detection, monitoring, and understanding of neurological disorders.
Elke Deuerling's research project investigates whether age-related changes in protein synthesis contribute to neurodegenerative diseases like Alzheimer's and Parkinson's. By targeting the process of protein synthesis, her team aims to prevent the formation of toxic proteins that can lead to disease progression.
A decade-long study in California has found that select earthquake forecasting models can consistently describe patterns of earthquake activity over the following day. The study provides strong evidence for the use of these models in public operational forecasting systems, potentially improving disaster preparedness for millions.
Researchers designed a new lipid recipe that improves mRNA delivery precision, reducing liver accumulation and improving local expression. The new formulation, SM102M, showed strong local expression while sharply reducing liver expression in mice, and maintained delivery over repeated doses.
Steffen Mau recognized for his sociological research on social inequality, welfare state, Europeanisation, and digitalisation. His work combines empirical data, historical context, and sociological theory to understand societal transformation and its impact on politics and democracy.
A new control theory framework introduces a mathematical framework for understanding aging and guiding the development of therapies. The framework prioritizes maintaining or recovering acceptable physiological function, rather than targeting every molecular feature to a youthful state.
A study by Ruhr University Bochum finds that exchange rates react to protectionist measures, with countries heavily reliant on US exports seeing their currencies devalue. Emerging markets are disproportionately affected, but some nations have more resilient financial markets and currency reserves.