Researchers discovered that mosquitoes use RNA interference to combat dengue virus, allowing the virus to multiply and be transmitted to humans. Genetic manipulation of this response could help stop dengue virus transmission by Aedes aegypti.
Researchers at University of Pennsylvania School of Medicine discovered that Ebola virus disables tetherin protein to prevent its inhibition, allowing the virus to spread. Understanding this mechanism may facilitate the development of therapeutics to slow down viral replication.
Researchers have solved the structure of VP35, a key part of the Ebola protein that interferes with host cell defense mechanisms. This discovery paves the way for designing drugs that can bind to and inhibit VP35 function, potentially neutralizing the Ebola virus.
A recent study found a nanoscale motor in the T4 virus, which drives DNA packaging into its capsid. This discovery could inspire engineers designing sophisticated nanomachines and may also help pharmaceutical companies develop methods to sabotage virus machinery.
The discovery of Bundibugyo ebolavirus represents a significant addition to the puzzle of the Ebola virus genus. The new virus is genetically distinct from all other known Ebola virus species, differing by more than 30% at the genetic level. This finding has implications for the development of diagnostics, antivirals, and vaccines.
Researchers at the University of Texas Medical Branch have discovered a key biochemical link in the process by which Ebola Zaire virus infects cells. By activating the PI3 kinase pathway, Ebola tricks the cell into drawing it into an endosome, where it can reproduce itself.
Researchers describe the shape of the Ebola virus spike protein bound to an immune system antibody, providing a major step forward in understanding how the deadly virus works. The structure reveals vulnerable sites that can be exploited to develop potential Ebola virus vaccines or treatments.
Duke University scientists discovered how the herpes simplex virus 1 (HSV1) hides during its inactive phase, using molecular understanding to provide a framework for studying latent viruses. The findings also offer hope for a potential cure by activating and killing the dormant virus with a new drug.
Scientists have found that Deformed Wing Virus (DWV) does not replicate in Varroa mites, highlighting the need for further investigation into its transmission. Research suggests that the virus is transmitted to bees when the mite bites and picks up infected bees' saliva or gut contents.
Researchers have successfully tested Ebola vaccines in primates, triggering a cell-mediated response and producing effective protection. The candidates are now set to be tested on humans for the first time, offering hope for controlling outbreaks and protecting healthcare workers.
Researchers found evidence of canine influenza virus circulation in the greyhound population dating back to 1999. The discovery sheds light on a potential earlier introduction of the virus, which may have caused respiratory outbreaks at racing tracks.
Researchers at the University of Pennsylvania have identified a protein, ISG15, that slows down the spread of Ebola virus by blocking its ability to escape from cells. This finding offers promise for future treatments against Ebola outbreaks.
A combination vaccine using virus-like particles (VLPs) provides complete protection against Ebola and Marburg viruses in monkeys. This innovative approach has the potential to offer broad-based immunity and is considered a leading candidate for use as a filovirus vaccine in humans.
The Uukuniemi virus structure reveals how bunyaviruses infect host cells by changing shape in acidic environments, a mechanism shared with influenza and dengue viruses. The discovery may aid in developing drugs for treating hemorrhagic fever and encephalitis.
Researchers at Virginia Tech are developing a treatment for prostate cancer using the Newcastle Disease virus. The virus targets specific proteases secreted by cancer cells, generating apoptosis and killing diseased cells. This is a promising new approach to fighting cancer.
Researchers found that the M2 protein's motion and structure change when treated with amantadine, blocking the flu virus from infecting healthy cells. The study provides insight into developing alternative antiviral drugs for resistant flu strains.
Researchers from the University of Wisconsin-Madison have developed a system to genetically disarm the Ebola virus by removing its VP30 gene. This allows for safe study of the pathogen in specialized cells, enabling the development of countermeasures such as vaccines and antiviral compounds.
Researchers found a key protein switch in Chikungunya Virus that allows it to infect and transmit through the Asian tiger mosquito, increasing its ability to spread to new locations. This mutation enables the virus to adapt to areas without typical vectors, posing a global health threat.
Researchers found that blocking blood vessel growth with an antiangiogenic agent can reduce inflammation and improve antitumor efficacy of oncolytic virus therapy. This approach may increase survival rates for patients with aggressive brain tumors.
Scientists have identified a new genetic lineage of the Ebola virus in great apes, which contradicts previous assumptions about its evolutionary development. This discovery suggests that wild strains of Ebolavirus can exchange genetic material through recombination processes.
Researchers have identified multiple genes that confer broad-spectrum resistance to Turnip Mosaic Virus in brassicas like broccoli and cabbage. This discovery has the potential to develop resilient crop varieties that can withstand virus mutations.
Experts from the American Society of Tropical Medicine and Hygiene meet to address global health concerns and share research on infectious diseases such as Chagas and Dengue fever, which pose a threat to the US blood supply. Researchers also discuss using NASA technology to monitor deadly outbreaks like Ebola and malaria.
Human and avian influenza viruses target different cells in the lower respiratory tract, with human virus targeting upper respiratory tract cells and avian virus targeting deeper lung cells. The study provides insights into the pathogenesis of these divergent diseases.
Scientists have found Marburg virus in Egyptian rousette fruit bats, a non-symptom developing carrier species that likely transmits the virus to humans. The discovery reveals this bat as Africa's natural reservoir and highlights the need for public health measures to prevent future outbreaks.
A team of researchers from the University of Wisconsin-Madison identified a single change in a viral protein that facilitates the H5N1 avian flu virus's ability to infect the upper respiratory system in mammals. This adaptation enables efficient transmission through coughing and sneezing, potentially setting the stage for a pandemic.
Biologists have found that the influenza A virus migrates globally and mixes with other viral strains during the summer off-season before returning to the Northern Hemisphere as a genetically different virus. The research suggests widespread viral traffic across the equator, contributing to new epidemics in both hemispheres.
Scientists have identified Marburg virus RNA genome and antibodies in African fruit bats (Rousettus aegyptiacus), providing new insight into a deadly disease that has long baffled epidemiologists. The discovery, published in PLoS ONE, offers potential for understanding transmission and development of a vaccine or drug therapy.
A new study suggests that infection with human adenovirus-36 (Ad-36) may contribute to the development of obesity in some individuals. The virus transforms adult stem cells into fat cells, leading to increased fat accumulation.
Danish researchers have shed light on how viruses, like HIV and bird flu, trick human cells into producing proteins needed for replication. They developed optical tweezers to investigate the mechanical unfolding of pseudoknots, a crucial step in virus replication.
Researchers at University of Texas Medical Branch have discovered a way to identify the biochemical profile of an inappropriate immune response to viral infection. The study uses a protein-scanning chip and computer database to examine over 1,200 protein interactions in guinea pigs infected with two different strains of Pichinde virus.
Researchers developed a novel virus culture system that enables sustained replication and production of HCV particles in nontransformed hepatocytes. This breakthrough allows for better understanding of HCV differences between strains and may improve treatment strategies.
Researchers found that the 1918 flu virus triggers a deadly respiratory infection by attacking the lungs, leading to death. The study provides insight into how the virus killed so quickly and efficiently, offering potential clues for developing novel antiviral strategies.
A new study finds that 93% of gorillas at the Lossi Sanctuary in Congo were killed by Ebola during outbreaks in 2002 and 2003. The research suggests that targeted vaccination strategies could be effective in controlling the spread of the disease, which has devastated ape populations in Africa.
Researchers discovered a pattern to Ebola's spread, linking it to wildlife populations and climate. The study found that the virus spreads both within and between species, with outbreaks more frequent than previously believed.
Researchers have identified a key mechanism by which Filoviruses, including Ebola and Marburg, cause immunosuppression. By targeting specific amino acid sequences, new drugs may be developed to disrupt the virus's ability to shut down the immune system.
Researchers at Ohio State University have discovered how a chemotherapy drug aids an anti-cancer virus in targeting brain tumors. The study found that the drug slows immune cells' activity, allowing the virus to spread and kill more cancer cells. This may lead to new treatment options for incurable human brain tumors.
Researchers studied gorilla population during Ebola outbreak and found transmission between groups led to high mortality rate. The study suggests ape-to-ape transmission plays a significant role in the spread of the virus.
Researchers used mathematical modeling to simulate worldwide outbreaks and concluded that restrictions on air travel would achieve very little in controlling the spread of a new flu virus. Local measures such as vaccines and antiviral drugs could be more effective in controlling the spread of the virus.
Researchers have developed a vaccine that prevents haemorrhagic fever developing in monkeys infected with the deadly Marburg virus. The vaccine was found to be highly effective as a post-exposure treatment, with all treated monkeys surviving for at least 80 days.
A new experimental vaccine has been shown to protect nonhuman primates against Marburg virus infection, even when administered after exposure. The study found that all treated monkeys survived for at least 80 days, while controls succumbed to the disease within 12 days.
Researchers detected a novel virus, XMRV, in human prostate tumors with two copies of the RNASEL gene mutation. The study validates the use of DNA-hunting 'virus chip' technology to discover previously unknown viruses and potentially uncover new viral causes for disease.
A Phase 1 trial of an Ebola DNA vaccine demonstrated strong immune responses in all fully vaccinated volunteers. The vaccine, developed by Vical, was well-tolerated and showed effectiveness against Ebola-specific antibodies.
Researchers used novel antisense drugs to interrupt normal Ebola virus replication, showing protection in non-human primates. The therapy directly targets the virus and may be more potent than current anti-viral treatments.
Researchers analyzed genetic data and outbreak patterns to find that the Zaire strain of Ebola virus is spreading as a wave from its first epidemic in Yambuku, Gabon. This suggests that the virus may reach populated areas within 1-2 years and devastated gorilla populations in 3-6 years.
Researchers at Columbia University Irving Medical Center have developed a new type of virus, called a
Researchers at UGA College of Veterinary Medicine have identified a new way to combat viral diseases by blocking a protein that helps transport viruses out of cells. This approach, targeting the host gene Rab9, shows promise in preventing the replication of four different viruses: Marburg, Ebola, HIV-1, and measles.
Researchers at the University of Pennsylvania School of Medicine have found that inhibitors of cellular enzyme cathepsin L prevent the SARS virus from entering target cells. This breakthrough discovery could lead to the development of new therapeutics against the SARS virus.
Researchers have developed a way to engineer an alternative outer covering for the measles virus, allowing it to recognize and target only cancerous cells. The 'virus in stealth' approach uses pieces from an animal virus that cannot infect humans to disguise the measles virus, enabling it to evade the immune system and reach tumors.
Researchers at Purdue University have determined the combined structure of Coxsackievirus A21 and ICAM-1, a receptor molecule that enables the virus to infect host cells. The study reveals how the virus recognizes and anchors to the cell, providing insights into the initial stages of infection.
Researchers identified a cell receptor called Ephrin-B2 as the key used by the Nipah virus to unlock cells, allowing them to develop vaccines and drugs to block viral entry. The discovery could help prevent infection and outbreaks of this deadly virus.
A new experimental vaccine has shown promising results in protecting nonhuman primates from Lassa fever. The vaccine, developed using a non-pathogenic form of vesicular stomatitis virus as a carrier, has been successfully tested with all vaccinated monkeys surviving infection.
Researchers have developed a new vaccine that is 100 percent effective in protecting monkeys from infection with deadly viruses Ebola and Marburg. The vaccine targets dendritic cells, which are the same cells attacked by these viruses.
Researchers identified cathepsin B and L as essential enzymes for Ebola virus reproduction, shedding light on its infection mechanism. Inhibiting these enzymes could lead to the development of a broad-spectrum antiviral therapy against multiple hemorrhagic fever viruses.
Researchers found that 12.9% of wild chimpanzees carry Ebola virus antibodies, indicating regular contact with the animal reservoir and non-fatal infections. Dogs also carry the virus, with high antibody prevalence near epidemic foci, suggesting they could become a potential source of infection for humans.
Research reveals that Ebola viruses can spread from wild animals to humans through handling or consuming animal carcasses. This finding emphasizes the need for improved awareness and monitoring of wildlife in Central Africa to prevent future outbreaks.
Researchers at the Mayo Clinic have successfully created an 'obedient virus' that can specifically target and destroy cancer cells, paving the way for potential use in human therapies. The virus was engineered to seek out cancer cells instead of healthy cells, and has been shown to be effective in laboratory tests.
Researchers have discovered a novel way to block the smallpox virus by targeting a cellular signaling pathway. The approach, which uses an experimental drug called CI-1033, significantly impaired the production of new virus particles and spread of the virus in infected cells.
Jefferson scientists discovered that certain parts of the silver-haired bat rabies virus, specifically its glycoprotein cover, enable it to infect the brain rapidly. The researchers found that this type of rabies is capable of evading the immune system more effectively than other strains, making it a key factor in viral pathogenesis.
A possible new Ebola outbreak could lead to the deaths of over 20,000 western lowland gorillas within months if confirmed. The park is home to an estimated 30,000 gorillas, and a study suggests that when Ebola affects an area, more than 80% of great apes die from the disease.
Researchers discovered that certain tobacco plant species are resistant to the cowpea mosaic virus. The virus spreads through a plant's vascular system, causing damage and death, but the specific channels it uses to transmit the virus were identified. This knowledge could lead to strategies for creating virus-resistant crops.