The Kraft Prize for Excellence and Innovation in Community Health recognizes organizations driving measurable improvements in community health. The prize recipient will receive $100,000 and tailored support from the Kraft Center.
A review of 300 peer-reviewed studies found roadkill being used to map species distributions, monitor disease and environmental pollution, study diets, track invasive species, supply museum collections, and discover new species. This approach offers ethical advantages by avoiding live capture and handling.
The new platform developed by UVA Health scientists can produce vaccines much faster, cheaper, and more easily than traditional approaches. The platform's proof-of-concept demonstrates its ability to produce highly immunogenic vaccines that can be manufactured at extremely low cost.
A new study suggests an experimental peptide, TXM-CB3, reduces recurring seizures and protects brain function in preclinical studies. Early treatment with the peptide shows significant benefits in reducing seizure activity and improving cognitive function.
Lipid droplets regulate diverse cellular processes in cancer, including membrane biosynthesis and metabolic homeostasis. Targeting lipid metabolism may disrupt tumor survival and counteract immune cell-mediated protumorigenic effects.
ABCA–ABCG transporters play a crucial role in biliary secretion, with mutations leading to various hepatobiliary disorders. Next-generation genetic testing enables tailored management, while emerging therapies hold promise for cholestatic diseases. Genetic counseling is recommended for family planning and risk assessment.
A new system integrates terahertz spectroscopy with deep learning to accurately image, detect, and classify explosives. It achieved a remarkable average classification accuracy of 99.42% at the pixel level for exposed samples.
The Society for Laboratory Automation and Screening (SLAS) has developed a comprehensive framework to educate scientists on laboratory automation, addressing the growing gap between technology adoption and training pathways. The project aims to create shared standards for automation education, expanding access to training across instit...
A new rapid test using a mobile phone has been developed to identify the most severe cases of imported malaria within minutes. The test uses video analysis and two biomarkers to predict which patients are at risk of developing severe disease.
A study found that serum interleukin-8 (IL-8) levels can differentiate invasive pulmonary aspergillosis from bacterial pneumonia in patients with HBV-associated acute-on-chronic liver failure. IL-6 levels were significantly higher in IPA patients compared to non-infection controls.
The 'Desire on the Couch' exhibition examines how sexuality has been measured, medicalized, and experienced over a century. The show features rare archival materials and letters from key figures in the field.
A randomized, open-label trial evaluated an unmedicated acne-concealing hydrogel patch on appearance and psychological impact. The treatment group experienced significant reductions in lesion size and severity, as well as improved quality of life scores.
A study published in NeuroImage found that even a short afternoon nap can reorganize connections between nerve cells, improving the brain's capacity to encode new information. This 'synaptic reset' helps relieve mental fatigue and prepare the brain for learning.
Research shows that bitter taste receptors can be activated by steroid hormones, influencing physiological processes. The study found that certain hormone types, like progesterone and testosterone, activate these receptors, which may play a role in pregnancy-related taste changes or stress-induced physiological responses.
A study found that the TF-rs1049296 C>T variant is associated with a higher risk of significant liver fibrosis in patients with MASLD, particularly in those with RES iron deposition. The variant was also linked to increased risk of SF in mixed hepatocellular/RES iron deposition patterns.
Scientists discover a new method to engineer crystalline materials with exceptionally low thermal conductivity by alloying YbN into AlN. This innovation has the potential to revolutionize industries such as semiconductor packaging and chemical reactors.
The Watson College Seed Grant Program supports six projects that aim to tackle pressing scientific challenges. Projects include developing a world-first quantum computing platform, creating microprinting technology for soft neural interfaces, and designing autonomous AI agents with verifiable physical reality.
Researchers identified statins as a potential booster for cancer immunotherapy by preventing the release of PD-L1-containing sEVs. Statin treatment suppressed UBL3 modification, reduced PD-L1 sorting into sEVs, and improved survival outcomes in lung cancer patients.
Researchers have developed a passive, solar-powered orbital data center that can scale AI computing and reduce environmental impact. The system leverages decades of research on 'tethers' and could host thousands of computing nodes to replicate terrestrial data centers.
A team of researchers from Chiba University discovered the structural evolution of poloxamer mixtures at different temperatures, enabling customized gelation behavior. Their findings support precise design of sustained-release formulations for localized therapies, enhancing drug retention and minimizing side effects.
A recent study analyzed data from the Coronary Artery Risk Development in Young Adults (CARDIA) study and found that men developed coronary heart disease 10 years before women. The study indicates that this sex gap remains, with men having a higher cumulative incidence of cardiovascular disease and its subtypes.
A new study found that fecal microbiota transplantation can enhance the effectiveness of immunotherapy in patients with advanced metastatic renal cell carcinoma. The research showed improved clinical outcomes, including longer progression-free survival and higher response rates, in patients who received donor-derived fecal microbiota t...
Middle-aged and older adults who were more active in the evenings had poorer cardiovascular health compared to their peers who were more active during the day. This study, published in the Journal of the American Heart Association, found that evening chronotypes are associated with behaviors that can affect cardiovascular health, such ...
The world's forests are becoming homogenized, with fast-growing tree species dominating landscapes. Biodiversity is declining as slow-growing, specialized species disappear, compromising ecosystem stability and carbon storage. Active ecosystem management is essential to halt the loss of these threatened species.
Researchers developed an innovative centrifugal system called SpinEx that separates plasma, enriches EVs, and labels proteins in one device. The technology enables fast and automated EV isolation from small blood volumes, accurately distinguishing cancer from non-cancer samples and identifying specific tumor types.
A new American Heart Association scientific statement highlights the importance of aggressive blood pressure control, early recognition of stroke symptoms, and prompt treatment for pregnant and postpartum women. Controlling blood pressure before and after delivery can help save lives and improve outcomes for mothers and their babies.
A study published in the New England Journal of Medicine found that children whose parents were injured by firearms experience substantial mental health impacts, with a 42% increase in psychiatric diagnoses and 60% increase in mental health visits. Early, targeted interventions are needed to address this growing need.
A clinical trial has shown that a novel cooled laser focal therapy device can effectively treat prostate cancer with minimal side effects. The treatment provided similar cancer-related outcomes to traditional methods but with an improved safety profile and low rates of incontinence.
The report projects a significant increase in dementia cases across Europe by 2050, with estimated numbers rising to 14.3 million in the EU27 and 19.9 million in EU and non-EU countries combined. Alzheimer Europe urges decision-makers to prioritize dementia research, healthcare infrastructure, and support for families and carers.
A study analyzing data from Berlin's Flora Protection Program found that biological threats, especially from highly competitive native species, pose a greater threat to urban biodiversity than non-native species. Threats related to agriculture, nutrient inputs, and urban development are also significant drivers of decline.
A study found that TikTok influences dietary habits by leveraging algorithmic mechanisms, entertainment content, and users' emotional connections. The platform affects food preferences, dining choices, and recipe evaluations among young people.
A study of 700 teens found that screen time negatively affects sleep quality and beliefs about healthy lifestyles. The researchers suggest reducing screen exposure, increasing social interaction, and promoting alternative activities to promote healthier lifestyles and better sleep.
A new study found that men's coronary heart disease risk begins to diverge from women's in the mid-30s, with differences emerging as early as age 50.5 versus 57.5 years. This suggests that heart disease prevention and screening should start earlier in adulthood for men.
Researchers developed a new framework called SOLVE to overcome data challenges in precision cancer treatment. By jointly modeling known and unknown factors, SOLVE provides a robust tool for biomarker discovery and investigating tumor responses.
A new study based on data from over 17,000 women across 158 countries found inconsistent knowledge of perimenopause symptoms and actual experiences. Commonly recognized symptoms included hot flashes, sleep problems, and weight gain, but women most reported experiencing fatigue, physical and mental exhaustion, and irritability.
A large international study found that patients with long COVID-19 in the US report higher rates of brain fog, depression, and cognitive symptoms compared to those in India and Nigeria. The study suggests that lower stigma and greater access to neurological and mental health care may contribute to these differences.
A four-biomarker blood panel including aminopeptidase N, polymeric immunoglobulin receptor, and thrombospondin-2 has been shown to enhance the detection of pancreatic ductal adenocarcinoma compared to CA19-9 alone. The panel correctly detected 91.9% of pancreatic cancers across all stages.
A global genomics study reveals that genetic variants influence gene activity and protein abundance in multiple tissues, not just blood samples. This analysis identifies causal evidence for 676 genes linked to type 2 diabetes.
The AMALIA project develops a scalable screening platform to identify anti-amyloid therapies, bypassing the challenge of studying amyloid nucleation. This approach enables parallel discovery campaigns on multiple targets, offering unprecedented speed and scalability.
A study published in EBioMedicine found changes in blood samples from almost 1,000 people hospitalized for COVID-19 may pinpoint patients at risk of long-term lung disease. The study identified elevated levels of certain molecules, which could lead to the development of simple blood tests to detect ongoing lung problems.
The NeuroBRIDGE project aims to transform two-photon microscopy for studying neural circuits during natural behaviors. The miniaturized, fibre-optic-based microscope enables high-resolution studies under free-moving conditions.
The CAMP platform enables simultaneous analysis of up to 30 samples, increasing sensitivity by over 50% for rare diseases like hepatoblastoma. This technology facilitates advances towards personalized medicine through deeper and more accurate metabolic analyses.
Researchers found clouds in North Atlantic region formed with fewer, larger droplets, yet remained unchanged in reflectivity; overall water content increased to maintain balance.
A BiVO4 photoanode modified with a highly electronegative fluoride ion shows enhanced adsorption and activation of CH3OH molecules. The formed V–F bond promotes O–H fracture and activates the C–H bond, leading to improved selectivity and efficiency for HCHO production.
A team of researchers has found that a common soil fungus can extract large amounts of residual phosphorus from phosphogypsum, a byproduct of phosphoric acid production. The study shows that more than 40% of the phosphorus locked inside this waste material can be recovered through a biological process.
Researchers found that naturally occurring fungi on and within almond trees can strongly suppress Colletotrichum godetiae, the primary cause of almond anthracnose in the Mediterranean Basin. Several species of Trichoderma and Neurospora intermedia proved effective in suppressing pathogen growth and reducing spore production.
Researchers successfully diagnosed and treated ten PCNSL patients using liquid biopsy, detecting hotspot MYD88 L265P mutations in circulating tumor DNA. This method offers a reliable alternative to surgical biopsies for patients with difficult-to-access lesions or frailty, enabling timely treatment initiation.
The AAVLINK method harnesses Cre/lox-mediated intermolecular DNA recombination to enable efficient full-length gene reconstitution and robust expression of therapeutic genes. This approach overcomes the limited packaging capacity of adeno-associated viruses, offering a strategy for delivering large gene cargoes in gene therapy.
Researchers developed a rapid zebrafish-based functional assay to determine the pathogenicity of novel SMN1 mutations, potentially informing urgent clinical decisions. The test showed that many previously uncertain variants were harmless, reducing distress for families and saving lives.
A new Griffith University study found altered brain connection in people with ME/CFS and Long COVID, leading to cognitive difficulties such as memory problems and slowed thinking. The research used ultra-high field MRI technology to investigate the disruption in brain connectivity during a mentally demanding task.
A new study finds that transcranial magnetic stimulation (TMS) is a cost-effective treatment option for moderate and severe forms of depression. TMS reduces depressive symptoms, eases pressures on informal carers, and helps people get back to work, recovering its costs over time through savings to the NHS.
Research reveals leading US tobacco brands violate Instagram, FTC, and FDA marketing policies to restrict young people's access. Lax/missing age verification, disclosure on brand-influencer relationships, and health warnings are common violations.
Researchers have discovered a neural circuit hidden in an understudied region of the brain plays a critical role in turning temporary pain into chronic pain. Silencing this pathway can prevent or halt chronic pain, offering new hope for treating severe chronic pain with injections or infusions targeting specific brain cells.
Dissociation is a complex survival mechanism in response to overwhelming trauma, affecting memory, identity, and perception. Research confirms its prevalence among individuals who have experienced trauma, and effective dissociation-specific treatment options are needed.
The study found that mania accounts for more than 80% of the genetic variation in bipolar disorder. The researchers identified 71 genetic variants linked specifically to mania, including 18 regions of genes that had never previously been associated with bipolar disorder.
A groundbreaking field-based research study from Nankai University found the average carbon emission of dismantling a single unit of E-waste increased from 1.2513 kgCO2 to 1.3335 kgCO2 between 2013 and 2020, highlighting the urgent need for more efficient recycling technologies.
A new study reveals significant differences in growth patterns between nurse sharks off the coast of Miami and those living just across the Gulf Stream. The research found that juvenile nurse sharks in Biscayne Bay grow more rapidly and reach smaller maximum sizes than their counterparts in Bimini, Bahamas.
Researchers at University of Queensland conducted hearing tests across ocean off Australian coast, finding humpbacks react to higher frequency sounds than expected. The study provides direct evidence humpbacks are highly sensitive to higher frequencies at the upper end of human hearing range.
Recent U.S. policy changes have significant environmental implications, affecting ecosystems and public health. Stanford research projects track the impact of these changes in real-time, from forest management to clean-energy investments and climate migration.
A $4.9 million Gates Foundation grant will support the development of self-cloning crops in India, improving agricultural productivity and accessibility for smallholder farmers. The project aims to expand synthetic apomixis technology into staple crops like pearl millet and Indian mustard.