Researchers used molecular docking and computational modeling to identify a superior mutant of L-amino acid deaminase, overcoming substrate inhibition at high concentrations. The mutant showed significantly enhanced catalytic efficiency and high-substrate tolerance, demonstrating a powerful approach for optimizing industrial biocatalysts.
Research in Singapore finds that households relying heavily on air-conditioning are less likely to adopt energy-saving habits and support collective climate action. The study highlights the need for city-scale heat mitigation strategies alongside individual adaptation.
New research reveals that see-through or cut-out product packaging on a shelf increases the psychological desire to own it. Customers rely on various cues when making purchasing decisions, with visibility of a product influencing choices.
Researchers discovered that long-term exposure to high viscosity environments makes glioblastoma cells smaller and more deformable, allowing them to invade healthy tissue more effectively. The study found that viscosity is not just a passive barrier but an active driver of aggressive behavior.
Shandong University researchers have developed MuSE-Promoter, a deep learning framework that integrates multiple complementary ways of looking at DNA sequences. The method consistently outperforms state-of-the-art tools in challenging cross-cell-line transfer and promoter-enhancer discrimination tasks.
Researchers have identified blood-based proteomic biomarkers that may help predict the development of psychosis in at-risk Asian youths. The study, which used data from the Longitudinal Youth at Risk Study (LYRIKS), found that models developed using the LYRIKS dataset performed better than those based on Caucasian protein patterns.
A study identified key tumor microenvironment features that can predict immunotherapy response in rare cancers, offering new insight into treatment options. The findings suggest that analyzing the tumor microenvironment beyond genomic analysis may help improve treatment selection for patients with rare cancers.
Scientists propose a strategy to control π-electron delocalization in polycyclic aromatic hydrocarbons, enabling the synthesis of narrow-spectrum emission materials. This approach results in red emitters with high efficiency, narrow spectral width, and record-high performance in OLED devices.
The University of Maryland School of Medicine has received a $2.9 million federal grant to establish an advanced microscopy facility, enabling researchers to study cellular processes with nanoscale precision. The facility will house cutting-edge instruments like the MINFLUX microscope, which can visualize molecular events in brain cell...
Researchers found that increasing ADAR2 expression in osteosarcoma cells forces them to differentiate, slowing growth and invasive capacity. The treated cells began producing mineralized matrix, a hallmark of mature bone tissue. In mice, ADAR2-restored tumors were smaller and less invasive.
YTHDF2 plays critical roles in regulating HSC fate, immune cell development, and tumor-immune interactions. It also modulates the tumor microenvironment to promote tumor progression.
The LUNA-2 trial will pair immunotherapy with fecal microbiota transplantation (FMT) to boost treatment effectiveness in people with non-small cell lung cancer. If successful, it could provide new treatment options for those living with the disease, helping them live longer and with fewer side effects.
A study found nearly 10% of surgeons left clinical practice in 8 years, with mid-career surgeons and certain specialties most likely to depart. Researchers identified specific areas where policy changes and support are needed to retain these high-risk surgeons.
A study reveals that medical exposure can rapidly change the human microbiome, with gut microbes shifting toward patterns more commonly seen in urban populations. The research found a decline in microbial diversity and a shift towards bacterial groups more common in industrialized societies.
Researchers argue that childhood behaviors are being pathologized, and instead propose addressing the root causes of psychological distress by reforming education and mental health systems. They advocate for a more collaborative approach, trusting children and families to define themselves and co-construct their support needs.
New research from McGill University and the University of California, Santa Barbara, shows that the earliest eukaryotes inhabited shallow, oxygenated coastal environments nearly 1.7 billion years ago. This finding challenges the long-held belief that early complex life emerged in oxygen-poor environments.
Aging across the female reproductive tract is characterized by declining estrogen, cellular senescence, and chronic inflammation. Multi-omics datasets provide a powerful framework to measure biological age and reveal tissue-specific vulnerabilities.
Researchers at UNF will develop a system to spot and fix problems during the printing process, reducing flaws in 3D-printed metal parts. The project aims to dramatically reduce defects, leading to fewer failed builds, lower costs, and more sustainable production methods.
A new study reveals that Mohenjo-daro, the Indus civilization's largest city, became more egalitarian over time as it matured. The city's inhabitants worked together to ensure fair access to a good standard of life, with investment in practical things like drainage and street maintenance.
Researchers identified OsSD7, an F-box protein that regulates seed dormancy and resistance to pre-harvest sprouting (PHS) in rice. The study found that natural variation in this gene provides valuable resources for breeding PHS resistance.
Scientists at McGill University developed new composite materials by mimicking the natural adhesives and fibers found in mussels and mistletoe. These sustainable materials can be reused and have potential biomedical applications.
Research reveals that rivers are exceeding their resilience limits, leading to local extinctions, food chain collapses, and permanent changes in services provided by rivers. A paradigm shift is needed from reactive actions to proactive large-scale strategies for watershed management and river resilience.
Researchers found a combination of measuring shame—self-report, language, and body posture—are necessary to predict stress and avoidance behaviors in healthcare settings. This multi-modal approach provides a way to examine the different ways individuals experience and express shame.
A new study by Concordia researchers found that well-liked friends can help reduce peer exclusion, but not social withdrawal in isolated children. The study tracked 252 fifth- and sixth-grade students over eight weeks and found that friendships with high-status peers reinforced existing social status, rather than improving inclusion.
Researchers found that shrouding blankets increase dignity for parents who lose a child, offering a tangible way to cope with grief. The blankets provide comfort and stability, allowing parents to hold their child without feeling overwhelmed.
A Kaiser Permanente study found that HPV self-collection increased cervical cancer screening completion by 2.2% among over 95,000 members, with higher gains in diverse populations. The program also reduced clinician-performed pelvic exams and improved follow-up for high-risk HPV results.
A new tool has been developed to identify blackouts during drinking, using objective memory tests that can detect blackouts in real-time. The study found a moderate correlation between not remembering an image while drinking and self-reported blackouts the next day.
Paligenosis is a three-stage process involving autophagy, stemness gene induction, and proliferation. It ensures efficient regeneration in tissues like the stomach and pancreas, but its dysregulated activation can drive metaplasia and cancer. The review discusses biomarker prospects for distinguishing adaptive repair from malignant drift.
A new AI-powered detection system developed by University of East London researchers combines language analysis with behavioural clues to identify genuine reviews. The hybrid fusion model achieved 93% accuracy on Amazon review data and 91% accuracy on Yelp reviews, outperforming traditional methods.
The Universitat Jaume I has secured funding for five research projects worth nearly one million euros to strengthen its research activity. These projects focus on improving neural networks, understanding memory, tackling antimicrobial resistance, developing new materials, and assessing the impact of air pollution on neurocognitive health.
Researchers developed a new tool, RNAanalyzer 3, to analyze RNA structures and motifs. The tool uses large databases and combines structure and context to make accurate predictions, enabling researchers to study RNA's role in various biological processes.
This study evaluates provincial expressway PV potential using a multi-scenario and credibility interval model, revealing that slopes exceed service areas in generating power. The research provides a standardized tool for assessing expressway PV potential worldwide, supporting the construction of zero-carbon green power corridors.
A digital literacy program designed by McGill researchers improved students' ability to evaluate websites and identify credible sources. The program targeted key skills such as searching for information and addressing conflicting data. Students showed significant improvements in their global performance across all skill categories.
A new study found that people with atherosclerotic cardiovascular disease consumed higher amounts of fat and followed more inflammatory dietary patterns than healthy individuals. Regular physical activity reduced the risk by half, but only when combined with an anti-inflammatory diet.
Researchers synthesized preclinical and clinical evidence of mRNA cancer vaccines across various cancers, including melanoma, non-small cell lung cancer, and acute myeloid leukemia. Key findings include improved recurrence-free survival in patients treated with mRNA-4157 plus pembrolizumab for melanoma.
A study assesses carbon unlocking levels in China's transportation infrastructure across 30 provinces. The results show a clear regional pattern, with eastern provinces leading and western provinces lagging behind. Key driving factors include green patents, R&D investment, and low-carbon regulation.
Researchers have found that aerosols and clouds in polluted regions grow faster, leading to a slower rate of global warming in Asia and Africa. This is due to the increased hygroscopicity of particles in urban and populated areas, which can absorb more water vapor and influence cloud formation.
Researchers developed an AI framework, MouseMapper, to map disease-related changes in the entire mouse body. They found widespread inflammation and previously unrecognized damage to facial sensory nerves caused by obesity, which was also observed in human tissue.
The editorial highlights the growing importance of public health interventions to extend healthspan alongside lifespan. Key findings include the need for integrated strategies addressing environmental, metabolic, social, and behavioral exposures that accelerate biological aging and increase vulnerability to chronic disease. The authors...
New research suggests that overly aggressive whistleblower incentives can cut down internal communication, allowing problems to go unresolved. Regulators should consider a more calibrated approach to encourage reporting without discouraging internal information-sharing.
H2AK119Ub is a versatile histone mark that organizes the genome into functional domains, orchestrates gene silencing, and maintains cell identities during development. Disruption of its signaling network is recognized as a driver of human diseases, particularly cancer.
Research reveals US forests face significant risk of carbon loss due to wildfires, droughts, and insects. Current carbon-credit systems fail to account for these risks, but the study provides a solution by proposing larger buffer pools to mitigate losses.
A recent study published in PNAS has found no meaningful health impacts from exposure to wind turbines. The researchers analyzed data from over 120,000 households and found no correlations between turbine installation and health problems such as headaches, depression, or sleep disturbances.
A study finds that US forests are at risk of releasing stored carbon due to droughts, pests, and fires exacerbated by climate change. The researchers recommend increasing buffer pools in carbon-credit systems to account for these risks.
The Florida Inventors Hall of Fame has inducted 10 pioneers whose work transformed modern life, advanced critical industries, and improved patient care. The 2026 class collectively holds more than 300 U.S. patents across fields like telecommunications, cancer immunotherapy, and artificial intelligence.
The discovery reveals that early complex life required oxygen and lived on or within the seafloor, contrary to previous expectations. The study's findings suggest that ancient eukaryotes were restricted to oxygenated environments, including offshore waters and coastal regions.
A University of Bristol-led pilot trial found that tocilizumab reduced symptoms of depression, fatigue and anxiety in people who had not responded to standard treatments. The study provides early evidence for a new treatment option for patients with inflammation-related depression.
A team from Hokkaido University found that red auroras can extend to extremely high altitudes even during moderately intense storms, suggesting these storms may be stronger than conventional indices indicate. This could have implications for satellite operations and space weather forecasting.
A new study by University of East London researchers aims to gather data on microplastic contamination across the Thames, combining new sampling with existing datasets. The findings could inform discussions around wastewater management, river protection, and plastic pollution policy.
Researchers found that ancient eukaryotes required oxygen to survive, living primarily on the seafloor. The team's study overturns long-held assumptions and provides new insights into the evolution of these lifeforms.
A nationwide implementation of a uniform multimodal prehabilitation program significantly reduced complication rates and length of hospital stay among patients undergoing colorectal cancer surgery. This study highlights the benefits of standardized preoperative care in improving patient outcomes.
A new method combines holographic optical tweezers with AC electric fields to pre-align and trap nanowires with improved stability and efficiency. This hybrid approach enables predictable, programmable movement, turning random motion into controlled assembly tasks.
Researchers developed a new analysis of sound wave behavior, revealing surprising effects that have been overlooked for decades. At high sound levels, the shape of the wave becomes progressively distorted, with crests compressing into narrow spikes.
A global study of marine litter has identified food and beverage plastics as the leading contributors to ocean pollution, with plastic packaging, caps, and bottles dominating shoreline debris worldwide. The research highlights the urgent need for reduced plastic production and more efficient waste management practices.
A cohort study found increased pediatric capability was not linked to differences in imaging use by insurance or racial/ethnic groups. Additional efforts are needed to improve quality and equity of care for children.
Scientists identified distinctive microbial patterns associated with oesophageal squamous cell carcinoma, a mysterious subtype common in South Africa. The study, published in Communications Medicine, suggests a potential low-cost warning signal for early detection using saliva bacteria analysis.
A digital tool developed by researchers at the University of Copenhagen can make a real difference in the lives of children and young people after their parents' divorce. The SES NXT platform helps children understand their emotions, put them into words, and make tangible changes to improve their everyday life.
A study in British Columbia, Canada found that old oil and gas wells continue to leak methane into the environment, leaving a broader signature than surface measurements alone reveal. The researchers used multiple measurement domains, including shallow geophysical measurements and soil geochemical analysis, to detect persistent leakage.
Scientists have discovered that continental crust can be dragged deep into the Earth's mantle during subduction and later rise again to mix with deeper rocks. This process, known as 'relamination', creates a hybrid crust-mantle source that generates post-collisional magmas.
A new AI system, Empirical Research Assistance (ERA), can automatically write scientific software programs that outperform human-written ones. ERA combines a large language model with search strategies to explore and refine thousands of pieces of code, reducing the time required for exploration from months to hours or days.