Analysis of unintended side effect reports reveals that Wegovy carries the highest risk of 'eye stroke' and sudden sight loss among semaglutide drugs, with odds nearly 5 times higher than Ozempic. The risk is particularly pronounced in men, with a signal nearly 3 times higher than in women.
Scientists from southern Africa and the US have discovered a new species of magic mushroom, Psilocybe ochraceocentrata, which shares a common ancestor with Psilocybe cubensis approximately 1.5 million years ago. This finding challenges the prevailing view of Psilocybe cubensis introduction to the Americas and provides new genetic resou...
Research found that Roseburia inulinivorans is positively associated with muscle mass and strength in both young and older adults. The study suggests that R inulinivorans may play a causal role in muscle strength, with notable increases in forelimb grip strength and larger muscle fibre size in mice treated with the bacteria.
A large population study found that female relatives' suicidal intentions may influence women's suicide risk, with shared familial environment and social factors having a key role. The study also found that genetic factors only partly explain the observed sex difference in suicidal behaviors.
A new study found that Texas' migrant busing program, which transported immigrants to Democratic-led cities, contributed to President Trump's increased vote share in affected counties during the 2024 election. The study also highlights the enduring power of perceived threats from racial minorities in shaping voting decisions.
The study introduces a domain generalization method for EEG that leverages domain-invariant features and data augmentation to improve cross-subject generalization and noise robustness. The model achieved state-of-the-art accuracy across three public datasets, demonstrating stability and strong noise robustness.
Researchers found that depleting fibrinogen, a clotting protein, slows down pancreatic cancer by shrinking tumors and reducing liver metastasis. Fibrinogen contributes to tumor growth and environment, and its depletion changes tumor cells to alter behavior and aggressiveness.
Researchers have synthesized long noncoding RNA molecules with anti-inflammatory properties, demonstrating a new paradigm in drug discovery. The team identified three lncRNA sequences that regulate inflammation and used them to create nanoparticles that reduced inflammation in human cell cultures and mice.
Researchers developed a new noninvasive brain stimulation technique by combining focused ultrasound with electrical stimulation, producing stronger, targeted brain responses. This approach, called transcranial electro-acoustic stimulation, clarifies conflicting results in the field and introduces a new approach to noninvasive brain sti...
A new study finds that Pune's reservoirs will likely dry up and groundwater levels will plummet by the middle of this century if the city maintains current policies. However, the research shows these outcomes can be avoided with certain policy interventions.
A recent article highlights the need for human moral agency in nursing, as AI systems simulate empathy but lack sentience and accountability. Nurses must be active leaders in AI design and implementation to preserve public trust and ensure compassionate care.
A recent study suggests that social media users are more likely to watch TV programs endorsed by members of their political party. However, individuals' racial identity and perceptions of racial and political ingroup norms also play a role in their decisions. The study found that white Republicans reported the weakest intentions to wat...
Researchers identified new neurons that respond to different spatial frequencies, allowing for more precise object recognition, and used digital twins to confirm the findings in mouse brains.
Scientists discovered a built-in 'avoid' switch in the mosquito brain that is highly tuned to detect borneol, a naturally occurring organic compound found in aromatic plants. This finding could lead to the development of more effective mosquito repellents protecting human health.
A new study found that functional impairment worsened over time in individuals with early Parkinson's disease, despite plateaued symptoms, with gait, balance, and posture being the most bothersome issues. The study's results underscore the importance of incorporating real-world measures of disease progression in clinical trial design.
Scientists at The Wistar Institute have designed a two-vaccine approach targeting T cell receptors and cancer-specific mutations, significantly improving tumor control and survival in preclinical models. The combination therapy, developed in collaboration with Geneos Therapeutics, offers a promising new tool for treating T cell lymphom...
Researchers will investigate how a common dietary nutrient controls a hidden layer of gene regulation in cancer cells. The study aims to understand how changes in RNA modifications and methionine availability impact cancer cell behavior, with potential therapeutic implications.
A new study discovered that a multifaceted infection prevention and control intervention successfully disrupted a large and long-running bacterial outbreak of Klebsiella pneumoniae in a Zambian neonatal intensive care unit. The study found that low-cost measures, including IPC training, enhanced cleaning, and hand hygiene, reduced neon...
Researchers developed a dynamic optimization model to help NGOs in rural Africa optimize maintenance schedules, reducing downtime and logistics costs. The model achieved significant reductions in maintenance downtime, ranging from 47-62% in Ethiopia and 53% in Malawi.
Researchers at the University of California, Irvine, have identified asprosin as a key biological target for obesity prevention in postmenopausal women. Higher levels of asprosin were linked to reduced weight gain in metabolically healthy women, suggesting its potential role in maintaining weight stability when metabolic health is intact.
A new study by UCL researchers found that 6 out of 10 older people in England view climate change as a serious risk, with many aware of its consequences and ready to take action. The study also revealed that older adults are more likely to be engaged with climate change, particularly those who are better off financially and more social...
Researchers have developed a robotic gripper called ChicGrasp, which can learn to handle chickens by imitating human movements. The system uses advanced imitation learning algorithm and camera perceptions to grasp a chicken carcass by the legs and lift it on a shackle conveyor.
A new study from Duke University found that most lethal mutations in wild fruit flies are driven by newly transferred jumping genes, not small DNA errors. The research reveals a hidden layer of evolution where lethal mutations persist in generations due to the impact of transposable elements.
Researchers at Cedars-Sinai Medical Center have discovered that gut bacteria produce nicotinic acid, a molecule that activates a protective mechanism in colon cells, reducing the risk of tissue injury and disease. This finding has important implications for understanding how intestinal disorders, such as Crohn's disease, develop.
Researchers have completed the most comprehensive survey of DNA associated with plankton in the Southern Ocean, revealing a vast genetic diversity that affects the carbon cycle. The study sheds light on the role of microbial ecosystems in climate change and highlights the need to understand how these genes control ocean chemistry.
A new study reveals that the hippocampus represents emotion concepts in a structured hierarchy of pleasantness and bodily reaction, while the ventromedial prefrontal cortex tracks relationships between these nodes. This map-like representation may help in the treatment of mental illnesses, such as depression and anxiety.
Ochsner MD Anderson Cancer Center will be the first in the southern US to offer biology-guided radiotherapy (BgRT), a breakthrough treatment that uses cancer biology to guide radiotherapy delivery. This new therapy aims to provide more focused and accurate treatment with fewer side effects for patients.
A community-based study in New Jersey found meaningful progress in maternal care, but inequities persist, especially for women of color. The study highlights the need to strengthen policies, expand support services, and address transportation barriers to improve maternal health outcomes.
USC researchers developed a method that enables AI to dramatically improve its performance in untrained territory by providing feedback on errors, increasing success rates from 39% to 96%. The approach has potential applications in various domains, including software, 3D modeling, mathematical reasoning, and legal logic.
A new study by Mount Sinai researchers found that distributed multi-agent AI systems can maintain superior accuracy levels while using significantly fewer computing resources compared to single-agent designs. This approach can help healthcare organizations scale AI without sacrificing quality or safety.
Researchers achieved a transition temperature of 151 Kelvin, setting the stage for future advancements in superconductivity. The breakthrough could lead to more efficient ways to generate, transmit, and store energy, conserving billions of dollars in savings and reducing environmental impacts.
Cognitive neuroscientists are integrating genetics and AI to study language development and disorders. AI-based models can predict language development in children, while genetics research links rhythm disorders and dyslexia. The brain's wiring connecting language regions also reveals that language is a system, not a single 'thing'.
Conventional oil and gas infrastructure leaves a deeper mark on freshwater biodiversity than shale gas development in Pennsylvania, according to a new study. The research analyzed over 6,800 benthic macroinvertebrate samples and found conventional development was linked with fewer species and a decline in ecosystem health.
Researchers at Penn State have developed a new class of tunable biomaterials, known as granular aerogel scaffolds, to support tissue regeneration and vascularization in wound healing. The material offers improved cell infiltration and may help rapidly form new blood vessels and regenerate damaged tissue.
Leora Westbrook joins the NR2F1 Foundation as Executive Director, bringing expertise in healthcare, nonprofit leadership, and fundraising. She will strengthen operations, broaden reach, and speed up progress toward BBSOAS treatments.
The Hebrew University team designed an adiabatic transition to convert multiple few-mode sources into a single multimode fiber, enabling efficient combining of dozens of small semiconductor lasers. The technology simplifies high-power laser systems and optical communications, preserving brightness and easing alignment constraints.
The Proceedings of the National Academy of Sciences has selected six papers for the 2025 Cozzarelli Prize, recognizing outstanding contributions to physics, biology, and engineering. The winners include studies on dusty plasmas, eukaryote evolution, and sound absorption.
A study by the University of Texas M. D. Anderson Cancer Center found that men with low testosterone levels are 60% more likely to have their prostate cancer progress to a more aggressive state during surveillance. Low testosterone may serve as a useful clinical marker to guide treatment and surveillance strategies.
Researchers discovered pairing targeted treatments with CAR T-cell therapy can help control cancer recurrence in triple-negative breast cancer. The study found that using CAR T-cells shortly after surgery or radiation may prevent cancer spread to distant organs.
A study examines the occupational health and safety implications of AI tools, revealing psychosocial, ethical, and privacy risks. The rapid integration of AI into the workplace has often outpaced the adaptation of regulatory and ethical frameworks, highlighting the need for a people-centered approach.
A study analyzing ancient parrot DNA has uncovered a thriving pre-Inca trade network that connected Amazonian forests with arid communities across the Andes. The research shows that parrots were transported alive across the Andes, over 500 kilometers, to be used in coastal ritual contexts.
Research shows that bacteria harbor resistance genes may respond differently to antibiotics under non-standard conditions. This affects treatment efficacy and contributes to understanding antimicrobial resistance development and spread. Understanding these variations is crucial to combat global public health threats.
UT San Antonio has emerged as a unified academic powerhouse, with strong performances in the Blue Ridge Institute for Medical Research rankings. The university has climbed 5 spots to No. 64 among 2,702 institutions, with $147,098,904 in NIH funding, reflecting its commitment to biomedical discovery and research excellence.
Researchers at Weill Cornell Medicine have identified the FOXJ1 gene as a key player in chemotherapy resistance in prostate cancer. The study found that increased FOXJ1 levels in tumors can make cancer cells less responsive to taxane chemotherapy, leading to poorer outcomes for patients.
Researchers found three types of relational fractures: co-performance, co-learning, and marketplace. Vegans employ strategies such as decoding, decoupling, divesting, and chameleoning to cope with conflicts. These findings are transferable to other contexts, highlighting the need for social skills to navigate moral differences.
A comprehensive review of 82 studies found no evidence of Ginkgo biloba's benefit for cognitive impairment, but suggests a possible benefit for dementia. The supplement was not associated with an increased risk of serious harm compared to placebo.
A new study reveals that p38 MAPK plays a key role in epigenetic regulation of fibrotic genes in lung fibroblasts, particularly in senescent cells. Pharmacological inhibition of p38 MAPK significantly reduced α-SMA and Col3A1 expression, suggesting a potential therapeutic target for treating age-related fibrotic diseases like IPF.
Researchers at the University at Albany and Rutgers University have developed an early-warning framework that can predict harmful social media interactions before they erupt. The model, called Comment Storm Severity (CSS), uses publicly available datasets from Reddit and Instagram to predict whether a thread will escalate into a toxic ...
A University of Kentucky study has identified a distinct immune fingerprint in the blood of patients who develop amyloid-related imaging abnormalities (ARIA) after treatment with lecanemab, the first FDA-approved drug to slow Alzheimer's disease progression. This finding could lead to a more personalized approach to Alzheimer's care an...
The University of Tennessee has launched the Center for Pet Family Well-Being, reflecting its national recognition for advancing research and community-based solutions for pet-inclusive families. The center aims to integrate systems in ways that recognize pets as part of the family and essential to family and community resilience.
A study of 470 patients who underwent free flap reconstruction found that holding blood thinners for too long increases complications. The researchers suggest that resuming blood thinners within 48 hours after surgery may be safe, reducing the risk of excessive bleeding and dangerous clotting.
A Europe-wide citizen science study reveals that common buzzards are becoming more uniform in color, with lighter birds found in north and central Europe and darker birds in Brittany and Iberia. The study's findings suggest that the loss of color diversity may compromise the species' ability to adapt to future environmental changes.
Researchers discovered a simple strategy for snakes to stand upright without limbs, concentrating bending and muscle activity into a short boundary layer near their base. This approach reduces energy required while maintaining balance, offering design principles for soft robots and medical devices.
A large survey of stroke survivors under 50 found that they experience more difficulties concentrating and have poorer mental health days compared to older survivors. Younger survivors who were not working faced the greatest challenges in their recovery, highlighting the need for unique support services.
Professor Geim's appointment aims to transform humanity's future through world-changing innovation. His groundbreaking graphene research has reshaped modern materials science and condensed matter physics, enabling bespoke atomic-scale architectures with profound impact on science and technology.
This work demonstrates a synergistic strategy utilizing water molecules and BHT additive to achieve high-quality perovskite films with low defect density, resulting in an unprecedented amplified spontaneous emission threshold of 8.987 μJ cm-2. The dual-triggered film completes ASE intensity retention after 30-day ambient storage.
A new model explains how planetary radiation belt intensity is limited by the planet's surface magnetic field strength, with an upper limit of about 0.0004 tesla for protons and 0.00004 tesla for electrons. The model can be used to explore exoplanets and study the energy limits of radiation belts.
A team of researchers developed a computational model to study how pollen disperses in urban areas, influenced by factors such as tree geometry, wind speed, and direction. The model provides quantitative insight to inform urban planning decisions and reduce the risks associated with airborne allergenic pollen exposure.
Scientists have successfully constructed a phthalocyanine pentamer, a novel nanoarchitecture that integrates electronic and magnetic properties into a single molecule. The hybrid strategy combines solution chemistry and on-surface reactions on metal substrates, enabling the creation of complex molecular structures.
A protein receptor, PAR1, plays a critical role in maintaining blood vessel structure. The receptor can trigger protective responses to counteract inflammation, potentially leading to new treatments for conditions like sepsis, heart attack, and stroke