A psoriasis researcher has received a third NIH grant to explore the nervous system's involvement in psoriasis. The study aims to identify new targets for drug development and improve patient care by investigating nerve-derived peptides critical to sustaining the disease.
A Penn study found that psoriasis patients with more severe skin disease are at higher odds of having major medical diseases, including lung disease, heart problems, and kidney issues. The researchers identified a common pathway involving TH-1 cytokines promoting inflammation and insulin resistance.
A new study found that visual images of skin cancer are most effective in prompting skin self-examinations, leading to more frequent and accurate checks. The findings could inform patient education strategies and public health communication efforts.
A recent study by University Hospitals Case Medical Center found that poor sleep quality accelerates signs of skin aging and weakens the skin's ability to repair itself. The study involved 60 pre-menopausal women and showed increased fine lines, uneven pigmentation, and reduced elasticity in poor quality sleepers.
The National Psoriasis Foundation has awarded the inaugural Dr. Mark G. Lebwohl Medical Dermatology Fellowship to Zelma Chiesa, a third-year dermatology resident. Through this one-year fellowship, Chiesa will investigate treatments and health risks of psoriasis, aiming to predict skin clearance and cardiovascular events.
Scientists at NYU Langone Health have discovered a population of self-renewing stem cells in the nail matrix that depend on Wnt signaling proteins to regenerate bone and tissue. This breakthrough holds promise for therapies to help people regenerate lost limbs, affecting an estimated 1.7 million Americans with amputations.
Researchers found that only 19% of dermatologists accept Medicaid-insured children, and those who do often require additional paperwork and identification. Eczema affects 20% of US children and can have severe physical and emotional consequences if left untreated.
Researchers at Boston University School of Medicine found that UVA induces progerin protein, accelerating skin aging, linked to genetic and environmental factors. Long-term exposure to UVA rays, particularly from tanning beds, accelerates photoaging by causing alternative splicing of the LaminA gene pre-mRNA.
Researchers from P&G Beauty & Grooming present advancements in skin aging and stress sweat, including a facial moisturizer that improves uneven skin texture and a study showing niacinamide's ability to prevent and restore cellular metabolism. The findings have potential for innovation in Olay and Secret brand products.
A Missouri survey found that 65% of tanning salon operators would allow children aged 10-12 to use tanning beds, despite evidence showing a link between tanning bed use and an increased risk of skin cancers. Many employees claimed no risks or benefits from indoor tanning, but these claims are false.
A new study published in JAMA Dermatology has found that the common acne drug isotretinoin does not increase the risk of inflammatory bowel disease. The research, led by Dr. Mahyar Etminan, statistically adjusted for severe acne and found no association between the drug and IBD.
A study found that smartphone apps incorrectly diagnose 30% or more melanomas as 'unconcerning', potentially delaying doctor visits and life-saving treatment. The apps often lack regulatory oversight and are marketed to nonclinical users, increasing the risk of harm to the uninsured or economically disadvantaged.
Barbara Gilchrest, a renowned dermatologist at Boston University School of Medicine, has been elected as a 2012 Charter Fellow of the National Academy of Inventors. She is being honored for her prolific spirit of innovation in creating outstanding inventions that have improved quality of life and economic development.
A study by Wake Forest Baptist Medical Center reveals that hair care complications are a primary factor deterring African-American women from exercising. The research found that over 40% of respondents reported avoiding exercise due to hair-related issues, with many using heat straighteners or chemical products to style their hair.
The University of Kentucky has developed a pioneering electronic health record (EHR) reporting system for cancer cases to the state's cancer registry. This innovation enables real-time data transmission, facilitating faster trend analysis and informed statewide cancer control efforts.
Researchers at Stanford University School of Medicine have identified a master regulator of epidermal differentiation, a complex process in skin development. The newly discovered molecule, TINCR, plays a unique role in directing precursor cells down specific developmental pathways by binding to and stabilizing messenger RNAs.
A new study published in The American Journal of Pathology found that topical application of simvastatin significantly accelerates wound healing in diabetic mice by increasing angiogenesis and lymphangiogenesis. This is attributed to the increased number of infiltrating macrophages producing VEGF-C, suggesting a simple strategy with po...
A large international study shows that children with psoriasis are twice as likely to be overweight or obese as healthy children, and US children with severe psoriasis have four times the odds. Lifestyle interventions, such as increasing exercise and decreasing caloric intake, are crucial to reducing the risk of metabolic diseases.
A systematic review and meta-analysis of 27 studies found a strong correlation between psoriasis and an increased risk of developing diabetes. Patients with severe psoriasis are nearly twice as likely to have diabetes compared to the general population.
A study published in Archives of Dermatology found that nearly 40% of participants in Germany had ever used a sunbed, with women being more likely to use them. The main motivations for tanning were relaxation and attractiveness, while the risk of skin cancer was significantly increased by sunbed use.
Case Western Reserve University researcher Nicole Ward is leading a study to identify the mechanistic link between psoriasis and heart attack/stroke. The study aims to provide first-ever evidence that cell-specific events in psoriasis can be targeted for treatment, potentially improving cardiovascular disease outcomes.
A retrospective study published in Archives of Dermatology found that patients with psoriasis treated with tumor necrosis factor (TNF) inhibitors have a significantly lower risk of heart attack compared to those not treated with TNF inhibitors. The study included 8,845 patients and adjusted for other MI risk factors.
Researchers at Mayo Clinic and University of California, San Francisco found that infantile hemangiomas, also known as 'strawberry' birthmarks, grow rapidly in infants between 5.5 and 7.5 weeks old. Early referral to dermatologists for further evaluation is recommended to prevent potential complications.
A new study found that basal cell carcinoma risk can persist even after multiple instances of the disease, with predictors including a history of eczema and early sun exposure. Researchers are exploring preventive medication options to minimize damage.
Researchers found that patients with psoriasis are at increased risk of developing Type 2 Diabetes, even without common risk factors like obesity. The study estimated an additional 115,500 people will develop diabetes each year due to the risk posed by psoriasis.
A population-based study from the UK suggests that psoriasis is associated with an increased risk of developing type 2 diabetes. The study found that patients with severe psoriasis were more likely to receive prescription diabetic therapy and had a trend towards being prescribed insulin.
The new skin cancer drug vismodegib was approved by the FDA in 2012 for treating locally advanced and metastatic basal cell carcinomas. It blocks the Hedgehog signaling pathway and has shown promising results for patients with inherited genetic susceptibility.
A customized patch treatment for basal cell carcinoma has shown an 80% cure rate without surgery or major radiation therapy. The phosphorus-32 skin patch delivers a fragmented dose of radiation to cancerous lesions, killing facial tumors in patients with facial basal cell carcinoma.
A recent study published at EULAR 2012 found that obese patients with psoriatic arthritis have a lower chance of achieving minimal disease activity when treated with anti-TNFs. However, following a hypocaloric diet can increase the likelihood of achieving treatment goals.
A new study published in the New England Journal of Medicine shows that vismodegib is effective in treating basal cell carcinoma, a common cancer caused by sun exposure. Researchers found that patients with Gorlin syndrome who took vismodegib developed an average of two new tumors per year, compared to 29 in those taking placebo.
A phase II clinical study shows that vismodegib can dramatically shrink basal cell skin cancers and prevent new ones in patients with basal cell nevus syndrome, a rare genetic condition. The treatment offers an alternative to surgical removal, but side effects remain a consideration.
Lt. Col. Dore Gilbert, a California-based dermatologist, received the Members Making a Difference award for his service in the U.S. Army Reserve providing skin cancer screenings and supporting patients undergoing chemotherapy and radiation treatments.
Researchers found that skin transplant surgery is safe and effective in treating vitiligo, with treated areas regaining an average of 43-68% of their natural skin color. The procedure involves transferring melanocyte cells from healthy skin to damaged areas.
A hormone previously associated with calcium homeostasis boosts immune response when dietary vitamin D levels are inadequate. The discovery may provide an alternative to current antibiotic therapies for treating skin infections.
Researchers found that patients taking oral acne medications like Accutane or Roaccutane doubled their risk of developing conjunctivitis, also known as pink eye. Using artificial tears or eye drops can help minimize this risk and prevent long-term damage.
A study published in Archives of Dermatology suggests that vigorous physical activity is associated with a reduced risk of psoriasis in US women. Participating in at least 20.9 MET-hours of vigorous exercise per week may reduce the risk by 25-30%. The study found no association between walking and psoriasis risk.
Researchers discovered a causal link between chronic skin inflammation and cardiovascular disease, with aggressive reversal of psoriasis reducing the risk. A mouse model demonstrated that persistent inflammation leads to vessel wall inflammation and blood clot formation, which can increase stroke or heart attack risk.
Scientists at Cincinnati Children's Hospital Medical Center have found that inhibiting the protein Cdc42 can reverse the aging of hematopoietic stem cells, restoring their functional efficiency. This breakthrough has significant implications for understanding and combating age-related diseases.
A recent study published in Sports Medicine found that skin problems are a common complaint among Summer Games athletes. Early correct diagnosis is crucial for athletes to participate and compete at their full potential.
Researchers at Karolinska Institutet have made a significant breakthrough in understanding the stratum corneum, the outermost layer of human skin. By determining its molecular structure and function at a detailed level, they aim to develop new methods for drug delivery via the skin.
A newly launched clinical trial at URMC is testing whether lower doses of an established blood pressure medication can provide the same benefits as a standard dose, potentially reducing side effects and costs. The study aims to learn how varying amounts of the medication affect patients with mild hypertension.
A study of Medicare data reveals that surgical treatment for nonmelanoma skin cancer has increased substantially since 2001, primarily due to the growing use of Mohs micrographic surgery (MMS). MMS was more likely performed on lesions on the lip and eyelid, and its use varied by age and region.
Researchers found EPR to be 30-46% better at identifying nonmelanoma skin cancer cases compared to claims data. The study suggests using EPR as an alternative for effectively tracking these cases, potentially improving disease burden estimates.
A study by UCLA's Jonsson Comprehensive Cancer Center found that patients with both MEK1 and BRAF mutations respond equally well to BRAF inhibitor drugs, challenging conventional wisdom. The presence of both mutations does not contribute to drug resistance in melanoma patients.
A new breast cancer susceptibility gene, XRCC2, has been discovered by researchers at the University of Utah Health. The study found that mutations in this gene increase breast cancer risk, providing a new target for chemotherapy and improving diagnostic accuracy.
Researchers developed a novel compound that stops cancer cells from invading healthy brain tissue, improving treatment outcomes in animal models. The compound, imipramine blue, is combined with chemotherapy to enhance its effectiveness.
A recent study published in the Journal of the American Academy of Dermatology found that UV photographs can predict melanoma risk factors in 12-year-olds. The study's results suggest that primary care physicians can use UV photography to provide better sun protection counseling, potentially preventing melanoma cases.
Researchers have designed a new treatment approach that appears to halt the spread of cancer cells into normal brain tissue in animal models. The results show that imipramine blue stops tumor invasion and enhances the efficacy of chemotherapy.
Researchers identified a protein called NOD2 that triggers the activation of dendritic cells, which deliver critical information about the pathogen to T-cells. The study found this pathway to be potent in fighting leprosy, but inhibited in more serious forms of the disease.
Scientists discovered that a prostaglandin called PGD2 and its derivative inhibit hair growth, targeting GPR44 as a promising therapeutic target for androgenetic alopecia. Elevated PGD2 levels were found in the bald scalp tissue of men with male pattern baldness.
Research highlights the importance of proper styling practices for preventing hair and scalp diseases in African-Americans. Dr. Jackson-Richards recommends using natural hair oils and gentle grooming techniques to reduce the risk of conditions like seborrheic dermatitis and alopecia.
A clinical study found that treating psoriasis with adalimumab significantly decreased vascular inflammation, a major risk factor for cardiovascular disease. The study also showed a 51% decrease in C-reactive protein levels among treated patients, compared to a 2% decrease in the control group.
Spanish scientists have confirmed a clear relationship between androgenetic alopecia and benign prostate hyperplasia, with men experiencing premature baldness at higher risk for BPH. The study, published in the Journal of the American Academy of Dermatology, found an association between hormone levels and prostate volume.
A combined therapy of Epiduo Gel containing adapalene and benzoyl peroxide with doxycycline proved more effective in reducing acne lesions compared to other regimens. Patients who received this treatment experienced significant improvement, with 50% reporting nearly clear or cleared acne.
Ingenol mebutate, a new topical gel, is applied for just a few days and shows comparable results to current therapies. The treatment significantly reduces the time needed to treat actinic keratosis, a common precursor to sun-related squamous-cell carcinoma.
Researchers have identified a specific gene linked to throat cancer in a family study. A mutation in the ATR gene was found to be present in all members of the affected family who developed throat cancer.
Researchers at UCLA's Jonsson Comprehensive Cancer Center have uncovered a mechanism by which melanoma becomes resistant to the BRAF inhibitor Zelboraf. By amplifying the mutated BRAF gene, cancer cells can overproduce the drug target protein, rendering the treatment ineffective.
Researchers at Brigham and Women's Hospital discovered memory T cells living in skin that protect against infection and disease. These resident cells are more important for immunity than previously thought and suggest a fundamental shift in how vaccines are designed and delivered.
Researchers found that resident memory T cells in the skin, called TREMs, provide a powerful and effective immune response against infection. This new understanding challenges immunological dogma and suggests a more effective path to immunity through delivering vaccines to upper layers of the skin.
Researchers discovered that leprosy pathogen Mycobacterium leprae manipulates micro-RNs to evade the human immune system, specifically targeting vitamin D-dependent immune pathways. This finding offers new treatment avenues for infectious diseases.