Researchers found two widely used blood tests accurate in detecting Alzheimer’s pathology in participants with Down syndrome. The tests, Lumipulse G p-tau217 and PrecivityAD2, offer an easier path to diagnosis for this high-risk population.
This open-access publication presents journalism, poetry, fiction, and artwork produced by Indigenous writers and artists on climate change. The book introduces the relational worldview – an Indigenous way of thinking where everything impacts everything else.
Epithelial tissues respond to sustained mechanical stress by slowly reorganising their keratin cytoskeleton, forming supracellular networks that push the cell nucleus out of its protective cage. This process reveals a new mechanism for tissue adaptation and has implications for development and disease understanding.
PeroCycle announces global ambitions to decarbonise steel, cement, and chemicals industries with patented technology. Strategic partnerships with PKU Pioneer and io consulting enable rapid progress for PeroCycle.
Dr. Yi Li receives CPRIT funding to develop treatments for solitary fibrous tumor, a rare cancer driven by gene fusions. Researchers are working on novel therapies, including immunotherapy and antisense oligonucleotides, to reduce cancer-causing signal activity.
Researchers develop synthetic microbial communities to degrade persistent herbicides, improving degradation rates by 1.5-3 times compared to individual strains or natural attenuation. The approach promotes more complete mineralization of pollutants and resilience in complex soil environments.
A randomized controlled trial found that a comprehensive navigation service significantly improved self-reported access to needed resources among primary care patients. The study also highlighted the benefits of this model for Francophone minority populations, particularly in accessing French-language services.
Researchers at UCLA found a statistically significant relationship between cellphone ownership and lower reading scores in third and sixth graders. Children who owned cellphones had poorer comprehension regardless of whether they brought the phone to school or not.
A qualitative study identified four self-care decision-making patterns among adults with multiple cardiometabolic conditions, including past experiences and leveraging resources. Effective self-care behaviors can improve quality of life for these patients, particularly those with type 2 diabetes, coronary heart disease, and stroke.
Health system physicians value financial protections and clinical support teams, while independent physicians prioritize patient continuity and autonomy. The study's findings highlight substantial contrasts between daily practice experiences across the two organizational models.
Patients with long-term relationships to their family physicians may experience fewer urgent hospital admissions and lower hospital costs. This is due to consistently seeing the same general practitioner, which is associated with reduced hospital costs but not fewer urgent admissions.
A retrospective study found patients registered for longer periods had 9-21% lower odds of urgent hospital admission and 17-28% lower costs. Consistently seeing the same general practitioner was associated with 6-7% lower hospital costs but not fewer urgent admissions.
A new program taught family physicians to perform echocardiography using an AI-guided handheld ultrasound device, reducing wait times and costs. The approach, piloted in nine clinics across Spain, estimates annual savings of €70,000 per clinic.
A growing trend of patients turning to AI chatbots for health advice reflects broader healthcare system strain and patient dissatisfaction with traditional care options. Critical care doctor Robert B. Shpiner argues that addressing underlying structural issues is essential to mitigate AI risks.
A theory study identified 12 paradoxes in social care, including whether it promotes equity or stigma and tailoring care to context. The authors proposed three reconciliation strategies to address these tensions and integrate social care into primary care.
A qualitative theory study reveals three themes in how generalist physicians understand their work and role. The 'Way', 'Privilege', and 'Indescribable Whole' capture the essence of generalism as a time-centered, relational approach to patient care.
A three-year research award from Gabrielle’s Angel Foundation will support the study of transcutaneous auricular vagus nerve stimulation (taVNS) to manage chemotherapy-induced peripheral neuropathy symptoms. The goal is to improve quality of life for cancer patients with long-term effects of treatment.
A survey of 314 family medicine residency program directors found that only 44% have written expectations around self-directed learning. Despite this, 93.6% of directors believe recent graduates model lifelong learning, and over half (57.6%) consider self-directed learning a high curricular priority.
A new study reveals that forest structure, tree species evenness, and terrain slope jointly influence how carbon is divided among living vegetation, forest litter, and soil. The research found that soil contained the largest share of total carbon in most locations, while vegetation stored more carbon than soil in several plots.
Researchers found that plants absorb more elements with longer hydrated metal ion distances, suggesting a basic chemical influence on mobility. The metric may help estimate poorly studied contaminants and reduce reliance on complex variables.
A Canadian pilot study examined ways to link dementia patients' medical records with those of their caregivers. The report highlights critical gaps in clinical application due to EMR incompatibility, varying provincial privacy rules, and consent requirements.
The chosen fellows will undertake residencies in eight European countries, tackling topics such as earthquakes, fusion energy, quantum mechanics, and biodiversity loss. The cohort brings together nine nationalities and includes early-career, mid-career, and established professionals.
A middle school substance-use prevention program led to wide-ranging benefits well into adulthood, including better communication with romantic partners and better-adjusted children. Parents who participated in the program reported lower levels of family conflict and higher levels of family cohesion.
Researchers at Kennedy Krieger Institute discovered that memory consolidation during sleep depends on coordinated activity among three brain regions, disrupting this activity impairs memory performance. Epileptic spikes can also interfere with brain activity, leading to cognitive effects in patients with epilepsy.
A randomized controlled trial in Singapore found that offering self-sampling increased both high-risk HPV detection and overall screening uptake among previously unscreened women. Screening uptake also increased particularly among women with no prior screening history. In contrast, patients registered with their general practice for lo...
Studies show that plant fibers and proteins, known as 'proteins imitating fiber,' reprogram microbial metabolism to produce beneficial phenol metabolites. These findings highlight the potential of diet in controlling the microbiome and its outputs.
A new type of 3D-printable material mimics human tissue's ability to sort and filter, allowing certain molecules to pass through while keeping others out. This broad function means the material can be used in various applications across medicine, water, and robotics.
A new study from Costa Rica's Área de Conservación Guanacaste found that high-elevation species of rove beetles are poorly equipped for warmer temperatures, while low-elevation insects live close to their heat limits. This suggests that tropical biodiversity may be vulnerable to rapid climate change.
Researchers identified a rare genetic mutation, BTK A428D, that blocks both BTK inhibitors and next-generation BTK degraders. The study provides new insight into how cancers evolve under treatment pressure and may help develop strategies to overcome resistance in patients with chronic lymphocytic leukemia.
A new grant will support research into how strokes disrupt brain networks controlling the bladder, aiming to identify imaging biomarkers predicting treatment response. Researchers will use advanced brain imaging and non-invasive spinal stimulation to develop a personalized approach for treating bladder problems after stroke.
The program combines technical innovation and strategic business thinking, offering four specialized tracks: business analytics, finance, marketing, and IT management. Students will earn both a Bachelor of Science in engineering and a Master of Science in business.
Researchers discovered a lipid regulator, arachidonic acid, boosts Smoothened activity through a newly found binding site, enhancing SHH signaling in tissues like the heart and lungs. Disrupting this interaction impaired cardiopulmonary development, providing insight into how the SHH pathway may be modulated in diseases.
A large-scale genetic study suggests that inherited taste preferences for sweet and fatty foods can influence eating behaviors and contribute to chronic disease risk. People with a higher genetic predisposition for these tastes tend to eat more of them, leading to a higher risk of obesity and type 2 diabetes.
A new study reveals that industrial poultry farming has led to a 100-fold increase in Campylobacter movement, allowing strains to mix extensively in commercial poultry populations. This has resulted in more than 3.5 times as many gastroenteritis cases in the UK each year compared to other foodborne bacteria.
A study of ancient human relatives' fossil footprints reveals that a previously thought smaller species was actually larger, while also showing evidence of group travel. The tracks, preserved over 1.4 million years ago in northern Kenya, offer insights into the behavior and interactions of these early humans.
A new study documents fossil footprints of eight adult Paranthropus boisei individuals, indicating human-like body sizes and complex social structures. The discovery provides a rare snapshot of 'fossil behavior' from an ancient hominin group in northern Kenya.
A new AI model called Biogeochemistry-Informed Neural Network (BINN) has been developed to advance scientific discovery in agriculture and biogeochemistry. It is 50 times more efficient than its predecessors and can predict biological processes not yet well understood.
Researchers found that genetic factors play a role in how individuals respond to a low-carb, high-fat diet, with those at higher risk experiencing greater increases in LDL cholesterol. The study suggests personalized dietary guidance based on genetic profiles could help identify who may experience adverse responses to certain diets.
The VERITAS project establishes AI Assurance as a core function of scientific research infrastructure to document, review, and stress-test AI systems. It aims to develop practical methods for detecting vulnerabilities before they compromise scientific results.
Baskin is the first female and first Black woman to be named director of a National Cancer Institute-designated cancer center, leading Massey Comprehensive Cancer Center. She champions the community-to-bench model, prioritizing rural areas and underserved groups in cancer prevention and treatment research.
A soft, wearable fingertip patch continuously monitors levodopa levels in patients' sweat, comparable to standard laboratory blood tests. This technology enables precise customization of daily medication schedules for patients at home, potentially improving treatment outcomes.
USC researchers have been selected for the U.S. Department of Energy's Genesis Mission to harness artificial intelligence for scientific discovery and innovation. Two projects led by USC will explore ways to develop faster and more energy-efficient computing hardware and better understand the natural concentration of critical minerals.
Researchers developed an antibiotic-free multifunctional injectable hydrogel that promotes tissue repair through synergistic antioxidant and antibacterial activity. The hydrogel shows compatibility with blood and surrounding tissues, delivering therapeutic agents in a controlled and sustained manner.
A new study reveals that lignin can be transformed into a bioactive material that promotes the formation of bone-like minerals while supporting the growth of bone-forming cells. The material also degrades gradually under physiological conditions, making it suitable for scaffolds intended to be replaced by newly formed bone during healing.
A study by USC researchers found that signals from the gut through the vagus nerve can help form memories, particularly those related to food. The brain responds to a food's nutrients rather than just its flavor, suggesting a potential mechanism for memory formation.
Researchers have developed an AI tool that can detect online propaganda in Kinyarwanda, a Bantu language spoken by 350 million Africans. The dataset, called KinyaProp, provides examples of misinformation in Kinyarwanda for large language models to learn from and recognize.
Researchers have created a new, recyclable yarn that mimics the properties of spandex-based yarns, offering an alternative to non-recyclable stretchy garments. The yarn is made from a form of plastic and can be melted down and reused multiple times without losing its strength and flexibility.
The Genesis Mission aims to accelerate breakthroughs in energy, scientific discovery and national security through AI-powered research. Texas A&M University has joined the initiative, contributing to a unified discovery platform connecting government, industry, academia and philanthropy.
Researchers detected chlorinated organophosphorus esters in solid waste, linked to toxic effects on the endocrine and reproductive systems. The substances, used as flame retardants, can cause cancer and harm human health if not managed properly.
Researchers at UC Irvine analyzed 100,000 inspection records to identify key factors responsible for severe wildfires in California. The team developed a high-resolution fire risk map that highlights areas with the highest probability of property losses.
A study by North Carolina State University researchers found that an AVP stimulation test can reliably diagnose endocrine dysfunction in sick foals. The test, which involves administering arginine vasopressin to stimulate the release of hormones, showed promising results in detecting hypothalamic-pituitary-adrenal gland axis (HPAA) dys...
A randomized trial found a significant reduction in alcohol use among refugees and locals in Mantapala refugee settlement. The SBIRT intervention was more effective than treatment as usual, with sustained effects over 12 months.
Researchers have created a new approach to cancer vaccine design by leveraging pre-existing antiviral immune memories. PROTEXI, a dendritic cell vaccine platform, converts dormant antiviral memory into a catalyst for antitumor immunity, slowing tumor growth and improving survival in multiple preclinical models.
Researchers identified key genes controlling cellulose, hemicellulose, and lignin synthesis in Ginkgo biloba wood. The study's findings offer a roadmap for breeding superior timber varieties with tailored properties.
A UTEP researcher has developed a simple, low-dose leaf spray that can substantially reverse the damage caused by salty soil on tomato plants. The treatment pairs manganese oxide nanoparticles with chitosan and has been shown to increase shoot weight, root growth, and antioxidant enzyme activity in stressed plants.
A recent international workshop led by UC Santa Barbara researchers has taken the first steps toward developing a large-scale strategy for carbon sequestration by burying plant biomass in anoxic marine basins. The concept, known as marine anoxic carbon storage (MACS), has the potential to operate at a massive scale required to mitigate...
Researchers discovered that dengue virus can infect memory B cells, immune cells traditionally understood to help protect the body from infection. This finding points towards new strategies for treating dengue, a disease threatening 40% of the world's population.
A new $3.3 million study aims to investigate how people perceive cognitive changes as they age, with a focus on identifying predictive markers for dementia. The 'worried well' - individuals with cognitive complaints but normal test results - may hold clues to early disease detection.
The University of Tennessee has appointed Carolyn J. Anderson as a UT-Oak Ridge National Laboratory Governor's Chair for Nuclear Medicine. She will focus on researching radioisotopes produced at ORNL for targeted alpha-emitting radiotherapy, which can precisely kill cancer cells with minimal side effects.
A SKKU study finds that concentrated aid support from a single agency reduces local corruption, but overlapping aid agencies increase the risk of corruption. The research team analyzed data from over 30,000 projects across Afghanistan and found that moderate aid volumes with collaborative project ideas have a positive impact.